Erratum: Pneumonia research to reduce childhood mortality in the developing world (The Journal of Clinical Investigation (2008), 118, 4 (1291-1300) DOI: 10.1172/JCI33947);Pneumonia research to reduce childhood mortality in the developing world

Journal of Clinical Investigation

Volumn 118, Issue 4, 2008, Pages 1291-1300

  Scott, J Anthony G ^a,b   Brooks, W Abdullah ^c   Peiris, J S Malik ^d   Holtzman, Douglas ^e   Mulholland, E Kim ^f  

^a Wellcome Trust/KEMRI Collaborative Programme   (Kenya)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c ICDDR B Centre for Health and Population Research   (Bangladesh)

^d UNIVERSITY OF HONG KONG   (Hong Kong)

^e BILL AND MELINDA GATES FOUNDATION   (United States)

^f LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; ANTIBIOTIC AGENT; COTRIMOXAZOLE; HAEMOPHILUS INFLUENZAE TYPE B VACCINE;

AIR QUALITY; CAUSE OF DEATH; CHILDHOOD MORTALITY; COUGHING; DEVELOPING COUNTRY; DYSPNEA; EPIDEMIC; HIGH RISK POPULATION; HUMAN; IMMUNIZATION; INFLAMMATION; NONHUMAN; NUTRITION; OXYGEN TRANSPORT; PATHOPHYSIOLOGY; PNEUMONIA; PRIORITY JOURNAL; REVIEW;

EID: 41849109884     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI33947E1     Document Type: Erratum

References (158)

1. Williams, B.G., Gouws, E., Boschi-Pinto, C., Bryce, J., and Dye, C. 2002. Estimates of world-wide distribution of child deaths from acute respiratory infections. Lancet Infect. Dis. 2:25-32.
2. WHO Programme for Control of Acute Respiratory Infections. 1990. Acute respiratory infections in children: case management in small hospitals in developing countries. A manual for doctors and other senior health workers. WHO. Geneva, Switzerland. 74 pp.
3. Scott, J.A., et al. 2000. Aetiology, outcome, and risk factors for mortality among adults with acute pneumonia in Kenya. Lancet. 355:1225-1230.
4. Metlay, J.P., Fishman, N.O., Joffe, M., and Edelstein, P.H. 2006. Impact of pediatric vaccination with pneumococcal conjugate vaccine on the risk of bacteremic pneumococcal pneumonia in adults. Vaccine. 24:468-475.
5. Preston, S.R., and Haines, M.R. 1991. Fatal years - child mortality in late 19th century America. Princeton University Press. Princeton, New Jersey, USA. 4-5.
6. Grove, R.D., and Hetzel, A.M. 1968. Vital statistics rates in the United States, 1940-1960. US Department of Health, Education and Welfare, Public Health Service. Washington, DC, USA. 478-479.
7. Linder, F.E., and Grove, R.D. 1947. Vital statistics rates in the United States, 1900-1940. United States Government Printing Office. Washington, DC, USA. 254-255.
8. Mulholland, K. 2007. Perspectives on the burden of pneumonia in children. Vaccine. 25:2394-2397.
9. Rudan, I., Tomaskovic, L., Boschi-Pinto, C., and Campbell, H. 2004. Global estimate of the incidence of clinical pneumonia among children under five years of age. Bull. World Health Organ. 82:895-903.
10. UNICEF. 2007. State of the World's Children. New York: United Nations Children's Fund.
11. Cherian, T., et al. 2005. Standardized interpretation of paediatric chest radiographs for the diagnosis of pneumonia in epidemiological studies. Bull. World Health Organ. 83:353-359.
12. Cutts, F.T., et al. 2005. Efficacy of nine-valent pneumococcal conjugate vaccine against pneumonia and invasive pneumococcal disease in The Gambia: randomised, double-blind, placebo-controlled trial. Lancet. 365:1139-1146.
13. Scott, J.A., and Hall, A.J. 1999. The value and complications of percutaneous transthoracic lung aspiration for the etiologic diagnosis of community-acquired pneumonia. Chest. 116:1716-1732.
14. Shann, F., et al. 1984. Aetiology of pneumonia in children in Goroka Hospital, Papua New Guinea. Lancet. 2:537-541.
15. Adegbola, R.A., et al. 1994. The etiology of pneumonia in malnourished and well-nourished Gambian children. Pediatr. Infect. Dis. J. 13:975-982.
