Short-term therapeutic role of zinc in children < 5 years of age hospitalised for severe acute lower respiratory tract infection

Paediatric Respiratory Reviews

Volumn 13, Issue 3, 2012, Pages 184-191

  Das, Rashmi Ranjan ^a   Singh, Meenu ^b   Shafiq, Nusrat ^b  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^b POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

Meta analysis; Micronutrient; Paediatric; Pneumonia; Randomised trial; Respiratory illness

Indexed keywords

ANTIBIOTIC AGENT; GLUCONATE ZINC; PLACEBO; RETINOL; ZINC; ZINC ACETATE; ZINC SULFATE;

ACUTE DISEASE; ACUTE LOWER RESPIRATORY TRACT INFECTION; DISEASE SEVERITY; DRUG EFFICACY; DRUG TREATMENT FAILURE; HOSPITAL PATIENT; HUMAN; HYPOXIA; LENGTH OF STAY; META ANALYSIS; PNEUMONIA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RESPIRATORY TRACT INFECTION; REVIEW; SUPPLEMENTATION; TACHYPNEA; UNSPECIFIED SIDE EFFECT;

ACUTE DISEASE; CHILD, PRESCHOOL; DIETARY SUPPLEMENTS; HOSPITALIZATION; HUMANS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RESPIRATORY TRACT INFECTIONS; TREATMENT OUTCOME; ZINC;

EID: 84862679436     PISSN: 15260542     EISSN: 15260550     Source Type: Journal    
DOI: 10.1016/j.prrv.2012.01.004     Document Type: Review

References (38)

