Evaluation of the conditioned reinforcing effects of phentermine and fenfluramine in the rat: Concordance with clinical studies

Synapse

Volumn 30, Issue 1, 1998, Pages 107-111

  Rea, William P ^a   Rothman, Richard B ^a   Shippenberg, Toni S ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

Conditioned place preference paradigm; Conditioned reward; Psychostimulants

Indexed keywords

FENFLURAMINE; PHENTERMINE;

ALCOHOLISM; ANIMAL EXPERIMENT; ARTICLE; CONDITIONED REFLEX; CONTROLLED STUDY; DRUG ABUSE; DRUG EFFECT; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REINFORCEMENT;

ANIMALS; CHOICE BEHAVIOR; CONDITIONING (PSYCHOLOGY); DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; FENFLURAMINE; MALE; PHENTERMINE; RATS; RATS, SPRAGUE-DAWLEY; REINFORCEMENT (PSYCHOLOGY);

EID: 0031854682     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2396(199809)30:1<107::AID-SYN13>3.0.CO;2-1     Document Type: Article

References (29)

1. Appel, J.B., Baker, B.E., Barrett, R.L., Broadbent, J., Michael, E.M., Riddle, E.E., and Van Groll, J. (1991) Use of drug discrimination in drug abuse research. In: Drug Discrimination: Applications to Drug Abuse Research. R.A. Glennon, T.U. Jarbe, and J. Frankenheim, eds. NIDA Research Monograph 116, DHHS Publication no. (ADM) 92-1878 pp 369-397. Washington, DC: US Government Printing Office.
2. Ayestas, M., Baumann, M.H., and Rothman, R.B. (1995) Effects of phentermine and fenfluramine on extracellular dopamine and serotonin in rats nucleus accumbens. In: Problems of Drug Dependence 1994. L.S. Harris, ed. NIDA Research Monograph 153, DHHS Publication no. 95-38883. Washington, DC: US Government Printing Office, p 404.
3. Brauer, L.H., Johanson, C.E., Schuster, C.R., Rothman, R.B., de Witt, H. (1996) Evaluation of phentermine and fenfluramine, alone and in combination, in normal, healthy volunteers. Neuropsychopharmacology, 14:233-241.
4. Carr, G.D., Fibiger, H.C., Phillips, A.G. (1989) Conditioned place preference as a measure of drug reward. In: The Neuropharmacological Basis of Reward. J.M. Liebman and S.J. Cooper, eds. Oxford: Oxford Science Publications, pp 264-317.
5. Chait, L.D., Uhlenhuth, E.H., Johanson, C.E. (1986) The discriminative stimulus and subjective effects of d-amphetamine, phenmetrazine, and fenfluramine in humans. Psychopharmacology (Berlin), 89:301-306.
6. Childress, A.R., McLellan, A.T., O'Brien, C.P. (1986) Abstinent opiate abusers exhibit conditioned craving, conditioned withdrawal and reductions in both through extinction. Br J. Addict., 81:655-660.
7. Connolly, H.M., Crary, J.L., McGoon, M.D., Hensrud, D.D., Edwards, B.S., Schaff, H.V. (1997) Valvular heart disease associated with fenfluramine-phentermine. N. Engl. J. Med., 337:581-588.
8. Di Chiara, G. (1995) The role of dopamine in drug abuse viewed from the perspective of its role in motivation. Drug Alcohol Depend., 38:95-137 [published erratum appears in Drug Alcohol Depend. 39:155].
9. Glowa, J.R., Rice, K.C., Matecka, D., Rothman, R.B. (1997) Phentermine/fenfluramine decreases cocaine self-administration in rhesus monkeys. Neuroreport, 8:1347-1351.
10. Griffiths, R.R., Winger, G., Brady, J.V., Snell, J.D. (1976) Comparison of behavior maintained by infusions of eight phenethylamines in baboons. Psychopharmacology (Berlin), 50:251-256.
