Environmental exposure to methylmercury is associated with a decrease in nitric oxide production

Basic and Clinical Pharmacology and Toxicology

Volumn 106, Issue 5, 2010, Pages 411-415

  De Marco, Kátia Cristina ^a   Passos, Carlos J S ^a   Sertorio, Jonas ^a   Tanus Santos, José Eduardo ^a   Barbosa Jr , Fernando ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

METHYLMERCURY; NITRIC OXIDE; NITRITE;

ADULT; AGED; ARTICLE; BLOOD ANALYSIS; CARDIOVASCULAR RISK; CONTAMINATED FISH; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; FEMALE; HAIR ANALYSIS; HUMAN; MALE; MASS SPECTROMETRY; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; ANIMALS; ENVIRONMENTAL EXPOSURE; FEMALE; FOOD CONTAMINATION; HAIR; HUMANS; MALE; MERCURY; METHYLMERCURY COMPOUNDS; MIDDLE AGED; NITRIC OXIDE; NITRITES; SEAFOOD;

EID: 77951059956     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2009.00519.x     Document Type: Article

References (31)

1. WHO. Environmental Health Criteria 101. Methylmercury. International Program on Chemical Safety. World Health Organization
2. Clarkson TW. The three modern faces of mercury. Environ Health Perspect 2002 110 : 11 23.
3. EPA. Water Quality Criterion for the Protection of Human Health: Methylmercury. Environmental Protection Agency
4. Malm O, Branches FJ, Akagi H, Castro MB, Pfeiffer WC, Harada M et al. Mercury and methylmercury in fish and human hair from the Tapajos river basin, Brazil. Sci Total Environ 1995 175 : 141 150. (Pubitemid 126738360)
5. Harada H, Nakanishi J, Yasoda E, Pinheiro MDN, Oikawa T, Guimarães GD et al. Mercury pollution in the Tapajos River basin, Amazon: mercury level of head hair and health effects. Environ Int 2001 27 : 285 290. (Pubitemid 32998667)
6. Santos ECD, de Jesus IM, Brabo ED, Loureiro ECB, Mascarenhas AFD, Weirich J et al. Mercury exposures in riverside Amazon communities in Para, Brazil. Environ Res 2000 84 : 100 107.
7. Lebel J, Mergler D, Branches F, Lucotte M, Amorim M, Larribe F et al. Neurotoxic effects of low-level methylmercury contamination in the Amazonian Basin. Environ Res 1998 79 : 20 32. (Pubitemid 28433712)
8. Salonen JT, Seppanen K, Nyyssonen K, Korpela H, Kauhanen J, Kantola M et al. Intake of mercury from fish, lipid peroxidation, and the risk of myocardial infarction and coronary, cardiovascular, and any death in eastern Finnish men. Circulation 1995 91 : 645 655.
9. Salonen JT, Seppanen K, Lakka TA, Salonen R, Kaplan GA. Mercury accumulation and accelerated progression of carotid atherosclerosis: a population based prospective 4-year follow-up study in men in eastern Finland. Atherosclerosis 2000 148 : 265 273. (Pubitemid 30064457)
10. Guallar E, Sanz-Gallardo MI, van't Veer P, Bode P, Aro A, Gomez-Aracena J et al. Mercury, fish oils, and the risk of myocardial infarction. N Engl J Med 2002 347 : 1747 1754. (Pubitemid 35375613)
11. Virtanen JK, Voutilainen S, Rissanen TH, Mursu J, Tuomainen TP, Korhonen MJ et al. Mercury, fish oils, and risk of acute coronary events and cardiovascular disease, coronary heart disease, and all-cause mortality in men in eastern Finland. Arterioscler Thromb Vasc Biol 2005 25 : 228 233. (Pubitemid 40054281)
12. Kuo TC, Huang CI, Lin-Shiau SY. Methylmercury inhibits nitric oxide production mediated by Ca(2+) overload and protein kinase A activation. Toxicology 2002 176 : 113 122.
13. Kishimoto T, Oguri T, Tada M. Effect of methylmercury (CH3HgCl) injury on nitric oxide synthase (NOS) activity in cultured human umbilical vascular endothelial cells. Toxicology 1995 103 : 1 7. (Pubitemid 3007079)
