Erythropoietin treatment enhances muscle mitochondria capacity in humans

Frontiers in Physiology

Volumn 3 MAR, Issue , 2012, Pages

  Plenge, Ulla ^a   Belhage, Bo ^a   Guadalupe Grau, Amelia ^b   Andersen, Peter Riis ^c   Lundby, Carsten ^d   Dela, Flemming ^c   Stride, Nis ^d   Pott, Frank Christian ^a   Helge, Jørn W ^c   Boushel, Robert ^a,c  

^a BISPEBJERG HOSPITAL   (Denmark)

^b UNIVERSITY OF LAS PALMAS DE GRAN CANARIA   (Spain)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Humans; Mitochondria; Muscle; Oxidative phosphorylation; rhEPO

Indexed keywords

EID: 84866274600     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2012.00050     Document Type: Article

References (26)

1. Anderson, E. J., Lustig, M. E., Boyle, K. E., Woodlief, T. L., Kane, D. A., Lin, C. T., Price, J. W. III, Kang, L., Rabinovitch,P. S., Szeto, H. H.,Houmard, J. A., Cortright, R. N., Wasserman, D. H., and Neufer, P. D. (2009). Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans. J. Clin. Invest. 119, 573-581.
2. Boushel, R., Gnaiger, E., Calbet, J. A., Gonzalez-Alonso, J., Wright-Paradis, C., Sondergaard, H., Ara, I., Helge, J. W., and Saltin, B. (2011). Muscle mitochondrial capacity exceeds maximal oxygen delivery in humans. Mitochondrion 11, 303-307.
3. Carraway, M. S., Suliman, H. B., Jones, W. S., Chen, C. W., Babiker, A., and Piantadosi, C. A. (2010). Erythro-poietin activates mitochondrial biogenesis and couples red cell mass to mitochondrial mass in the heart. Circ. Res. 106, 1722-1730.
4. Cayla, J.-L., Maire, P., Duvallet, A., and Wahrmann, J. P. (2008). Erythro-poietin induces a shift of muscle phenotype from fast glycolytic to slow oxidative. Int. J. Sports Med. 29, 460-465.
5. Farrell, F., and Lee, A. (2004). The erythropoietin receptor and its expression in tumor cells and other tissues. Oncologist 9(Suppl. 5), 18-30.
6. Fernström, M., Tonkonogi, M., and Sahlin, K. (2004). Effects of acute and chronic endurance exercise on mitochondrial uncoupling in human skeletal muscle. J. Physiol. (Lond.) 554(Pt 3), 755-763.
7. Hojman, P., Brolin, C., Gissel, H., Brandt, C., Zerahn, B., Pedersen, B. K., and Gehl, J. (2009). Ery-thropoietin over-expression protects against diet-induced obesity in mice through increased fat oxidation in muscles. PLoS ONE 4, e5894. doi:10.1371/journal.pone.0005894
8. Holloszy, J. O. (1967). Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle. J. Biol. Chem. 242, 2278-2282.
9. Jelkmann, W. (1992). Erythropoietin: structure, control of production, and function. Physiol. Rev. 72, 449-489.
10. Lundby, C., Hellsten, Y., Jensen, M. B., Munch, A. S., and Pilegaard, H. (2008a). Erythropoietin receptor in human skeletal muscle and the effects of acute and long-term injections with recombinant human erythropoietin on the skeletal muscle. J. Appl. Physiol. 104, 1154-1160.
11. Lundby, C., Robach, P., Boushel, R., Thomsen, J. J., Rasmussen, P., Koskolou, M., and Calbet, J. A. (2008b). Does recombinant human Epo increase exercise capacity by means other than augmenting oxygen transport? J. Appl. Physiol. 105, 581-587.
12. Lundby, C., Thomsen, J. J., Boushel, R., Koskolou, M., Warberg, J., Calbet, J. A., and Robach, P. (2007). Erythro-poietin treatment elevates haemoglobin concentration by increasing red cell volume and depressing plasma volume. J. Physiol. (Lond.). 578(Pt 1), 309-314.
13. Mogensen, M., Sahlin, K., Fernström, M., Glintborg, D., Vind, B. F., Beck-Nielsen, H., and Højlund, K. (2007). Mitochondrial respiration is decreased in skeletal muscle of patients with type 2 diabetes. Diabetes. 56, 1592-1599.
