Tankyrase 1 inhibitior XAV939 increases chemosensitivity in colon cancer cell lines via inhibition of the Wnt signaling pathway

International Journal of Oncology

Volumn 48, Issue 4, 2016, Pages 1333-1340

  Wu, Xuefang ^a   Luo, Feng ^a   Li, Jinbang ^a   Zhong, Xueyun ^b   Liu, Kunping ^a  

^a JINAN UNIVERSITY   (China)

^b MEDICAL COLLEGE OF JINAN UNIVERSITY   (China)

Author keywords

cancer stem cells; colorectal cancer; drug resistance; WNT signaling pathway; XAV939

Indexed keywords

7,8 DIHYDRO 2 [4 (TRIFLUOROMETHYL)PHENYL] 5H THIOPYRANO[4,3 D]PYRIMIDIN 4 OL; AXIN; BETA CATENIN; CD133 ANTIGEN; CISPLATIN; DCAMKL 1 PROTEIN; EPITHELIAL CELL ADHESION MOLECULE; FLUOROURACIL; TANKYRASE; TELOMERASE REVERSE TRANSCRIPTASE; TUMOR MARKER; UNCLASSIFIED DRUG; WNT PROTEIN; FUSED HETEROCYCLIC RINGS; TNKS PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CANCER CELL LINE; CANCER STEM CELL; CELL CYCLE PROGRESSION; CHEMOSENSITIVITY; COLON CANCER; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; DRUG TARGETING; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; WESTERN BLOTTING; WNT SIGNALING PATHWAY; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL PROLIFERATION; COLONIC NEOPLASMS; DRUG EFFECTS; DRUG RESISTANCE; GENE EXPRESSION REGULATION; GENETICS; PATHOLOGY; TUMOR CELL LINE;

APOPTOSIS; AXIN PROTEIN; BETA CATENIN; CELL LINE, TUMOR; CELL PROLIFERATION; CISPLATIN; COLONIC NEOPLASMS; DRUG RESISTANCE, NEOPLASM; FLUOROURACIL; GENE EXPRESSION REGULATION, NEOPLASTIC; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; NEOPLASTIC STEM CELLS; TANKYRASES; WNT SIGNALING PATHWAY;

EID: 84959036826     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2016.3360     Document Type: Article

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