Structural and functional connectivity in healthy aging: Associations for cognition and motor behavior

Human Brain Mapping

Volumn 37, Issue 3, 2016, Pages 855-867

  Hirsiger, Sarah ^a   Koppelmans, Vincent ^b   Mérillat, Susan ^a   Liem, Franziskus ^a   Erdeniz, Burak ^b   Seidler, Rachael D ^b,c   Jäncke, Lutz ^a,d  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^d KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

Cingulum; Cognitive aging; Functional connectivity; Multimodal imaging; Tractography

Indexed keywords

ADULT; AGED; ANISOTROPY; ARTICLE; BRAIN FUNCTION; CINGULUM (BRAIN); COGNITIVE AGING; COGNITIVE FUNCTION TEST; CONNECTOME; CORPUS CALLOSUM; DEFAULT MODE NETWORK; DIFFUSION WEIGHTED IMAGING; EPISODIC MEMORY; EXECUTIVE FUNCTION; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GRIP STRENGTH; HUMAN; HUMAN EXPERIMENT; KNOWLEDGE; MALE; MEDIAL PREFRONTAL CORTEX; MOTOR PERFORMANCE; NORMAL HUMAN; POSTERIOR CINGULATE; PRIORITY JOURNAL; RECALL; TRACTOGRAPHY; VISUAL MEMORY; WHITE MATTER; AGING; BRAIN; COGNITION; DIFFUSION TENSOR IMAGING; HAND STRENGTH; MEMORY; MIDDLE AGED; MOTOR ACTIVITY; NERVE TRACT; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; ORGAN SIZE; PATHOLOGY; PHYSIOLOGY; PSYCHOLOGY; REST; VERY ELDERLY;

AGED; AGED, 80 AND OVER; AGING; BRAIN; COGNITION; DIFFUSION TENSOR IMAGING; EXECUTIVE FUNCTION; FEMALE; HAND STRENGTH; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MEMORY; MIDDLE AGED; MOTOR ACTIVITY; NEURAL PATHWAYS; NEUROPSYCHOLOGICAL TESTS; ORGAN SIZE; REST;

EID: 84958176150     PISSN: 10659471     EISSN: 10970193     Source Type: Journal    
DOI: 10.1002/hbm.23067     Document Type: Article

References (63)

