메뉴 건너뛰기




Volumn 233, Issue 8, 2016, Pages 1405-1413

Phentermine induces conditioned rewarding effects via activation of the PI3K/Akt signaling pathway in the nucleus accumbens

Author keywords

Accumbens; Dopamine transporter; Reward

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; APOMORPHINE; DOPAMINE; DOPAMINE TRANSPORTER; METHAMPHETAMINE; PHENTERMINE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; ANTIOBESITY AGENT; ONCOPROTEIN;

EID: 84958761025     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-016-4231-z     Document Type: Article
Times cited : (8)

References (44)
  • 1
    • 84255190041 scopus 로고    scopus 로고
    • A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health
    • 21711983 3244494
    • Beaulieu JM (2012) A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health. J Psychiatry Neurosci 37:7-16
    • (2012) J Psychiatry Neurosci , vol.37 , pp. 7-16
    • Beaulieu, J.M.1
  • 2
    • 62149119762 scopus 로고    scopus 로고
    • Akt/GSK3 signaling in the action of psychotropic drugs
    • 1:CAS:528:DC%2BD1MXisV2jsb0%3D 18928402
    • Beaulieu JM, Gainetdinov RR, Caron MG (2009) Akt/GSK3 signaling in the action of psychotropic drugs. Annu Rev Pharmacol Toxicol 49:327-347
    • (2009) Annu Rev Pharmacol Toxicol , vol.49 , pp. 327-347
    • Beaulieu, J.M.1    Gainetdinov, R.R.2    Caron, M.G.3
  • 3
    • 24044460136 scopus 로고    scopus 로고
    • Biogenic amine neurotransmitter transporters: Just when you thought you knew them
    • 1:CAS:528:DC%2BD2MXpslSmtbY%3D (Bethesda)
    • Blakely RD, Defelice LJ, Galli A (2005) Biogenic amine neurotransmitter transporters: just when you thought you knew them. Physiology (Bethesda) 20:225-231
    • (2005) Physiology , vol.20 , pp. 225-231
    • Blakely, R.D.1    Defelice, L.J.2    Galli, A.3
  • 4
    • 84919422054 scopus 로고    scopus 로고
    • Methamphetamine-induced short-term increase and long-term decrease in spatial working memory affects protein Kinase M zeta (PKMzeta), dopamine, and glutamate receptors
    • 25566006 4270177
    • Braren SH, Drapala D, Tulloch IK, Serrano PA (2014) Methamphetamine-induced short-term increase and long-term decrease in spatial working memory affects protein Kinase M zeta (PKMzeta), dopamine, and glutamate receptors. Front Behav Neurosci 8:438
    • (2014) Front Behav Neurosci , vol.8 , pp. 438
    • Braren, S.H.1    Drapala, D.2    Tulloch, I.K.3    Serrano, P.A.4
  • 6
    • 84881034053 scopus 로고    scopus 로고
    • Dependence potential of quetiapine: Behavioral pharmacology in rodents
    • 1:CAS:528:DC%2BC3sXhs1Sls7bP (Seoul)
    • Cha HJ, Lee HA, Ahn JI, Jeon SH, Kim EJ, Jeong HS (2013) Dependence potential of quetiapine: behavioral pharmacology in rodents. Biomol Ther (Seoul) 21:307-312
    • (2013) Biomol Ther , vol.21 , pp. 307-312
    • Cha, H.J.1    Lee, H.A.2    Ahn, J.I.3    Jeon, S.H.4    Kim, E.J.5    Jeong, H.S.6
  • 8
    • 84898617931 scopus 로고    scopus 로고
    • Single and binge methamphetamine administrations have different effects on the levels of dopamine D2 autoreceptor and dopamine transporter in rat striatum
    • 1:CAS:528:DC%2BC2cXhtlWlur7J 24717411 4013602
    • Chauhan H, Killinger BA, Miller CV, Moszczynska A (2014) Single and binge methamphetamine administrations have different effects on the levels of dopamine D2 autoreceptor and dopamine transporter in rat striatum. Int J Mol Sci 15:5884-5906
    • (2014) Int J Mol Sci , vol.15 , pp. 5884-5906
    • Chauhan, H.1    Killinger, B.A.2    Miller, C.V.3    Moszczynska, A.4
  • 10
    • 77957876994 scopus 로고    scopus 로고
