Investigating therapeutic potential of trigonella foenum-graecum L. As our defense mechanism against several human diseases

Journal of Toxicology

Volumn 2016, Issue , 2016, Pages

  Goyal, Shivangi ^a   Gupta, Nidhi ^a   Chatterjee, Sreemoyee ^a  

^a IIS UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; DEFENSE MECHANISM; FENUGREEK; GENERAL ASPECTS OF DISEASE; HUMAN; PRIORITY JOURNAL; REVIEW;

EID: 84958280383     PISSN: 16878191     EISSN: 16878205     Source Type: Journal    
DOI: 10.1155/2016/1250387     Document Type: Review

References (73)

1. H. Mukhtar, H. F. Merk, and M. Athar, "Skin chemical carcinogenesis, " Clinics in Dermatology, vol. 7, no. 3, pp. 1-10, 1989.
2. C. Heidelberger, "Chemical carcinogenesis, chemotherapy: cancers continuing core challenges, " Cancer Research, vol. 30, no. 6, pp. 1549-1569, 1970.
3. J. W. Flesher and K. L. Sydnor, "Carcinogenicity of derivatives of 7, 12-dimethylbenz(a) anthracene, " Cancer Research, vol. 31, no. 12, pp. 1951-1954, 1971.
4. L. Vellaichamy, S. Balakrishnan, K. Panjamurthy, S. Manoharan, and L. M. Alias, "Chemopreventive potential of piperine in 7, 12-dimethylbenzaanthracene-induced skin carcinogenesis in Swiss albino mice, " Environmental Toxicology and Pharmacology, vol. 28, no. 1, pp. 11-18, 2009.
5. S. V. Deo, S. Hazarika, N. K. Shukla, S. Kumar, M. Kar, and A. Samaiya, "Surgical management of skin cancers: experience from a regional cancer centre in North India, " Indian Journal of Cancer, vol. 42, no. 3, pp. 145-150, 2005.
6. S. Panda, "Non-melanoma skin cancer in India: current scenario, " Indian Journal ofDermatology, vol. 55, no. 4, pp. 373-378, 2010.
7. S. K. Wattanapitayakul, L. Chularojmontri, A. Herunsalee, S. Charuchongkolwongse, S. Niumsakul, and J. A. Bauer, "Screening of antioxidants from medicinal plants for cardioprotective effect against doxorubicin toxicity, " Basic & Clinical Pharmacology & Toxicology, vol. 96, no. 1, pp. 80-87, 2005.
8. C. Fimognari, M. N. Nusse, M. Lenzi, D. Sciuscio, G. Cantelli-Forti, and P. Hrelia, "Sulforaphane increases the efficacy of doxorubicin in mouse fibroblasts characterized by p53 mutations, " Mutation Research, vol. 601, no. 1-2, pp. 92-101, 2006.
9. A. Uliasz and J. M. Spencer, "Chemoprevention of skin cancer and photoaging, " Clinics in Dermatology, vol. 22, no. 3, pp. 178-182, 2004.
10. B. H. Youn and H. J. Yang, "Chemoprevention of skin cancer with dietary phytochemicals, " in Skin Cancer Overview, Y. Xi, Ed. , chapter 8, InTech, 2011.
11. N. Merina, K. J. Chandra, and K. Joben, "Medicinal plants with potential anticancer activity: a review, " International Research Journal of Pharmacy, vol. 3, no. 6, pp. 26-30, 2012.
12. B. B. Li, B. Smith, and M. M. Hossain, "Extraction of phenolics fromcitrus peels: I. Solvent extractionmethod, " Separation and Purification Technology, vol. 48, no. 2, pp. 182-188, 2006.
13. S. N. Acharya, J. E. Thomas, and S. K. Basu, "Fenugreek: an old world crop for the new world, " Biodiversity, vol. 7, no. 3-4, pp. 27-30, 2006.
14. E. Basch, C. Ulbricht, G. Kuo, P. Szapary, and M. Smith, "Therapeutic applications of fenugreek, " Alternative Medicine Review, vol. 8, no. 1, pp. 20-27, 2003.
