Tear Fluid SIgA as a Noninvasive Biomarker of Mucosal Immunity and Common Cold Risk

Medicine and Science in Sports and Exercise

Volumn 48, Issue 3, 2016, Pages 569-577

  Hanstock, Helen G ^a   Walsh, Neil P ^a   Edwards, Jason P ^a   Fortes, Matthew B ^a   Cosby, Sara L ^b   Nugent, Aaron ^b   Curran, Tanya ^c   Coyle, Peter V ^c   Ward, Mark D ^a   Yong, Xin Hui Aw ^a  

^a BANGOR UNIVERSITY   (United Kingdom)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^c ROYAL VICTORIA HOSPITAL   (United Kingdom)

Author keywords

CONTACT LENS; DEHYDRATION; EXERCISE; IMMUNE; INFECTION; STRESS

Indexed keywords

BIOLOGICAL MARKER; SECRETORY IMMUNOGLOBULIN;

ADOLESCENT; ADULT; CHEMISTRY; COMMON COLD; CONTROLLED STUDY; CROSSOVER PROCEDURE; DEHYDRATION; EXERCISE; EXERCISE TEST; FEMALE; HUMAN; LACRIMAL FLUID; MALE; MUCOSAL IMMUNITY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; SALIVA; YOUNG ADULT;

ADOLESCENT; ADULT; BIOMARKERS; COMMON COLD; CROSS-OVER STUDIES; DEHYDRATION; EXERCISE; EXERCISE TEST; FEMALE; HUMANS; IMMUNITY, MUCOSAL; IMMUNOGLOBULIN A, SECRETORY; MALE; PROSPECTIVE STUDIES; RISK FACTORS; SALIVA; TEARS; YOUNG ADULT;

EID: 84958871575     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/MSS.0000000000000801     Document Type: Article

References (45)

