Identification of IGHCδ-BACH2 fusion transcripts resulting from cryptic chromosomal rearrangements of 14q32 with 6q15 in aggressive B-cell lymphoma/leukemia

Genes Chromosomes and Cancer

Volumn 50, Issue 4, 2011, Pages 207-216

  Kobayashi, Satoru ^a   Taki, Tomohiko ^a   Chinen, Yoshiaki ^a   Tsutsumi, Yasuhiko ^a   Ohshiro, Muneo ^a   Kobayashi, Tsutomu ^a   Matsumoto, Yosuke ^a   Kuroda, Junya ^a   Horiike, Shigeo ^a   Nishida, Kazuhiro ^a   Taniwaki, Masafumi ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; TRANSCRIPTION FACTOR;

5' UNTRANSLATED REGION; AGED; ARTICLE; B CELL LEUKEMIA; B CELL LYMPHOMA; CHROMOSOME 14Q; CHROMOSOME 6Q; CHROMOSOME BREAKAGE; CHROMOSOME REARRANGEMENT; DNA MICROARRAY; FLUORESCENCE IN SITU HYBRIDIZATION; FOLLICULAR LYMPHOMA; GENE LOCUS; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MALE; NONHODGKIN LYMPHOMA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

AGED; B-LYMPHOCYTES; BASE SEQUENCE; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; CHROMOSOME BREAKPOINTS; CHROMOSOMES, HUMAN, PAIR 14; CHROMOSOMES, HUMAN, PAIR 6; DNA, NEOPLASM; GENE EXPRESSION REGULATION, LEUKEMIC; GENE FUSION; GENES, MYC; HUMANS; IMMUNOGLOBULIN DELTA-CHAINS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA; LYMPHOMA, B-CELL; MALE; MOLECULAR SEQUENCE DATA; SEQUENCE ANALYSIS, DNA; TRANSLOCATION, GENETIC;

EID: 79851507338     PISSN: 10452257     EISSN: 10982264     Source Type: Journal    
DOI: 10.1002/gcc.20845     Document Type: Article

References (36)