16. Lee, W.M., et al. 2007. High-throughput, sensitive, and accurate multiplex PCR-Microsphere flow cytometry system for large-scale comprehensive detection of respiratory viruses. J. Clin. Microbiol. 45:2626-2634.
17. Fan, J., Henrickson, K.J., and Savatski, L.L. 1998. Rapid simultaneous diagnosis of infections with respiratory syncytial viruses A and B, influenza viruses A and B, and human parainfluenza virus types 1, 2, and 3 by multiplex quantitative reverse transcription-polymerase chain reaction-enzyme hybridization assay (Hexaplex). Clin. Infect. Dis. 26:1397-1402.
18. Coiras, M.T., Aguilar, J.C., Garcia, M.L., Casas, I., and Perez-Brena, P. 2004. Simultaneous detection of fourteen respiratory viruses in clinical specimens by two multiplex reverse transcription nested-PCR assays. J. Med. Virol. 72:484-495.
19. Syrmis, M.W., et al. 2004. A sensitive, specific, and cost-effective multiplex reverse transcriptase-PCR assay for the detection of seven common respiratory viruses in respiratory samples. J. Mol. Diagn. 6:125-131.
20. Templeton, K.E., Scheltinga, S.A., Beersma, M.F.C., Kroes, A.C.M., and Claas, E.C.J. 2004. Rapid and sensitive method using multiplex real-time PCR for diagnosis of infections by influenza a and influenza B viruses, respiratory syncytial virus, and parainfluenza viruses 1, 2, 3, and 4. J. Clin. Microbiol. 42:1564-1569.
21. Khanna, M., et al. 2005. The pneumoplex assays, a multiplex PCR-enzyme hybridization assay that allows simultaneous detection of five organisms, Mycoplasma pneumoniae, Chlamydia (Chlamydophila) pneumoniae, Legionella pneumophila, Legionella micdadei, and Bordetella pertussis, and its real-time counterpart. J. Clin. Microbiol. 43:565-571.
22. Mahony, J., et al. 2007. Development of a Respiratory Virus Panel (RVP) test for the detection of twenty human respiratory viruses using Multiplex PCR and a fluid microbead-based assay. J. Clin. Microbiol. 45:2965-2970.
23. Briese, T., et al. 2005. Diagnostic system for rapid and sensitive differential detection of pathogens. Emerg. Infect. Dis. 11:310-313.
24. Wang, D., et al. 2002. Microarray-based detection and genotyping of viral pathogens. Proc. Natl. Acad. Sci. U. S. A. 99:15687-15692.
25. Ecker, D.J., et al. 2005. Rapid identification and strain-typing of respiratory pathogens for epidemic surveillance. Proc. Natl. Acad. Sci. U. S. A. 102:8012-8017.
26. Chiu, C.Y., et al. 2007. Diagnosis of a critical respiratory illness caused by human metapneumovirus by use of a pan-virus microarray. J. Clin. Microbiol. 45:2340-2343.
27. Palacios, G., et al. 2007. Panmicrobial oligonucleotide array for diagnosis of infectious diseases. Emerg. Infect. Dis. 13:73-81.
28. Murdoch, D.R., et al. 2001. Evaluation of a rapid immunochromatographic test for detection of Streptococcus pneumoniae antigen in urine samples from adults with community-acquired pneumonia. J. Clin. Microbiol. 39:3495-3498.
29. Leeming, J.P., Cartwright, K., Morris, R., Martin, S.A., and Smith, M.D. 2005. Diagnosis of invasive pneumococcal infection by serotype-specific urinary antigen detection. J. Clin. Microbiol. 43:4972-4976.
30. Dowell, S.F., Garman, R.L., Liu, G., Levine, O.S., and Yang, Y.H. 2001. Evaluation of Binax NOW, an assay for the detection of pneumococcal antigen in urine samples, performed among pediatric patients. Clin. Infect. Dis. 32:824-825.
31. Hill, P.C., et al. 2006. Nasopharyngeal carriage of Streptococcus pneumoniae in Gambian villagers. Clin. Infect. Dis. 43:673-679.
32. Korppi, M. 2004. Non-specific host response markers in the differentiation between pneumococcal and viral pneumonia: what is the most accurate combination? Pediatr. Int. 46:545-550.
