Long-term retention of pristine multi-walled carbon nanotubes in rat lungs after intratracheal instillation

Journal of Applied Toxicology

Volumn 36, Issue 4, 2016, Pages 501-509

  Shinohara, Naohide ^a   Nakazato, Tetsuya ^a   Ohkawa, Kumiko ^a   Tamura, Moritaka ^a   Kobayashi, Norihiro ^a,b   Morimoto, Yasuo ^c   Oyabu, Takako ^c   Myojo, Toshihiko ^c   Shimada, Manabu ^d   Yamamoto, Kazuhiro ^a   Tao, Hiroaki ^a   Ema, Makoto ^a   Naya, Masato ^a,e   Nakanishi, Junko ^a  

^a NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^c UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^d HIROSHIMA UNIVERSITY   (Japan)

^e BioSafety Research Center (BSRC)   (Japan)

Author keywords

Intratracheal instillation; Multi walled carbon nanotube; Nanomaterial; Pulmonary clearance; Toxicokinetics

Indexed keywords

KETOCONAZOLE; MULTI WALLED NANOTUBE; OCTOXINOL; CARBON NANOTUBE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MOTION; COMBUSTION; CONTROLLED STUDY; DIGESTION; DISPERSION; DRUG INSTILLATION; DRUG RETENTION; HEAT; INFRARED RADIATION; INTRATRACHEAL DRUG ADMINISTRATION; LUNG ALVEOLUS MACROPHAGE; LUNG CLEARANCE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; BRAIN; CHEMISTRY; DOSE RESPONSE; INHALATIONAL DRUG ADMINISTRATION; LIMIT OF DETECTION; LIVER; LUNG; METABOLISM; WISTAR RAT;

ADMINISTRATION, INHALATION; ANIMALS; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; LIMIT OF DETECTION; LIVER; LUNG; MACROPHAGES, ALVEOLAR; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; NANOTUBES, CARBON; RATS; RATS, WISTAR;

EID: 84958875298     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.3271     Document Type: Article

References (53)

