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Volumn 16, Issue 1-2, 2016, Pages 34-38

Tau immunotherapy

Author keywords

Alzheimer's disease; Tau immunotherapy; Tauopathies

Indexed keywords

TAU PROTEIN;

EID: 84958059727     PISSN: 16602854     EISSN: 16602862     Source Type: Journal    
DOI: 10.1159/000440842     Document Type: Conference Paper
Times cited : (54)

References (36)
  • 1
    • 34548146119 scopus 로고    scopus 로고
    • Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements
    • Asuni AA, Boutajangout A, Quartermain D, Sigurdsson EM: Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements. J Neurosci 2007; 27: 9115-9129.
    • (2007) J Neurosci , vol.27 , pp. 9115-9129
    • Asuni, A.A.1    Boutajangout, A.2    Quartermain, D.3    Sigurdsson, E.M.4
  • 2
    • 78650065372 scopus 로고    scopus 로고
    • Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model
    • Boutajangout A, Quartermain D, Sigurdsson EM: Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model. J Neurosci 2010; 30: 16559-16566.
    • (2010) J Neurosci , vol.30 , pp. 16559-16566
    • Boutajangout, A.1    Quartermain, D.2    Sigurdsson, E.M.3
  • 3
    • 79960563632 scopus 로고    scopus 로고
    • Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain
    • Boutajangout A, Ingadottir J, Davies P, Sigurdsson EM: Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain. J Neurochem 2011; 118: 658-667.
    • (2011) J Neurochem , vol.118 , pp. 658-667
    • Boutajangout, A.1    Ingadottir, J.2    Davies, P.3    Sigurdsson, E.M.4
  • 5
    • 82955194797 scopus 로고    scopus 로고
    • Tautargeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau transgenic mice
    • Bi M, Ittner A, Ke YD, Gotz J, Ittner LM: Tautargeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau transgenic mice. PLoS One 2011; 6:e26860.
    • (2011) PLoS One , vol.6 , pp. e26860
    • Bi, M.1    Ittner, A.2    Ke, Y.D.3    Gotz, J.4    Ittner, L.M.5
  • 7
    • 84923626096 scopus 로고    scopus 로고
    • Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice
    • Ittner A, Bertz J, Suh LS, Stevens CH, Gotz J, Ittner LM: Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice. J Neurochem 2015; 132: 135-145.
    • (2015) J Neurochem , vol.132 , pp. 135-145
    • Ittner, A.1    Bertz, J.2    Suh, L.S.3    Stevens, C.H.4    Gotz, J.5    Ittner, L.M.6
  • 8
    • 84890282160 scopus 로고    scopus 로고
    • Antibody uptake into neurons occurs primarily via clathrin-dependent Fcgamma receptor endocytosis and is a prerequisite for acute tau protein clearance
    • Congdon EE, Gu J, Sait HB, Sigurdsson EM: Antibody uptake into neurons occurs primarily via clathrin-dependent Fcgamma receptor endocytosis and is a prerequisite for acute tau protein clearance. J Biol Chem 2013; 288: 35452-35465.
    • (2013) J Biol Chem , vol.288 , pp. 35452-35465
    • Congdon, E.E.1    Gu, J.2    Sait, H.B.3    Sigurdsson, E.M.4
  • 9
    • 84887837879 scopus 로고    scopus 로고
    • Two novel tau antibodies targeting the 396/404 region are primarily taken up by neurons and reduce tau protein pathology
    • Gu J, Congdon EE, Sigurdsson EM: Two novel tau antibodies targeting the 396/404 region are primarily taken up by neurons and reduce tau protein pathology. J Biol Chem 2013; 288: 33081-33095.
    • (2013) J Biol Chem , vol.288 , pp. 33081-33095
    • Gu, J.1    Congdon, E.E.2    Sigurdsson, E.M.3
  • 12
    • 84930538607 scopus 로고    scopus 로고
    • Tau immunotherapy for Alzheimer's disease
    • Pedersen JT, Sigurdsson EM: Tau immunotherapy for Alzheimer's disease. Trends Mol Med 2015; 21: 394-402.
    • (2015) Trends Mol Med , vol.21 , pp. 394-402
    • Pedersen, J.T.1    Sigurdsson, E.M.2
  • 13
    • 84876908676 scopus 로고    scopus 로고