33. Simon, L., Gauvin, F., Amre, D.K., Saint-Louis, P., and Lacroix, J. 2004. Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: a systematic review and meta-analysis. Clin. Infect. Dis. 39:206-217.
34. van der Meer, V., Neven, A.K., van den Broek, P.J., and Assendelft, W.J. 2005. Diagnostic value of C reactive protein in infections of the lower respiratory tract: systematic review. BMJ. 331:26.
35. Madhi, S.A., Kohler, M., Kuwanda, L., Cutland, C., and Klugman, K.P. 2006. Usefulness of C-reactive protein to define pneumococcal conjugate vaccine efficacy in the prevention of pneumonia. Pediatr. Infect. Dis. J. 25:30-36.
36. Pauksen, K., Elfman, L., Ulfgren, A.K., and Venge, P. 1994. Serum levels of granulocyte-colony stimulating factor (G-CSF) in bacterial and viral infections, and in atypical pneumonia. Br. J. Haematol. 88:256-260.
37. Kragsbjerg, P., Jones, I., Vikerfors, T., and Holmberg, H. 1995. Diagnostic value of blood cytokine concentrations in acute pneumonia. Thorax. 50:1253-1257.
38. Ortqvist, A., Hedlund, J., Wretlind, B., Carlstrom, A., and Kalin, M. 1995. Diagnostic and prognostic value of interleukin-6 and C-reactive protein in community-acquired pneumonia. Scand. J. Infect. Dis. 27:457-462.
39. Kennon, C., et al. 1996. Granulocyte colony-stimulating factor as a marker for bacterial infection in neonates. J. Pediatr. 128:765-769.
40. Fischer, J.E., Benn, A., Harbarth, S., Nadal, D., and Fanconi, S. 2002. Diagnostic accuracy of G-CSF, IL-8, and IL-1ra in critically ill children with suspected infection. Intensive Care Med. 28:1324-1331.
41. Gibot, S., et al. 2004. Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia. N. Engl. J. Med. 350:451-458.
42. Neuzil, K.M., Mellen, B.G., Wright, P.F., Mitchel, E.F., Jr., and Griffin, M.R. 2000. The effect of influenza on hospitalizations, outpatient visits, and courses of antibiotics in children. N. Engl. J. Med. 342:225-231.
43. Chiu, S.S., Lau, Y.L., Chan, K.H., Wong, W.H.S., and Peiris, J.S.M. 2002. Influenza-related hospitalizations among children in Hong Kong. N. Engl. J. Med. 347:2097-2103.
44. Katz, M.A., et al. 2007. Who gets hospitalized for influenza pneumonia in Thailand? Implications for vaccine policy. Vaccine. 25:3827-3833.
45. Schwarzmann, S.W., Adler, J.L., Sullivan, R.J., Jr., and Marine, W.M. 1971. Bacterial pneumonia during the Hong Kong influenza epidemic of 1968-1969. Arch. Intern. Med. 127:1037-1041.
46. O'Brien, K.L., et al. 2000. Severe pneumococcal pneumonia in previously healthy children: the role of preceding influenza infection. Clin. Infect. Dis. 30:784-789.
47. McCullers, J.A. 2006. Insights into the interaction between influenza virus and pneumococcus. Clin. Microbiol. Rev. 19:571-582.
48. Madhi, S.A., and Klugman, K.P. 2004. A role for Streptococcus pneumoniae in virus-associated pneumonia. Nat. Med. 10:811-813.
49. Jennings, L.C., Anderson, T.P., Werno, A.M., Beynon, K.A., and Murdoch, D.R. 2004. Viral etiology of acute respiratory tract infections in children presenting to hospital: role of polymerase chain reaction and demonstration of multiple infections. Pediatr. Infect. Dis. J. 23:1003-1007.
50. Templeton, K.E., et al. 2005. Improved diagnosis of the etiology of community-acquired pneumonia with real-time polymerase chain reaction. Clin. Infect. Dis. 41:345-351.
51. van der Hoek, L., et al. 2004. Identification of a new human coronavirus. Nat. Med. 10:368-373.
52. Woo, P.C., et al. 2005. Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia. J. Virol. 79:884-895.
53. Lamson, D., et al. 2006. MassTag polymerasechain-reaction detection of respiratory pathogens, including a new rhinovirus genotype, that caused influenza-like illness in New York State during 2004-2005. J. Infect. Dis. 194:1398-1402.
