A novel high content imaging-based screen identifies the anti-helminthic niclosamide as an inhibitor of lysosome anterograde trafficking and prostate cancer cell invasion

PLoS ONE

Volumn 11, Issue 1, 2016, Pages

  Circu, Magdalena L ^a   Dykes, Samantha S ^a   Carroll, Jennifer ^a   Kelly, Kinsey ^a   Galiano, Floyd ^a   Greer, Adam ^a   Cardelli, James ^a   El Osta, Hazem ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; BAFILOMYCIN; CATHEPSIN B; EPIDERMAL GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; NICLOSAMIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEINASE; SCATTER FACTOR; ANTINEMATODAL AGENT;

ACTIN FILAMENT; ARTICLE; CANCER CELL; CELL AGGREGATION; CELL INVASION; CELL MIGRATION; CELL MOTILITY; CELL PH; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG SCREENING; ENZYME PHOSPHORYLATION; ENZYME RELEASE; GLIOMA CELL LINE; HUMAN; HUMAN CELL; JUXTANUCLEAR LYSOSOME AGGREGATION; LYSOSOME; LYSOSOME MEMBRANE; MICROTUBULE; MOLECULAR IMAGING; PROSTATE CANCER CELL LINE; PROTEIN PROCESSING; CELL MOTION; CELL NUCLEUS; CELL PROLIFERATION; DRUG EFFECTS; MALE; METABOLISM; PATHOLOGY; PROSTATE TUMOR; SIGNAL TRANSDUCTION; TUMOR CELL LINE; ULTRASTRUCTURE;

ANTINEMATODAL AGENTS; CELL LINE, TUMOR; CELL MOVEMENT; CELL NUCLEUS; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LYSOSOMES; MALE; NICLOSAMIDE; PROSTATIC NEOPLASMS; SIGNAL TRANSDUCTION;

EID: 84958225924     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0146931     Document Type: Article

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