1. Akasaka T, Muramatsu M, Ohno H, Miura I, Tatsumi E, Fukuhara S, Mori T, Okuma M. 1996. Application of long-distance polymerase chain reaction to detection of junctional sequences created by chromosomal translocation in mature B-cell neoplasms. Blood 8: 985-994.
2. Akasaka T, Akasaka H, Ueda C, Yonetani N, Maesako Y, Shimizu A, Yamabe H, Fukuhara S, Uchiyama T, Ohno H. 2000. Molecular and clinical features of non-Burkitt's, diffuse large-cell lymphoma of B-cell type associated with the c-MYC/immunoglobulin heavy-chain fusion gene. J Clin Oncol 18: 510-518.
3. Blanco JG, Edick MJ, Relling MV. 2004. Etoposide induces chimeric Mll gene fusions. FASEB J 18: 173-175.
4. Boerma EG, Siebert R, Kluin PM, Baudis M. 2009. Translocations involving 8q24 in Burkitt lymphoma and other malignant lymphomas: A historical review of cytogenetics in the light of todays knowledge. Leukemia 23: 225-234.
5. Chesi M, Nardini E, Lim RS, Smith KD, Kuehl WM, Bergsagel PL. 1998. The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts. Blood 92: 3025-3034.
6. Chinen Y, Taki T, Nishida K, Shimizu D, Okuda T, Yoshida N, Kobayashi C, Koike K, Tsuchida M, Hayashi Y, Taniwaki M. 2008. Identification of the novel AML1 fusion partner gene, LAF4, a fusion partner of MLL, in childhood T-cell acute lymphoblastic leukemia with t(2;21)(q11;q22) by bubble PCR method for cDNA. Oncogene 27: 2249-2256.
7. Dyer MJ, Lillington DM, Bastard C, Tilly H, Lens D, Heward JM, Stranks G, Morilla R, Monrad S, Guglielmi P, Kluin-Nelemans JC, Hagemeijer A, Young BD, Catovsky D. 1996. Concurrent activation of MYC and BCL2 in B cell non-Hodgkin lymphoma cell lines by translocation of both oncogenes to the same immunoglobulin heavy chain locus. Leukemia 10: 1198-1208.
8. Guikema JE, Schuuring E, Kluin PM. 2008. Structure and consequences of IGH switch breakpoints in Burkitt lymphoma. J Natl Cancer Inst Monogr 39: 32-36.
9. Hatzivassiliou G, Miller I, Takizawa J, Palanisamy N, Rao PH, Iida S, Tagawa S, Taniwaki M, Russo J, Neri A, Cattoretti G, Clynes R, Mendelsohn C, Chaganti RS, Dalla-Favera R. 2001. IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy. Immunity 14: 277-289.
10. Hayama M, Niitsu N, Higashihara M, Nakamine H, Miura I. 2007. t(6;14)(q15;q32) in a patient with CD5+CD10+ diffuse large B-cell lymphoma. Int J Hematol 86: 147-149.
11. Hu XT, Chen YW, Liang AC, Au WY, Wong KY, Wan TS, Wong ML, Shen L, Chan KK, Guo T, Chu KM, Tao Q, Chim CS, Loong F, Choi WW, Lu L, So CC, Chan LC, Kwong YL, Liang RH, Srivastava G. 2010. CD44 activation in mature B-cell malignancies by a novel recurrent IGH translocation. Blood 115: 2458-2461.
12. ISCN. 2009. In: Shaffer LG, Slovak ML, Campbell LJ, editors. An International System for Human Cytogenetic Nomenclature. Basel: S. Karger.
13. Iwakawa M, Goto M, Noda S, Sagara M, Yamada S, Yamamoto N, Kawakami Y, Matsui Y, Miyazawa Y, Yamazaki H, Tsuji H, Ohno T, Mizoe J, Tsujii H, Imai T. 2005. DNA repair capacity measured by high throughput alkaline comet assays in EBV-transformed cell lines and peripheral blood cells from cancer patients and healthy volunteers. Mutat Res 588: 1-6.
14. Johnson NA, Savage KJ, Ludkovski O, Ben-Neriah S, Woods R, Steidl C, Dyer MJ, Siebert R, Kuruvilla J, Klasa R, Connors JM, Gascoyne RD, Horsman DE. 2009. Lymphomas with concurrent BCL2 and MYC translocations: The critical factors associated with survival. Blood 114: 2273-2279.
15. Kanda-Akano Y, Nomura K, Fujita Y, Horiike S, Nishida K, Nagai M, Miura I, Nakamura S, Seto M, Iida S, Ueda R, Taniwaki M. 2004. Molecular-cytogenetic characterization of non-Hodgkin's lymphoma with double and cryptic translocations of the immunoglobulin heavy chain gene. Leuk Lymphoma 45: 1559-1567.
16. Kanungo A, Medeiros LJ, Abruzzo LV, Lin P. 2006. Lymphoid neoplasms associated with concurrent t(14;18) and 8q24/c-MYC translocation generally have a poor prognosis. Mod Pathol 19: 25-33.
