A novel DPP-4 inhibitor teneligliptin scavenges hydroxyl radicals: In vitro study evaluated by electron spin resonance spectroscopy and in vivo study using DPP-4 deficient rats

Metabolism: Clinical and Experimental

Volumn 65, Issue 3, 2016, Pages 138-145

  Kimura, Shinichiro ^a   Inoguchi, Toyoshi ^a,b   Yamasaki, Toshihide ^b   Yamato, Mayumi ^b   Ide, Makoto ^a   Sonoda, Noriyuki ^a,b   Yamada, Kenichi ^b   Takayanagi, Ryoichi ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

DPP 4 inhibitor; Electron spin resonance; Oxidative stress; Radical scavenging activity; Teneligliptin

Indexed keywords

3-(4-(4-(3-METHYL-1-PHENYL-1H-PYRAZOL-5-YL)PIPERAZIN-1-YL)PYRROLIDIN-2-YLCARBONYL)THIAZOLIDINE; DIPEPTIDYL PEPTIDASE IV; DIPEPTIDYL PEPTIDASE IV INHIBITOR; GLUCOSE BLOOD LEVEL; HYDROXYL RADICAL; PYRAZOLE DERIVATIVE; REACTIVE OXYGEN METABOLITE; SCAVENGER; THIAZOLIDINE DERIVATIVE;

ANIMAL; DEFICIENCY; DOSE RESPONSE; ELECTRON SPIN RESONANCE; EXPERIMENTAL DIABETES MELLITUS; FISCHER 344 RAT; GENETICS; GLUCOSE BLOOD LEVEL; METABOLISM; RAT; THIN LAYER CHROMATOGRAPHY;

ANIMALS; BLOOD GLUCOSE; CHROMATOGRAPHY, THIN LAYER; DIABETES MELLITUS, EXPERIMENTAL; DIPEPTIDYL PEPTIDASE 4; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON SPIN RESONANCE SPECTROSCOPY; FREE RADICAL SCAVENGERS; HYDROXYL RADICAL; PYRAZOLES; RATS; RATS, INBRED F344; REACTIVE OXYGEN SPECIES; THIAZOLIDINES;

EID: 84958154955     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2015.10.030     Document Type: Article

References (30)