11. Hiroi, N., White, N.M. (1991) The lateral nucleus of the amygdala mediates expression of the amphetamine-produced conditioned place preference. Neuroscience, 11:2107-2116.
12. Hitzig, P. (1993) Combined dopamine and serotonin agonists: A synergistic approach to alcoholism and other addictive behaviors. Md. Med. J., 42:153-156.
13. Marona-Lewicka, D., Rhee, G.S., Sprague, J.E., Nichols, D.E. (1996) Reinforcing effects of certain serotonin-releasing amphetamine derivatives. Pharmacol. Biochem. Behav., 53:99-105.
14. Masukawa, Y., Suzuki, T., Misawa, M. (1993) Differential modification of the rewarding effects of methamphetamine and cocaine by opioids and antihistamines. Psychopharmacology (Berlin), 111:139-143.
15. Mirovsky, Y., Yu, Y.L., Wagner, G.C., Sekowski, A., Goldberg, M., Fisher, H. (1995) Novel synergistic treatment of ethanol withdrawal seizures in rats with dopamine and serotonin agonists. Alcohol Clin. Exp. Res., 19:160-163.
16. Papasava, M., Singer, G., Papasava, C.L. (1985) Self-administration of phentermine by naive rats: Effects of body weight and a food delivery schedule. Pharmacol. Biochem. Behav., 22:1071-1073.
17. Preston, K.L. (1991) Drug discrimination methods in human drug abuse liability evaluation. Br. J. Addict., 86:1587-1594.
18. Rothman, R.B., Glowa, J.R. (1995) A review of the effects of dopaminergic agents on humans, animals, and drug-seeking behavior, and its implications for medication development. Focus on GBR 12909. Mol. Neurobiol., 11:1-19.
19. Rothman, R.B., Ayestas, M., Baumann, M.H. (1996) Phentermine pretreatment antagonizes the cocaine-induced rise in mesolimbic dopamine. Neuroreport, 8:7-9.
20. Rothman, R.B., Gendron, T., Hitzig, P. (1994) Letter to editor. J. Subst. Abuse Treatment, 11:273-275.
21. Schechter, M.D., McBurney, D. (1996) Phentermine + fenfluramine produce cocaine-like discriminative cues. Life Sci., 59:303-308.
22. Shippenberg, T.S., Bals-Kubik, R., Herz, A. (1993) Examination of the neurochemical substrates mediating the motivational effects of opioids: Role of the mesolimbic dopamine system and D-1 vs. D-2 dopamine receptors. J. Pharmacol. Exp. Ther., 265:53-59.
23. Shippenberg, T.S., Heidbreder, C., Lefevour, A. (1996) Sensitization to the conditioned rewarding effects of morphine: Pharmacology and temporal aspects. Eur. J. Pharmacol., 299:33-39.
24. Shoaib, M., Baumann, M.H., Rothman, R.B., Goldberg, S.R., Schindler, C.W. (1997) Behavioural and neurochemical characteristics of phentermine and fenfluramine administered separately and as a mixture in rats. Psychopharmacology (Berlin), 131:296-306.
25. Weintraub, M. (1992) Long-term weight control study. Conclusions. Clin. Pharmacol. Ther., 51:642-646.
26. Weintraub, M., Bray, G.A. (1989) Drug treatment of obesity. Med. Clin. North Am., 73:237-249.
27. Woods, J.H., Emmett-Oglesby, M.W. (1988) Substitution and cross-tolerance profiles of anorectic drugs in rats trained to detect the discriminative stimulus properties of cocaine. Psychopharmacology (Berlin), 95:364-368.
28. Woods, J.H., Tessel, R. E. (1974) Fenfluramine: Amphetamine congener that fails to maintain drug-taking behavior in the rhesus monkey. Science, 185:1067-1069.
29. Yu, Y.L., Fisher, H., Sekowski, A., Wagner, G.C. (1997) Amphetamine and fenfluramine suppress ethanol intake in ethanol-dependent rats. Alcohol, 14:45-48.