1. Alley D, Suthers K, Crimmins E (2007): Education and cognitive decline in older Americans: results from the AHEAD sample. Res Aging 29:73-94.
2. Andrews-Hanna JR, Snyder AZ, Vincent JL, Lustig C, Head D, Raichle ME, Buckner RL (2007): Disruption of large-scale brain systems in advanced aging. Neuron 56:924-935.
3. Aschenbrenner S, Tucha O, Lange KW. (2000): RWT. Regensburger Wortflüssigkeits-Test. Göttingen: Hogrefe.
4. Aoki T, Fukuoka Y (2010): Finger tapping ability in healthy elderly and young adults. Med Sci Sports Exercise 42:449-455.
5. Aster Von M, Neubauer A, Horn R (2006): Hamburg-Wechsler-Intelligenz-Test für Erwachsene III. Frankfurt: Harcourt.
6. Barrick TR, Charlton RA, Clark CA, Markus HS (2010): White matter structural decline in normal ageing: a prospective longitudinal study using tract-based spatial statistics. NeuroImage 51:565-577.
7. Bartzokis G, Lu PH, Tingus K, Mendez MF, Richard A, Peters DG, Oluwadara B, Barrall KA, Finn JP, Villablanca P, Thompson PM, Mintz J (2010): Lifespan trajectory of myelin integrity and maximum motor speed. Neurobiol Aging 31:1554-1562.
8. Beauchet O, Celle S, Roche F, Bartha R, Montero-Odasso M, Allali G, Annweiler C (2013): Blood pressure levels and brain volume reduction: a systematic review and meta-analysis. J Hypertens 31:1502-1516.
9. Bennett IJ, Madden DJ (2014): Disconnected aging: Cerebral white matter integrity and age-related differences in cognition. Neuroscience 276:187-205.
10. Bennett IJ, Madden DJ, Vaidya CJ, Howard JH, Howard DV (2011): White matter integrity correlates of implicit sequence learning in healthy aging. Neurobiol Aging 32:2317.e1-2312.
11. Bennett IJ, Rypma B (2013): Advances in functional neuroanatomy: a review of combined DTI and fMRI studies in healthy younger and older adults. Neurosci Biobehav Rev 37:1201-1210.
12. Borghesani PR, Madhyastha TM, Aylward EH, Reiter MA, Swarny BR, Schaie KW, Willis SL (2013): The association between higher order abilities, processing speed, and age are variably mediated by white matter integrity during typical aging. Neuropsychologia 51:1435-1444.
13. Buckner RL, Andrews-Hanna JR, Schacter DL (2008): The brain's default network: anatomy, function, and relevance to disease. Ann NY Acad Sci 1124:1-38.
14. Chao-Gan Y, Yu-Feng Z (2010): DPARSF: A MATLAB Toolbox for "Pipeline" data analysis of resting-state fMRI. Front Syst Neurosci 4:13
15. Damoiseaux JS, Beckmann CF, Arigita EJS, Barkhof F, Scheltens P, Stam CJ, Smith SM, Rombouts SARB (2008): Reduced resting-state brain activity in the "default network" in normal aging. Cereb Cortex 18:1856-1864.
16. Davis SW, Dennis NA, Buchler NG, White LE, Madden DJ, Cabeza R (2009): Assessing the effects of age on long white matter tracts using diffusion tensor tractography. NeuroImage 46:530-541.
17. Dennis EL, Thompson PM (2014): Functional brain connectivity using fMRI in aging and Alzheimer's disease. Neuropsychol Rev 24:49-62.
18. Ferreira LK, Busatto GF (2013): Resting-state functional connectivity in normal brain aging. Neurosci Biobehav Rev 37:384-400.
19. Fjell AM, Walhovd KB (2010): Structural brain changes in aging: courses, causes and cognitive consequences. Rev Neurosci 21:187-221.
20. Folstein MF, Folstein SE, McHugh PR (1975): "Mini-mental state": a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189-198.
21. Fox MD, Raichle ME (2007): Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nat Rev Neurosci 8:700-711.
22. Frederiksen H, Hjelmborg J, Mortensen J, McGue M, Vaupel JW, Christensen K (2006): Age trajectories of grip strength: cross-sectional and longitudinal data among 8, 342 Danes aged 46 to 102. Ann Epidemiol 16:554-562.
23. Geschwind N (1965): Disconnexion syndromes in animals and man. Brain 88:237-294, 585-564.