15. M. M. Al-Oqail, N. N. Farshori, E. S. Al-Sheddi, J. Musarrat, A. A. Al-Khedhairy, and M. A. Siddiqui, "In vitro cytotoxic activity of seed oil of fenugreek against various cancer cell lines, " Asian Pacific Journal of Cancer Prevention, vol. 14, no. 3, pp. 1829-1832, 2013.
16. H. S. Snehlata and D. R. Payal, "Fenugreek (Trigonella foenum graecum L. ): an overview, " International Journal of Current Pharmaceutical Review and Research, vol. 2, no. 4, pp. 169-187, 2012.
17. D. Tiran, "The use of fenugreek for breast feeding women, " ComplementaryTherapies in Nursing and Midwifery, vol. 9, no. 3, pp. 155-156, 2003.
18. E. K. Kalra, "Nutraceutical-definition and introduction, " American Association of Pharmaceutical Sciences, vol. 5, no. 3, pp. 27-28, 2003.
19. J. Raju, D. Gupta, A. R. Rao, P. K. Yadava, and N. Z. Baquer, "Trigonella foenum graecum (fenugreek) seed powder improves glucose homeostasis in alloxan diabetic rat tissues by reversing the altered glycolytic, gluconeogenic and lipogenic enzymes, " Molecular and Cellular Biochemistry, vol. 224, no. 1-2, pp. 45-51, 2001.
20. W.-L. Xue, X.-S. Li, J. Zhang, Y.-H. Liu, Z.-L. Wang, and R.-J. Zhang, "Effect of Trigonella foenum-graecum (Fenugreek) extract on blood glucose, blood lipid and hemorheological properties in streptozotocin-induced diabetic rats, " Asia Pacific Journal of Clinical Nutrition, vol. 16, no. 1, pp. 422-426, 2007.
21. A. M. Abdelatif, M. Y. Ibrahim, and A. S. Mahmoud, "Antidiabetic effects of fenugreek (Trigonella foenum-graecum) seeds in the domestic rabbit (Oryctolagus cuniculus), " Research Journal of Medicinal Plant, vol. 6, no. 6, pp. 449-455, 2012.
22. B. K. Ramesh, Yogesh, H. L. Raghavendra, S. M. Kantikar, and K. B. Prakash, "Antidiabetic and histopathological analysis of fenugreek extract on alloxan induced diabetic rats, " International Journal ofDrugDevelopment and Research, vol. 2, no. 2, pp. 356-364, 2010.
23. R. Moorthy, K. M. Prabhu, and P. S. Murthy, "Anti-hyperglycemic compound (GII) from fenugreek (Trigonella foenumgraecum linn. ) seeds, its purification and effect in diabetes mellitus, " Indian Journal of Experimental Biology, vol. 48, no. 11, pp. 1111-1118, 2010.
24. M. Z. Gad, M. M. El-Sawalhi, M. F. Ismail, and N. D. El-Tanbouly, "Biochemical study of the anti-diabetic action of the egyptian plants fenugreek and balanites, "Molecular and Cellular Biochemistry, vol. 281, no. 1-2, pp. 173-183, 2006.
25. R. D. Sharma, "Effect of fenugreek seeds and leaves on blood glucose and serum insulin responses in human subjects, " Nutrition Research, vol. 6, no. 12, pp. 1353-1364, 1986.
26. R. D. Sharma, T. C. Raghuram, and N. S. Rao, "Effect of fenugreek seeds on blood glucose and serum lipids in type I diabetes, " European Journal of Clinical Nutrition, vol. 44, no. 4, pp. 301-306, 1990.
27. M. Al-Habori and A. Raman, "Antidiabetic and hypocholesterolemic effects of fenugreek, " Phytotherapy Research, vol. 12, no. 4, pp. 233-242, 1998.
28. S. Kaviarasan, G. H. Naik, R. Gangabhagirathi, C. V. Anuradha, and K. I. Priyadarsini, "In vitro studies on antiradical and antioxidant activity of (Trigonella foenum graecum) fenugreek seeds, " Food Chemistry, vol. 103, pp. 31-37, 2007.
29. S. Kaviarasan, R. Sundarapandiyan, and C. V. Anuradha, "Protective action of fenugreek (Trigonella foenum graecum) seed polyphenols against alcohol-induced protein and lipid damage in rat liver, " Cell Biology and Toxicology, vol. 24, no. 5, pp. 391-400, 2008.
