Polymorphisms in HLA class II genes are associated with susceptibility to staphylococcus aureus infection in a white population

Journal of Infectious Diseases

Volumn 212, Issue 11, 2015, Pages 816-823

  DeLorenze, Gerald N ^a   Nelson, Charlotte L ^b   Scott, William K ^e   Allen, Andrew S ^d   Ray, G Thomas ^a   Tsai, Ai Lin ^a   Quesenberry, Charles P ^a   Fowler, Vance G ^b,c  

^a DIVISION OF RESEARCH   (United States)

^b DUKE CLINICAL RESEARCH INSTITUTE   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

HLA; Host genetics; Staphylococcus aureus

Indexed keywords

HLA ANTIGEN CLASS 2; HLA DR ANTIGEN; HLA DRB1 ANTIGEN;

ADULT; AGED; ARTICLE; BACTERIUM CULTURE; CAUCASIAN; CHROMOSOME 6; COHORT ANALYSIS; COMMUNITY ACQUIRED INFECTION; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC MODEL; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HUMAN; INFECTION RISK; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PRIORITY JOURNAL; SEROTYPE; SINGLE NUCLEOTIDE POLYMORPHISM; SKIN INFECTION; SOFT TISSUE INFECTION; STAPHYLOCOCCUS INFECTION; VERY ELDERLY; YOUNG ADULT; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; METABOLISM; MICROBIOLOGY; ODDS RATIO; PHYSIOLOGY; STAPHYLOCOCCUS AUREUS;

ADULT; AGED; AGED, 80 AND OVER; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; MALE; MIDDLE AGED; ODDS RATIO; POLYMORPHISM, GENETIC; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; YOUNG ADULT;

EID: 84958592890     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiv483     Document Type: Article

References (47)

