Zinc as adjunct treatment in infants aged between 7 and 120 days with probable serious bacterial infection: A randomised, double-blind, placebo-controlled trial

The Lancet

Volumn 379, Issue 9831, 2012, Pages 2072-2078

  Bhatnagar, Shinjini ^a,c   Wadhwa, Nitya ^a,c   Aneja, Satinder ^d   Lodha, Rakesh ^b   Kabra, Sushil Kumar ^b   Natchu, Uma Chandra Mouli ^c,e   Sommerfelt, Halvor ^f,g   Dutta, Ashok Kumar ^d   Chandra, Jagdish ^d   Rath, Bimbadhar ^d   Sharma, Mamta ^h   Sharma, Vinod Kumar ^h   Kumari, Mohini ^h   Strand, Tor A ^f,g,i  

^a Paediatric Biology Centre   (India)

^b ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^c Translational Health Science and Technology Institute   (India)

^d KALAWATI SARAN CHILDREN'S HOSPITAL   (India)

^e HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^f UNIVERSITY OF BERGEN   (Norway)

^g NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^h Deen Dayal Upadhyay Hospital   (India)

ⁱ INNLANDET HOSPITAL TRUST   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE ANTIBIOTIC AGENT; AMPICILLIN; CEPHALOSPORIN DERIVATIVE; CLOXACILLIN; GENTAMICIN; PLACEBO; ZINC;

ANTIBIOTIC THERAPY; ARTICLE; ASPHYXIA; BACTERIAL INFECTION; BIOTECHNOLOGY; CONTROLLED STUDY; CONVULSION; DIARRHEA; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; INFANT; INFANT DISEASE; INFANT MORTALITY; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PSEUDOMONAS INFECTION; RANDOMIZED CONTROLLED TRIAL; STAPHYLOCOCCUS INFECTION; THERAPY EFFECT; TREATMENT FAILURE; UNDERWEIGHT; UNSPECIFIED SIDE EFFECT;

EID: 84861586787     PISSN: 01406736     EISSN: 1474547X     Source Type: Journal    
DOI: 10.1016/S0140-6736(12)60477-2     Document Type: Article

References (27)

