Analysis of key molecules of the innate immune system in mammary epithelial cells isolated from marker-assisted and conventionally selected cattle

Journal of Dairy Science

Volumn 92, Issue 9, 2009, Pages 4621-4633

  Griesbeck Zilch, B ^a   Osman, M ^a   Kuhn C ^b   Schwerin, M ^b   Bruckmaier, R H ^c   Pfaffl, M W ^a   Hammerle Fickinger, A ^a   Meyer, H H D ^a   Wellnitz, O ^c  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b LEIBNIZ INSTITUTE FOR FARM ANIMAL BIOLOGY FBN   (Germany)

^c UNIVERSITY OF BERN   (Switzerland)

Author keywords

Dairy cattle; Mammary epithelial cell; Mastitis; Quantitative trait locus

Indexed keywords

ANIMALIA; BOS; BOS TAURUS; BOVINAE; ESCHERICHIA COLI; STAPHYLOCOCCUS AUREUS;

MESSENGER RNA;

ANIMAL; ANIMAL DISEASE; ARTICLE; BOVINE MASTITIS; CATTLE; CELL CULTURE; CYTOLOGY; EPITHELIUM CELL; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTION; FEMALE; GENE EXPRESSION REGULATION; GENETIC MARKER; GENETIC PREDISPOSITION; GENETIC SELECTION; GENETICS; IMMUNOLOGY; INNATE IMMUNITY; MALE; METABOLISM; PHYSIOLOGY; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; UDDER;

ANIMALS; CATTLE; CELLS, CULTURED; EPITHELIAL CELLS; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; FEMALE; GENE EXPRESSION REGULATION; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; IMMUNITY, INNATE; MALE; MAMMARY GLANDS, ANIMAL; MASTITIS, BOVINE; RNA, MESSENGER; SELECTION, GENETIC; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS;

EID: 70349283593     PISSN: 00220302     EISSN: 15253198     Source Type: Journal    
DOI: 10.3168/jds.2008-1954     Document Type: Article

References (47)