24. Grady C (2012): The cognitive neuroscience of ageing. Nat Rev Neurosci 13:491-505.
25. Greicius MD, Supekar K, Menon V, Dougherty RF (2009): Resting-state functional connectivity reflects structural connectivity in the default mode network. Cereb Cortex 19:72-78.
26. Helmstaedter C, Lendt M, Lux S (2001): Verbaler Lern- und Merkfähigkeitstest [Verbal Learning and Memory Test]. Beltz.
27. Holm S (1979): A simple sequentially rejective multiple test procedure. Scandinavian journal of statistics.
28. Hsu J-L, Leemans A, Bai C-H, Lee C-H, Tsai Y-F, Chiu H-C, Chen W-H (2008): Gender differences and age-related white matter changes of the human brain: A diffusion tensor imaging study. NeuroImage 39:566-577.
29. Inano S, Takao H, Hayashi N, Yoshioka N, Mori H, Kunimatsu A, Abe O, Ohtomo K (2012): Effects of age and gender on neuroanatomical volumes. J Magn Reson Imaging 2013:1072-1076.
30. Khalsa S, Mayhew SD, Chechlacz M, Bagary M, Bagshaw AP (2013): The structural and functional connectivity of the posterior cingulate cortex: Comparison between deterministic and probabilistic tractography for the investigation of structure-function relationships. NeuroImage 102:118-127.
31. Madden DJ, Bennett IJ, Burzynska A, Potter GG, Chen N-K, Song AW (2012): Diffusion tensor imaging of cerebral white matter integrity in cognitive aging. Biochim Biophys Acta 1822:386-400.
32. Marcus J, Gardener H, Rundek T, Elkind MSV, Sacco RL, Decarli C, Wright CB (2011): Baseline and longitudinal increases in diastolic blood pressure are associated with greater white matter hyperintensity volume: the northern Manhattan study. Stroke 42:2639-2641.
33. Maylor EA, Reimers S, Choi J, Collaer ML, Peters M, Silverman I (2007): Gender and sexual orientation differences in cognition across adulthood: age is kinder to women than to men regardless of sexual orientation. Arch Sex Behav 36:235-249.
34. Metzler-Baddeley C, Jones DK, Steventon J, Westacott L, Aggleton JP, O'Sullivan MJ (2012): Cingulum microstructure predicts cognitive control in older age and mild cognitive impairment. J Neurosci 32:17612-17619.
35. Mevel K, Landeau B, Fouquet M, La Joie R, Villain N, Mézenge F, Perrotin A, Eustache F, Desgranges B, Chételat G (2013): Age effect on the default mode network, inner thoughts, and cognitive abilities. Neurobiol Aging 34:1292-1301.
36. Noble JW, Eng JJ, Kokotilo KJ, Boyd LA (2011): Aging effects on the control of grip force magnitude: an fMRI study. Exp Gerontol 46:453-461.
37. Noble KG, Korgaonkar MS, Grieve SM, Brickman AM (2013): Higher education is an age-independent predictor of white matter integrity and cognitive control in late adolescence. Dev Sci 16:653-664.
38. O'Sullivan M, Jones DK, Summers PE, Morris RG, Williams SC, Markus HS (2001): Evidence for cortical "disconnection" as a mechanism of age-related cognitive decline. Neurology 57:632-638.
39. Onoda K, Ishihara M, Yamaguchi S (2012): Decreased functional connectivity by aging is associated with cognitive decline. J Cogn Neurosci 24:2186-2198.
40. Persson J, Pudas S, Nilsson L-G, Nyberg L (2014): Longitudinal assessment of default-mode brain function in aging. Neurobiol Aging 35:2107-2117.
41. Rantanen T, Harris T, Leveille SG, Visser M, Foley D, Masaki K, Guralnik JM (2000a): Muscle strength and body mass index as long-term predictors of mortality in initially healthy men. J Gerontol A Biol Sci Med Sci 55:M168-M173.
42. Rantanen T, Penninx BW, Masaki K, Lintunen T, Foley D, Guralnik JM (2000b): Depressed mood and body mass index as predictors of muscle strength decline in old men. J Am Geriatr Soc 48:613-617.
43. Raz N, Rodrigue KM (2006): Differential aging of the brain: Patterns, cognitive correlates and modifiers. Neurosci Biobehav Rev 30:730-748.
44. Reitan RM, Wolfson D (1985): The Halstead-Reitan neuropsychological test battery. Tucson, AZ: Neuropsychological Press.
