Tear fluid osmolarity as a potential marker of hydration status

Medicine and Science in Sports and Exercise

Volumn 43, Issue 8, 2011, Pages 1590-1597

  Fortes, Matthew B ^a   Diment, Bethany C ^a   Di Felice, Umberto ^a,b   Gunn, Adrian E ^a   Kendall, Joe L ^a   Esmaeelpour, Marieh ^c,d   Walsh, Neil P ^a  

^a BANGOR UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF L'AQUILA   (Italy)

^c CARDIFF UNIVERSITY   (United Kingdom)

^d KRANKENANSTALT RUDOLFSTIFTUNG   (Austria)

Author keywords

DEHYDRATION; DRY EYE; EUHYDRATION; EYE; HYPOHYDRATION; OSMOLALITY

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; CHEMISTRY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEHYDRATION; EXERCISE; FEMALE; FLUID THERAPY; HUMAN; HYPOVOLEMIA; LACRIMAL FLUID; MALE; OSMOLARITY; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; RELATIVE DENSITY;

ADOLESCENT; ADULT; DEHYDRATION; EXERCISE; FEMALE; FLUID THERAPY; HUMANS; HYPOVOLEMIA; MALE; OSMOLAR CONCENTRATION; SPECIFIC GRAVITY; TEARS; YOUNG ADULT;

EID: 79961026767     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/MSS.0b013e31820e7cb6     Document Type: Article

References (42)