1. Arruda E, Pitkäranta A, Witek TJ Jr, Doyle CA, Hayden FG,. Frequency and natural history of rhinovirus infections in adults during autumn. J Clin Microbiol. 1997; 35 (11): 2864-8.
2. Belser JA, Wadford DA, Xu J, Katz JM, Tumpey TM,. Ocular infection of mice with Influenza A (H7) viruses: a site of primary replication and spread to the respiratory tract. J Virol. 2009; 83 (14): 7075-84.
3. Bennet KR, Reade PC,. Salivary immunoglobulin A levels in normal subjects, tobacco smokers, and patients with minor aphthous ulceration. Oral Surg Oral Med Oral Pathol. 1982; 53 (5): 461-5.
4. Bischoff WE, Reid T, Russell GB, Peters TR,. Transocular entry of seasonal influenza-attenuated virus aerosols and the efficacy of N95 respirators, surgical masks, and eye protection in humans. J Infect Dis. 2011; 204 (2): 193-9.
5. Bishop NC, Blannin AK, Armstrong E, Rickman M, Gleeson M,. Carbohydrate and fluid intake affect the saliva flow rate and IgA response to cycling. Med Sci Sports Exerc. 2000; 32 (12): 2046-51.
6. Bitko V, Musiyenko A, Barik S,. Viral infection of the lungs through the eye. J Virol. 2007; 81 (2): 783-90.
7. Blannin AK, Robson PJ, Walsh NP, Clark AM, Glennon L, Gleeson M,. The effect of exercising to exhaustion at different intensities on saliva immunoglobulin A, protein and electrolyte secretion. Int J Sports Med. 1998; 19 (8): 547-52.
8. Brandtzaeg P,. Secretory immunity with special reference to the oral cavity. J Oral Microbiol. 2013; 5.
9. Carins J, Booth C,. Salivary immunoglobulin-A as a marker of stress during strenuous physical training. Aviat Space Environ Med. 2002; 73 (12): 1203-7.
10. Clow A, Hucklebridge F,. The impact of psychological stress on immune function in the athletic population. Exerc Immunol Rev. 2001; 7: 5-17.
11. Cope JR, Collier SA, Rao MM, Contact lens wearer demographics and risk behaviors for contact lens-related eye infections-United States, 2014. MMWR Morb Mortal Wkly Rep. 2015; 64 (32): 865-70.
12. Cox AJ, Gleeson M, Pyne DB, Callister R, Hopkins WG, Fricker PA,. Clinical and laboratory evaluation of upper respiratory symptoms in elite athletes. Clin J Sport Med. 2008; 18 (5): 438-45.
13. Dartt DA,. Neural regulation of lacrimal gland secretory processes: relevance in dry eye diseases. Prog Retin Eye Res. 2009; 28: 155-77.
14. Diment BC, Fortes MB, Edwards JP, Exercise intensity and duration effects on in vivo immunity. Med Sci Sports Exerc. 2015; 47 (7): 1390-8.
15. Fahlman MM, Engels HJ,. Mucosal IgA and URTI in American college football players: a year longitudinal study. Med Sci Sports Exerc. 2005; 37 (3): 374-80.
16. Farandos NM, Yetisen AK, Monteiro MJ, Lowe CR, Yun SH,. Contact lens sensors in ocular diagnostics. Adv Healthc Mater. 2015; 4 (6): 792-810.
17. Fortes MB, Diment BC, Di Felice U, Tear fluid osmolarity as a potential marker of hydration status. Med Sci Sports Exerc. 2011; 43 (8): 1590-7.
18. Fortes MB, Diment BC, Di Felice U, Walsh NP,. Dehydration decreases saliva antimicrobial proteins important for mucosal immunity. Appl Physiol Nutr Metab. 2012; 37: 850-9.
19. Fullard RJ, Snyder C,. Protein levels in nonstimulated and stimulated tears of normal human subjects. Invest Ophthalmol Vis Sci. 1990; 31: 1119-26.
20. Gleeson M, Bishop N, Oliveira M, McCauley T, Tauler P,. Sex differences in immune variables and respiratory infection incidence in an athletic population. Exerc Immunol Rev. 2011; 17: 122-35.
21. Gleeson M, Bishop N, Oliveira M, McCauley T, Tauler P, Muhamad AS,. Respiratory infection risk in athletes: association with antigen-stimulated IL-10 production and salivary IgA secretion. Scand J Med Sci Sports. 2012; 22 (3): 410-7.
22. Gleeson M, McDonald WA, Pyne DB, Salivary IgA levels and infection risk in elite swimmers. Med Sci Sports Exerc. 1999; 31 (1): 67-73.
23. Gleeson M, Pyne DB, Austin JP, Epstein-Barr virus reactivation and upper-respiratory illness in elite swimmers. Med Sci Sports Exerc. 2002; 34 (3): 411-7.
24. Harris JM 2nd, Gwaltney JM Jr,. Incubation periods of experimental rhinovirus infection and illness. Clin Infect Dis. 1996; 6: 1287-90.
25. Jackson GG, Dowling HF, Spiesman IG, Boand AV,. Transmission of the common cold to volunteers under controlled conditions. I. The common cold as a clinical entity. AMA Arch Intern Med. 1958; 101 (2): 267-78.
26. Johnston NW, Lambert K, Hussack P, Detection of COPD Exacerbations and compliance with patient-reported daily symptom diaries using a smart phone-based information system [corrected]. Chest. 2013; 144 (2): 507-14.
27. Killer SC, Svendsen IS, Gleeson M,. The influence of hydration status during prolonged endurance exercise on salivary antimicrobial proteins. Eur J Appl Physiol. 2015; 115 (9): 1887-95.
28. Mäkelä MJ, Puhakka T, Ruuskanen O, Viruses and bacteria in the etiology of the common cold. J Clin Microbiol. 1998; 36 (2): 539-42.
29. Maurya RP, Bhushan P, Singh VP, Immunoglobulin concentration in tears of contact lens wearers. J Ophthalmic Vis Res. 2014; 9: 320-3.
30. Neville V, Gleeson M, Folland JP,. Salivary IgA as a risk factor for upper respiratory infections in elite professional athletes. Med Sci Sports Exerc. 2008; 40: 1228-36.
31. Nieman DC,. Exercise, infection, and immunity. Int J Sports Med. 1994; 15: S131-41.
32. Oliver SJ, Laing SJ, Wilson S, Bilzon JL, Walters R, Walsh NP,. Salivary immunoglobulin A response at rest and after exercise following a 48 h period of fluid and/or energy restriction. Br J Nutr. 2007; 97 (6): 1109-16.
33. Papacosta E, Nassis GP,. Saliva as a tool for monitoring steroid, peptide and immune markers in sport and exercise science. J Sci Med Sport. 2011; 14 (5): 424-34.
34. Pearce DJ, Demirci G, Willcox MD,. Secretory IgA epitopes in basal tears of extended-wear soft contact lens wearers and in non-lens wearers. Aust N Z J Ophthalmol. 1999; 27 (3-4): 221-3.
35. Pyne DB, Hopkins WG, Batterham AM, Gleeson M, Fricker PA,. Characterising the individual performance responses to mild illness in international swimmers. Br J Sports Med. 2005; 39: 752-6.
36. Robson-Ansley P, Howatson G, Tallent J, Prevalence of allergy and upper respiratory tract symptoms in runners of the London marathon. Med Sci Sports Exerc. 2012; 44 (6): 999-1004.
37. Smith AP,. Effects of the common cold on mood, psychomotor performance, the encoding of new information, speed of working memory and semantic processing. Brain Behav Immun. 2012; 26 (7): 1072-6.
38. Spence L, Brown WJ, Pyne DB, Incidence, etiology, and symptomatology of upper respiratory illness in elite athletes. Med Sci Sports Exerc. 2007; 39 (4): 577-86.
39. Temel A, Kazokoglu H, Taga Y, Orkan AL,. The effect of contact lens wear on tear immunoglobulins. CLAO J. 1991; 17 (1): 69-71.
40. Tomasi TB, Trudeau FB, Czerwinski D, Erredge S,. Immune parameters in athletes before and after strenuous exercise. J Clin Immunol. 1982; 2 (3): 173-8.
41. Vinding T, Eriksen JS, Nielsen NV,. The concentration of lysozyme and secretory IgA in tears from healthy persons with and without contact lens use. Acta Ophthalmol (Copenh). 1987; 65 (1): 23-6.
42. Walsh NP, Blannin AK, Clark AM, Cook L, Robson PJ, Gleeson M,. The effects of high-intensity intermittent exercise on saliva IgA, total protein and alpha-amylase. J Sports Sci. 1999; 17: 129-34.
43. Walsh NP, Bishop NC, Blackwell J, Wierzbicki SG, Montague JC,. Salivary IgA response to prolonged exercise in a cold environment in trained cyclists. Med Sci Sports Exerc. 2002; 34 (10): 1632-7.
44. Walsh NP, Gleeson M, Shephard RJ, Position statement. Part one: immune function and exercise. Exerc Immunol Rev. 2011; 17: 6-63.
45. Zhou L, Beuerman RW,. Tear analysis in ocular surface diseases. Prog Retin Eye Res. 2012; 31: 527-50.