    • Activation of phosphatidylinositol 3-kinase/Akt-mammalian target of Rapamycin signaling pathway in the hippocampus is essential for the acquisition of morphine-induced place preference in rats
    • 1:CAS:528:DC%2BC3cXhtlSht7fI 20826199
    • Cui Y, Zhang XQ, Xin WJ, Jing J, Liu XG (2010) Activation of phosphatidylinositol 3-kinase/Akt-mammalian target of Rapamycin signaling pathway in the hippocampus is essential for the acquisition of morphine-induced place preference in rats. Neuroscience 171:134-143
    • (2010) Neuroscience , vol.171 , pp. 134-143
    • Cui, Y.1    Zhang, X.Q.2    Xin, W.J.3    Jing, J.4    Liu, X.G.5
  • 11
    • 0028230437 scopus 로고
    • Intraventricular insulin increases dopamine transporter mRNA in rat VTA/substantia nigra
    • 1:CAS:528:DyaK2cXivFSnur8%3D 8050044
    • Figlewicz DP, Szot P, Chavez M, Woods SC, Veith RC (1994) Intraventricular insulin increases dopamine transporter mRNA in rat VTA/substantia nigra. Brain Res 644:331-334
    • (1994) Brain Res , vol.644 , pp. 331-334
    • Figlewicz, D.P.1    Szot, P.2    Chavez, M.3    Woods, S.C.4    Veith, R.C.5
  • 12
    • 0037221587 scopus 로고    scopus 로고
    • Selective decreases in amphetamine self-administration and regulation of dopamine transporter function in diabetic rats
    • 1:CAS:528:DC%2BD3sXhvFyit78%3D 12624535
    • Galici R, Galli A, Jones DJ, Sanchez TA, Saunders C, Frazer A, Gould GG, Lin RZ, France CP (2003) Selective decreases in amphetamine self-administration and regulation of dopamine transporter function in diabetic rats. Neuroendocrinology 77:132-140
    • (2003) Neuroendocrinology , vol.77 , pp. 132-140
    • Galici, R.1    Galli, A.2    Jones, D.J.3    Sanchez, T.A.4    Saunders, C.5    Frazer, A.6    Gould, G.G.7    Lin, R.Z.8    France, C.P.9
  • 13
    • 22344431879 scopus 로고    scopus 로고
    • Akt is essential for insulin modulation of amphetamine-induced human dopamine transporter cell-surface redistribution
    • 1:CAS:528:DC%2BD2MXlvVSqtbY%3D 15795321
    • Garcia BG, Wei Y, Moron JA, Lin RZ, Javitch JA, Galli A (2005) Akt is essential for insulin modulation of amphetamine-induced human dopamine transporter cell-surface redistribution. Mol Pharmacol 68:102-109
    • (2005) Mol Pharmacol , vol.68 , pp. 102-109
    • Garcia, B.G.1    Wei, Y.2    Moron, J.A.3    Lin, R.Z.4    Javitch, J.A.5    Galli, A.6
  • 14
    • 56949096742 scopus 로고    scopus 로고
    • Reduced D2-mediated signaling activity and trans-synaptic upregulation of D1 and D2 dopamine receptors in mice overexpressing the dopamine transporter
    • 1:CAS:528:DC%2BD1cXhsVeks7%2FK 18929645 3536494
    • Ghisi V, Ramsey AJ, Masri B, Gainetdinov RR, Caron MG, Salahpour A (2009) Reduced D2-mediated signaling activity and trans-synaptic upregulation of D1 and D2 dopamine receptors in mice overexpressing the dopamine transporter. Cell Signal 21:87-94
    • (2009) Cell Signal , vol.21 , pp. 87-94
    • Ghisi, V.1    Ramsey, A.J.2    Masri, B.3    Gainetdinov, R.R.4    Caron, M.G.5    Salahpour, A.6
  • 15
    • 84942545134 scopus 로고    scopus 로고
    • Effects of anti-obesity drugs, phentermine and mahuang, on the behavioral patterns in Sprague-Dawley rat model
    • 24999361 4079834
    • Go RE, Hwang KA, Kim SH, Lee MY, Kim CW, Jeon SY, Kim YB, Choi KC (2014) Effects of anti-obesity drugs, phentermine and mahuang, on the behavioral patterns in Sprague-Dawley rat model. Lab Anim Res 30:73-78
    • (2014) Lab Anim Res , vol.30 , pp. 73-78
    • Go, R.E.1    Hwang, K.A.2    Kim, S.H.3    Lee, M.Y.4    Kim, C.W.5    Jeon, S.Y.6    Kim, Y.B.7    Choi, K.C.8