14. Jacob-Ferreira A, Passos CJS, Jordao A, Fillion M, Mergler D, Lamire M et al. Mercury exposure increases circulating net matrix metalloproteinase (MMP)-2 and MMP-9 activities. Basic Clin Pharmacol Toxicol 2009 105 : 281 288.
15. Yetik-Anacak G, Catravas JD. Nitric oxide and the endothelium: history and impact on cardiovascular disease. Vascul Pharmacol 2006 45 : 268 276. (Pubitemid 44765289)
16. Kleinbongard P, Dejam A, Lauer T, Rassaf T, Schindler A, Picker O et al. Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals. Free Radic Biol Med 2003 35 : 790 796. (Pubitemid 37329482)
17. Kleinbongard P, Dejam A, Lauer T, Jax T, Kerber S, Gharini P et al. Plasma nitrite concentrations reflect the degree of endothelial dysfunction in humans. Free Radic Biol Med 2006 40 : 295 302. (Pubitemid 43069353)
18. Rodrigues JL, Nunes JA, Batista BL, de Souza SS, Barbosa F Jr. A fast method for the determination of 16 elements in hair samples by inductively coupled plasma mass spectrometry (ICP-MS) with tetramethylammonium hydroxide solubilization at room temperature. J Anal Atom Spectrom 2008 23 : 47 51.
19. Palmer CD, Lewis ME Jr., Geraghty CM, Barbosa F Jr., Parsons PJ. Determination of lead, cadmium and mercury in blood for assessment of environmental exposure: a comparison between inductively coupled plasma-mass spectrometry and atomic absorption spectrometry. Spectrochim Acta, Part B 2006 61 : 980 990.
20. Goulle JP, Mahieu L, Castermant J, Neveu N, Bonneau L, Laine G et al. Metal and metalloid multi-elementary ICP-MS validation in whole blood, plasma, urine and hair. Reference values. Forensic Sci Int 2005 153 : 39 44. (Pubitemid 41008650)
21. Barbosa F Jr., Sartorio J, Gerlach RF, Tanus-Santos JE. Clinical evidence for lead induced inhibition of nitric oxide formation. Arch Toxicol 2006 80 : 811 816.
22. Barbosa F Jr., Sandrim VC, Uzuelli JA, Gerlach RF, Tanus-Santos JE. eNOS genotype-dependent correlation between whole blood lead and plasma nitric oxide products concentrations. Nitric Oxide 2006 14 : 58 64.
23. Barbosa F Jr., Palmer CD, Krug FJ, Parsons PJ. Determination of total mercury in whole blood by flow injection cold vapor atomic absorption spectrometry with room temperature digestion using tetramethylammonium hydroxide. J Anal Atom Spectrom 2004 19 : 1000 1005.
24. NCLLS. Control of Pre-Analytical Variation in Trace Element Determinations; Approved Guideline. National Committee for Clinical Laboratory Standards
25. Wakita Y. Hypertension induced by methyl mercury in rats. Toxicol Appl Pharmacol 1987 89 : 144 147. (Pubitemid 17106665)
26. Fillion M, Mergler D, Passos CJS, Larribe F, Lemire M, Guimarães JRD. A preliminary study of mercury exposure and blood pressure in the Brazilian Amazon. Environ Health 2005 5 : 29 37.
27. Grotto D, Barcelos GM, Garcia SC, Barbosa F. Low level and sub-chronic exposure to methylmercury induces hypertension in rats: nitric oxide depletion and oxidative damage as possible mechanisms. Arch Toxicol 2009 83 : 653 662.
28. Cengel A, Sahinarslan A. Nitric oxide and cardiovascular system. Anadolu Kardiyol Derg 2006 6 : 364 368.
29. Grundy SM, Pasternak R, Greenland P, Smith S Jr., Fuster V. Assessment of cardiovascular risk by use of multiple-risk-factor assessment equations: a statement for healthcare professionals from the American Heart Association and the American College of Cardiology. Circulation 1999 100 : 1481 1492. (Pubitemid 29451714)
30. Chan HM, Egeland GM. Fish consumption, mercury exposure, and heart diseases. Nutr Rev 2004 62 : 68 72.
31. Berglund M, Lind B, Björnberg KA, Palm B, Einarsson O, Vahter M. Inter-individual variations of human mercury exposure biomarkers: a cross-sectional assessment. Environ Health 2005 4 : 20 31.