1. D.J. Drucker, and M.A. Nauck The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes Lancet 368 2006 1696 1705
2. M.A. Nauck Incretin-based therapies for type 2 diabetes mellitus: properties, functions, and clinical implications Am J Med 124 2011 S3 S18
3. A.J. Scheen A review of gliptins in 2011 Expert Opin Pharmacother 13 2012 81 99
4. C.F. Deacon Dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes: a comparative review Diabetes Obes Metab 13 2011 7 18
5. M. Nabeno, F. Akahoshi, H. Kishida, I. Miyaguchi, Y. Tanaka, S. Ishii, and et al. A comparative study of the binding modes of recently launched dipeptidyl peptidase IV inhibitors in the active site Biochem Biophys Res Commun 434 2013 191 196
6. Z. Shah, T. Kampfrath, J.A. Deiuliis, J. Zhong, C. Pineda, Z. Ying, and et al. Long-term dipeptidyl-peptidase 4 inhibition reduces atherosclerosis and inflammation via effects on monocyte recruitment and chemotaxis Circulation 124 2011 2338 2349
7. Z. Shah, C. Pineda, T. Kampfrath, A. Maiseyeu, Z. Ying, I. Racoma, and et al. Acute DPP-4 inhibition modulates vascular tone through GLP-1 independent pathways Vascul Pharmacol 55 2011 2 9
8. S. Kroller-Schon, M. Knorr, M. Hausding, M. Oelze, A. Schuff, R. Schell, and et al. Glucose-independent improvement of vascular dysfunction in experimental sepsis by dipeptidyl-peptidase 4 inhibition Cardiovasc Res 96 2012 140 149
9. J. Matsubara, S. Sugiyama, K. Sugamura, T. Nakamura, Y. Fujiwara, E. Akiyama, and et al. A dipeptidyl peptidase-4 inhibitor, des-fluoro-sitagliptin, improves endothelial function and reduces atherosclerotic lesion formation in apolipoprotein E-deficient mice J Am Coll Cardiol 59 2012 265 276
10. A.R. Aroor, J.R. Sowers, G. Jia, and V.G. DeMarco Pleiotropic effects of the dipeptidylpeptidase-4 inhibitors on the cardiovascular system Am J Physiol Heart Circ Physiol 307 2014 H477 H492
11. H. Hendarto, T. Inoguchi, Y. Maeda, N. Ikeda, J. Zheng, R. Takei, and et al. GLP-1 analog liraglutide protects against oxidative stress and albuminuria in streptozotocin-induced diabetic rats via protein kinase A-mediated inhibition of renal NAD(P)H oxidases Metabolism 61 2012 1422 1434
12. H. Fujita, T. Morii, H. Fujishima, T. Sato, T. Shimizu, M. Hosoba, and et al. The protective roles of GLP-1R signaling in diabetic nephropathy: possible mechanism and therapeutic potential Kidney Int 85 2014 579 589
13. T. Matsui, Y. Nishino, M. Takeuchi, and S. Yamagishi Vildagliptin blocks vascular injury in thoracic aorta of diabetic rats by suppressing advanced glycation end product-receptor axis Pharmacol Res 63 2011 383 388
14. S. Maeda, T. Matsui, and S. Yamagishi Vildagliptin inhibits oxidative stress and vascular damage in streptozotocin-induced diabetic rats Int J Cardiol 158 2012 171 173
15. S.I. Dikalov, and R.P. Mason Spin trapping of polyunsaturated fatty acid-derived peroxyl radicals: reassignment to alkoxyl radical adducts Free Radic Biol Med 30 2001 187 197
16. S. Xavier, K. Yamada, A.M. Samuni, A. Samuni, W. DeGraff, M.C. Krishna, and et al. Differential protection by nitroxides and hydroxylamines to radiation-induced and metal ion-catalyzed oxidative damage Biochim Biophys Acta 1573 2002 109 120
17. S. Fukuda-Tsuru, J. Anabuki, Y. Abe, K. Yoshida, and S. Ishii A novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor, teneligliptin, improves postprandial hyperglycemia and dyslipidemia after single and repeated administrations Eur J Pharmacol 696 2012 194 202
18. Y. Nakamaru, Y. Hayashi, R. Ikegawa, S. Kinoshita, B. Perez Madera, D. Gunput, and et al. Metabolism and disposition of the dipeptidyl peptidase IV inhibitor teneligliptin in humans Xenobiotica 44 2014 242 253
19. Y. Watanabe, T. Kojima, and Y. Fujimoto Deficiency of membrane-bound dipeptidyl aminopeptidase IV in a certain rat strain Experientia 43 1987 400 401
20. R.H. Erickson, Y. Suzuki, A. Sedlmayer, and Y.S. Kim Biosynthesis and degradation of altered immature forms of intestinal dipeptidyl peptidase IV in a rat strain lacking the enzyme J Biol Chem 267 1992 21623 21629
21. L.W. Oberley Free radicals and diabetes Free Radic Biol Med 5 1988 113 124
22. J.W. Baynes Role of oxidative stress in development of complications in diabetes Diabetes 40 1991 405 412
23. J.R. Williamson, K. Chang, M. Frangos, K.S. Hasan, Y. Ido, T. Kawamura, and et al. Hyperglycemic pseudohypoxia and diabetic complications Diabetes 42 1993 801 813
24. M. Brownlee, A. Cerami, and H. Vlassara Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications N Engl J Med 318 1988 1315 1321
25. M. Kakimoto, T. Inoguchi, T. Sonta, H.Y. Yu, M. Imamura, T. Etoh, and et al. Accumulation of 8-hydroxy-2′-deoxyguanosine and mitochondrial DNA deletion in kidney of diabetic rats Diabetes 51 2002 1588 1595
26. T. Inoguchi, P. Li, F. Umeda, H.Y. Yu, M. Kakimoto, M. Imamura, and et al. High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C - dependent activation of NAD(P)H oxidase in cultured vascular cells Diabetes 49 2000 1939 1945
27. T. Inoguchi, T. Sonta, H. Tsubouchi, T. Etoh, M. Kakimoto, N. Sonoda, and et al. Protein kinase C-dependent increase in reactive oxygen species (ROS) production in vascular tissues of diabetes: role of vascular NAD(P)H oxidase J Am Soc Nephrol 14 2003 S227 S232
28. T. Nishikawa, D. Edelstein, X.L. Du, S. Yamagishi, T. Matsumura, Y. Kaneda, and et al. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage Nature 404 2000 787 790
29. M.C. Desco, M. Asensi, R. Marquez, J. Martinez-Valls, M. Vento, F.V. Pallardo, and et al. Xanthine oxidase is involved in free radical production in type 1 diabetes: protection by allopurinol Diabetes 51 2002 1118 1124
30. M. Satoh, S. Fujimoto, Y. Haruna, S. Arakawa, H. Horike, N. Komai, and et al. NAD(P)H oxidase and uncoupled nitric oxide synthase are major sources of glomerular superoxide in rats with experimental diabetic nephropathy Am J Physiol Renal Physiol 288 2005 F1144 F1152