Downregulation of tumor suppressing STF cDNA 3 promotes epithelial-mesenchymal transition and tumor metastasis of osteosarcoma by the Wnt/GSK-3β/β-catenin/Snail signaling pathway

Cancer Letters

Volumn 373, Issue 2, 2016, Pages 164-173

  Lv, Yang fan ^a   Dai, Huanzi ^a,b   Yan, Guang ning ^a   Meng, Gang ^a   Zhang, Xi ^a   Guo, Qiao nan ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

EMT; Metastasis; Osteosarcoma; TSSC3

Indexed keywords

BETA CATENIN; COMPLEMENTARY DNA; GLYCOGEN SYNTHASE KINASE 3BETA; HERMES ANTIGEN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; MATRILYSIN; T CELL FACTOR PROTEIN; TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR SNAIL; TSSC3 PROTEIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN; WNT3A PROTEIN; CTNNB1 PROTEIN, HUMAN; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; NUCLEAR PROTEIN; SNAIL FAMILY TRANSCRIPTION FACTORS; TRANSCRIPTION FACTOR;

ARTICLE; CANCER GROWTH; CELL INVASION; CELL MIGRATION; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INACTIVATION; EPITHELIAL MESENCHYMAL TRANSITION; GENE OVEREXPRESSION; LUNG METASTASIS; MALIGNANT TRANSFORMATION; METASTASIS POTENTIAL; MICROARRAY ANALYSIS; NONHUMAN; OSTEOSARCOMA; OSTEOSARCOMA CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TSSC3 GENE; TUMOR GENE; UPREGULATION; ANIMAL; BONE TUMOR; CELL MOTION; FEMALE; HUMAN; LUNG TUMOR; MOUSE; PATHOLOGY; PHYSIOLOGY; SECONDARY; TUMOR CELL LINE; TUMOR INVASION;

ANIMALS; BETA CATENIN; BONE NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; DOWN-REGULATION; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GLYCOGEN SYNTHASE KINASE 3; HUMANS; LUNG NEOPLASMS; MICE; NEOPLASM INVASIVENESS; NUCLEAR PROTEINS; OSTEOSARCOMA; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 84958653149     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2016.01.046     Document Type: Article

References (48)