54. Leung, C.-W., et al. 2004. Severe acute respiratory syndrome among children. Pediatrics. 113:e535-e543.
55. Wong, G.W.K., Li, A.M., Ng, P.C., and Fok, T.F. 2003. Severe acute respiratory syndrome in children. Pediatr. Pulmonol. 36:261-266.
56. Chen, J.-M., Chen, J.-W., Dai, J.-J., and Sun, Y.-X. 2007. A survey of human cases of H5N1 avian influenza reported by the WHO before June 2006 for infection control. Am. J. Infect. Control. 35:351-353.
57. Lipsitch, M., et al. 2003. Transmission dynamics and control of severe acute respiratory syndrome. Science. 300:1966-1970.
58. Gillim-Ross, L., and Subbarao, K. 2006. Emerging respiratory viruses: challenges and vaccine strategies. Clin. Microbiol. Rev. 19:614-636.
59. Yang, Z.-Y., et al. 2005. Evasion of antibody neutralization in emerging severe acute respiratory syndrome coronaviruses. Proc. Natl. Acad. Sci. U. S. A. 102:797-801.
60. Bell, D.M. 2006. Non-pharmaceutical interventions for pandemic influenza, international measures. Emerg. Infect. Dis. 12:81-87.
61. Fox, J.P., and Hall, C.E. 1980. Viruses in families: surveillance of families as a key to epidemiology of virus infection. PSG Publishing Company. Littleton, Massachusetts, USA. 441 pp.
62. Lloyd-Smith, J.O., Schreiber, S.J., Kopp, P.E., and Getz, W.M. 2005. Superspreading and the effect of individual variation on disease emergence. Nature. 438:355-359.
63. Weber, M.W., Palmer, A., Oparaugo, A., and Mulholland, E.K. 1995. Comparison of nasal prongs and nasopharyngeal catheter for the delivery of oxygen in children with hypoxemia because of a lower respiratory tract infection. J. Pediatr. 127:378-383.
64. Onyango, F.E., et al. 1993. Hypoxaemia in young Kenyan children with acute lower respiratory infection. BMJ. 306:612-615.
65. Smyth, A., Carty, H., and Hart, C.A. 1998. Clinical predictors of hypoxaemia in children with pneumonia. Ann. Trop. Paediatr. 18:31-40.
66. Duke, T., Mgone, J., and Frank, D. 2001. Hypoxaemia in children with severe pneumonia in Papua New Guinea. Int. J. Tuberc. Lung Dis. 5:511-519.
67. [Anonymous]. 2004. Informal consultation on clinical use of oxygen. Meeting report 2-3 October 2003. Child and Adolescent Health and Development. WHO. Geneva, Switzerland. 18 pp.
68. Wandi, F., Peel, D., and Duke, T. 2006. Hypoxaemia among children in rural hospitals in Papua New Guinea: epidemiology and resource availability - a study to support a national oxygen programme. Ann. Trop. Paediatr. 26:277-284.
69. L'Her, P., et al. 2006. The problem of oxygen in developing countries [In French]. Med. Trop. (Mars). 66:631-638.
70. Sommer, A., Katz, J., and Tarwotjo, I. 1984. Increased risk of respiratory disease and diarrhea in children with preexisting mild vitamin A deficiency. Am. J. Clin. Nutr. 40:1090-1095.
71. Bloem, M.W., et al. 1990. Mild vitamin A deficiency and risk of respiratory tract diseases and diarrhea in preschool and school children in northeastern Thailand. Am. J. Epidemiol. 131:332-339.
72. Huiming, Y., Chaomin, W., and Meng, M. 2005. Vitamin A for treating measles in children. Cochrane Database Syst. Rev. CD001479.
73. Brown, N., and Roberts, C. 2004. Vitamin A for acute respiratory infection in developing countries: a meta-analysis. Acta Paediatr. 93:1437-1442.
74. The Vitamin A and Pneumonia Working Group. 1995. Potential interventions for the prevention of childhood pneumonia in developing countries: a meta-analysis of data from field trials to assess the impact of vitamin A supplementation on pneumonia morbidity and mortality. Bull. World Health Organ. 73:609-619.
75. Grotto, I., Mimouni, M., Gdalevich, M., and Mimouni, D. 2003. Vitamin A supplementation and childhood morbidity from diarrhea and respiratory infections: a meta-analysis. J. Pediatr. 142:297-304.
