Analysis of B Cell Repertoire Dynamics Following Hepatitis B Vaccination in Humans, and Enrichment of Vaccine-specific Antibody Sequences

EBioMedicine

Volumn 2, Issue 12, 2015, Pages 2070-2079

  Galson, Jacob D ^a,b   Trück, Johannes ^a,f   Fowler, Anna ^b   Clutterbuck, Elizabeth A ^a   Münz, Márton ^b   Cerundolo, Vincenzo ^c   Reinhard, Claudia ^d   van der Most, Robbert ^e   Pollard, Andrew J ^a   Lunter, Gerton ^b   Kelly, Dominic F ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e MILTENYI BIOTEC GMBH   (Germany)

^f GSK   (Belgium)

Author keywords

B cell repertoire; Immunoglobulin repertoire; MAbs; Vaccination

Indexed keywords

HEPATITIS B VACCINE; TETANUS TOXOID; HEPATITIS B ANTIBODY; IMMUNOGLOBULIN CLASS;

ADULT; ANTIBODY SPECIFICITY; ARTICLE; B LYMPHOCYTE; BIOINFORMATICS; CELL EXPANSION; CELL ISOLATION; CLUSTER ANALYSIS; ENZYME LINKED IMMUNOSPOT ASSAY; FLUORESCENCE ACTIVATED CELL SORTING; GENE MUTATION; GENETIC VARIABILITY; HEPATITIS B; HIGH THROUGHPUT SEQUENCING; HUMAN; IMMUNE RESPONSE; IMMUNOGENICITY; MOLECULAR DYNAMICS; MULTIPLEX POLYMERASE CHAIN REACTION; NORMAL HUMAN; PRIORITY JOURNAL; RNA EXTRACTION; RNA SEQUENCE; SEQUENCE ANALYSIS; VACCINATION; VACCINATION REACTION; BIOLOGY; DNA SEQUENCE; GENETIC DATABASE; GENETICS; HEPATITIS B VIRUS; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; LYMPHOCYTE COUNT; METABOLISM; MIDDLE AGED; PLASMA CELL; PROCEDURES; TIME FACTOR; YOUNG ADULT;

ADULT; ANTIBODY SPECIFICITY; B-LYMPHOCYTE SUBSETS; COMPUTATIONAL BIOLOGY; DATABASES, GENETIC; HEPATITIS B; HEPATITIS B ANTIBODIES; HEPATITIS B VACCINES; HEPATITIS B VIRUS; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; IMMUNOGLOBULIN ISOTYPES; IMMUNOLOGIC MEMORY; LYMPHOCYTE COUNT; MIDDLE AGED; PLASMA CELLS; SEQUENCE ANALYSIS, DNA; TIME FACTORS; VACCINATION; YOUNG ADULT;

EID: 84958968963     PISSN: None     EISSN: 23523964     Source Type: Journal    
DOI: 10.1016/j.ebiom.2015.11.034     Document Type: Article

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