14. Naimi, A. I., Bourbeau, J., Perrault, H., Baril, J., Wright-Paradis, C., Rossi, A., Taivassalo, T., Sheel, A. W., Rabøl, R., Dela, F., and Boushel, R. (2011). Altered mitochondrial regulation in quadriceps muscles of patients with COPD. Clin. Physiol. Funct. Imaging. 31, 124-131.
15. Olsen, N. V., Aachmann-Andersen, N. J., Oturai, P., Munch-Andersen, T., Bornø, A., Hulston, C., Holstein-Rathlou, N. H., Robach, P., and Lundby, C. (2011). Erythropoi-etin down-regulates proximal renal tubular reabsorption and causes a fall in glomerular filtration rate in humans. J. Physiol. (Lond.). 589(Pt 6), 1273-1281.
16. Phielix, E., Schrauwen-Hinderling, V. B., Mensink, M., Lenaers, E., Meex, R., Hoeks, J., Kooi, M. E., Moonen-Kornips, E., Sels, J. P., Hesselink, M. K., and Schrauwen, P. (2008). Lower intrinsic ADP-stimulated mitochondrial respiration underlies in vivo mitochondrial dysfunction in muscle of male type 2 diabetic patients. Diabetes 57, 2943-2949.
17. Reichmann, H., Hoppeler, H., Mathieu-Costello, O., von Bergen, F., and Pette, D. (1985). Biochemical and ultrastructural changes of skeletal muscle mitochondria after chronic electrical stimulation in rabbits. Pflügers Arch. 404, 1-9.
18. Robach, P., Recalcati, S., Girelli, D., Gelfi, C., Aachmann-Andersen, N. J., Thomsen, J. J., Norgaard, A. M., Alberghini, A., Campostrini, N., Castagna, A., Viganò, A., Santambrogio, P., Kempf, T., Wollert, K. C., Moutereau, S., Lundby, C., and Cairo, G. (2009). Alterations of systemic and muscle iron metabolism in human subjects treated with low-dose recombinant erythropoietin. Blood. 113, 6707-6715.
19. Rundqvist, H., Rullman, E., Sundberg, C. J., Fischer, H., Eisleitner, K., Ståhlberg, M., Sundblad, P., Jansson, E., and Gustafsson, T. (2009). Activation of the erythropoietin receptor in human skeletal muscle. Eur. J. Endocrinol. 161, 427-434.
20. Schwerzmann, K., Hoppeler, H., Kayar, S. R., and Weibel, E. R. (1989). Oxidative capacity of muscle and mitochondria: correlation of physiological, biochemical, and morphometric characteristics. Proc. Natl. Acad. Sci. U.S.A. 86, 1583-1587.
21. Sinclair, A. M., Coxon, A., McCaffery, I., Kaufman, S., Paweletz, K., Liu, L., Busse, L., Swift, S., Elliott, S., and Begley, C. G. (2010). Functional erythropoietin receptor is unde-tectable in endothelial, cardiac, neu-ronal, and renal cells. Blood 115, 4264-4272.
22. Skovbro, M., Boushel, R., Hansen, C. N., Helge, J. W., and Dela, F. (2011). High-fat feeding inhibits exercise-induced increase in mitochondrial respiratory flux in skeletal muscle. J. Appl. Physiol. 110, 1607-1614.
23. Thomsen, J. J., Rentsch, R. L., Robach, P., Calbet, J. A., Boushel, R., Ras-mussen, P., Juel, C., and Lundby, C. (2007). Prolonged administration of recombinant human erythropoietin increases submaximal performance more than maximal aerobic capacity. Eur. J. Appl. Physiol. 101, 481-486.
24. Tonkonogi, M., Harris, B., and Sahlin, K. (1997). Increased activity of citrate synthase in human skeletal muscle after a single bout of prolonged exercise. Acta Physiol. Scand. 161, 435-436.
25. Tonkonogi, M., and Sahlin, K. (1997). Rate of oxidative phosphorylation in isolated mitochondria from human skeletal muscle: effect of training status. Acta Physiol. Scand. 161, 345-353.
26. Tonkonogi, M., Walsh, B., Svensson, M., and Sahlin, K. (2000). Mito-chondrial function and antioxidative defence in human muscle: effects of endurance training and oxidative stress. J. Physiol. (Lond.). 528(Pt 2), 379-388.