1. Black RE, Cousens S, Johnson HL, et al. Global, regional, and national causes of child mortality in 2008: a systematic analysis. Lancet 2010; 375: 1969-87
2. The Million Death Study Collaborators. Causes of neonatal and child mortality in India: a nationally representative mortality survey. Lancet 2010; 376: 1853-60.
3. The Young Infants Clinical Signs Study Group. Clinical signs that predict severe illness in children under age 2 months: a multicentre study. Lancet 2008; 371: 135-42.
4. The WHO Young Infants Study Group. Bacterial etiology of serious infections in young infants in developing countries: results of a multicenter study. Pediatr Infect Dis J 1999; 18: S17-22.
5. Prasad AS, Meftah S, Abdallah J, et al. Serum thymulin in human zinc defi ciency. J Clin Invest 1988; 82: 1202-10.
6. Shankar AH, Prasad AS. Zinc and immune function: the biological basis of altered resistance to infection. Am J Clin Nutr 1998; 68: 447S-63S.
7. Prasad AS. Zinc and immunity. Mol Cell Biochem 1998; 188: 63-69.
8. Bhutta ZA, Black RE, Brown KH, et al, for the Zinc Investigators' Collaborative Group. Prevention of diarrhea and pneumonia by zinc supplementation in children in developing countries: pooled analysis of randomized controlled trials. J Pediatr 1999; 135: 689-97
9. Bhatnagar S, Bahl R, Sharma PK, Kumar GT, Saxena SK, Bhan MK. Zinc with oral rehydration therapy reduces stool output and duration of diarrhea in hospitalized children: a randomized controlled trial. J Pediatr Gastroenterol Nutr 2004; 38: 34-40.
10. Lazzerini M, Ronfani L. Oral zinc for treating diarrhoea in children. Cochrane Database Syst Rev 2008; 3: CD005436.
11. Lukacik M, Thomas RL, Aranda JV. A meta-analysis of the Effects of oral zinc in the treatment of acute and persistent diarrhea. Pediatrics 2008; 121: 326-36.
12. Sazawal S, Jalla S, Mazumder S, Sinha A, Black RE, Bhan MK. Effect of zinc supplementation on cell-mediated immunity and lymphocyte subsets in preschool children. Indian Pediatr 1997; 34: 589-97
13. WHO UNICEF, and the Ministry of Health and Family Welfare Government of India. Integrated management of neonatal and childhood illness: physician chart booklet. 2003. http://mohfw.nic. in/NRHM/IMNCI/IMNCI-index.htm (accessed March 1, 2012).
14. National Center for Health Statistics. Individual growth charts. May 30, 2000. http://www.cdc.gov/growthcharts/charts.htm (accessed March 1, 2012).
15. Hambidge KM, King JC, Kern DL, English-Westcott JL, Stall C. Pre-breakfast plasma zinc concentrations: the Effect of previous meals. J Trace Elem Electrolytes Health Dis 1990; 4: 229-31.
16. Smith PG, Morrow RH. Field trials of health intervention in developing countries: a toolbox, 2nd edn. London: Macmillan Education, 1996: 42-71.
17. Natchu UC, Fataki MR, Fawzi WW. Zinc as an adjunct for childhood pneumonia\-interpreting early results. Nutr Rev 2008; 66: 398-405.
18. Valentiner-Branth P, Shrestha PS, Chandyo RK, et al. A randomized controlled trial of the Effect of zinc as adjuvant therapy in children 2-35 mo of age with severe or non severe pneumonia in Bhaktapur, Nepal. Am J Clin Nutr 2010; 91: 1667-74.
19. Beck FW, Prasad AS, Kaplan J, Fitzgerald JT, Brewer GJ. Changes in cytokine production and T cell subpopulations in experimentally induced zinc-defi cient humans. Am J Physiol 1997; 272: E1002-07
20. Mocchegiani E, Veccia S, Ancarani F, Scalise G, Fabris N. Benefit of oral zinc supplementation as an adjunct to zidovudine (AZT) therapy against opportunistic infections in AIDS. Int J Immunopharmacol 1995; 17: 719-27
21. Prasad AS, Beck FW, Kaplan J, et al. Effect of zinc supplementation on incidence of infections and hospital admissions in sickle cell disease (SCD). Am J Hematol 1999; 61: 194-202.
22. Sheikh A, Shamsuzzaman S, Ahmad SM, et al. Zinc influences innate immune responses in children with enterotoxigenic Escherichia coli-induced diarrhea. J Nutr 2010; 140: 1049-56.
23. Bao S, Liu M-J, Lee B, et al. Zinc modulates the innate immune response in vivo to polymicrobial sepsis through regulation of NF-kappaB. Am J Physiol Lung Cell Mol Physiol 2010; 298: L744-54.
24. Knoell DL, Liu MJ. Impact of zinc metabolism on innate immune function in the setting of sepsis. Int J Vitam Nutr Res 2010; 80: 271-77.
25. Palmer A, Carlin JB, Freihorst J, et al. The use of CRP for diagnosing infections in young infants <3 months of age in developing countries. Ann Trop Paediatr 2004; 24: 205-12
26. Fernandez Lopez A, Luaces Cubells C, Garcia Garcia JJ, Fernandez Pou J, for the Spanish Society of Pediatric Emergencies. Procalcitonin in pediatric emergency departments for the early diagnosis of invasive bacterial infections in febrile infants: results of a multicenter study and utility of a rapid qualitative test for this marker. Pediatr Infect Dis J 2003; 22: 895-903.
27. Auriti C, Fiscarelli E, Ronchetti MP, et al. Procalcitonin in detecting neonatal nosocomial sepsis. Arch Dis Child Fetal Neonatal Ed 2011; published online March 15. DOI:10.1136/adc.2010.194100.