TSSC3 overexpression associates with growth inhibition, apoptosis induction and enhances chemotherapeutic effects in human osteosarcoma

Carcinogenesis

Volumn 33, Issue 1, 2012, Pages 30-40

  Dai, Huanzi ^a   Huang, Yusheng ^a   Li, Yi ^a   Meng, Gang ^a   Wang, Yongqiang ^a   Guo, Qiao Nan ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BETA ACTIN; CASPASE 3; CISPLATIN; DNA NUCLEOTIDYLEXOTRANSFERASE; EPIRUBICIN; KI 67 ANTIGEN; LIPOCORTIN 5; PLECKSTRIN; PROPIDIUM IODIDE; PROTEIN BAX; PROTEIN BCL 2; TSSC3 PROTEIN; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER INHIBITION; CANCER SIZE; CANCER TISSUE; CARCINOGENESIS; CELL CYCLE G0 PHASE; CELL GROWTH; CELL PROLIFERATION; CHILD; CLINICAL ARTICLE; COLONY FORMATION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; G1 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MALE; MALIGNANT TRANSFORMATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOBLAST; OSTEOSARCOMA; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCHOOL CHILD; SENESCENCE;

EID: 84855396785     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgr232     Document Type: Article

References (55)

1. Fuchs,B. et al. (2002) Etiology of osteosarcoma. Clin. Orthop. Relat. Res., 397, 40-52.
2. Gibbs, C.P. Jr et al. (2002) Malignant bone tumors. Instr. Course Lect., 51, 413-428.
3. Wachtel,M. et al. (2010) Targets for cancer therapy in childhood sarcomas. Cancer Treat. Rev., 36, 318-327.
4. Hanahan,D. et al. (2000) The hallmarks of cancer. Cell, 100, 57-70.
5. Jelinic,P. et al. (2007) Loss of imprinting and cancer. J. Pathol., 211, 261-268.
6. Li,Y. et al. (2008) Changes in genomic imprinting and gene expression associated with transformation in a model of human osteosarcoma. Exp. Mol. Pathol., 84, 234-239.
7. Lee,M.P. et al. (1998) Genomic imprinting of a human apoptosis gene homologue, TSSC3. Cancer Res., 58, 1052-1056.
8. Hengartner,M.O. (2000) The biochemistry of apoptosis. Nature, 407, 770-776.
9. Adams,J.M. (2003) Ways of dying: multiple pathways to apoptosis. Genes Dev., 17, 2481-2495.
10. Riedl,S.J. et al. (2004) Molecular mechanisms of caspase regulation during apoptosis. Nat. Rev. Mol. Cell Biol., 5, 897-907.
11. Johnstone,R.W. et al. (2002) Apoptosis: a link between cancer genetics and chemotherapy. Cell, 108, 153-164.
12. Chou,K.C. et al. (2008) Cell-PLoc: a package ofWeb servers for predicting subcellular localization of proteins in various organisms. Nat. Protoc., 3, 153-162.
13. Shen,H.B. et al. (2007) Hum-mPLoc: an ensemble classifier for large-scale human protein subcellular location prediction by incorporating samples with multiple sites. Biochem. Biophys. Res. Commun., 355, 1006-1011.
14. Zhu,X.J. et al. (2009) The effects of BAFF and BAFF-R-Fc fusion protein in immune thrombocytopenia. Blood, 114, 5362-5367.
15. Su,X. et al. (2009) Lanthanum citrate induces anoikis of Hela cells. Cancer Lett., 285, 200-209.
16. Ferguson-Smith,A.C. et al. (1990) Genomic imprinting and cancer. Cancer Surv., 9, 487-503.
17. Derrane,M. (1999) Gene imprinting: making an impression on cancer research. J. Natl Cancer Inst., 91, 16-18.
18. Frank,D. et al. (1999) A novel pleckstrin homology-related gene family defined by Ipl/Tssc3, TDAG51, and Tih1: tissue-specific expression, chromosomal location, and parental imprinting. Mamm. Genome, 10, 1150-1159.
19. Qian,N. et al. (1997) The IPL gene on chromosome 11p15.5 is imprinted in humans and mice and is similar to TDAG51, implicated in Fas expression and apoptosis. Hum. Mol. Genet., 6, 2021-2029.
20. Kim,H.S. et al. (2007) Hypoxia regulates the expression of PHLDA2 in primary term human trophoblasts. Placenta, 28, 77-84.
21. Tunster,S.J. et al. (2010) The imprinted Phlda2 gene regulates extraembryonic energy stores. Mol. Cell. Biol., 30, 295-306.
22. Salas,M. et al. (2004) Placental growth retardation due to loss of imprinting of Phlda2. Mech. Dev., 121, 1199-1210.
23. Mancini-Dinardo,D. et al. (2006) Elongation of the Kcnq1ot1 transcript is required for genomic imprinting of neighboring genes. Genes Dev., 20, 1268-1282.
24. Apostolidou,S. et al. (2007) Elevated placental expression of the imprinted PHLDA2 gene is associated with low birth weight. J. Mol. Med., 85, 379-387.
25. Nagai,M.A. et al. (2007) Down-regulation of PHLDA1 gene expression is associated with breast cancer progression. Breast Cancer Res. Treat., 106, 49-56.