1. Gavert N., Ben-Ze'ev A. Epithelial-mesenchymal transition and the invasive potential of tumors. Trends Mol. Med 2008, 14:199-209.
2. Micalizzi D.S., Ford H.L. Epithelial-mesenchymal transition in development and cancer. Future Oncol 2009, 5:1129-1143.
3. Guarino M. Epithelial-mesenchymal transition and tumour invasion. Int. J. Biochem. Cell Biol 2007, 39:2153-2160.
4. Geiger T.R., Peeper D.S. Metastasis mechanisms. Biochim. Biophys. Acta 2009, 1796:293-308.
5. Voulgari A., Pintzas A. Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic. Biochim. Biophys. Acta 2009, 1796:75-90.
6. Lin C.H., Ji T., Chen C.-F., Hoang B.H. Wnt signaling in osteosarcoma. Adv. Exp. Med. Biol 2014, 804:33-45.
7. Tian J., He H., Lei G. Wnt/β-catenin pathway in bone cancers. Tumour Biol 2014, 35:9439-9445.
8. McQueen P., Ghaffar S., Guo Y., Rubin E.M., Zi X., Hoang B.H. The Wnt signaling pathway: implications for therapy in osteosarcoma. Expert Rev. Anticancer Ther 2011, 11:1223-1232.
9. Cai Y., Cai T., Chen Y. Wnt pathway in osteosarcoma, from oncogenic to therapeutic. J. Cell. Biochem 2014, 115:625-631.
10. Lee M.P., Feinberg A.P. Genomic imprinting of a human apoptosis gene homologue, TSSC3. Cancer Res 1998, 58:1052-1056.
11. Li Y., Meng G., Guo Q. Changes in genomic imprinting and gene expression associated with transformation in a model of human osteosarcoma. Exp. Mol. Pathol 2008, 84:234-239.
12. Muller S., van den Boom D., Zirkel D., Koster H., Berthold F., Schwab M., et al. Retention of imprinting of the human apoptosis-related gene TSSC3 in human brain tumors. Hum. Mol. Genet 2000, 9:757-763.
13. Schwienbacher C., Angioni A., Scelfo R., Veronese A., Calin G.A., Massazza G., et al. Abnormal RNA expression of 11p15 imprinted genes and kidney developmental genes in Wilms' tumor. Cancer Res 2000, 60:1521-1525.
14. Marchiori A.C., Casolari D.A., Nagai M.A. Transcriptional up-regulation of PHLDA1 by 17beta-estradiol in MCF-breast cancer cells. Braz. J. Med. Biol. Res 2008, 41:579-582.
15. Nagai M.A., Fregnani J.H., Netto M.M., Brentani M.M., Soares F.A. Down-regulation of PHLDA1 gene expression is associated with breast cancer progression. Breast Cancer Res. Treat 2007, 106:49-56.
16. Neef R., Kuske M.A., Prols E., Johnson J.P. Identification of the human PHLDA1/TDAG51 gene: down-regulation in metastatic melanoma contributes to apoptosis resistance and growth deregulation. Cancer Res 2002, 62:5920-5929.
17. Dai H., Huang Y., Li Y., Meng G., Wang Y., Guo Q.N. TSSC3 overexpression associates with growth inhibition, apoptosis induction and enhances chemotherapeutic effects in human osteosarcoma. Carcinogenesis 2011, 33:30-40.
18. Huang Y., Dai H., Guo Q.-N. TSSC3 overexpression reduces stemness and induces apoptosis of osteosarcoma tumor-initiating cells. Apoptosis 2012, 17:749-761.
19. Li Y., Huang Y., Lv Y., Meng G., Guo Q.N. Epigenetic regulation of the pro-apoptosis gene TSSC3 in human osteosarcoma cells. Biomed. Pharmacother 2014, 68:45-50.
20. Meng G., Lv Y., Dai H., Zhang X., Guo Q.N. Epigenetic silencing of methyl-CpG-binding protein 2 gene affects proliferation, invasion, migration, and apoptosis of human osteosarcoma cells. Tumour Biol 2014, 35:11819-11827.
21. Hou C.H., Lin F.L., Hou S.M., Liu J.F. Cyr61 promotes epithelial-mesenchymal transition and tumor metastasis of osteosarcoma by Raf-1/MEK/ERK/Elk-1/TWIST-signaling pathway. Mol. Cancer 2014, 13:236.
22. Wang Y., Shi J., Chai K., Ying X., Zhou B.P. The role of Snail in EMT and tumorigenesis. Curr. Cancer Drug Targets 2013, 13:963-972.
23. Kaufhold S., Bonavida B. Central role of Snail1 in the regulation of EMT and resistance in cancer: a target for therapeutic intervention. J. Exp. Clin. Cancer Res 2014, 33:62.
24. Zi X., Guo Y., Simoneau A.R., Hope C., Xie J., Holcombe R.F., et al. Expression of Frzb/secreted Frizzled-related protein 3, a secreted Wnt antagonist, in human androgen-independent prostate cancer PC-cells suppresses tumor growth and cellular invasiveness. Cancer Res 2005, 65:9762-9770.