1. Aderem, A., and R. J. Ulevitch. 2000. Toll-like receptors in the induction of the innate immune response. Nature 406:782-787.
2. Bannerman, D. D., M. J. Paape, J. W. Lee, X. Zhao, J. C. Hope, and P. Rainard. 2004. Escherichia coli and Staphylococcus aureus elicit differential innate immune responses following intramammary infection. Clin. Diagn. Lab. Immunol. 11:463-472.
3. Boudjellab, N., H. S. Chan-Tang, and X. Zhao. 2000. Bovine interleukin-1 expression by cultured mammary epithelial cells (MAC-T) and its involvement in the release of MAC-T derived interleukin-8. Comp. Biochem. Physiol. A 127:191-199.
4. Boutet, P., J. Sulon, R. Closset, J. Detilleux, J. F. Beckers, F. Bureau, and P. Lekeux. 2007. Prolactin-induced activation of nuclear factor kappaB in bovine mammary epithelial cells: role in chronic mastitis. J. Dairy Sci. 90:155-164.
5. Bramley, A. J., A. H. Patel, M. O'Reilly, R. Forster, and T. J. Forster. 1989. Roles of alpha-toxin and beta-toxin in virulence of Staphylococcus aureus for the mouse mammary gland. Infect. Immun. 57:2489-2494.
6. Burvenich, C., V. Van Merris, J. Mehrzad, A. Diez-Fraile, and L. Duchateau. 2003. Severity of E. coli mastitis is mainly determined by cow factors. Vet. Res. 34:521-564.
7. Fernando, R. L., and M. Grossman. 1989. Marker assisted selection using best linear unbiased prediction. Genet. Sel. Evol. 21:467-477.
8. Gadjeva, M., K. Takahashi, and S. Thiel. 2004. Mannan-binding lectin-A soluble pattern recognition molecule. Mol. Immunol. 41:113-121.
9. Hagiwara, S., K. Kawai, A. Anri, and H. Nagahata. 2003. Lactoferrin concentrations in milk from normal and subclinical mastitic cows. J. Vet. Med. Sci. 65:319-323.
10. Harmon, R. J. 1994. Physiology of mastitis and factors affecting somatic cell counts. J. Dairy Sci. 77:2103-2112.
11. Hinrichs, D., E. Stamer, W. Junge, and E. Kalm. 2005. Genetic analyses of mastitis data using animal threshold models and genetic correlation with production traits. J. Dairy Sci. 88:2260-2268.
12. Khatkar, M. S., P. C. Thomson, I. Tammen, and H. W. Raadsma. 2004. Quantitative trait loci mapping in dairy cattle: Review and meta-analysis. Genet. Sel. Evol. 36:163-190.
13. Klungland, H., A. Sabry, B. Heringstad, H. G. Olsen, L. Gomez-Raya, D. I. Våge, I. Olsaker, J. Ødegård, G. Klemetsdal, N. Schulman, J. Vilkki, J. Ruane, M. Aasland, K. Rønningen, and S. Lien. 2001. Quantitative trait loci affecting clinical mastitis and somatic cell count in dairy cattle. Mamm. Genome 12: 837-842.
14. Korhonen, H., P. Marnila, and H. S. Gill. 2000. Milk immunoglobulins and complement factors. Br. J. Nutr. 84(Suppl. 1):75-80.
15. Kühn, Ch., J. Bennewitz, N. Reinsch, N. Xu, H. Thomsen, C. Looft, G. A. Brockmann, M. Schwerin, C. Weimann, S. Hiendleder, G. Erhardt, I. Medjugorac, M. Förster, B. Brenig, F. Reinhardt, R. Reents, I. Russ, G. Averdunk, J. Blümel, and E. Kalm. 2003. Quantitative trait loci mapping of functional traits in the German Holstein cattle population. J. Dairy Sci. 86:360-368.
16. Kühn, Ch., F. Reinhardt, and M. Schwerin. 2008. Marker assisted selection of heifers improved milk somatic cell count compared to selection on conventional pedigree breeding values. Arch. Tierz. Dummerstorf 51:23-32.
17. Liang, Y., Y. Zhou, and P. Shen. 2004. NF-kappaB and its regulation on the immune system. Cell. Mol. Immunol. 1:343-350.
18. Livak, K. J., and T. D. Schmittgen. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402-408.
19. Lorenz, E., J. P. Mira, K. L. Cornish, N. C. Arbour, and D. A. Schwartz. 2000. A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection. Infect. Immun. 68:6398-6401.
20. Lorenz, E., J. P. Mira, K. L. Frees, and D. A. Schwartz. 2004. Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock. Arch. Intern. Med. 162:1028-1032.
21. Miglior, F., B. L. Muir, and B. J. Van Doormaal. 2005. Selection indices in Holstein cattle of various countries. J. Dairy Sci. 88:1255-1263.
22. Misch, E. A., and T. R. Hawn. 2008. Toll-like receptor polymorphisms and susceptibility to human disease. Clin. Sci. (Lond.) 114:347-360.
23. Mrode, R. A., and G. J. T. Swanson. 1996. Genetic and statistical properties of somatic cell counts and its suitability as an indirect means of reducing the incidence of mastitis in dairy cattle. Anim. Breed. Abstr. 64:847-857.
24. Pahl, H. L. 1999. Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 18:6853-6866.