  • 16
    • 70649099211 scopus 로고    scopus 로고
    • The roles of dopamine transport inhibition and dopamine release facilitation in wake enhancement and rebound hypersomnolence induced by dopaminergic agents
    • 19928382 2768949
    • Gruner JA, Marcy VR, Lin YG, Bozyczko-Coyne D, Marino MJ, Gasior M (2009) The roles of dopamine transport inhibition and dopamine release facilitation in wake enhancement and rebound hypersomnolence induced by dopaminergic agents. Sleep 32:1425-1438
    • (2009) Sleep , vol.32 , pp. 1425-1438
    • Gruner, J.A.1    Marcy, V.R.2    Lin, Y.G.3    Bozyczko-Coyne, D.4    Marino, M.J.5    Gasior, M.6
  • 17
    • 78649946434 scopus 로고    scopus 로고
    • Drug treatment of obesity - Current situation and perspectives
    • 21391349
    • Hainer V (2010) Drug treatment of obesity - current situation and perspectives. Cas Lek Cesk 149:513-519
    • (2010) Cas Lek Cesk , vol.149 , pp. 513-519
    • Hainer, V.1
  • 18
    • 84898984161 scopus 로고    scopus 로고
    • The effect of early environmental manipulation on locomotor sensitivity and methamphetamine conditioned place preference reward
    • 1:CAS:528:DC%2BC2cXnvFSktrg%3D 24713150 4109814
    • Hensleigh E, Pritchard LM (2014) The effect of early environmental manipulation on locomotor sensitivity and methamphetamine conditioned place preference reward. Behav Brain Res 268:66-71
    • (2014) Behav Brain Res , vol.268 , pp. 66-71
    • Hensleigh, E.1    Pritchard, L.M.2
  • 19
    • 0036898713 scopus 로고    scopus 로고
    • Neural plasticity and addiction: PI3-kinase and cocaine behavioral sensitization
    • 1:CAS:528:DC%2BD38XovFChs7c%3D 12436114
    • Izzo E, Martin-Fardon R, Koob GF, Weiss F, Sanna PP (2002) Neural plasticity and addiction: PI3-kinase and cocaine behavioral sensitization. Nat Neurosci 5:1263-1264
    • (2002) Nat Neurosci , vol.5 , pp. 1263-1264
    • Izzo, E.1    Martin-Fardon, R.2    Koob, G.F.3    Weiss, F.4    Sanna, P.P.5
  • 20
    • 34249742612 scopus 로고    scopus 로고
    • Voltammetric characterization of the effect of monoamine uptake inhibitors and releasers on dopamine and serotonin uptake in mouse caudate-putamen and substantia nigra slices
    • 1:CAS:528:DC%2BD2sXmtVegsro%3D 17459426 2041899
    • John CE, Jones SR (2007) Voltammetric characterization of the effect of monoamine uptake inhibitors and releasers on dopamine and serotonin uptake in mouse caudate-putamen and substantia nigra slices. Neuropharmacology 52:1596-1605
    • (2007) Neuropharmacology , vol.52 , pp. 1596-1605
    • John, C.E.1    Jones, S.R.2
  • 22
    • 84876038398 scopus 로고    scopus 로고
    • The abuse potential of oxethazaine: Effects of oxethazaine on drug-seeking behavior and analysis of its metabolites in plasma and hair in animal models
    • 1:CAS:528:DC%2BC3sXls1eksrw%3D 23402942
    • Lee SY, You IJ, Kim MJ, Kwon SH, Hong SI, Kim JH, Jang MH, Oh SM, Chung KH, Jang CG (2013) The abuse potential of oxethazaine: effects of oxethazaine on drug-seeking behavior and analysis of its metabolites in plasma and hair in animal models. Pharmacol Biochem Behav 105:98-104
    • (2013) Pharmacol Biochem Behav , vol.105 , pp. 98-104
    • Lee, S.Y.1    You, I.J.2    Kim, M.J.3    Kwon, S.H.4    Hong, S.I.5    Kim, J.H.6    Jang, M.H.7    Oh, S.M.8    Chung, K.H.9    Jang, C.G.10
  • 24
    • 84876672902 scopus 로고    scopus 로고
    • Thioredoxin-1 was required for CREB activity by methamphetamine in rat pheochromocytoma cells
    • 1:CAS:528:DC%2BC3sXktlKhsrs%3D 23239345