1. Alexander JH, van Lennep EW, Young JA. Water and electrolyte secretion by the exorbital lacrimal gland of the rat studied by micropuncture and catheterization techniques. Pflugers Arch. 1972; 337:299-309.
2. Armstrong LE. Assessing hydration status: the elusive gold standard. J Am Coll Nutr. 2007;26:575-84S.
3. Armstrong LE, Costill DL, Fink WJ. Influence of diuretic-induced dehydration on competitive running performance. Med Sci Sports Exerc. 1985;17(4):456-61. (Pubitemid 15013382)
4. Armstrong LE, Maresh CM, Castellani JW, et al. Urinary indices of hydration status. Int J Sport Nutr. 1994;4:265-79.
5. Bausell RB, Li YF. The Paired T-Test. Cambridge (UK): Cambridge University Press; 2002. p. 57-70.
6. Benelli U, Nardi M, Posarelli C, Albert TG. Tear osmolarity measurement using the TearLab Osmolarity System in the assessment of dry eye treatment effectiveness. Cont Lens Anterior Eye. 2010; 33:61-7.
7. Benjamin WJ, Hill RM. Human tears: osmotic characteristics. Invest Ophthalmol Vis Sci. 1983;24:1624-6. (Pubitemid 14220960)
8. Botelho SY, Martinez EV. Electrolytes in lacrimal gland fluid and in tears at various flow rates in the rabbit. Am J Physiol. 1973; 225:606-9.
9. Bryce J, Boschi-Pinto C, Shibuya K, Black RE. WHO estimates of the causes of death in children. Lancet. 2005;365:1147-52. (Pubitemid 40417564)
10. Casa DJ, Stearns RL, Lopez RM, et al. Influence of hydration on physiological function and performance during trail running in the heat. J Athl Train. 2010;45:147-56.
11. Cheuvront SN, Ely BR, Kenefick RW, Sawka MN. Biological variation and diagnostic accuracy of dehydration assessment markers. Am J Clin Nutr. 2010;92:565-73.
12. Chia EM, Mitchell P, Rochtchina E, Lee AJ, Maroun R, Wang JJ. Prevalence and associations of dry eye syndrome in an older population: the Blue Mountains Eye Study. Clin Experiment Ophthalmol. 2003;31:229-32. (Pubitemid 36833372)
13. Esmaeelpour M, Cai J, Watts P, Boulton M, Murphy PJ. Tear sample collection using cellulose acetate absorbent filters. Ophthalmic Physiol Opt. 2008;28:577-83.
14. Francesconi RP, Hubbard RW, Szlyk PC, et al. Urinary and hematologic indexes of hypohydration. J Appl Physiol. 1987;62: 1271-6. (Pubitemid 17073933)
15. Fraser CG, Harris EK. Generation and application of data on biological variation in clinical chemistry. Crit Rev Clin Lab Sci. 1989; 27:409-37.
16. Fraser CG, Hyltoft PP, Larsen ML. Setting analytical goals for random analytical error in specific clinical monitoring situations. Clin Chem. 1990;36:1625-8.
17. Gilbard JP, Dartt DA. Changes in rabbit lacrimal gland fluid osmolarity with flow rate. Invest Ophthalmol Vis Sci. 1982;23:804-6. (Pubitemid 13212353)
18. Gilbard JP, Farris RL, Santamaria J. Osmolarity of tear microvolumes in keratoconjunctivitis sicca. Arch Ophthalmol. 1978;96: 677-81. (Pubitemid 8301697)
19. Harris EK. Effects of intra-and interindividual variation on the appropriate use of normal ranges. Clin Chem. 1974;20:1535-42.
20. Harris JA, Benedict FG. A Biometric Study of Basal Metabolism in Man. Washington (DC): Carnegie Institution; 1919. p. 227.
21. Manz F, Wentz A. The importance of good hydration for the prevention of chronic diseases. Nutr Rev. 2005;63:S2-5. (Pubitemid 40840400)
22. Meng XL, Rosenthal R, Rubin DB. Comparing correlated correlation coefficients. Psychol Bull. 1992;11:172-5.
23. O'Brien C, Young AJ, Sawka MN. Bioelectrical impedance to estimate changes in hydration status. Int J Sports Med. 2002;23: 361-6. (Pubitemid 34785682)
24. Oliver SJ, Laing SJ, Wilson S, Bilzon JL, Walsh NP. Saliva indices track hypohydration during 48 h of fluid restriction or combined fluid and energy restriction. Arch Oral Biol. 2008;53: 975-80.
25. Popowski LA, Oppliger RA, Patrick LG, Johnson RF, Kim JA, Gisolfi CV. Blood and urinary measures of hydration status during progressive acute dehydration. Med Sci Sports Exerc. 2001;33(5): 747-53. (Pubitemid 32336634)
26. Ritz P, Berrut G. The importance of good hydration for day-to-day health. Nutr Rev. 2005;63:S6-13. (Pubitemid 40840401)
27. Rolando M, Zierhut M. The ocular surface and tear film and their dysfunction in dry eye disease. Survey Ophthalmol. 2001;45: S203-10.
28. Schoeller DA, Webb P. Five-day comparison of the doubly labeled water method with respiratory gas exchange. Am J Clin Nutr. 1984;40:153-8. (Pubitemid 14096656)
29. Shavelson RJ. Statistical Reasoning for the Behavioural Sciences. Boston (MA): Allyn and Bacon; 1988. p. 631.
30. Shirreffs SM. Markers of hydration status. J Sports Med Phys Fitness. 2000;40:80-4. (Pubitemid 30241017)
31. Shirreffs SM. The importance of good hydration for work and exercise performance. Nutr Rev. 2005;63:S14-21. (Pubitemid 40840402)
32. Stachenfeld NS, Silva C, Keefe DL, Kokoszka CA, Nadel ER. Effects of oral contraceptives on body fluid regulation. J Appl Physiol. 1999;87:1016-25. (Pubitemid 29436979)
33. Sullivan BD, Whitmer D, Nichols KK, et al. An objective approach to dry eye disease severity. Invest Ophthalmol Vis Sci. 2010; 51:6125-30.
34. Thomas JR, Nelson JK. Research Methods in Physical Activity. Champaign (IL): Human Kinetics; 1996. p. 432-3.
35. Tiffany JM. Tears in health and disease. Eye. 2003;17:923-6. (Pubitemid 37541046)
36. Tiffany JM. The normal tear film. Dev Ophthalmol. 2008;41:1-20.
37. Tomlinson A, Khanal S, Ramaesh K, Diaper C, McFayden A. Tear film osmolarity: determination of a referent for dry eye diagnosis. Invest Ophthalmol Vis Sci. 2006;47:4309-15. (Pubitemid 46579353)
38. Ubels JL, Williams KK, Lopez BD, Edelhauser HF. Evaluation of effects of a physiologic artificial tear on the corneal epithelial barrier: electrical resistance and carboxyfluorescein permeability. Adv Exp Med Biol. 1994;350:441-52. (Pubitemid 24130672)
39. Walsh NP, Laing SJ, Oliver SO, Montague JC, Walters R, Bilzon JL. Saliva parameters as potential indices of hydration status during acute dehydration. Med Sci Sports Exerc. 2004;36(9): 1535-42. (Pubitemid 39202622)
40. Walsh NP, Montague JC, Callow N, Rowlands AV. Saliva flow rate, total protein concentration and osmolality as potential markers of whole body hydration status during progressive acute dehydration in humans. Arch Oral Biol. 2004;49:149-54. (Pubitemid 38157578)
41. World Health Organization. Energy and Protein Requirements. Report of a Joint FAO/WHO/UNU Expert Consultation. Geneva (Switzerland): World Health Organization, Technical Report Series 724; 1985. p. 266.
42. Xiao H, Barber J, Campbell ES. Economic burden of dehydration among hospitalized elderly patients. Am J Health Syst Pharm. 2004; 61:2534-40. (Pubitemid 40403563)