25. Pareek, R., O. Wellnitz, R. van Dorp, J. Burton, and D. Kerr. 2005. Immunorelevant gene expression in LPS-challenged bovine mammary epithelial cells. J. Appl. Genet. 46:171-177.
26. Persson Waller, K., I. G. Colditz, S. Lun, and K. Ostensson. 2003. Cytokines in mammary lymph and milk during endotoxin-induced bovine mastitis. Res. Vet. Sci. 74:31-36.
27. Pfaffl, M. W., S. L. Wittmann, H. H. Meyer, and R. M. Bruckmaier. 2003. Gene expression of immunologically important factors in blood cells, milk cells, and mammary tissue of cows. J. Dairy Sci. 86:538-545.
28. R Development Core Team. 2008. R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria. http://www.R-project.org.
29. Rainard, P. 2003. The complement in milk and defense of the bovine mammary gland against infections. Vet. Res. 34:647-670.
30. Rainard, P. 2005. Tackling mastitis in dairy cows. Nat. Biotechnol. 23:430-432.
31. Rainard, P., and C. Riollet. 2006. Innate immunity of the bovine mammary gland. Vet. Res. 37:369-400.
32. Riollet, C., P. Rainard, and B. Poutrel. 2000. Differential induction of complement fragment C5a and inflammatory cytokines during intramammary infections with Escherichia coli and Staphylococcus aureus. Clin. Diagn. Lab. Immunol. 7:161-167.
33. Rupp, R., and D. Boichard. 2003. Genetics of resistance to mastitis in dairy cattle. Vet. Res. 34:671-688.
34. Schmitz, S., M. W. Pfaffl, H. H. Meyer, and R. M. Bruckmaier. 2004. Short-term changes of mRNA expression of various inflammatory factors and milk proteins in mammary tissue during LPS-induced mastitis. Domest. Anim. Endocrinol. 26:111-126.
35. Schukken, Y. H., B. A. Mallard, J. C. Dekkers, K. E. Leslie, and M. J. Stear. 1994. Genetic impact on the risk of intramammary infection following Staphylococcus aureus challenge. J. Dairy Sci. 77:639-647.
36. Schulman, N. F., S. M. Viitala, D. J. de Koning, J. Virta, A. Makitanila, and J. H. Vilkki. 2004. Quantitative trait loci for health traits in Finnish Ayrshire cattle. J. Dairy Sci. 87:443-449.
37. Seegers, H., C. Fourichon, and F. Beaudeau. 2003. Production effects related to mastitis and mastitis economics in dairy cattle herds. Vet. Res. 34:475-491.
38. Shuster, D. E., M. E. Jr. Kehrli, P. Rainard, and M. Paape. 1997. Complement fragment C5a and inflammatory cytokines in neutrophil recruitment during intramammary infection with Escherichia coli. Infect. Immun. 65:3286-3292.
39. Soyeurt, H., F. G. Colinet, V. M. Arnould, P. Dardenne, C. Bertozzi, R. Renaville, D. Portetelle, and N. Gengler. 2007. Genetic variability of lactoferrin content estimated by mid-infrared spectrometry in bovine milk. J. Dairy Sci. 90:4443-4445.
40. Strandberg, Y., C. Gray, T. Vuocolo, L. Donaldson, M. Broadway, and R. Tellam. 2005. Lipopolysaccharide and lipoteichoic acid induce different innate immune responses in bovine mammary epithelial cells. Cytokine 31:72-86.
41. Stuber, F., S. Klaschik, L. E. Lehmann, J. C. Schewe, S. Weber, and M. Book. 2005. Cytokine promoter polymorphisms in severe sepsis. Clin. Infect. Dis. 41(Suppl. 7):416-420.
42. Weikard, R., C. Kühn, T. Goldammer, G. Freyer, and M. Schwerin. 2005. The bovine PPARGC1A gene: Molecular characterization and association of an SNP with variation of milk fat synthesis. Physiol. Genomics 21:1-3.
43. Wellnitz, O., and D. E. Kerr. 2004. Cryopreserved bovine mammary cells to model epithelial response to infection. Vet. Immunol. Immunopathol. 101:191-202.
44. Wellnitz, O., P. Reith, and H. H. D. Meyer. 2006. Immune relevant gene expression of mammary epithelial cells and their influence on leukocyte chemotaxis in response to different mastitis pathogens. Vet. Med. Czech 51:125-132.
45. Wilkens, J., A. Bünger, and F. Reinhardt. 2006. Marker assisted selection in German Holsteins. Proc. 10th QTL-MAS Workshop, Salzburg, Austria.
46. Wurfel, M. M., W. Y. Park, F. Radella, J. Ruzinski, A. Sandstrom, J. Strout, R.E. Bumgarner, and T. R. Martin. 2006. Identification of high and low responders to lipopolysaccharide in normal subjects: An unbiased approach to identify modulators of innate immunity. J. Immunol. 175: 2570-2578.
47. Xu, N. Y., S. Paul, J. Bennewitz, N. Reinsch, G. Thaller, F. Reinhard, Ch. Kühn, M. Schwerin, G. Erhardt, C. Weimann, N. Thomsen, S. Mishra, and E. Kalm. 2006. Conformation of quantitative trait loci for somatic cell score on bovine chromosome 18 in the German Holstein. Arch. Tierzucht. 49:111-119.