30. V. Thirunavukkarasu, C. V. Anuradha, and P. Viswanathan, "Protective effect of fenugreek (Trigonella foenum graecum) seeds in experimental ethanol toxicity, " Phytotherapy Research, vol. 17, no. 7, pp. 737-743, 2003.
31. J. Raju, J. M. R. Patlolla, M. V. Swamy, and C. V. Rao, "Diosgenin, a steroid saponin of Trigonella foenum graecum (Fenugreek), inhibits azoxymethane-induced aberrant crypt foci formation in F344 rats and induces apoptosis in HT-29 human colon cancer cells, " Cancer Epidemiology Biomarkers and Prevention, vol. 13, no. 8, pp. 1392-1398, 2004.
32. G. Francis, Z. Kerem, P. S. Makkar, and K. Becker, "The biological action of saponins in animals systems: a review, " British Journal of Nutrition, vol. 88, pp. 587-605, 2002.
33. S. Shishodia and B. B. Aggarwal, "Diosgenin inhibits osteoclastogenesis, invasion, and proliferation through the downregulation of Akt, IκB kinase activation and NF-κB-regulated gene expression, " Oncogene, vol. 25, no. 10, pp. 1463-1473, 2006.
34. H. Hibasami, H. Moteki, K. Ishikawa et al. , "Protodioscin isolated from fenugreek (Trigonella foenumgraecum (L. ) induces cell death and morphological change indicative of apoptosis in leukemic cell line H-60, but not in gastric cancer cell line KATO III, " International Journal ofMolecularMedicine, vol. 11, no. 1, pp. 23-26, 2003.
35. R. D. Bhalke, S. J. Anarthe, K. D. Sasane, S. N. Satpute, S. N. Shinde, and V. S. Sangle, "Antinociceptive activity of Trigonella foenum graecum leaves and seeds (Fabaceae), " International Journal of Pharmacy and Technology, vol. 8, no. 2, pp. 57-59, 2009.
36. A. Amin, A. Alkaabi, S. Al-Falasi, and S. A. Daoud, "Chemopreventive activities of Trigonella foenum graecum (Fenugreek) against breast cancer, " Cell Biology International, vol. 29, no. 8, pp. 687-694, 2005.
37. A. Ardelean, G. Pribac, A. Hermenean et al. , "Cytostatic and cytotoxic effects of Trigonella foenum graecum (fenugreek) seed extract, " Studia Universitatis Vasile Goldis Seria Stiintele Vietii, vol. 20, no. 1, pp. 25-29, 2010.
38. S. Shabbeer, M. Sobolewski, R. K. Anchoori et al. , "Fenugreek: a naturally occurring edible spice as an anticancer agent, " Cancer Biology and Therapy, vol. 8, no. 3, pp. 272-278, 2009.
39. S. Moalic, B. Liagre, C. Corbiere et al. , "A plant steroid, diosgenin, induces apoptosis, cell cycle arrest and COX activity in osteosarcoma cells, " FEBS Letters, vol. 506, no. 3, pp. 225-230, 2001.
40. S. Chatterjee, M. Kumar, and A. Kumar, "Chemomodulatory effect of Trigonella foenum graecum ((L. ) seed extract on two stage mouse skin carcinogenesis, " Toxicology International, vol. 19, no. 3, pp. 287-294, 2012.
41. K. K. Khoja, G. Shafi, T. N. Hasan et al. , "Fenugreek, a naturally occurring edible spice, kills MCF-7 human breast cancer cells via an apoptotic pathway, " Asian Pacific Journal of Cancer Prevention, vol. 12, no. 12, pp. 3299-3304, 2011.
42. T. Devasena and V. P. Menon, "Fenugreek affects the activity of β-glucuronidase and mucinase in the colon, " Phytotherapy Research, vol. 17, no. 9, pp. 1088-1091, 2003.
43. P. C. Singhal, R. K. Gupta, and L. D. Joshi, "Hypocholesterolmic effect of seeds, " Current Science, vol. 51, pp. 136-137, 1982.
44. J. M. A. Hannan, B. Rokeya, O. Faruque et al. , "Effect of soluble dietary fibre fraction of Trigonella foenum graecumon glycemic, insulinemic, lipidemic and platelet aggregation status of Type 2 diabetic model rats, " Journal of Ethnopharmacology, vol. 88, no. 1, pp. 73-77, 2003.