76. Black, R.E. 2003. Zinc deficiency, infectious disease and mortality in the developing world. J. Nutr. 133:1485S-1489S.
77. Bhutta, Z.A., et al. 1999. Prevention of diarrhea and pneumonia by zinc supplementation in children in developing countries: pooled analysis of randomized controlled trials. Zinc Investigators' Collaborative Group. J. Pediatr. 135:689-697.
78. Brooks, W.A., et al. 2004. Zinc for severe pneumonia in very young children: double-blind placebo-controlled trial. Lancet. 363:1683-1688.
79. Brooks, W.A., et al. 2005. Effect of weekly zinc supplements on incidence of pneumonia and diarrhoea in children younger than 2 years in an urban, low-income population in Bangladesh: randomised controlled trial. Lancet. 366:999-1004.
80. Baqui, A.H., et al. 2002. Effect of zinc supplementation started during diarrhoea on morbidity and mortality in Bangladeshi children: community randomised trial. BMJ. 325:1059.
81. Gaetke, L.M., McClain, C.J., Talwalkar, R.T., and Shedlofsky, S.I. 1997. Effects of endotoxin on zinc metabolism in human volunteers. Am. J. Physiol. 272:E952-E956.
82. Cousins, R.J. 1985. Absorption, transport, and hepatic metabolism of copper and zinc: special reference to metallothionein and ceruloplasmin. Physiol. Rev. 65:238-309.
83. Truong-Tran, A.Q., et al. 2002. Altered zinc homeostasis and caspase-3 activity in murine allergic airway inflammation. Am. J. Respir. Cell Mol. Biol. 27:286-296.
84. Cho, Y.H., et al. 2002. Antibacterial effect of intraprostatic zinc injection in a rat model of chronic bacterial prostatitis. Int. J. Antimicrob Agents. 19:576-582.
85. Makonnen, B., Venter, A., and Joubert, G. 2003. A randomized controlled study of the impact of dietary zinc supplementation in the management of children with protein-energy malnutrition in Lesotho. I: Mortality and morbidity. J. Trop. Pediatr. 49:340-352.
86. Sazawal, S., et al. 2007. Effect of zinc supplementation on mortality in children aged 1-48 months: a community-based randomised placebo-controlled trial. Lancet. 369:927-934.
87. Bobat, R., et al. 2005. Safety and efficacy of zinc supplementation for children with HIV-1 infection in South Africa: a randomised double-blind placebo-controlled trial. Lancet. 366:1862-1867.
88. Bose, A., et al. 2006. Efficacy of zinc in the treatment of severe pneumonia in hospitalized children <2 y old. Am. J. Clin. Nutr. 83:1089-1096.
89. Howie, S., Zaman, S.M.A., Omoruyi, O., Adegbola, R., and Prentice, A. 2007. Severe pneumonia research and the problem of case definition: the example of zinc trials. Am. J. Clin. Nutr. 85:242-243.
90. Mahalanabis, D., et al. 2002. Zinc supplementation as adjunct therapy in children with measles accompanied by pneumonia: a double-blind, randomized controlled trial. Am. J. Clin. Nutr. 76:604-607.
91. Mahalanabis, D., et al. 2004. Randomized, double-blind, placebo-controlled clinical trial of the efficacy of treatment with zinc or vitamin A in infants and young children with severe acute lower respiratory infection. Am. J. Clin. Nutr. 79:430-436.
92. Knapp, S., et al. 2004. Toll-like receptor 2 plays a role in the early inflammatory response to murine pneumococcal pneumonia but does not contribute to antibacterial defense. J. Immunol. 172:3132-3138.
93. Lee, J.S., et al. 2005. TLR-4 pathway mediates the inflammatory response but not bacterial elimination in E. coli pneumonia. Am. J. Physiol. Lung Cell Mol. Physiol. 289:L731-L738.
94. Alexopoulou, L., Holt, A.C., Medzhitov, R., and Flavell, R.A. 2001. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature. 413:732-738.
95. Miettinen, M., Sareneva, T., Julkunen, I., and Matikainen, S. 2001. IFNs activate toll-like receptor gene expression in viral infections. Genes Immun. 2:349-355.
96. Monton, C., and Torres, A. 1998. Lung inflammatory response in pneumonia. Monaldi Arch. Chest Dis. 53:56-63.
97. Fernandez-Serrano, S., et al. 2003. Molecular inflammatory responses measured in blood of patients with severe community-acquired pneumonia. Clin. Diagn. Lab. Immunol. 10:813-820.