1. Ahn SH, Deshmukh H, Johnson N, et al. Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses. PLoS Pathog 2010; 6:e1001088
2. Johnson NV, Ahn SH, Deshmukh H, et al. Haplotype association mapping identifies a candidate gene region in mice infected with Staphylococcus aureus. G3 (Bethesda) 2012; 2:693-700
3. Griesbeck-Zilch B, Osman M, Kuhn C, et al. Analysis of key molecules of the innate immune system in mammary epithelial cells isolated from marker-assisted and conventionally selected cattle. J Dairy Sci 2009; 92:4621-33
4. Bonnefont CM, Rainard P, Cunha P, et al. Genetic susceptibility to S. aureus mastitis in sheep: differential expression of mammary epithelial cells in response to live bacteria or supernatant. Physiol Genomics 2012; 44:403-16
5. Zimakoff J, Rosdahl VT, Petersen W, Scheibel J. Recurrent staphylococcal furunculosis in families. Scand J Infect Dis 1988; 20:403-5
6. Holland SM, DeLeo FR, Elloumi HZ, et al. STAT3 mutations in the hyper-IgE syndrome. N Engl J Med 2007; 357:1608-19
7. Tanabe F, Kasai H, He L, et al. Improvement of deficient natural killer activity and delayed bactericidal activity by a thiol proteinase inhibitor, E-64-d, in leukocytes from Chediak-Higashi syndrome patients in vitro. Int Immunopharmacol 2009; 9:366-70
8. Nelson CL, Pelak K, Podgoreanu MV, et al. A genome-wide association study of variants associated with acquisition of Staphylococcus aureus bacteremia in a healthcare setting. BMC Infect Dis 2014; 14:83
9. Ye Z, Vasco DA, Carter TC, Brilliant MH, Schrodi SJ, Shukla SK. Genome wide association study of SNP-, gene-, and pathway-based approaches to identify genes influencing susceptibility to Staphylococcus aureus infections. Front Genet 2014; 5:125
10. Howie B, Fuchsberger C, Stephens M, Marchini J, Abecasis GR. Fast and accurate genotype imputation in genome-wide association studies through pre-phasing. Nat Genet 2012; 44:955-9
11. Jia X, Han B, Onengut-Gumuscu S, et al. Imputing amino acid polymorphisms in human leukocyte antigens. PLoS One 2013; 8:e64683
12. Ray GT, Suaya JA, Baxter R. Trends and characteristics of culture-confirmed Staphylococcus aureus infections in a large U.S. integrated health care organization. J Clin Microbiol 2012; 50:1950-7
13. Shannon KP, French GL. Validation of the NCCLS proposal to use results only from the first isolate of a species per patient in the calculation of susceptibility frequencies. J Antimicrob Chemother 2002; 50:965-9
14. Liu C, Graber CJ, Karr M, et al. A population-based study of the incidence and molecular epidemiology of methicillin-resistant Staphylococcus aureus disease in San Francisco, 2004-2005. Clin Infect Dis 2008; 46:1637-46
15. Frazer KA, Ballinger DG, Cox DR, et al. A second generation human haplotype map of over 3.1 million SNPs. Nature 2007; 449:851-61
16. Banda Y, Kvale MN, Hoffmann TJ, et al. Characterizing race/ethnicity and genetic ancestry for 100,000 subjects in the genetic epidemiology research on adult health and aging (GERA) cohort. Genetics 2015; 200:1285-95
17. Manichaikul A, Mychaleckyj JC, Rich SS, Daly K, Sale M, Chen WM. Robust relationship inference in genome-wide association studies. Bioinformatics 2010; 26:2867-73
18. Porcu E, Sanna S, Fuchsberger C, Fritsche LG. Genotype imputation in genomewide association studies. Curr Protoc Hum Genet 2013; 78:1.25.1-1.25.14
19. Delaneau O, Marchini J. Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel. Nat Commun 2014; 5:3934
20. O'Connell J, Gurdasani D, Delaneau O, et al. A general approach for haplotype phasing across the full spectrum of relatedness. PLoS Genet 2014; 10:e1004234
21. Howie BN, Donnelly P, Marchini J. A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet 2009; 5:e1000529
22. de Bakker PI, McVean G, Sabeti PC, et al. A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet 2006; 38:1166-72
23. Consortium WTCC. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007; 447:661-78
24. Price AL, Patterson NJ, Plenge RM,Weinblatt ME, Shadick NA, Reich D. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 2006; 38:904-9
25. Purcell S, Neale B, Todd-Brown K, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007; 81:559-75
26. Kotb M, Norrby-Teglund A, McGeer A, et al. An immunogenetic and molecular basis for differences in outcomes of invasive group A streptococcal infections. Nat Med 2002; 8:1398-404
27. Nooh MM, El-Gengehi N, Kansal R, David CS, Kotb M. HLA transgenic mice provide evidence for a direct and dominant role of HLA class II variation in modulating the severity of streptococcal sepsis. J Immunol 2007; 178:3076-83
28. Llewelyn M, Sriskandan S, Peakman M, et al. HLA class II polymorphisms determine responses to bacterial superantigens. J Immunol 2004; 172:1719-26
29. Kim J, Urban RG, Strominger JL, Wiley DC. Toxic shock syndrome toxin-1 complexed with a class II major histocompatibility molecule HLA-DR1. Science 1994; 266:1870-4
30. Lavoie PM, Thibodeau J, Cloutier I, Busch R, Sekaly RP. Selective binding of bacterial toxins to major histocompatibility complex class II-expressing cells is controlled by invariant chain and HLA-DM. Proc Natl Acad Sci U S A 1997; 94:6892-7
31. Salgado-Pabon W, Breshears L, Spaulding AR, et al. Superantigens are critical for Staphylococcus aureus Infective endocarditis, sepsis, and acute kidney injury. MBio 2013; 4
32. Pragman AA, Yarwood JM, Tripp TJ, Schlievert PM. Characterization of virulence factor regulation by SrrAB, a two-component system in Staphylococcus aureus. J Bacteriol 2004; 186:2430-8
33. Kinsman OS, McKenna R, Noble WC. Association between histocompatability antigens (HLA) and nasal carriage of Staphylococcus aureus. J Med Microbiol 1983; 16:215-20
34. Suarez-Almazor ME, Tao S, Moustarah F, Russell AS, Maksymowych W. HLADR1, DR4, and DRB1 disease related subtypes in rheumatoid arthritis. Association with susceptibility but not severity in a city wide community based study. J Rheumatol 1995; 22:2027-33
35. Thomson W, Harrison B, Ollier B, et al. Quantifying the exact role of HLA-DRB1 alleles in susceptibility to inflammatory polyarthritis: results from a large, population- based study. Arthritis Rheum 1999; 42:757-62
36. Rau R, Herborn G, Zueger S, Fenner H. The effect of HLA-DRB1 genes, rheumatoid factor, and treatment on radiographic disease progression in rheumatoid arthritis over 6 years. J Rheumatol 2000; 27:2566-75
37. Diep BA, Gill SR, Chang RF, et al. Complete genome sequence of USA300, an epidemic clone of community-acquired methicillin-resistant Staphylococcus aureus. Lancet 2006; 367:731-9
38. Gorlov IP, Gorlova OY, Frazier ML, Spitz MR, Amos CI. Evolutionary evidence of the effect of rare variants on disease etiology. Clin Genet 2011; 79:199-206
39. Imamura M, Maeda S. Genetics of type 2 diabetes: the GWAS era and future perspectives [Review]. Endocr J 2011; 58:723-39
40. Ishak MB, Giri VN. A systematic review of replication studies of prostate cancer susceptibility genetic variants in high-risk men originally identified from genomewide association studies. Cancer Epidemiol Biomarkers Prev 2011; 20:1599-610
41. Rafiq S, Khan S, Tapper W, et al. A genome wide meta-analysis study for identification of common variation associated with breast cancer prognosis. PLoS One 2014; 9:e101488
42. Yan Q, Sharma-Kuinkel BK, Deshmukh H, et al. Dusp3 and Psme3 are associated with murine susceptibility to Staphylococcus aureus infection and human sepsis. PLoS Pathog 2014; 10:e1004149
43. Nienaber JJ, Sharma Kuinkel BK, Clarke-Pearson M, et al. Methicillin-susceptible Staphylococcus aureus endocarditis isolates are associated with clonal complex 30 genotype and a distinct repertoire of enterotoxins and adhesins. J Infect Dis 2011; 204:704-13
44. Li M, Du X, Villaruz AE, et al. MRSA epidemic linked to a quickly spreading colonization and virulence determinant. Nat Med 2012; 18:816-9
45. Spaan AN, Surewaard BG, Nijland R, van Strijp JA. Neutrophils versus Staphylococcus aureus: a biological tug of war. Annu Rev Microbiol 2013; 67:629-50
46. Lower SK, Lamlertthon S, Casillas-Ituarte NN, et al. Polymorphisms in fibronectin binding protein A of Staphylococcus aureus are associated with infection of cardiovascular devices. Proc Natl Acad Sci U S A 2011; 108:18372-7
47. DeLeo FR, Kennedy AD, Chen L, et al. Molecular differentiation of historic phagetype 80/81 and contemporary epidemic Staphylococcus aureus. Proc Natl Acad Sci U S A 2011; 108:18091-6