Expression of perilipin 5 promotes lipid droplet formation in yeast

Communicative and Integrative Biology

Volumn 8, Issue 6, 2015, Pages 1-5

  Mishra, Shirish ^a   Schneiter, Roger ^a  

^a UNIVERSITY OF FRIBOURG   (Switzerland)

Author keywords

Endoplasmatic reticulum; Lipid droplets; Organelle biogenesis; Perilipins; PLIN5 (OXPAT); Saccharomyces cerevisiae; Steryl esters; Triacylglycerol

Indexed keywords

EID: 84958537470     PISSN: None     EISSN: 19420889     Source Type: Journal    
DOI: 10.1080/19420889.2015.1071728     Document Type: Article

References (19)

1. Walther TC, Farese RVJ. Lipid droplets and cellular lipid metabolism. Annu Rev Biochem 2012; 81:687-714;PMID:22524315; http://dx.doi.org/10.1146/annurev-biochem-061009-102430
2. Jacquier N, Choudhary V, Mari M, Toulmay A, Reggiori F, Schneiter R. Lipid droplets are functionally connected to the endoplasmic reticulum in Saccharomyces cerevisiae. J Cell Sci 2011; 124:2424-37;PMID:21693588; http://dx.doi.org/10.1242/jcs.076836
3. Wilfling F, Wang H, Haas JT, Krahmer N, Gould TJ, Uchida A, Cheng JX, Graham M, Christiano R, Fröhlich F, et al. Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing fromthe ER to lipid droplets. Dev Cell 2013; 24:384-99;PMID:23415954; http://dx. doi.org/10.1016/j.devcel.2013.01.013
4. Kimmel AR, Brasaemle DL, McAndrews-Hill M, Sztalryd C, Londos C. Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins. J Lipid Res 2010; 51:468-71;PMID:19638644; http://dx.doi.org/10.1194/jlr.R000034
5. Brasaemle DL. Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis. J Lipid Res 2007; 48:2547-59;PMID:17878492; http://dx.doi.org/10.1194/jlr.R700014-JLR200
6. Wolins NE, Skinner JR, Schoenfish MJ, Tzekov A, Bensch KG, Bickel PE. Adipocyte protein S3–12 coats nascent lipid droplets. J Biol Chem 2003; 278:37713-21;PMID:12840023; http://dx.doi.org/10.1074/jbc. M304025200
7. Wolins NE, Quaynor BK, Skinner JR, Tzekov A, Croce MA, Gropler MC, Varma V, Yao-Borengasser A, Rasouli N, Kern PA, et al. OXPAT/PAT-1 is a PPAR-induced lipid droplet protein that promotes fatty acid utilization. Diabetes 2006; 55:3418-28;PMID:17130488; http://dx.doi.org/10.2337/db06-0399
8. Bickel PE, Tansey JT, Welte MA. PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores. Biochim Biophys Acta 2009; 1791:419-40;PMID:19375517; http://dx.doi.org/10.1016/j.bbalip.2009.04.002
9. Scherer PE, Bickel PE, Kotler M, Lodish HF. Cloning of cell-specific secreted and surface proteins by subtractive antibody screening. Nat Biotechnol 1998; 16:581-6;PMID:9624692; http://dx.doi.org/10.1038/nbt0698-581
10. Wolins NE, Quaynor BK, Skinner JR, Schoenfish MJ, Tzekov A, Bickel PE. S3–12, Adipophilin, and TIP47 package lipid in adipocytes. J Biol Chem 2005; 280:19146-55;PMID:15731108; http://dx.doi.org/10.1074/jbc.M500978200
11. Dalen KT, Schoonjans K, Ulven SM, Weedon-Fekjaer MS, Bentzen TG, Koutnikova H, Auwerx J, Nebb HI. Adipose tissue expression of the lipid droplet-associating proteins S3–12 and perilipin is controlled by peroxisome proliferator-activated receptor-gamma. Diabetes 2004; 53:1243-52;PMID:15111493; http://dx.doi.org/10.2337/diabetes.53.5.1243
12. Yamaguchi T, Matsushita S, Motojima K, Hirose F, Osumi T. MLDP, a novel PAT family protein localized to lipid droplets and enriched in the heart, is regulated by peroxisome proliferator-activated receptor alpha. J Biol Chem 2006; 281:14232-40;PMID:16571721; http://dx.doi.org/10.1074/jbc.M601682200
13. Dalen KT, Dahl T, Holter E, Arntsen B, Londos C, Sztalryd C, Nebb HI. LSDP5 is a PAT protein specifically expressed in fatty acid oxidizing tissues. Biochim Biophys Acta 2007; 1771:210-27;PMID:17234449; http://dx.doi.org/10.1016/j. bbalip.2006.11.011
14. Jacquier N, Mishra S, Choudhary V, Schneiter R. Expression of oleosin and perilipins in yeast promotes formation of lipid droplets from the endoplasmic reticulum. J Cell Sci 2013; 126:5198-209;PMID:24006263; http://dx.doi.org/10.1242/jcs.131896
15. Carman GM, Han GS. Roles of phosphatidate phosphatase enzymes in lipid metabolism. Trends Biochem Sci 2006; 31:694-9;PMID:17079146; http://dx.doi.org/10.1016/j.tibs.2006.10.003
16. Csaki LS, Dwyer JR, Fong LG, Tontonoz P, Young SG, Reue K. Lipins, lipinopathies, and the modulation of cellular lipid storage and signaling. Prog Lipid Res 2013; 52:305-16;PMID:23603613; http://dx.doi.org/10.1016/j.plipres.2013.04.001
17. Adeyo O, Horn PJ, Lee S, Binns DD, Chandrahas A, Chapman KD, Goodman JM. The yeast lipin orthologue Pah1p is important for biogenesis of lipid droplets. J Cell Biol 2011; 192:1043-55;PMID:21422231; http://dx.doi.org/10.1083/jcb.201010111
18. Hsieh K, Lee YK, Londos C, Raaka BM, Dalen KT, Kimmel AR. Perilipin family members preferentially sequester to either triacylglycerol-specific or cholesterylester-specific intracellular lipid storage droplets. J Cell Sci 2012; 125:4067-76;PMID:22685330; http://dx. doi.org/10.1242/jcs.104943
19. Czabany T, Athenstaedt K, Daum G. Synthesis, storage and degradation of neutral lipids in yeast. Biochim Biophys Acta 2007; 1771:299-309;PMID:16916618; http://dx.doi.org/10.1016/j.bbalip.2006.07.001