26. Marchiori,A.C. et al. (2008) Transcriptional up-regulation of PHLDA1 by 17beta-estradiol in MCF-7 breast cancer cells. Braz. J. Med. Biol. Res., 41, 579-582.
27. Neef,R. et al. (2002) Identification of the human PHLDA1/TDAG51 gene: down-regulation in metastatic melanoma contributes to apoptosis resistance and growth deregulation. Cancer Res., 62, 5920-5929.
28. Saxena,A. et al. (2003) The product of the imprinted gene IPL marks human villous cytotrophoblast and is lost in complete hydatidiform mole. Placenta, 24, 835-842.
29. Schwienbacher,C. et al. (2000) Abnormal RNA expression of 11p15 imprinted genes and kidney developmental genes in Wilms' tumor. Cancer Res., 60, 1521-1525.
30. Müller,S. et al. (2000) Retention of imprinting of the human apoptosisrelated gene TSSC3 in human brain tumors. Hum. Mol. Genet., 9, 757-763.
31. Park,C.G. et al. (1996) A novel gene product that couples TCR signaling to Fas(CD95) expression in activation-induced cell death. Immunity, 4, 583-591.
32. Gomes,I. et al. (1999) A proline- and glutamine-rich protein promotes apoptosis in neuronal cells. J. Neurochem., 73, 612-622.
33. Trougakos,I.P. et al. (2010) Genome-wide transcriptome profile of the human osteosarcoma Sa OS and U-2 OS cell lines. Cancer Genet. Cytogenet., 196, 109-118.
34. Bakhshi,S. et al. (2010) Prognostic markers in osteosarcoma. Expert Rev. Anticancer Ther., 10, 271-287.
35. Oberg,H.H. et al. (2004) Regulation of T-cell death-associated gene 51 (TDAG51) expression in human T-cells. Cell Death Differ., 11, 674-684.
36. Rho,J. et al. (2001) TDAG51 is not essential for Fas/CD95 regulation and apoptosis in vivo. Mol. Cell. Biol., 21, 8365-8370.
37. Green,D.R. (2010) Cancer: a wolf in wolf's clothing. Nature, 465, 433.
38. Toyoshima,Y. et al. (2004) TDAG51 mediates the effects of insulin-like growth factor I (IGF-I) on cell survival. J. Biol. Chem., 279, 25898-25904.
39. Hossain,G.S. et al. (2003) TDAG51 is induced by homocysteine, promotes detachment-mediated programmed cell death, and contributes to the cevelopment of atherosclerosis in hyperhomocysteinemia. J. Biol. Chem., 278, 30317-30327.
40. Hinz,T. et al. (2001) Inhibition of protein synthesis by the T cell receptorinducible human TDAG51 gene product. Cell Signal., 13, 345-352.
41. Kawase,T. et al. (2009) PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt. Cell, 136, 535-550.
42. Oberst,M.D. et al. (2008) TDAG51 is an ERK signaling target that opposes ERK-mediated HME16C mammary epithelial cell transformation. BMC Cancer, 8, 189.
43. Zhan,S. et al. (1995) Loss of imprinting of IGF2 in Ewing's sarcoma. Oncogene, 11, 2503-2507.
44. Randhawa,G.S. et al. (1998) Loss of imprinting in disease progression in chronic myelogenous leukemia. Blood, 91, 3144-3147.
45. Huang,J. et al. (2007) Up-regulation of DLK1 as an imprinted gene could contribute to human hepatocellular carcinoma. Carcinogenesis, 28, 1094-1103.
46. Nakanishi,H. et al. (2004) Loss of imprinting of PEG1/MEST in lung cancer cell lines. Oncol. Rep., 12, 1273-1278.
47. Ulaner,G.A. et al. (2003) Loss of imprinting of IGF2 and H19 in osteosarcoma is accompanied by reciprocal methylation changes of a CTCF-binding site. Hum. Mol. Genet., 12, 535-549.
48. Yoon,B.J. et al. (2002) Regulation of DNA methylation of Rasgrf1. Nat. Genet., 30, 92-96.
49. Vilkaitis,G. et al. (2005) Processive methylation of hemimethylated CpG sites by mouse Dnmt1 DNA methyltransferase. J. Biol. Chem., 280, 64-72.
50. Sleutels,F. et al. (2002) The non-coding Air RNA is required for silencing autosomal imprinted genes. Nature, 415, 810-813.
51. McMinn,J. et al. (2006) Unbalanced placental expression of imprinted genes in human intrauterine growth restriction. Placenta, 27, 540-549.
52. Zuo,Q.S. et al. (2011) Loss of imprinting and abnormal expression of the insulin-like growth factor 2 gene in gastric cancer. Mol. Carcinog., 50, 390-396.
53. Yoshimizu,T. et al. (2008) The H19 locus acts in vivo as a tumor suppressor. Proc. Natl Acad. Sci. USA, 105, 12417-12422.
54. Jin,R.J. et al. (2008) Down-regulation of p57(Kip2) induces prostate cancer in the mouse. Cancer Res., 68, 3601-3608.
55. Li,Y. et al. (2009) Hypomethylation of the P3 promoter is associated with up-regulation of IGF2 expression in human osteosarcoma. Hum. Pathol., 40, 1441-1447.