1. Bryce J., Boschi-Pinto C., Shibuya K., Black R.E. WHO estimates of the causes of death in children. Lancet 2005, 365:1147-1152.
2. Rudan I., Boschi-Pinto C., Biloglav Z., Mulholand K., Campbell H. Epidemiology and etiology of childhood pneumonia. Bull WHO 2008, 86:408-416.
3. Aggarwal R., Sentz J., Miller M.A. Role of Zinc Administration in Prevention of Childhood Diarrhea and Respiratory Illnesses: A Meta-analysis. Pediatrics 2007, 119:1120-1130.
4. Higgins J, Altman DG. Chapter 8: Assessing risk of bias in included studies In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.0 (updated February 2008). The Cochrane Collaboration, 2008. Available from http://www.cochrane-handbook.org/.
5. Review Manager (RevMan) [Computer program]. Version 5.0. Copenhagen: Nordic Cochrane Centre, The Cochrane Collaboration, 2008.
6. Brooks W.A., Yunus M., Santosham M., et al. Zinc for severe pneumonia in very young children: double-blind placebo-controlled trial. Lancet 2004, 363:1683-1688.
7. Mahalanabis D., Lahiri M., Paul D., et al. Randomized, double-blind, placebo-controlled clinical trial of the efficacy of treatment with zinc or vitamin A in infants and young children with severe acute lower respiratory infection. Am J Clin Nutr 2004, 79:430-436.
8. Bose A., Coles C.L., Gunavathi, et al. Efficacy of zinc in the treatment of severe pneumonia in hospitalized children <2 y old. Am J Clin Nutr 2006, 83:1089-1096.
9. Bansal A., Parmar V.R., Basu S., et al. Zinc Supplementation in Severe Acute Lower Respiratory Tract Infection in Children: A Triple-Blind Randomized Placebo Controlled Trial. Indian J Pediatr 2011, 78:33-37.
10. Valentiner-Branth P., Shrestha P.S., Chandyo R.K., et al. A randomized controlled trial of the effect of zinc as adjuvant therapy in children 2-35 mo of age with severe or nonsevere pneumonia in Bhaktapur, Nepal. Am J Clin Nutr 2010, 91:1667-1674.
11. Valavi E., Hakimzadeh M., Shamsizadeh A., Aminzadeh M., Alghasi A. The Efficacy of Zinc Supplementation on Outcome of Children with Severe Pneumonia. A Randomized Double-blind Placebo-controlled Clinical Trial. Indian J Pediatr 2011, 78:1079-1084.
12. Ganguly A., Chakraborty S., Datta K., Hazra A., Datta S., Chakraborty J. A Randomized Controlled Trial of Oral Zinc in Acute Pneumonia in Children Aged between 2 Months to 5 Years. Indian J Pediatr 2011, 78:1085-1090.
13. Chang A.B., Torzillo P.J., Boyce N.C., et al. Zinc and vitamin A supplementation in indigenous Australian children hospitalised with lower respiratory tract infection: a randomised controlled trial. Med J Aust 2006, 184:107-112.
14. Mahalanabis D., Chowdhury A., Jana S., Bhattacharya M.K., Chakrabarti M.K., Wahed M.A. Zinc supplementation as adjunct therapy in children with measles accompanied by pneumonia: a double-blind, randomized controlled trial. Am J Clin Nutr 2002, 76:604-607.
15. Coles C.L., Bose A., Moses P.D., et al. Infectious etiology modifies the treatment effect of zinc in severe pneumonia. Am J Clin Nutr 2007, 8:397-403.
16. Mda S., van Raaij J.M., de Villiers F.P., MacIntyre U.E., Kok F.J. Short-term micronutrient supplementation reduces the duration of pneumonia and diarrheal episodes in HIV-infected children. J Nutr 2010, 140:969-974.
17. Wahed M.A., Islam M.A., Khondakar P., Haque M.A. Effect of micronutrients on morbidity and duration of hospital stay in childhood pneumonia. Mymensingh Med J 2008, 17:S77-S83.
18. Chandyo R.K., Shrestha P.S., Valentiner-Branth P., et al. Two weeks of zinc administration to Nepalese children with pneumonia does not reduce the incidence of pneumonia or diarrhea during the next six months. J Nutr 2010, 140:1677-1682.
19. Egger M., Davey S.G., Schneider M., Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997, 315:629-634.
20. Jiang S.L., Samols D., Sipe J., Kushner I. The acute phase response: overview and evidence of roles for both transcriptional and posttranscriptional mechanisms. Folia Histochem Cytobiol 1992, 30:133-135.
21. Peters M. Actions of cytokines on the immune response and viral interactions: an overview. Hepatology 1996, 23:909-916.
22. Stratowa C., Audette M. Transcriptional regulation of the human intercellular adhesion molecule-1 gene: a short overview. Immunobiology 1995, 193:293-304.
23. Roberts R.M., Mathialagan N., Duffy J.Y., Smith G.W. Regulation and regulatory role of proteinase inhibitors. Crit Rev Eukaryot Gene Expr 1995, 5:385-436.
24. Ramadori G., Christ B. Cytokines and the hepatic acute-phase response. Semin Liver Dis 1999, 19:141-155.
25. Ramadori G., Van Damme J., Rieder H., Meyer zum Buschenfelde K.H. Interleukin 6, the third mediator of acute-phase reaction, modulates hepatic protein synthesis in human and mouse. Comparison with interleukin 1 beta and tumor necrosis factor-alpha. Eur J Immunol 1988, 18:1259-1264.
26. Ramadori G., Sipe J.D., Dinarello C.A., Mizel S.B., Colten H.R. Pretranslational modulation of acute phase hepatic protein synthesis by murine recombinant interleukin 1 (IL-1) and purified human IL-1. J Exp Med 1985, 162:930-942.
27. Truong-Tran A.Q., Ruffin R.E., Foster P.S., et al. Altered zinc homeostasis and caspase-3 activity in murine allergic airway inflammation. Am J Respir Cell Mol Biol 2002, 27:286-296.
28. Cho Y.H., Lee S.J., Lee J.Y. Antibacterial effect of intraprostatic zinc injection in a rat model of chronic bacterial prostatitis. Int J Antimicrob Agents 2002, 19:576-582.
29. Duff M., Ettarh R.R. Crypt cell production rate in the small intestine of the zinc-supplemented mouse. Cells Tissues Organs 2002, 172:21-28.
30. Luk H.H., Ko J.K., Fung H.S., Cho C.H. Delineation of the protective action of zinc sulfate on ulcerative colitis in rats. Eur J Pharmacol 2002, 443:197-204.
31. Sazawal S., Black R.E., Bhan M.K., Bhandari N., Sinha A., Jalla S. Zinc supplementation in young children with acute diarrhea in India. N Engl J Med 1995, 333:839-844.
32. Brown K.H. Effect of infections on plasma zinc concentration and implications for zinc status assessment in low-income countries. Am J Clin Nutr 1998, 68:425S-429S.
33. Kumar S., Awasthi S., Jain A., Srivastava R.C. Blood zinc levels in children hospitalized with severe pneumonia: a case control study. Indian Pediatr 2004, 41:486-491.
34. Shakur M.S., Malek M.A., Bano N., Islam K. Zinc status in well nourished Bangladeshi children suffering from acute lower respiratory infection. Indian Pediatr 2004, 41:478-481.
35. Shanker A.H., Prasad A.S. Zinc and immune function: The biological basis of altered resistance to infection. Am J Clin Nutr 1998, 68(Suppl):447-463.
36. Heydarian F., Behmanesh F., Daluee M., Kianifar H., Hematian M. The role of zinc sulfate in acute bronchiolitis in patients aged 2 to 23 months. Iran J Pediatr 2011, 21:231-234.
37. Rahman M.M., Vermund S.H., Wahed M.A., Fuchs G.J., Baqui A.H., Alvarez J.O. Simultaneous zinc and vitamin A supplementation in Bangladeshi children: randomised double blind controlled trial. BMJ 2001, 323:314-318.
38. Bhutta Z.A., Black R.E., Brown K.H., et al. Prevention of diarrhea and pneumonia by zinc supplementation in children in developing countries: pooled analysis of randomized controlled trials. Zinc Investigators' Collaborative Group. J Pediatr 1999, 135:689-697.