17. Kluin PM, Harris NL, Stein H, Leoncini L, Raphael M, Campo E, Jaffe ES. 2008. B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW, editors.WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th ed. Lyon, France: IARC, Vol. 10, pp. 265-266.
18. Kramer MH, Hermans J, Wijburg E, Philippo K, Geelen E, van Krieken JH, de Jong D, Maartense E, Schuuring E, Kluin PM. 1998. Clinical relevance of BCL2, BCL6, and MYC rearrangements in diffuse large B-cell lymphoma. Blood 92: 3152-3162.
19. Kuppers R, Dalla-Favera R. 2001. Mechanisms of chromosomal translocations in B cell lymphomas. Oncogene 20: 5580-5594.
20. Lossos IS. 2005. Molecular pathogenesis of diffuse large B-cell lymphoma. J Clin Oncol 23: 6351-6357.
21. McBlane JF, van Gent DC, Ramsden DA, Romeo C, Cuomo CA, Gellert M, Oettinger MA. 1995. Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps. Cell 83: 387-395.
22. Muto A, Tashiro S, Nakajima O, Hoshino H, Takahashi S, Sakoda E, Ikebe D, Yamamoto M, Igarashi K. 2004. The transcriptional programme of antibody class switching involves the repressor Bach2. Nature 429: 566-571.
23. Nagel I, Akasaka T, Klapper W, Gesk S, Böttcher S, Ritgen M, Harder L, Kneba M, Dyer MJ, Siebert R. 2009. Identification of the gene encoding cyclin E1 (CCNE1) as a novel IGH translocation partner in t(14;19)(q32;q12) in diffuse large B-cell lymphoma. Haematologica 94: 1020-1023.
24. Nannya Y, Sanada M, Nakazaki K, Hosoya N, Wang L, Hangaishi A, Kurokawa M, Chiba S, Bailey DK, Kennedy GC, Ogawa S. 2005. A robust algorithm for copy number detection using high-density oligonucleotide single nucleotide polymorphism genotyping arrays. Cancer Res 65: 6071-6079.
25. Niitsu N, Okamoto M, Miura I, Hirano M. 2009. Clinical features and prognosis of de novo diffuse large B-cell lymphoma with t(14;18) and 8q24/c-MYC translocations. Leukemia 23: 777-783.
26. Ochiai K, Muto A, Tanaka H, Takahashi S, Igarashi K. 2008. Regulation of the plasma cell transcription factor Blimp-1 gene by Bach2 and Bcl6. Int Immunol 20: 453-460.
27. Pasqualucci L, Compagno M, Houldsworth J, Monti S, Grunn A, Nandula SV, Aster JC, Murty VV, Shipp MA, Dalla-Favera R. 2006. Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma. J Exp Med 203: 311-317.
28. Robbiani DF, Bothmer A, Callen E, Reina-San-Martin B, Dorsett Y, Difilippantonio S, Bolland DJ, Chen HT, Corcoran AE, Nussenzweig A, Nussenzweig MC. 2008. AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations. Cell 135: 1028-1038.
29. Robbiani DF, Bunting S, Feldhahn N, Bothmer A, Camps J, Deroubaix S, McBride KM, Klein IA, Stone G, Eisenreich TR, Ried T, Nussenzweig A, Nussenzweig MC. 2009. AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations. Mol Cell 36: 631-641.
30. Rogozin IB, Kolchanov NA. 1992. Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis. Biochim Biophys Acta 1171: 11-18.
31. Sasaki S, Ito E, Toki T, Maekawa T, Kanezaki R, Umenai T, Muto A, Nagai H, Kinoshita T, Yamamoto M, Inazawa J, Taketo MM, Nakahata T, Igarashi K, Yokoyama M. 2000. Cloning and expression of human B cell-specific transcription factor BACH2 mapped to chromosome 6q15. Oncogene 19: 3739-3749.
32. Spitzner JR, Muller MT. 1988. A consensus sequence for cleavage by vertebrate DNA topoisomerase II. Nucleic Acids Res 16: 5533-5556.
33. Stamatoullas A, Buchonnet G, Lepretre S, Lenain P, Lenormand B, Duval C, Callat MP, Gaulard P, Bastard C, Tilly H. 2000. De novo acute B cell leukemia/lymphoma with t(14;18). Leukemia 14: 1960-1966.
34. Taniwaki M, Nishida K, Ueda Y, Misawa S, Nagai M, Tagawa S, Yamagami T, Sugiyama H, Abe M, Fukuhara S. 1995. Interphase and metaphase detection of the breakpoint of 14q32 translocations in B-cell malignancies by double-color fluorescence in situ hybridization. Blood 85: 3223-3228.
35. Tirier C, Zhang Y, Plendl H, Weber-Matthiesen K, Langer W, Heit W, Schlegelberger B. 1996. Simultaneous presence of t(11;14) and a variant Burkitt's translocation in the terminal phase of a mantle cell lymphoma. Leukemia 10: 346-350.
36. Willis TG, Dyer MJ. 2000. The role of immunoglobulin translocations in the pathogenesis of B-cell malignancies. Blood 96: 808-822.