RhEPO improves time to exhaustion by non-hematopoietic factors in humans

European Journal of Applied Physiology

Volumn 116, Issue 3, 2016, Pages 623-633

  Annaheim, Simon ^a,b,c   Jacob, Matthias ^d   Krafft, Alexander ^e   Breymann, Christian ^e   Rehm, Markus ^d   Boutellier, Urs ^a,c  

^a ETH ZURICH   (Switzerland)

^b SWISS FEDERAL LABORATORIES FOR MATERIALS SCIENCE AND TECHNOLOGY   (Switzerland)

^c UNIVERSITY OF ZURICH   (Switzerland)

^d LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^e UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Oxygen transport capacity; Plasma volume; Red blood cell volume; rhEPO doping

Indexed keywords

ERYTHROPOIETIN; RECOMBINANT PROTEIN;

ADULT; CONTROLLED STUDY; DRUG EFFECTS; ERYTHROCYTE VOLUME; EXERCISE TOLERANCE; GENETICS; HUMAN; MALE; OXYGEN CONSUMPTION; PLASMA VOLUME; RANDOMIZED CONTROLLED TRIAL;

ADULT; ERYTHROCYTE VOLUME; ERYTHROPOIETIN; EXERCISE TOLERANCE; HUMANS; MALE; OXYGEN CONSUMPTION; PLASMA VOLUME; RECOMBINANT PROTEINS;

EID: 84958040660     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-015-3322-6     Document Type: Article

References (37)