25. Mohinta S., Wu H., Chaurasia P., Watabe K. Wnt pathway and breast cancer. Front. Biosci 2007, 12:4020-4033.
26. Tomita H., Yamada Y., Oyama T., Hata K., Hirose Y., Hara A., et al. Development of gastric tumors in Apc(Min/+) mice by the activation of the beta-catenin/Tcf signaling pathway. Cancer Res 2007, 67:4079-4087.
27. Najdi R., Holcombe R.F., Waterman M.L. Wnt signaling and colon carcinogenesis: beyond APC. J. Carcinog 2011, 10:5.
28. Larue L., Delmas V. The WNT/Beta-catenin pathway in melanoma. Front. Biosci 2006, 11:733-742.
29. Van't Veer L.J., Weigelt B. Road map to metastasis. Nat. Med 2003, 9:999-1000.
30. Hazan R.B., Qiao R., Keren R., Badano I., Suyama K. Cadherin switch in tumor progression. Ann. N. Y. Acad. Sci 2004, 1014:155-163.
31. Muqbil I., Wu J., Aboukameel A., Mohammad R.M., Azmi A.S. Snail nuclear transport: the gateways regulating epithelial-to-mesenchymal transition?. Semin. Cancer Biol 2014, 27:39-45.
32. Sharili A.-S., Allen S., Smith K., Price J., McGonnell I.M. Snail2 promotes osteosarcoma cell motility through remodelling of the actin cytoskeleton and regulates tumor development. Cancer Lett 2013, 333:170-179.
33. Haydon R.C., Deyrup A., Ishikawa A., Heck R., Jiang W., Zhou L., et al. Cytoplasmic and/or nuclear accumulation of the beta-catenin protein is a frequent event in human osteosarcoma. Int. J. Cancer 2002, 102:338-342.
34. Iwaya K., Ogawa H., Kuroda M., Izumi M., Ishida T., Mukai K. Cytoplasmic and/or nuclear staining of beta-catenin is associated with lung metastasis. Clin. Exp. Metastasis 2003, 20:525-529.
35. Cohen P., Frame S. The renaissance of GSK3. Nat. Rev. Mol. Cell Biol 2001, 2:769-776.
36. Doble B.W., Woodgett J.R. GSK-3: tricks of the trade for a multi-tasking kinase. J. Cell Sci 2003, 116:1175-1186.
37. Takahashi-Yanaga F. Activator or inhibitor? GSK-as a new drug target. Biochem. Pharmacol 2013, 86:191-199.
38. Wang Z., Smith K.S., Murphy M., Piloto O., Somervaille T.C.P., Cleary M.L. Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy. Nature 2008, 455:1205-1209.
39. Kotliarova S., Pastorino S., Kovell L.C., Kotliarov Y., Song H., Zhang W., et al. Glycogen synthase kinase-inhibition induces glioma cell death through c-MYC, nuclear factor- B, and glucose regulation. Cancer Res 2008, 68:6643-6651.
40. Ougolkov A.V. Aberrant nuclear accumulation of glycogen synthase kinase-in human pancreatic cancer: association with kinase activity and tumor dedifferentiation. Clin. Cancer Res 2006, 12:5074-5081.
41. Mishra R. Glycogen synthase kinase 3 beta: can it be a target for oral cancer. Mol. Cancer 2010, 9:144.
42. Chen C., Zhao M., Tian A., Zhang X., Yao Z., Ma X. Aberrant activation of Wnt/beta-catenin signaling drives proliferation of bone sarcoma cells. Oncotarget 2015, 6:17570-17583.
43. Xia J.J., Pei L.B., Zhuang J.P., Ji Y., Xu G.P., Zhang Z.P., et al. Celecoxib inhibits beta-catenin-dependent survival of the human osteosarcoma MG-63 cell line. J. Int. Med. Res 2010, 38:1294-1304.
44. Daino K., Ugolin N., Altmeyer-Morel S., Guilly M.-N., Chevillard S. Gene expression profiling of alpha-radiation-induced rat osteosarcomas: identification of dysregulated genes involved in radiation-induced tumorigenesis of bone. Int. J. Cancer 2009, 125:612-620.
45. Wang Y., Yang Z., Meng Z., Cao H., Zhu G., Liu T., et al. Knockdown of TRPM8 suppresses cancer malignancy and enhances epirubicin-induced apoptosis in human osteosarcoma cells. Int. J. Biol. Sci 2014, 10:90-102.
46. Wu J., Liao Q., He H., Zhong D., Yin K. TWIST interacts with β-catenin signaling on osteosarcoma cell survival against cisplatin. Mol. Carcinog 2014, 53:440-446.
47. Tang Q.L., Xie X.B., Wang J., Chen Q., Han A.J., Zou C.Y., et al. Glycogen synthase kinase-, NF- B signaling, and tumorigenesis of human OsteosarcomaA. J. Natl Cancer Inst 2012, 104:749-763.
48. Zeng X., Tamai K., Doble B., Li S., Huang H., Habas R., et al. A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation. Nature 2005, 438:873-877.