1. Akiyama I, Ogami A, Oyabu T, Yamato H, Morimoto Y, Tanaka I. 2007. Pulmonary effects and biopersistence of deposited silicon carbide whisker after 1-year inhalation in rats. Inhal. Toxicol. 19: 141-147.
2. Allen TM, Cullis PR. 2004. Drug delivery systems: entering the mainstream. Science 303: 1818-1822.
3. Boncel S, Muller KH, Skepper JN, Walczak KZ, Koziol KKK. 2011. Tunable chemistry and morphology of multi-wall carbon nanotubes as a route to non-toxic, theranostic systems. Biomaterials 32(30): 7677-7686.
4. Brain JD, Knudson DE, Sorokin SP, Davis MA. 1976. Pulmonary distribution of particles given by intratracheal instillation or by aerosol inhalation. Environ. Res. 11(1): 13-33.
5. Chen B, Liu Y, Song WM, Hayashi Y, Ding XC, Li WH. 2011. In vitro evaluation of cytotoxicity and oxidative stress induced by multiwalled carbon nanotubes in murine RAW 264.7 macrophages and human A549 lung cells. Biomed. Environ. Sci. 24(6): 593-601.
6. Cheng C, Muller KH, Koziol KKK, Skepper JN, Midgley PA, Welland ME, Porter AE. 2009. Toxicity and imaging of multi-walled carbon nanotubes in human macrophage cells. Biomaterials 30(25): 4152-4160.
7. 14C-radiolabeling and tissue radioimaging. ACS Nano 8: 5715-5724.
8. De Jong WH, Hagens WI, Krystek P, Burger MC, Sips AJAM, Geertsma RE. 2008. Particle size-dependent organ distribution of gold nanoparticles after intravenous administration. Biomaterials 29: 1912-1919.
9. Deng X et al. 2007. Translocation and fate of multi-walled carbon nanotubes in vivo. Carbon 45(7): 1419-1424.
10. Donaldson K, Murphy FA, Duffin R, Poland CA. 2010. Asbestos, carbon nanotubes and the pleural mesothelium: a review of the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma. Part Fibre Toxicol 7: 5.
11. Fraczek-Szczypta A, Menaszek E, Stanislaw B. 2011. Some observations on carbon nanotubes susceptibility to cell phagocytosis. J. Nanomater. 473516: 1-8.
12. Hesterberg TW, Hart GA. 2000. Lung biopersistence and in vitro dissolution rate predict the pathogenic potential of synthetic vitreous fibers. Inhalation Toxicology 12: 91-97.
13. Hiraiwa Y, Uchida A, Yoshida H. 1960. Reproduction and Anatomy of Rat. Nakayama Shoten Co. Ltd., Tokyo, Japan. [in Japanease]
14. Hirano S, Kanno S, Furuyama A. 2008. Multi-walled carbon nanotubes injure the plasma membrane of macrophages. Toxicol. App. Pharmacol. 232(2): 244-251.
15. Hirano S, Fujitani Y, Furuyama A, Kanno S. 2010. Uptake and cytotoxic effects of multi-walled carbon nanotubes in human bronchial epithelial cells. Toxicol. App. Pharmacol. 249(1): 8-15.
16. Huang YW, Wu C, Aronstam RS. 2010. Toxicity of transition metal oxide nanoparticles: recent insights from in vitro studies. Materials 3: 4842-4859.
17. IARC. 2002. Man-made vitreous fibres. IARC Monographs on the Evaluation of Carcinogenic Risk to Humans. Vol. 81, International Agency for Research on Cancer (IARC), Lyon, France.
18. Javey A, Guo J, Wang Q, Lundstrom M, Dai H. 2003. Ballistic carbon nanotube field-effect transistors. Nature 424: 654-657.
19. Jia G, Wang HF, Yan L, Wang X, Pei RJ, Yan T, Zhao YL, Guo XB. 2005. Cytotoxicity of carbon nanomaterials: Single-wall nanotube, multi-wall nanotube, and fullerene. Environ. Sci. Tech. 39(5): 1378-1383.
20. Kam NW, O'Connell M, Wisdom JA, Dai H. 2005. Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction. Proct. Natl. Acad. Sci. USA 102(33): 11600-11605.
21. 2 particles of different sizes and agglomerations in rats: Different short- and long-term post-instillation results. Toxicology 264(1-2): 110-118.
22. Kobayashi N et al. 2010. Biological response and morphological assessment of individually dispersed multi-wall carbon nanotubes in the lung after intratracheal instillation in rats. Toxicology 276(3): 143-153.
23. Kouno K; Ito R, Sakamoto H. 2006. Anatomical Science. Ishiyaku Pub, Inc., Tokyo, Japan. [in Japanease]
24. Leeuw TK et al. 2007. Single-walled carbon nanotubes in the intact organism: near-IR imaging and biocompatibility studies in Drosophila. Nano Lett. 7(9): 2650-2654.
25. Li JG et al. 2007. Comparative study of pathological lesions induced by multiwalled carbon nanotubes in lungs of mice by intratracheal instillation and inhalation. Environ. Toxicol. 22(4): 415-421.
26. Lightowler NM, Williams JR. 1969. Tracheal mucus flow rates in experimental bronchitis in rats. Brit. J. Exp. Pathol. 50: 139-149.
27. Liu Z et al. 2007. In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice. Nat. Nanotechnol. 2(1): 47-52.