45. S. Chatterjee, N. Goswami, P. Bhatnagar, M. Kumar, and A. Kumar, "Antimutagenic and chemopreventive potentialities of fenugreek (Trigonella foenum graecum) graecum seed extract, " Oxidants and Antioxidants in Medical Science, vol. 2, no. 1, pp. 45-53, 2013.
46. A. Sharma, M. Kumar, M. Chandel, and S. J. Kaur, "Modulation of chromium trioxide induced genotoxicity bymethanol extract of leaves of Trigonella foenum-graecum L. , " Journal of Experimental and Integrative Medicine, vol. 29, no. 1, pp. 77-83, 2012.
47. F. Sharififara, P. Khazaelia, and N. Alli, "Evaluation of antiinflammatory activity of topical preparations from Fenugreek (Trigonella foenum graecum (L. ) seeds in a cream base, " Iranian Journal of Pharmaceutical Sciences: Summer, vol. 5, no. 3, pp. 157-162, 2009.
48. T. Kawabata, M.-Y. Cui, T. Hasegawa, F. Takano, and T. Ohta, "Anti-inflammatory and anti-melanogenic steroidal saponin glycosides from fenugreek (Trigonella foenum graecum (L. ) seeds, " Planta Medica, vol. 77, no. 7, pp. 705-710, 2011.
49. J. Raju and R. P. Bird, "Alleviation of hepatic steatosis accompanied by modulation of plasma and liver TNF-α levels by Trigonella foenum graecum (fenugreek) seeds in Zucker obese (fa/fa) rats, " International Journal of Obesity, vol. 30, no. 8, pp. 1298-1307, 2006.
50. M. Sumanth, P. Kapil, and P. Mihir, "Screening of aqueous extract of Trigonella foenum graecum seeds for its antiulcer activity, " International Journal of Research in Pharmaceutical and Biomedical Sciences, vol. 2, no. 3, pp. 1085-1089, 2011.
51. A. Ahmadiani, M. Javan, S. Semnanian, E. Barat, and M. Kamalinejad, "Anti-inflammatory and antipyretic effects of Trigonella foenum-graecum leaves extract in the rat, " Journal of Ethnopharmacology, vol. 75, no. 2-3, pp. 283-286, 2001.
52. V. Ravichandiran and S. Jayakumari, "Comparative study of bioactive fraction of Trigonella foenum graecum L. leaf and seed extracts for inflammation, " International Journal of Frontiers in Science and Technology, vol. 1, no. 2, pp. 128-148, 2013.
53. B. K. Dash, S. Sultana, and N. Sultana, "Antibacterial activities of methanol and acetone extracts of Fenugreek (Trigonella foenum) and Coriander (Coriandrum sativum), " Life Sciences and Medicine Research, vol. 2011, pp. 1-8, 2011.
54. A. Sheikhlar, A. R. Alimon, H. M. Daud, C. R. Saad, and H. Shanagi, "Screening of Morus alba, Citrus limon and Trigonella foenum-graecum extracts for antimicrobial properties and phytochemical compounds, " Journal of Biological Sciences, vol. 13, no. 5, pp. 386-392, 2013.
55. R. Chandra, V. Dwivedi, K. Shivam, and A. K. Jha, "Detection of antimicrobial activity of Oscimum sanctum (Tulsi) & Trigonella foenum graecum (Methi) against some selected bacterial & fungal strains, " Research Journal of Pharmaceutical, Biological and Chemical Sciences, vol. 2, no. 4, pp. 809-813, 2011.
56. N. Moradi and K. Moradi, "Physiological and pharmaceutical effects of fenugreek (Trigonella foenum graecum (L. ) as a multipurpose and valuable medicinal plant, " Global Journal of Medicinal Plant Research, vol. 1, no. 2, pp. 199-206, 2013.
57. S. Olli and P. B. Kirti, "Cloning, characterization and antifungal activity of defensin Tfgd1 from Trigonella foenum graecum L. , " Journal of Biochemistry and Molecular Biology, vol. 39, no. 3, pp. 278-283, 2006.