98. Renckens, R., et al. 2006. The acute-phase response and serum amyloid A inhibit the inflammatory response to Acinetobacter baumannii Pneumonia. J. Infect. Dis. 193:187-195.
99. Cheung, C.Y., et al. 2002. Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease? Lancet. 360:1831-1837.
100. Kobasa, D., et al. 2007. Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus. Nature. 445:319-323.
101. Belshe, R.B., et al. 2004. Evaluation of combined live, attenuated respiratory syncytial virus and parainfluenza 3 virus vaccines in infants and young children. J. Infect. Dis. 190:2096-2103.
102. Kuklin, N.A., et al. 2006. A novel Staphylococcus aureus vaccine: iron surface determinant B induces rapid antibody responses in rhesus macaques and specific increased survival in a murine S. aureus sepsis model. Infect. Immun. 74:2215-2223.
103. Andersen, P. 2007. Tuberculosis vaccines - an update. Nat. Rev. Microbiol. 5:484-487.
104. Barrett, D.J. 1985. Human immune responses to polysaccharide antigens: an analysis of bacterial polysaccharide vaccines in infants. Adv. Pediatr. 32:139-158.
105. Rijkers, G.T., Sanders, E.A., Breukels, M.A., and Zegers, B.J. 1998. Infant B cell responses to polysaccharide determinants. Vaccine. 16:1396-1400.
106. Douglas, R.M., Paton, J.C., Duncan, S.J., and Hansman, D.J. 1983. Antibody response to pneumococcal vaccination in children younger than five years of age. J. Infect. Dis. 148:131-137.
107. Avery, O.T., and Goebel, W.F. 1929. Chemo-immunological studies on conjugated carbohydrate-proteins: II. Immunological specificity of synthetic sugar-protein antigens. J. Exp. Med. 50:533-550.
108. Bisgard, K.M., et al. 1998. Haemophilus influenzae invasive disease in the United States, 1994-1995: near disappearance of a vaccine-preventable childhood disease. Emerg. Infect. Dis. 4:229-237.
109. [Anonymous]. 2005. Direct and indirect effects of routine vaccination of children with 7-valent pneumococcal conjugate vaccine on incidence of invasive pneumococcal disease - United States, 1998-2003. MMWR Morb. Mortal Wkly. Rep. 54:893-897.
110. Adegbola, R.A., et al. 2005. Elimination of Haemophilus influenzae type b (Hib) disease from The Gambia after the introduction of routine immunisation with a Hib conjugate vaccine: a prospective study. Lancet. 366:144-150.
111. Wall, R.A., Corrah, P.T., Mabey, D.C., and Greenwood, B.M. 1986. The etiology of lobar pneumonia in the Gambia. Bull. World Health Organ. 64:553-558.
112. Forgie, I.M., et al. 1991. Etiology of acute lower respiratory tract infections in Gambian children: I. Acute lower respiratory tract infections in infants presenting at the hospital. Pediatr. Infect. Dis. J. 10:33-41.
113. Mulholland, K., et al. 1997. Randomised trial of Haemophilus influenzae type-b tetanus protein conjugate vaccine for prevention of pneumonia and meningitis in Gambian infants. Lancet. 349:1191- 1197.
114. Jodar, L., et al. 2003. Serological criteria for evaluation and licensure of new pneumococcal conjugate vaccine formulations for use in infants. Vaccine. 21:3265-3272.
115. Mbelle, N., et al. 1999. Immunogenicity and impact on nasopharyngeal carriage of a nonavalent pneumococcal conjugate vaccine. J. Infect. Dis. 180:1171-1176.
116. Goldblatt, D., et al. 2005. Antibody responses to nasopharyngeal carriage of Streptococcus pneumoniae in adults: A longitudinal household study. J. Infect. Dis. 192:387-393.
117. Dagan, R., et al. 2002. Reduction of nasopharyngeal carriage of Streptococcus pneumoniae after administration of a 9-valent pneumococcal conjugate vaccine to toddlers attending day care centers. J. Infect. Dis. 185:927-936.
118. Singleton, R.J., et al. 2007. Invasive pneumococcal disease caused by nonvaccine serotypes among alaska native children with high levels of 7-valent pneumococcal conjugate vaccine coverage. JAMA. 297:1784-1792.
