Zinc as an adjunct to antibiotics for the treatment of severe pneumonia in children <5 years: A meta-analysis of randomised-controlled trials

British Journal of Nutrition

Volumn 115, Issue 5, 2016, Pages 807-816

  Tie, Hong Tao ^a   Tan, Qi ^b   Luo, Ming Zhu ^b   Li, Qiang ^a   Yu, Jia Lin ^b   Wu, Qing Chen ^a  

^a THE FIRST AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

^b CHILDREN S HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Children; Meta analyses; Severe pneumonia; Zinc

Indexed keywords

AMINOGLYCOSIDE; AMOXICILLIN; AMPICILLIN; ANTIBIOTIC AGENT; CEFOTAXIME; CEFTRIAXONE; CHLORAMPHENICOL; CLOXACILLIN; GENTAMICIN; PENICILLIN G; PLACEBO; ZINC; ANTIINFECTIVE AGENT;

ADD ON THERAPY; ARTICLE; CHILD; DISEASE SEVERITY; HOSPITALIZATION; HUMAN; INTENTION TO TREAT ANALYSIS; LENGTH OF STAY; MAJOR CLINICAL STUDY; META ANALYSIS; MORTALITY RATE; PNEUMONIA; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK FACTOR; STAPHYLOCOCCAL PNEUMONIA; TREATMENT FAILURE; DIETARY SUPPLEMENT; FEMALE; MALE; PRESCHOOL CHILD; TREATMENT OUTCOME;

ANTI-BACTERIAL AGENTS; CHILD, PRESCHOOL; DIETARY SUPPLEMENTS; FEMALE; HUMANS; MALE; PNEUMONIA; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TREATMENT OUTCOME; ZINC;

EID: 84958641322     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114515005449     Document Type: Article

References (35)