58. M. A. Kamel, R. Z. Hamza, N. E. Abdel-Hamid, and F. A. Mahmoud, "Anti-ulcer and gastro protective effects of fenugreek, ginger and peppermint oils in experimentally induced gastric ulcer in rats, " Journal of Chemical and Pharmaceutical Research, vol. 6, no. 2, pp. 451-468, 2014.
59. R. Kheirandish, O. Azari, and S. Shojaeepour, "Protective effect of Fenugreek (Trigonella foenum graecum) seed extract on experimental reflux esophagitis in rat, " Iranian Journal of Veterinary Surgery, vol. 8, no. 2, pp. 49-56, 2013.
60. D. N. Rao and B. Ganesh, "Estimate of cancer incidence in India in 1991, " Indian Journal of Cancer, vol. 35, no. 1, pp. 10-18, 1998.
61. F. Bray and B. Moller, "Predicting the future burden of cancer, " Nature Reviews Cancer, vol. 6, no. 1, pp. 63-74, 2006.
62. A. Stark and Z. Madar, "The effect of an ethanol extract derived from fenugreek (Trigonella foenum-graecum) on bile acid absorption and cholesterol levels in rats, " British Journal of Nutrition, vol. 69, no. 1, pp. 277-287, 1993.
63. T. Zia, S. N. Hasnain, and S. K. Hasan, "Evaluation of the oral hypoglycaemic effect of Trigonella foenum-graecum L. (methi) in normal mice, " Journal of Ethnopharmacology, vol. 75, no. 2-3, pp. 191-195, 2001.
64. B. Bin-Hafeez, R. Haque, S. Parvez, S. Pandey, I. Sayeed, and S. Raisuddin, "Immunomodulatory effects of fenugreek (Trigonella foenum graecum (L. ) extract in mice, " International Immunopharmacology, vol. 3, no. 2, pp. 257-265, 2003.
65. N. Subhashini, G. Nagarajan, and S. Kavimani, "Anti-inflammatory and in vitro antioxidant property of Trigonella foenum graecum seeds, " Journal of Pharmacology and Toxicology, vol. 6, no. 4, pp. 371-380, 2011.
66. S. A. Sakr, H. A. Mahran, and S. M. Abo-El-Yazid, "Effect of fenugreek seeds extract on cyclophosphamide-induced histomorphometrical, ultrastructural and biochemical changes in testes of albino mice, " Toxicology and Industrial Health, vol. 28, no. 3, pp. 276-288, 2012.
67. S. Panda, P. Tahiliani, and A. Kar, "Inhibition of triiodothyronine production by fenugreek seed extract in mice and rats, " Pharmacological Research, vol. 40, no. 5, pp. 405-409, 1999.
68. H. A. Lamfon, "Effect of fenugreek seed extract on carbendazim inhibited spermatogenesis in albino rats, " Journal of Applied Pharmaceutical Science, vol. 2, no. 4, pp. 9-13, 2010.
69. M. Ayesha, P. Ahmed, V. C. Gupta et al. , "A study of antimicrobial activity of few medicinally important herbal single drugs extracted in ethanol, methanol and aqueous solvents, " Pharmacognosy Journal, vol. 2, no. 10, pp. 351-356, 2010.
70. M. Al-Habori, A. Raman, M. J. Lawrence, and P. Skett, "In vitro effect of fenugreek extracts on intestinal sodium-dependent glucose uptake and hepatic glycogen phosphorylase A, " International Journal of Experimental Diabetes Research, vol. 2, no. 2, pp. 91-99, 2001.
71. A. Gupta, R. Gupta, and B. Lal, "Effect of T. foenum graecum (fenugreek) seeds on glycemic control and insulin resistance in type 2 diabetes mellitus: a double blind placebo controlled study, " Journal of the Association of Physicians of India, vol. 49, pp. 1057-1061, 2001.
72. M. M. Patel and S. Mishra, "Akinetic study for in-vitro intestinal uptake of monosaccharide across rat everted gut sacs in the presence of some antidiabetic medicinal plants, " The Internet Journal of Alternative Medicine, vol. 7, no. 1, pp. 1-7, 2009.
73. L. Langmead, C. Dawson, C. Hawkins, N. Banna, S. Loo, and D. S. Rampton, "Antioxidant effects of herbal therapies used by patients with inflammatory bowel disease: an in vitro study, " Alimentary Pharmacology and Therapeutics, vol. 16, no. 2, pp. 197-205, 2002.