119. Laine, C., et al. 2004. Age-specific immunoglobulin g (IgG) and IgA to pneumococcal protein antigens in a population in coastal Kenya. Infect. Immun. 72:3331-3335.
120. Hamel, J., et al. 2004. Prevention of pneumococcal disease in mice immunized with conserved surface-accessible proteins. Infect. Immun. 72:2659-2670.
121. Ogunniyi, A.D., Grabowicz, M., Briles, D.E., Cook, J., and Paton, J.C. 2007. Development of a vaccine against invasive pneumococcal disease based on combinations of virulence proteins of Streptococcus pneumoniae. Infect. Immun. 75:350-357.
122. Barocchi, M.A., et al. 2006. A pneumococcal pilus influences virulence and host inflammatory responses. Proc. Natl. Acad. Sci. U. S. A. 103:2857-2862.
123. Briles, D.E., et al. 2000. Immunization of humans with recombinant pneumococcal surface protein A (rPspA) elicits antibodies that passively protect mice from fatal infection with Streptococcus pneumoniae bearing heterologous PspA. J. Infect. Dis. 182:1694-1701.
124. Malley, R., et al. 2001. Intranasal immunization with killed unencapsulated whole cells prevents colonization and invasive disease by capsulated pneumococci. Infect. Immun. 69:4870-4873.
125. Malley, R., et al. 2005. CD4+ T cells mediate antibody-independent acquired immunity to pneumococcal colonization. Proc. Natl. Acad. Sci. U. S. A. 102:4848-4853.
126. Lehmann, D., Pomat, W.S., Riley, I.D., and Alpers, M.P. 2003. Studies of maternal immunisation with pneumococcal polysaccharide vaccine in Papua New Guinea. Vaccine. 21:3446-3450.
127. [Anonymous]. 1998. Report of a meeting on maternal and neonatal pneumococcal immunization. January 26-27. WHO. Geneva, Switzerland. 61 pp.
128. Weber, M.W., et al. 2002. An epidemiological study of RSV infection in the Gambia. Bull. World Health Organ. 80:562-568.
129. Robertson, S.E., et al. 2004. Respiratory syncytial virus infection: denominator-based studies in Indonesia, Mozambique, Nigeria and South Africa. Bull. World Health Organ. 82:914-922.
130. Nokes, D.J., et al. 2007. Respiratory Syncytial Virus infection and disease in infants and young children studied from birth in Kilifi District, Kenya. Clin. Infect. Dis. 46:50-57.
131. Chin, J., Magoffin, R.L., Shearer, L.A., Schieble, J.H., and Lennette, E.H. 1969. Field evaluation of a respiratory syncytial virus vaccine and a trivalent parainfluenza virus vaccine in a pediatric population. Am. J. Epidemiol. 89:449-463.
132. Kim, H.W., et al. 1969. Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine. Am. J. Epidemiol. 89:422-434.
133. Hall, C.B., Walsh, E.E., Long, C.E., and Schnabel, K.C. 1991. Immunity to and frequency of reinfection with respiratory syncytial virus. J. Infect. Dis. 163:693-698.
134. Henderson, F.W., Collier, A.M., Clyde, W.A., Jr., and Denny, F.W. 1979. Respiratory-syncytial-virus infections, reinfections and immunity. A prospective, longitudinal study in young children. N. Engl. J. Med. 300:530-534.
135. van Drunen Littel-van den Hurk, S., Mapletoft, J.W., Arsic, N., and Kovacs-Nolan, J. 2007. Immunopathology of RSV infection: prospects for developing vaccines without this complication. Rev. Med. Virol. 17:5-34.
136. Crowe, J.E., Jr., Bui, P.T., Davis, A.R., Chanock, R.M., and Murphy, B.R. 1994. A further attenuated derivative of a cold-passaged temperature-sensitive mutant of human respiratory syncytial virus retains immunogenicity and protective efficacy against wild-type challenge in seronegative chimpanzees. Vaccine. 12:783-790.
137. Wright, P.F., et al. 2000. Evaluation of a live, cold-passaged, temperature-sensitive, respiratory syncytial virus vaccine candidate in infancy. J. Infect. Dis. 182:1331-1342.
138. Karron, R.A., et al. 2005. Identification of a recombinant live attenuated respiratory syncytial virus vaccine candidate that is highly attenuated in infants. J. Infect. Dis. 191:1093-1104.
