A Continuous, Fluorogenic Sirtuin 2 Deacylase Assay: Substrate Screening and Inhibitor Evaluation

Journal of Medicinal Chemistry

Volumn 59, Issue 3, 2016, Pages 1021-1031

  Galleano, Iacopo ^a   Schiedel, Matthias ^b   Jung, Manfred ^b   Madsen, Andreas S ^a   Olsen, Christian A ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; SIRREAL2; SIRTUIN 2; SURAMIN; UNCLASSIFIED DRUG; ACETAMIDE DERIVATIVE; FLUORESCENT DYE; LYSINE; SIRT2 PROTEIN, HUMAN; THIAZOLE DERIVATIVE;

AMINO ACID SEQUENCE; ARTICLE; CHEMICAL MODIFICATION; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME SUBSTRATE; IN VITRO STUDY; KINETIC PARAMETERS; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; ENZYME SPECIFICITY; HUMAN; METABOLISM; PRECLINICAL STUDY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ACETAMIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; FLUORESCENT DYES; HUMANS; LYSINE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; SIRTUIN 2; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; SURAMIN; THIAZOLES;

EID: 84958211692     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b01532     Document Type: Article

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