45. Rey A (1964): L'examen clinique en psychologie. Paris: Presses Universitaires de France.
46. Salami A, Eriksson J, Nilsson L-G, Nyberg L (2011): Age-related white matter microstructural differences partly mediate age-related decline in processing speed but not cognition. BBA Mol Basis Disease:1-8.
47. Salthouse TA (1996): The processing-speed theory of adult age differences in cognition. Psychol Rev 103:403-428.
48. Salthouse TA, Atkinson TM, Berish DE (2003): Executive functioning as a potential mediator of age-related cognitive decline in normal adults. J Exp Psychol Gen 132:566-594.
49. Seidler RD, Bernard JA, Burutolu TB, Fling BW, Gordon MT, Gwin JT, Kwak Y, Lipps DB (2010): Motor control and aging: links to age-related brain structural, functional, and biochemical effects. Neurosci Biobehav Rev 34:721-733.
50. Seidler R, Erdeniz B, Koppelmans V, Hirsiger S, Mérillat S, Jäncke L (2015): Associations between age, motor function, and resting state sensorimotor network connectivity in healthy older adults. NeuroImage 108:47-59.
51. Smith SM, Jenkinson M, Woolrich MW, Beckmann CF, Behrens TEJ, Johansen-Berg H, Bannister PR, De Luca M, Drobnjak I, Flitney DE, Niazy RK, Saunders J, Vickers J, Zhang Y, De Stefano N, Brady JM, Matthews PM (2004): Advances in functional and structural MR image analysis and implementation as FSL. NeuroImage 23: S208-S219.
52. Song S-K, Sun S-W, Ju W-K, Lin S-J, Cross AH, Neufeld AH (2003): Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia. NeuroImage 20:1714-1722.
53. Song S-K, Sun S-W, Ramsbottom MJ, Chang C, Russell J, Cross AH (2002): Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water. NeuroImage 17:1429-1436.
54. Song X-W, Dong Z-Y, Long X-Y, Li S-F, Zuo X-N, Zhu C-Z, He Y, Yan C-G, Zang Y-F (2011): REST: a toolkit for resting-state functional magnetic resonance imaging data processing. PLoS One 6:e25031
55. Syddall H, Cooper C, Martin F, Briggs R, Aihie Sayer A (2003): Is grip strength a useful single marker of frailty? Age Ageing 32:650-656.
56. Teipel SJ, Bokde ALW, Meindl T, Amaro E, Soldner J, Reiser MF, Herpertz SC, Möller H-J, Hampel H (2010): White matter microstructure underlying default mode network connectivity in the human brain. NeuroImage 49:2021-2032.
57. Tustison NJ, Avants BB, Cook PA, Zheng Y, Egan A, Yushkevich PA, Gee JC (2010): N4ITK: improved N3 bias correction. IEEE Trans Med Imaging 29:1310-1320.
58. van den Heuvel M, Mandl R, Luigjes J, Hulshoff Pol H (2008): Microstructural organization of the cingulum tract and the level of default mode functional connectivity. J Neurosci 28:10844-10851.
59. Van Dijk KRA, Hedden T, Venkataraman A, Evans KC, Lazar SW, Buckner RL (2010): Intrinsic functional connectivity as a tool for human connectomics: theory, properties, and optimization. J Neurophysiol 103:297-321.
60. Wakana S, Caprihan A, Panzenboeck MM, Fallon JH, Perry M, Gollub RL, Hua K, Zhang J, Jiang H, Dubey P, Blitz A, van Zijl P, Mori S (2007): Reproducibility of quantitative tractography methods applied to cerebral white matter. NeuroImage 36:630-644.
61. Wu J-T, Wu H-Z, Yan C-G, Chen W-X, Zhang H-Y, He Y, Yang H-S (2011): Aging-related changes in the default mode network and its anti-correlated networks: a resting-state fMRI study. Neurosci Lett 504:62-67.
62. Zahr NM, Rohlfing T, Pfefferbaum A, Sullivan EV (2009): Problem solving, working memory, and motor correlates of association and commissural fiber bundles in normal aging: A quantitative fiber tracking study. NeuroImage 44:1050-1062.
63. Zöllig J, Mérillat S, Eschen A, Röcke C, Martin M, Jäncke L (2011): Plasticity and imaging research in healthy aging: core ideas and profile of the International Normal Aging and Plasticity Imaging Center (INAPIC). Gerontology 57:190-192.