    • Lv T, Wang SD, Bai J (2013) Thioredoxin-1 was required for CREB activity by methamphetamine in rat pheochromocytoma cells. Cell Mol Neurobiol 33:319-325
    • (2013) Cell Mol Neurobiol , vol.33 , pp. 319-325
    • Lv, T.1    Wang, S.D.2    Bai, J.3
  • 25
    • 0023857953 scopus 로고
    • Amphetamine and chlorpromazine modify cerebral insulin levels in rats
    • 1:CAS:528:DyaL1cXkvFaisQ%3D%3D 3275851
    • Manzanares J, Canton R, Grande C, Benedi J, Zaragoza F (1988) Amphetamine and chlorpromazine modify cerebral insulin levels in rats. Life Sci 42:21-25
    • (1988) Life Sci , vol.42 , pp. 21-25
    • Manzanares, J.1    Canton, R.2    Grande, C.3    Benedi, J.4    Zaragoza, F.5
  • 26
    • 0032531781 scopus 로고    scopus 로고
    • Reduced striatal dopamine transporter density in abstinent methamphetamine and methcathinone users: Evidence from positron emission tomography studies with [11C]WIN-35,428
    • 1:CAS:528:DyaK1cXms1ehurY%3D 9763484
    • McCann UD, Wong DF, Yokoi F, Villemagne V, Dannals RF, Ricaurte GA (1998) Reduced striatal dopamine transporter density in abstinent methamphetamine and methcathinone users: evidence from positron emission tomography studies with [11C]WIN-35,428. J Neurosci 18:8417-8422
    • (1998) J Neurosci , vol.18 , pp. 8417-8422
    • McCann, U.D.1    Wong, D.F.2    Yokoi, F.3    Villemagne, V.4    Dannals, R.F.5    Ricaurte, G.A.6
  • 27
    • 84859942960 scopus 로고    scopus 로고
    • Brain region differences in regulation of Akt and GSK3 by chronic stimulant administration in mice
    • 1:CAS:528:DC%2BC38XmtVCitrs%3D 22434044 3335955
    • Mines MA, Jope RS (2012) Brain region differences in regulation of Akt and GSK3 by chronic stimulant administration in mice. Cell Signal 24:1398-1405
    • (2012) Cell Signal , vol.24 , pp. 1398-1405
    • Mines, M.A.1    Jope, R.S.2
  • 28
    • 30044447631 scopus 로고    scopus 로고
    • Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons
    • 1:CAS:528:DC%2BD2MXhtlequrnN 16330326
    • Morton GJ, Gelling RW, Niswender KD, Morrison CD, Rhodes CJ, Schwartz MW (2005) Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons. Cell Metab 2:411-420
    • (2005) Cell Metab , vol.2 , pp. 411-420
    • Morton, G.J.1    Gelling, R.W.2    Niswender, K.D.3    Morrison, C.D.4    Rhodes, C.J.5    Schwartz, M.W.6
  • 29
    • 33646859222 scopus 로고    scopus 로고
    • Central nervous system biogenic amine targets for control of appetite and energy expenditure
    • 1:CAS:528:DC%2BD28XksFant74%3D 16622292
    • Nelson DL, Gehlert DR (2006) Central nervous system biogenic amine targets for control of appetite and energy expenditure. Endocrine 29:49-60
    • (2006) Endocrine , vol.29 , pp. 49-60
    • Nelson, D.L.1    Gehlert, D.R.2
  • 33
    • 0017119483 scopus 로고
    • Climbing behavior induced by apomorphine in mice: A simple test for the study of dopamine receptors in striatum
    • 1:CAS:528:DyaE28XlvVKlu7g%3D (Berl)
    • Protais P, Costentin J, Schwartz JC (1976) Climbing behavior induced by apomorphine in mice: a simple test for the study of dopamine receptors in striatum. Psychopharmacology (Berl) 50:1-6
    • (1976) Psychopharmacology , vol.50 , pp. 1-6
    • Protais, P.1    Costentin, J.2    Schwartz, J.C.3
  • 34
    • 0031854682 scopus 로고    scopus 로고
    • Evaluation of the conditioned reinforcing effects of phentermine and fenfluramine in the rat: Concordance with clinical studies
    • 1:CAS:528:DyaK1cXltVKqs7s%3D 9704887
    • Rea WP, Rothman RB, Shippenberg TS (1998) Evaluation of the conditioned reinforcing effects of phentermine and fenfluramine in the rat: concordance with clinical studies. Synapse 30:107-111