28. Liu Z et al. 2008. Drug delivery with carbon nanotubes for in vivo cancer treatment. Cancer. Res. 68(16): 6652-6660.
29. Luo M, Deng XY, Shen XZ, Dong L, Liu YF. 2012. Comparison of cytotoxicity of pristine and covalently functionalized multi-walled carbon nanotubes in RAW 264.7 macrophages. J. Nanosci. Nanotech. 12(1): 274-283.
30. Ma-Hock L et al. 2009. Inhalation toxicity of multiwall carbon nanotubes in rats exposed for 3 months. Toxicol. Sci. 112(2): 468-481.
31. Marquis BJ, Love SA, Braun KL, Haynes CL. 2009. Analytical methods to assess nanoparticle toxicity. Analyst 134(3): 425-439.
32. Mercer RR et al. 2013. Extrapulmonary transport of MWCNT following inhalation exposure. Part. Fibre. Toxicol. 10: 38.43.
33. Mills NL, Amin N, Robinson SD, Anand A, Davies J, Patel D, de la Fuente JM, Cassee FR, Boon NA, MacNee W, Millar AM, Donaldson K, Newby DE. 2006. Do inhaled carbon nanoparticles translocate directly into the circulation in humans? AM. J. Respir. Crit. Care. Med. 173(4): 426-431.
34. Mitchell LA et al. 2007. Pulmonary and systemic immune response to inhaled multiwalled carbon nanotubes. Toxicol. Sci. 100(1): 203-214.
35. Morimoto Y. 2005. Inhalation Toxicity Assessment of Carbon-Based Nanoparticles. Acc. Chem. Res. 46(3): 770-781.
36. Morimoto Y et al. 2012. Pulmonary toxicity of well-dispersed multi-wall carbon nanotubes following inhalation and intratracheal instillation. Nanotoxicology 6(6): 587-599.
37. Muller J et al. 2005. Respiratory toxicity of multi-wall carbon nanotubes. Toxicol. Appl. Pharmacol. 207(3): 221-231.
38. Muller J et al. 2009. Absence of carcinogenic response to multiwall carbon nanotubes in a 2-year bioassay in the peritoneal cavity of the rat. Toxicol. Sci. 110(2): 442-448.
39. Nagai H et al. 2011. Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis. Proct. Natl. Acad. Sci. USA 108(49): E1330-E1338.
40. Nakanishi J (ed.) 2011. Risk Assessment of Manufactured Nanomaterials: Carbon Nanotubes (CNT). Final report issued on August 17, 2011. NEDO project (P06041) "Research and Development of Nanoparticle Characterization Methods."
41. 2: effect of primary particle size and agglomeration state. Part. Fibre Toxicol. 10: 48.
42. Ohnishi M, Yajima H, Kasai T, Umeda Y, Yamamoto M, Yamamoto S, Okuda H, Suzuki M, Nishizawa T, Fukushima S. 2013. Novel method using hybrid markers: development of an approach for pulmonary measurement of multi-walled carbon nanotubes. J. Occup. Med. Toxicol. 8: 30.
43. Oyabu T et al. 2011. Biopersistence of inhaled MWCNT in rat lungs in a 4-week well-characterized exposure. Inhal. Toxicol. 23(13): 784-791.
44. Palomaki J, Valimaki E, Sund J, Vippola M, Clausen PA, Jensen KA, Savolainen K, Matikainen S, Alenius H. 2011. Long, needle-like carbon nanotubes and asbestos activate the NLRP3 inflammasome through a similar mechanism. ACS Nano 5(9): 6861-6870.
45. Pauluhn J. 2010. Subchronic 13-week inhalation exposure of rats to multiwalled carbon nanotubes: toxic effects are determined by density of agglomerate structures, not fibrillar structures. Toxicol. Sci. 113(1): 226-242.
46. Poland CA et al. 2008. Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. Nat. Nanotechnol. 3(7): 423-428.
47. Searl A et al. 1999. Biopersistence and durability of nine mineral fibre types in rat lungs over 12 months. Ann. Occup. Hyg. 43(3): 143-153.
48. 60 exposure. Toxicol. Sci. 118(2): 564-573.
49. Silva RM, Doudrick K, Franzi LM, Teesy C, Anderson DS, Wu ZQ, Mitra S, Vu V, Dutrow G, Evans JE. 2014. Instillation versus inhalation of multiwalled varbon nanotubes: exposure-related health effects, clearance, and the role of particle characteristics. ACS Nano 8(9): 8911-8931.
50. Tamura M et al. 2011. A determination method of pristine multiwall carbon nanotubes in rat lungs after intratracheal instillation exposure by combustive oxidation-nondispersive infrared analysis. Talanta 84(3): 802-808.
51. Wick P, Manser P, Limbach LK, Dettlaff-Weglikowska U, Krumeich F, Roth S, Stark WJ, Bruinink A. 2007. The degree and kind of agglomeration affect carbon nanotube cytotoxicity. Toxicol. Lett. 168: 121-131.
52. Yeh HC, Schum GM, Duggan MT. 1979. Anatomic models of the tracheobronchial and pulmonary regions of the rat. Anat. Rec. 195: 483-492.
53. Zhang T, Tang M, Kong L, Li H, Zhang T, Zhang SS, Xue YY, Pu YP. 2012. Comparison of cytotoxic and inflammatory responses of pristine and functionalized multi-walled carbon nanotubes in RAW 264.7 mouse macrophages. J. Hazard. Mater. 219: 203-212.