Reservoir expansion by T-cell proliferationmay be another barrier to curing HIV infection

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 7, 2016, Pages 1692-1694

  Kim, Michelle ^a   Siliciano, Robert F ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

REPETITIVE DNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR BACH2; TRANSCRIPTION FACTOR MKL2; UNCLASSIFIED DRUG; VIRUS DNA; VPR PROTEIN;

CELL CYCLE ARREST; CELL EXPANSION; CLONAL EXPANSION; GENE EXPRESSION; HALF LIFE TIME; HOMEOSTASIS; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; LYMPHOCYTE PROLIFERATION; NONHUMAN; NOTE; PRIORITY JOURNAL; PROVIRUS; T LYMPHOCYTE; UPREGULATION; VIREMIA; VIRUS GENOME; VIRUS LATENCY; VIRUS REPLICATION; CD4+ T LYMPHOCYTE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; PHYSIOLOGY; VIROLOGY;

CD4-POSITIVE T-LYMPHOCYTES; HIV-1; HUMANS; VIRUS REPLICATION;

EID: 84958960400     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1600097113     Document Type: Note

References (20)

1. Finzi D, et al. (1999) Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nat Med 5(5): 512-517.
2. Crooks AM, et al. (2015) Precise quantitation of the latent HIV-1 reservoir: Implications for eradication strategies. J Infect Dis 212(9): 1361-1365.
3. Simonetti FR, et al. (2016) Clonally expanded CD4+ T cells can produce infectious HIV-1 in vivo. Proc Natl Acad Sci USA 113: 1883-1888.
4. Günthard HF, et al.; International Antiviral Society-USA Panel (2014) Antiretroviral treatment of adult HIV infection: 2014 recommendations of the International Antiviral Society-USA Panel. JAMA 312(4): 410-425.
5. Maldarelli F, et al. (2014) HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science 345(6193): 179-183.
6. Wagner TA, et al. (2014) HIV latency. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science 345(6196): 570-573.
7. Cohn LB, et al. (2015) HIV-1 integration landscape during latent and active infection. Cell 160(3): 420-432.
8. Seddon B, Tomlinson P, Zamoyska R (2003) Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells. Nat Immunol 4(7): 680-686.
9. Perelson AS, et al. (1997) Decay characteristics of HIV-1-infected compartments during combination therapy. Nature 387(6629): 188-191.
10. Wei X, et al. (1995) Viral dynamics in human immunodeficiency virus type 1 infection. Nature 373(6510): 117-122.
11. Planelles V, et al. (1995) Fate of the human immunodeficiency virus type 1 provirus in infected cells: A role for vpr. J Virol 69(9): 5883-5889.
12. Bosque A, Planelles V (2009) Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells. Blood 113(1): 58-65.
13. Tobin NH, et al. (2005) Evidence that low-level viremias during effective highly active antiretroviral therapy result from two processes: Expression of archival virus and replication of virus. J Virol 79(15): 9625-9634.
14. Bailey JR, et al. (2006) Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating CD4+ T cells. J Virol 80(13): 6441-6457.
15. Dinoso JB, et al. (2009) Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy. Proc Natl Acad Sci USA 106(23): 9403-9408.
16. Schröder AR, et al. (2002) HIV-1 integration in the human genome favors active genes and local hotspots. Cell 110(4): 521-529.
17. Han Y, et al. (2004) Resting CD4+ T cells from human immunodeficiency virus type 1 (HIV-1)-infected individuals carry integrated HIV-1 genomes within actively transcribed host genes. J Virol 78(12): 6122-6133.
18. Kobayashi S, et al. (2011) Identification of IGHCd-BACH2 fusion transcripts resulting from cryptic chromosomal rearrangements of 14q32 with 6q15 in aggressive B-cell lymphoma/leukemia. Genes Chromosomes Cancer 50(4): 207-216.
19. Muehlich S, et al. (2012) The transcriptional coactivators megakaryoblastic leukemia 1/2 mediate the effects of loss of the tumor suppressor deleted in liver cancer 1. Oncogene 31(35): 3913-3923.
20. Ho YC, et al. (2013) Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure. Cell 155(3): 540-551.