1. Arcasoy MO (2008) The non-haematopoietic biological effects of erythropoietin. Br J Haematol 141:14–31
2. Berglund B, Ekblom B (1991) Effect of recombinant human erythropoietin treatment on blood pressure and some haematological parameters in healthy men. J Int Med 229:125–130
3. Böning D, Maassen N, Pries A (2011) The hematocrit paradox—how does blood doping really work? Int J Sports Med 32:242–246
4. Breymann C, Rohling R, Huch A, Huch R (2000) Intraoperative endogenous erythropoietin levels and changes in intravascular blood volume in healthy humans. Ann Hematol 79:183–186
5. Brines M, Cerami A (2006) Discovering erythropoietin’s extra-hematopoietic functions: biology and clinical promise. Kidney Int 70:246–250
6. Brun JF, Bouchahda C, Chaze D, Benhaddad AA, Micallef JP, Mercier J (2000) The paradox of hematocrit in exercise physiology: which is the “normal” range from an hemorheologist’s viewpoint? Clin Hemorheol Microcirc 22:287–303
7. Burge CM, Skinner SL (1995) Determination of hemoglobin mass and blood volume with CO: evaluation and application of a method. J Appl Physiol 79:623–631
8. Burgomaster KA, Hughes SC, Heigenhauser GJF, Bradwell SN, Gibala MJ (2005) Six sessions of sprint interval training increases muscle oxidative potential and cycle endurance capacity in humans. J Appl Physiol 98:1985–1990
9. Cayla JL, Maire P, Duvallet A, Wahrmann JP (2008) Erythropoietin induces a shift of muscle phenotype from fast glycolytic to slow oxidative. Int J Sports Med 29:460–465
10. Coyle EF, Hopper MK, Coggan AR (1990) Maximal oxygen uptake relative to plasma volume expansion. Int J Sports Med 11:116–119
11. Heuberger JAAC, Tervaert JMC, Schepers FML, Vliegenthart ADB, Rotmans JI, Daniels JMA, Burggraaf J, Cohen AF (2013) Erythropoietin doping in cycling: lack of evidence for efficacy and a negative riskbenefit. Br J Clin Pharmacol 75:1406–1421
12. Hilty L, Langer N, Pascual-Marqui R, Boutellier U, Lutz K (2011) Fatigue-induced increase in intracortical communication between mid/anterior insular and motor cortex during cycling exercise. Eur J Neurosci 34:2035–2042
13. Hojman P, Brolin C, Gissel H, Brandt C, Zerahn B, Pedersen BK, Gehl J (2009) Erythropoietin over-expression protects against diet-induced obesity in mice through increased fat oxidation in muscles. PLoS One 4:e5894
14. Holloszy JO, Coyle EF (1984) Adaptations of skeletal muscle of endurance exercise and their metabolic consequences. J Appl Physiol 56:831–838
15. Hopkins WG (2000) Measures of reliability in sports medicine and science. Sports Med 30:1–15
16. Hopkins WG (2006) Estimating sample size for magnitude-based inferences. Sportscience 10:63–70
17. Jacob M, Conzen P, Finsterer U, Krafft A, Becker BF, Rehm M (2007) Technical and physiological background of plasma volume measurement with indocyanine green: a clarification of misunderstandings. J Appl Physiol 102:1235–1242
18. Jeukendrup A, Saris WHM, Brouns F, Kester ADM (1996) A new validated endurance performance test. Med Sci Sports Exerc 28:266–270
19. Kanstrup IL, Ekblom B (1984) Blood volume and hemoglobin concentration as determinants of maximal aerobic power. Med Sci Sports Exerc 16:256–262
20. Lavoie C, Diguet A, Milot M, Gareau R (1998) Erythropoietin (rHuEPO) doping: effects of exercise on anaerobic metabolism in rats. Int J Sports Med 19:281–286
21. Lundby C, Thomsen JJ, Boushel R, Koskolou M, Warberg J, Calbet JAL, Robach P (2007) Erythropoietin treatment elevates haemoglobin concentration by increasing red cell volume and depressing plasma volume. J Physiol 578:309–314
22. Lundby C, Hellsten Y, Jensen MBF, Munch AS, Pilegaard H (2008) Erythropoietin receptor in human skeletal muscle and the effects of acute and long-term injections with recombinant human erythropoietin on the skeletal muscle. J Appl Physiol 104:1154–1160
23. Miura A, Endo M, Sato H, Barstow TJ, Fukuba Y (2002) Relationship between the curvature constant parameter of the power-duration curve and muscle cross-sectional area of the thigh for cycle ergometry in humans. Eur J Appl Physiol 87:238–244
24. Mortensen SP, Dawson EA, Yoshiga CC, Dalsgaard MK, Damsgaard R, Secher NH, Gonzalez-Alonso J (2005) Limitations to systemic and locomotor limb muscle oxygen delivery and uptake during maximal exercise in humans. J Physiol 566:273–285
25. Morton RH (2006) The critical power and related whole-body bioenergetic models. Eur J Appl Physiol 96:339–354
26. Noakes TD (2008) Testing for maximum oxygen consumption has produced a brainless model of human exercise performance. Br J Sports Med 42:551–555
27. Orth VH, Rehm M, Thiel M, Kreimeier U, Haller M, Brechtelsbauer H, Finsterer U (1998) First clinical implications of perioperative red cell volume measurement with a nonradioactive marker (sodium fluorescein). Anesth Analg 87:1234–1238
28. Plenge U, Belhage B, Guadaloupe-Grau A, Andersen PR, Lundby C, Dela F, Stride N, Pott FC, Helge JW, Boushel R (2012) Erythropoietin treatment enhances muscle mitochondrial capacity in humans. Front Physiol 3:50
29. Prommer N, Sottas PE, Schoch C, Schumacher YO, Schmidt W (2008) Total hemoglobin mass—new parameter to detect blood doping? Med Sci Sports Exerc 40:2112–2118
30. Ross R, Gray CM, Gill JMR (2015) Effects of an injected placebo on endurance running performance. Med Sci Sports Exerc 47:1672–1681
31. Rundqvist H, Rullman E, Sundberg CJ, Fischer H, Eisleitner K, Stahlberg M, Sundblad P, Jansson E, Gustafsson T (2009) Activation of the erythropoietin receptor in human skeletal muscle. Eur J Endocrinol 161:427–434
32. Russell G, Gore CJ, Ashenden MJ, Parisotto R, Hahn AG (2002) Effects of prolonged low doses of recombinant human erythropoietin during submaximal and maximal exercise. Eur J Appl Physiol 86:442–449
33. Sawka MN, Convertino VA, Eichner ER, Schnieder SM, Young AJ (2000) Blood volume: importance and adaptations to exercise training, environmental stresses, and trauma/sickness. Med Sci Sports Exerc 32:332–348
34. 2max. Exerc Sport Sci Rev 38:68–75
35. Schuler B, Vogel J, Grenacher B, Jacobs RA, Arras M, Gassmann M (2012) Acute and chronic elevation of erythropoietin in the brain improves exercise performance in mice without inducing erythropoiesis. FASEB J 26:3884–3890
36. Stallknecht B, Vissing J, Galbo H (1998) Lactate production and clearance in exercise: effects of training. A mini-review. Scand J Med Sci Sports 8:127–131
37. Thomsen JJ, Rentsch RL, Robach P, Calbet JAL, Boushel R, Rasmussen P, Juel C, Lundby C (2007) Prolonged administration of recombinant human erythropoietin increases submaximal performance more than maximal aerobic capacity. Eur J Appl Physiol 101:481–486