Small guanosine triphosphatase Rho/Rho-associated kinase as a novel regulator of intracellular redistribution of lysosomes in invasive tumor cells

Cell and Tissue Research

Volumn 301, Issue 3, 2000, Pages 341-351

  Nishimura, Yukio ^a   Itoh, Kazuyuki ^b   Yoshioka, Kiyoko ^b   Uehata, Masayoshi ^c   Himeno, Masaru ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b OSAKA MEDICAL CENTER FOR CANCER AND CARDIOVASCULAR DISEASES   (Japan)

^c Welfide Corporation   (Japan)

Author keywords

Cathepsin D; Cell culture; Cytoskeleton; Intracellular trafficking; Lysosomes; Microtubules; Rho GTPase; Rho associated kinase

Indexed keywords

GUANOSINE TRIPHOSPHATASE; RHO KINASE;

ANIMAL CELL; ARTICLE; CANCER INVASION; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVITY; HEPATOMA CELL; INTRACELLULAR TRANSPORT; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0033837823     PISSN: 0302766X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004410000243     Document Type: Article

References (42)

1. 17β-Estradiol regulates and v-Ha-ras transfection constitutively enhances MCF7 breast cancer cell interactions with basement membrane
2. Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase
3. Cytoplasmic dynein-dependent vesicular transport from early to late endosomes
4. Transformation of human breast epithelial cells by c-Ha-ras oncogene
5. Taxol induces the assembly of free microtubules in living cells and blocks the organizing capacity of the centrosomes and kinetochores
6. Small GTP-binding proteins and the regulation of the actin cytoskeleton
7. Molecular dissection of the Rho-associated kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells
8. Radial extension of macrophage tubular lysosomes supported by kinesin
9. A lipoxygenase metabolite, 12-(S)-HETE, stimulates protein kinase C-mediated release of cathepsin B from malignant cells
10. Genetic instability and the acquisition of metastatic ability by rat mammary cancer cells following v-Ha-ras oncogene transfection
11. p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesion
12. An essential part for Rho-associated kinase in the transcellular invasion of tumor cells
13. Biochemical and immunohistochemical analysis of cathepsins B, H, L and D in human melanocytic tumours
14. Activation of Rac1, RhoA, and mitogen-activated protein kinase is required for Ras transformation
15. Regulation of cytoplasmic division of Xenopus embryo by rhop21 and its inhibitory GDP/GTP exchange protein (rhoGDI)
16. A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to the peripheral membranes
17. Immunolocalization of cytoplasmic dynein to lysosomes in cultured cells
18. Cancer invasion and metastasis
19. Kinesin is the motor for microtubule-mediated Golgi-to-ER membrane traffic
20. Rho-associated kinase, a novel serine threonine kinase, as a putative target for the small GTP binding protein Rho
21. Translocation and clustering of endo-somes and lysosomes depends on microtubules
22. Xenograft model of human proliferative breast disease
23. Ras oncogene alters localization of cathepsins
24. ROCK-I and ROCK-II; two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice
25. Identification of a precursor form of cathepsin D in microsomal lumen: Characterization of enzymatic activation and proteolytic processing in vitro
26. Identification of latent procathepsins B and L in microsomal lumen: Characterization of enzymatic activation and proteolytic processing in vitro
27. Malignant transformation alters intracellular trafficking of lysosomal cathepsin D in human breast epithelial cells
28. Increased invasive, chemotactic and locomotive abilities of c-Ha-ras-transformed human breast epithelial cells
29. Microinjection of recombinant p21(rho) induces rapid changes in cell morphology
30. Tumorigenic activity of rho genes from Aplysia california
31. Critical role of Rho in cell transformation by oncogenic Ras
32. Cathepsin D: A protease involved in cancer metastasis
33. Taxol: A novel investigational antimicrotubule agent
34. Cathepsin B and D are localized at the surface of human breast cancer cells
35. Regulation of lysosomal endo-peptidases in malignant neoplasia
36. Membrane association of cathepsin B can be induced by transfection of human breast epithelial cells with c-Ha-ras oncogene
37. Isolation and characterization of a spontaneously immortalized human breast epithelial cell line MCF-10
38. Involvement of rhop21 and its inhibitory GDP/GTP exchange protein (rhoGDI) in cell motility
39. PKC mediates 12-(S)-HETE-induced cytoskeletal rearrangement in B16a melanoma cells
40. 3-integrin in melanoma cells
41. ++sensitization of smooth muscle in hypertension
42. Small GTP-binding protein Rho stimulates the actomyosin system, leading to invasion of tumor cells