Adjustment of cell-type composition minimizes systematic bias in blood DNA methylation profiles derived by DNA collection protocols

PLoS ONE

Volumn 11, Issue 1, 2016, Pages

  Shiwa, Yuh ^a   Hachiya, Tsuyoshi ^a   Furukawa, Ryohei ^a   Ohmomo, Hideki ^a   Ono, Kanako ^a   Kudo, Hisaaki ^b   Hata, Jun ^c   Hozawa, Atsushi ^b   Iwasaki, Motoki ^d   Matsuda, Koichi ^e   Minegishi, Naoko ^b   Satoh, Mamoru ^a   Tanno, Kozo ^a   Yamaji, Taiki ^d   Wakai, Kenji ^f   Hitomi, Jiro ^a   Kiyohara, Yutaka ^c   Kubo, Michiaki ^g   Tanaka, Hideo ^h   Tsugane, Shoichiro ^d   Yamamoto, Masayuki ^b,i   Sobue, Kenji ^a   Shimizu, Atsushi ^a   more..

^a IWATE MEDICAL UNIVERSITY   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

^d NATIONAL CANCER CENTER   (Japan)

^e UNIVERSITY OF TOKYO   (Japan)

^f NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^g RIKEN   (Japan)

^h AICHI CANCER CENTER HOSPITAL   (Japan)

ⁱ TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BLOOD ANALYSIS; CELL COMPOSITION; CLINICAL PROTOCOL; CONTROLLED STUDY; CPG ISLAND; CRYOPRESERVATION; DISEASE ASSOCIATION; DNA METHYLATION; DNA REPLICATION; FEMALE; HUMAN; JAPANESE (PEOPLE); MALE; PREDICTION; RISK FACTOR; SYSTEMATIC ERROR; BLOOD CELL; BLOOD SAMPLING; DNA MICROARRAY; FLOW CYTOMETRY; GENETICS; GENOME-WIDE ASSOCIATION STUDY; ISOLATION AND PURIFICATION; METABOLISM; PROCEDURES; STANDARDS; STATISTICAL BIAS;

DNA;

BIAS (EPIDEMIOLOGY); BLOOD CELLS; BLOOD SPECIMEN COLLECTION; CPG ISLANDS; DNA; DNA METHYLATION; FEMALE; FLOW CYTOMETRY; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS;

EID: 84958231422     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0147519     Document Type: Article

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