1. Scott JA, Brooks WA, Peiris JS, et al. (2008) Pneumonia research to reduce childhood mortality in the developing world. J Clin Invest 118, 1291-1300.
2. Liu L, Oza S, Hogan D, et al. (2015) Global, regional, and national causes of child mortality in 2000-13, with projections to inform post-2015 priorities: an updated systematic analysis. Lancet 385, 430-440.
3. Bryce J, Black RE & Victora CG (2013) Millennium Development Goals 4 and 5: progress and challenges. BMC Med 11, 225.
4. Scrimshaw NS & SanGiovanni JP (1997) Synergism of nutrition, infection, and immunity: an overview. Am J Clin Nutr 66, 464S-477S.
5. Caulfield LE, de Onis M, Blossner M, et al. (2004) Undernutrition as an underlying cause of child deaths associated with diarrhea, pneumonia, malaria, and measles. Am J Clin Nutr 80, 193-198.
6. Basnet S, Mathisen M & Strand TA (2014) Oral zinc and common childhood infections-an update. J Trace Elem Med Biol 31, 163-166.
7. Black RE & Sazawal S (2001) Zinc and childhood infectious disease morbidity and mortality. Br j Nutr 85, S125-S129.
8. Shankar AH & Prasad AS (1998) Zinc and immune function: The biological basis of altered resistance to infection. Am J Clin Nutr 68, 447S-463S.
9. Brooks WA, Yunus M, Santosham M, et al. (2004) Zinc for severe pneumonia in very young children: double-blind placebo-controlled trial. Lancet 363, 1683-1688.
10. Valavi E, Hakimzadeh M, Shamsizadeh A, et al. (2011) The efficacy of zinc supplementation on outcome of children with severe pneumonia. A randomized double-blind placebo-controlled clinical trial. Indian J Pediatr 78, 1079-1084.
11. Wadhwa N, Chandran A, Aneja S, et al. (2013) Efficacy of zinc given as an adjunct in the treatment of severe and very severe pneumonia in hospitalized children 2-24 mo of age: A randomized, double-blind, placebo-controlled trial. Am J Clin Nutr 97, 1387-1394.
12. Basnet S, Shrestha PS, Sharma A, et al. (2012) A randomized controlled trial of zinc as adjuvant therapy for severe pneumonia in young children. Pediatrics 129, 701-708.
13. Srinivasan MG, Ndeezi G, Mboijana CK, et al. (2012) Zinc adjunct therapy reduces case fatality in severe childhood pneumonia: A randomized double blind placebo-controlled trial. BMC Med 10, 14.
14. Bose A, Coles CL, Gunavathi, et al. (2006) Efficacy of zinc in the treatment of severe pneumonia in hospitalized children <2 y old. Am J Clin Nutr 83, 1089-1096.
15. Valentiner-Branth P, Shrestha PS, Chandyo RK, et al. (2010) A randomized controlled trial of the effect of zinc as adjuvant therapy in children 2-35 mo of age with severe or nonsevere pneumonia in Bhaktapur, Nepal. Am J Clin Nutr 91, 1667-1674.
16. Shah GS, Dutta AK, Shah D, et al. (2012) Role of zinc in severe pneumonia: A randomized double bind placebo controlled study. Ital J Pediatr 38, 36.
17. Sempertegui F, Estrella B, Rodriguez O, et al. (2014) Zinc as an adjunct to the treatment of severe pneumonia in Ecuadorian children: A randomized controlled trial. Am J Clin Nutr 99, 497-505.
18. Moher D, Liberati A, Tetzlaff J, et al. (2009) Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. BMJ 339, 2535.
19. Higgins JPT & Green S. (2008) Cochrane Handbook for Systematic Reviews of Interventions, vol 5. Wiley Online Library.
20. Higgins JP, Altman DG, Gotzsche PC, et al. (2011) The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ 343, d5928.
21. Hozo SP, Djulbegovic B & Hozo I (2005) Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol 5, 13.
22. Higgins JP, Thompson SG, Deeks JJ, et al. (2003) Measuring inconsistency in meta-analyses. BMJ 327, 557-560.
23. Shah G (2014) Role of zinc in severe pneumonia: A randomized double bind placebo controlled study. Pediatr Pulmonol 49, S81.
24. Bansal A, Parmar VR, Basu S, et al. (2011) Zinc supplementation in severe acute lower respiratory tract infection in children: A triple-blind randomized placebo controlled trial. Indian J Pediatr 78, 33-37.
25. Mahalanabis D, Lahiri M, Paul D, et al. (2004) Randomized, double-blind, placebo-controlled clinical trial of the efficacy of treatment with zinc or vitamin A in infants and young children with severe acute lower respiratory infection. Am J Clin Nutr 79, 430-436.
26. Coles CL, Bose A, Moses PD, et al. (2007) Infectious etiology modifies the treatment effect of zinc in severe pneumonia. Am J Clin Nutr 86, 397-403.
27. Das RR, Singh M & Shafiq N (2012) Short-term therapeutic role of zinc in children <5 years of age hospitalised for severe acute lower respiratory tract infection. Paediatr Respir Rev 13, 184-191.
28. Theodoratou E, Al-Jilaihawi S, Woodward F, et al. (2010) The effect of case management on childhood pneumonia mortality in developing countries. Int J Epidemiol 39, i155-i171.
29. le Roux DM, Myer L, Nicol MP, et al. (2015) Incidence and severity of childhood pneumonia in the first year of life in a South African birth cohort: The Drakenstein Child Health Study. Lancet Global Health 3, e95-e103.
30. Haider BA, Lassi ZS, Ahmed A, et al. (2011) Zinc supplementation as an adjunct to antibiotics in the treatment of pneumonia in children 2 to 59 months of age. Cochrane Database Syst Rev CD007368.
31. Bonaventura P, Benedetti G, Albarede F, et al. (2015) Zinc and its role in immunity and inflammation. Autoimmun Rev 14, 277-285.
32. Brown KH (1998) Effect of infections on plasma zinc concentration and implications for zinc status assessment in low-income countries. Am J Clin Nutr 68, 425S-429S.
33. Tsai KS & Grayson MH (2008) Pulmonary defense mechanisms against pneumonia and sepsis. Curr Opin Pulmonary Med 14, 260-265.
34. Mizgerd JP (2008) Acute lower respiratory tract infection. New Engl J Med 358, 716-727.
35. Bhatnagar S, Wadhwa N, Aneja S, et al. (2012) Zinc as adjunct treatment in infants aged between 7 and 120 days with probable serious bacterial infection: A randomised, doubleblind, placebo-controlled trial. Lancet 379, 2072-2078.