    • Tau passive immunotherapy in mutant P301L mice: Antibody affinity versus specificity
    • D'Abramo C, Acker CM, Jimenez HT, Davies P: Tau passive immunotherapy in mutant P301L mice: antibody affinity versus specificity. PLoS One 2013; 8:e62402.
    • (2013) PLoS One , vol.8 , pp. e62402
    • D'Abramo, C.1    Acker, C.M.2    Jimenez, H.T.3    Davies, P.4
  • 15
    • 84908290432 scopus 로고    scopus 로고
    • First-in-man tau vaccine targeting structural determinants essential for pathological tau-tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer's disease model
    • Kontsekova E, Zilka N, Kovacech B, Novak P, Novak M: First-in-man tau vaccine targeting structural determinants essential for pathological tau-tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer's disease model. Alzheimers Res Ther 2014; 6: 44.
    • (2014) Alzheimers Res Ther , vol.6 , pp. 44
    • Kontsekova, E.1    Zilka, N.2    Kovacech, B.3    Novak, P.4    Novak, M.5
  • 16
    • 84958100101 scopus 로고    scopus 로고
    • Axon Neuroscience SE: NCT01850238: safety study of AADvac1, a tau peptide-KLH-conjugate active vaccine to treat Alzheimer's disease
    • Axon Neuroscience SE: NCT01850238: safety study of AADvac1, a tau peptide-KLH-conjugate active vaccine to treat Alzheimer's disease. 2015. https://ClinicalTrials.gov.
    • (2015)
  • 17
    • 84958100102 scopus 로고    scopus 로고
    • Bristol-Meyers Squibb: NCT02294851: a randomized, double-blind, placebo-controlled, single ascending dose study of intravenously administered BMS-986168 in healthy subjects
    • Bristol-Meyers Squibb: NCT02294851: a randomized, double-blind, placebo-controlled, single ascending dose study of intravenously administered BMS-986168 in healthy subjects. 2015. https://ClinicalTrials.gov.
    • (2015)
  • 18
    • 84958100103 scopus 로고    scopus 로고
    • Bristol-Meyers Squibb: NCT02460094: multiple ascending dose study of intravenously administered BMS-986168 in patients with progressive supranuclear palsy (CN002-003)
    • Bristol-Meyers Squibb: NCT02460094: multiple ascending dose study of intravenously administered BMS-986168 in patients with progressive supranuclear palsy (CN002-003). 2015. https://ClinicalTrials.gov.
    • (2015)
  • 20
    • 84958100104 scopus 로고    scopus 로고
    • Hoffmann-La-Roche: NCT02281786: a study of RO6926496 in healthy volunteers
    • Hoffmann-La-Roche: NCT02281786: a study of RO6926496 in healthy volunteers. 2015. https://ClinicalTrials.gov.
    • (2015)
  • 22
    • 84958100105 scopus 로고    scopus 로고
    • C2N Diagnostics - Abbvie: NCT02494024: safety, tolerability and pharmacokinetics of C2N-8E12 in subjects with progressive supranuclear palsy
    • C2N Diagnostics - Abbvie: NCT02494024: safety, tolerability and pharmacokinetics of C2N-8E12 in subjects with progressive supranuclear palsy. 2015. https://ClinicalTrials.gov.
    • (2015)
  • 23
    • 84901811175 scopus 로고    scopus 로고
    • Harnessing the immune system for treatment and detection of tau pathology
    • Congdon EE, Krishnaswamy S, Sigurdsson EM: Harnessing the immune system for treatment and detection of tau pathology. J Alzheimers Dis 2014; 40(suppl 1):S113-S121.
    • (2014) J Alzheimers Dis , vol.40 , pp. S113-S121
    • Congdon, E.E.1    Krishnaswamy, S.2    Sigurdsson, E.M.3
  • 30
    • 54249156984 scopus 로고    scopus 로고
    • Immunotherapy targeting pathological tau protein in Alzheimer's disease and related tauopathies
    • Sigurdsson EM: Immunotherapy targeting pathological tau protein in Alzheimer's disease and related tauopathies. J Alzheimers Dis 2008; 15: 157-168.
    • (2008) J Alzheimers Dis , vol.15 , pp. 157-168
    • Sigurdsson, E.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.