Costunolide induces lung adenocarcinoma cell line A549 cells apoptosis through ROS (reactive oxygen species)-mediated endoplasmic reticulum stress

Cell Biology International

Volumn 40, Issue 3, 2016, Pages 289-297

  Wang, Zhen ^a   Zhao, Xin ^a   Gong, Xingguo ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Apoptosis; Costunolide; Endoplasmic reticulum stress; Mitochondrial apoptotic pathway; Reactive oxygen species (ROS)

Indexed keywords

CASPASE; COSTUNOLIDE; CYTOCHROME C; INOSITOL REQUIRING ENZYME 1ALPHA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN IRE1; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; ERN1 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; RIBONUCLEASE; SESQUITERPENE; STRESS ACTIVATED PROTEIN KINASE;

A549 CELL LINE; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG STRUCTURE; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; GENE SILENCING; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN PHOSPHORYLATION; UNFOLDED PROTEIN RESPONSE; ADENOCARCINOMA; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; DRUG EFFECTS; GENETICS; LUNG TUMOR; METABOLISM; MITOCHONDRION; PATHOLOGY; PHOSPHORYLATION; RNA INTERFERENCE; TUMOR CELL LINE;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; ENDOPLASMIC RETICULUM STRESS; ENDORIBONUCLEASES; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LUNG NEOPLASMS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; RNA, SMALL INTERFERING; SESQUITERPENES;

EID: 84959047570     PISSN: 10656995     EISSN: 10958355     Source Type: Journal    
DOI: 10.1002/cbin.10564     Document Type: Article

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