Stratified randomization controls better for batch effects in 450K methylation analysis: A cautionary tale

Frontiers in Genetics

Volumn 5, Issue SEP, 2014, Pages

  Buhule, Olive D ^a   Minster, Ryan L ^a   Hawley, Nicola L ^b   Medvedovic, Mario ^c   Sun, Guangyun ^c   Viali, Satupaitea ^d   Deka, Ranjan ^c   McGarvey, Stephen T ^e   Weeks, Daniel E ^a  

^a UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^b YALE UNIVERSITY   (United States)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^d Medical Specialist Clinic and National University of Samoa   (Samoa)

^e BROWN UNIVERSITY   (United States)

Author keywords

Array data; Batch effects; DNA Methylation; Epigenetics; Obesity; Study design

Indexed keywords

CYTOSINE; GENOMIC DNA; THYMINE; URACIL;

ABDOMINAL CIRCUMFERENCE; ADULT; ARTICLE; BISUFLITE MODIFICATION; BLOOD SAMPLING; BODY MASS; CONTROLLED STUDY; CPG ISLAND; DNA EXTRACTION; DNA METHYLATION; DNA MICROARRAY; DNA MODIFICATION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC TRAIT; GENOME; HUMAN; MAJOR CLINICAL STUDY; MALE; OBESITY; PRINCIPAL COMPONENT ANALYSIS; RANDOMIZATION;

CITRULLUS LANATUS VAR. LANATUS;

EID: 84917740537     PISSN: None     EISSN: 16648021     Source Type: Journal    
DOI: 10.3389/fgene.2014.00354     Document Type: Article

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