    • (1998) Synapse , vol.30 , pp. 107-111
    • Rea, W.P.1    Rothman, R.B.2    Shippenberg, T.S.3
  • 36
    • 0031818199 scopus 로고    scopus 로고
    • Phentermine and fenfluramine. Preclinical studies in animal models of cocaine addiction
    • 1:CAS:528:DyaK1cXks12lsr0%3D 9668665
    • Rothman RB, Elmer GI, Shippenberg TS, Rea W, Baumann MH (1998) Phentermine and fenfluramine. Preclinical studies in animal models of cocaine addiction. Ann N Y Acad Sci 844:59-74
    • (1998) Ann N Y Acad Sci , vol.844 , pp. 59-74
    • Rothman, R.B.1    Elmer, G.I.2    Shippenberg, T.S.3    Rea, W.4    Baumann, M.H.5
  • 38
  • 39
    • 70350449261 scopus 로고    scopus 로고
    • Extended methamphetamine self-administration in rats results in a selective reduction of dopamine transporter levels in the prefrontal cortex and dorsal striatum not accompanied by marked monoaminergic depletion
    • 1:CAS:528:DC%2BD1MXhtlKnu73M 19648469 2775260
    • Schwendt M, Rocha A, See RE, Pacchioni AM, McGinty JF, Kalivas PW (2009) Extended methamphetamine self-administration in rats results in a selective reduction of dopamine transporter levels in the prefrontal cortex and dorsal striatum not accompanied by marked monoaminergic depletion. J Pharmacol Exp Ther 331:555-562
    • (2009) J Pharmacol Exp Ther , vol.331 , pp. 555-562
    • Schwendt, M.1    Rocha, A.2    See, R.E.3    Pacchioni, A.M.4    McGinty, J.F.5    Kalivas, P.W.6
  • 40
    • 84862800172 scopus 로고    scopus 로고
    • Involvement of metabotropic glutamate receptor 5, AKT/PI3K signaling and NF-kappaB pathway in methamphetamine-mediated increase in IL-6 and IL-8 expression in astrocytes
    • 1:CAS:528:DC%2BC38XnvFShs7w%3D 22420994 3338363
    • Shah A, Silverstein PS, Singh DP, Kumar A (2012) Involvement of metabotropic glutamate receptor 5, AKT/PI3K signaling and NF-kappaB pathway in methamphetamine-mediated increase in IL-6 and IL-8 expression in astrocytes. J Neuroinflammation 9:52
    • (2012) J Neuroinflammation , vol.9 , pp. 52
    • Shah, A.1    Silverstein, P.S.2    Singh, D.P.3    Kumar, A.4
  • 41
    • 84876996189 scopus 로고    scopus 로고
    • Phentermine - A "weighty" or a dangerous substance?
    • 23678625
    • Skopp G, Jantos R (2013) Phentermine - a "weighty" or a dangerous substance? Arch Kriminol 231:116-129
    • (2013) Arch Kriminol , vol.231 , pp. 116-129
    • Skopp, G.1    Jantos, R.2
  • 43
    • 20644441994 scopus 로고    scopus 로고
    • Mechanisms of neurotransmitter release by amphetamines: A review
    • 1:CAS:528:DC%2BD2MXlt1Kisr8%3D 15955613
    • Sulzer D, Sonders MS, Poulsen NW, Galli A (2005) Mechanisms of neurotransmitter release by amphetamines: a review. Prog Neurobiol 75:406-433
    • (2005) Prog Neurobiol , vol.75 , pp. 406-433
    • Sulzer, D.1    Sonders, M.S.2    Poulsen, N.W.3    Galli, A.4
  • 44
    • 33847154690 scopus 로고    scopus 로고
    • Dopamine transporter activity mediates amphetamine-induced inhibition of Akt through a Ca2+/calmodulin-dependent kinase II-dependent mechanism
    • 1:CAS:528:DC%2BD2sXis1aquro%3D 17164407
    • Wei Y, Williams JM, Dipace C, Sung U, Javitch JA, Galli A, Saunders C (2007) Dopamine transporter activity mediates amphetamine-induced inhibition of Akt through a Ca2+/calmodulin-dependent kinase II-dependent mechanism. Mol Pharmacol 71:835-842
    • (2007) Mol Pharmacol , vol.71 , pp. 835-842
    • Wei, Y.1    Williams, J.M.2    Dipace, C.3    Sung, U.4    Javitch, J.A.5    Galli, A.6    Saunders, C.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.