139. [Anonymous]. 2000. Handbook IMCI integrated management of childhood illness. Department of Child and Adolescent Health and Development. WHO. Geneva, Switzerland. 173 pp.
140. Sazawal, S., and Black, R.E. 2003. Effect of pneumonia case management on mortality in neonates, infants, and preschool children: a meta-analysis of community-based trials. Lancet Infect. Dis. 3:547-556.
141. Gwatkin, D.R. 2006. IMCI: what can we learn from an innovation that didn't reach the poor? Bull. World Health Organ. 84:768.
142. Victora, C.G., et al. 2003. Applying an equity lens to child health and mortality: more of the same is not enough. Lancet. 362:233-241.
143. Benbachir, M., et al. 2001. Two-year surveillance of antibiotic resistance in Streptococcus pneumoniae in four African cities. Antimicrob. Agents Chemother. 45:627-629.
144. Buie, K.A., et al. 2004. Gender as a risk factor for both antibiotic resistance and infection with pediatric serogroups/serotypes, in HIV-infected and -uninfected adults with pneumococcal bacteremia. J. Infect. Dis. 189:1996-2000.
145. Straus, W.L., et al. 1998. Antimicrobial resistance and clinical effectiveness of co-trimoxazole versus amoxycillin for pneumonia among children in Pakistan: randomised controlled trial. Lancet. 352:270-274.
146. Catchup Study Group. 2002. Clinical efficacy of cotrimoxazole versus amoxicillin twice daily for treatment of pneumonia: a randomised controlled clinical trial in Pakistan. Arch. Dis. Child. 86:113-118.
147. Dobay, O., Rozgonyi, F., and Amyes, S. 2004. Virulence factors, antibiotic resistance mechanisms and the prevalence of resistance worldwide in Streptococcus pneumoniae. Rev. Med. Microbiol. 15:27-39.
148. Cohen, R., et al. 2006. Impact of Pneumococcal Conjugate Vaccine and of reduction of antibiotic use on nasopharyngeal carriage of nonsusceptible pneumococci in children with acute otitis media. Pediatr. Infect Dis. J. 25:1001-1007.
149. Messina, A.F., et al. 2007. Impact of the pneumococcal conjugate vaccine on serotype distribution and antimicrobial resistance of invasive Streptococcus pneumoniae isolates in Dallas, TX, children from 1999 through 2005. Pediatr. Infect. Dis. J. 26:461-467.
150. Dagan, R. 2000. Treatment of acute otitis media - challenges in the era of antibiotic resistance. Vaccine. 19(Suppl. 1):S9-S16.
151. Nolan, T., et al. 2001. Quality of hospital care for seriously ill children in less-developed countries. Lancet. 357:106-110.
152. Addo-Yobo, E., et al. 2004. Oral amoxicillin versus injectable penicillin for severe pneumonia in children aged 3 to 59 months: a randomised multicentre equivalency study. Lancet. 364:1141-1148.
153. Falade, A.G., Mulholland, E.K., Adegbola, R.A., and Greenwood, B.M. 1997. Bacterial isolates from blood and lung aspirate cultures in Gambian children with lobar pneumonia. Ann. Trop. Paediatr. 17:315-319.
154. Forgie, I.M., et al. 1991. Etiology of acute lower respiratory tract infections in Gambian children: II. Acute lower respiratory tract infection in children ages one to nine years presenting at the hospital. Pediatr. Infect. Dis. J. 10:42-47.
155. Tran, T.T., et al. 1998. The etiology of bacterial pneumonia and meningitis in Vietnam. Pediatr. Infect. Dis. J. 17:S192-S194.
156. Selwyn, B.J. 1990. The epidemiology of acute respiratory tract infection in young children: comparison of findings from several developing countries. Coordinated Data Group of BOSTID Researchers. Rev. Infect. Dis. 12(Suppl. 8):S870-S888.
157. McNally, L.M., et al. 2007. Effect of age, polymicrobial disease, and maternal HIV status on treatment response and cause of severe pneumonia in South African children: a prospective descriptive study. Lancet. 369:1440-1451.
158. Mimica, I., Donoso, E., Howard, J.E., and Ledermann, G.W. 1971. Lung puncture in the etiological diagnosis of pneumonia. A study of 543 infants and children. Am. J. Dis. Child. 122:278-282.