The drug target genes show higher evolutionary conservation than non-target genes

Oncotarget

Volumn 7, Issue 4, 2016, Pages 4961-4971

  Lv, Wenhua ^a   Xu, Yongdeng ^a   Guo, Yiying ^a   Yu, Ziqi ^a   Feng, Guanglong ^a   Liu, Panpan ^a   Luan, Meiwei ^a   Zhu, Hongjie ^a   Liu, Guiyou ^b   Zhang, Mingming ^a   Lv, Hongchao ^a   Duan, Lian ^a   Shang, Zhenwei ^a   Li, Jin ^a   Jiang, Yongshuai ^a   Zhang, Ruijie ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b Chinese Academy of Sciences   (China)

Author keywords

Drug target; Evolutionary conservation; Topological properties

Indexed keywords

AMINO ACID SEQUENCE; ARTICLE; GENE STRUCTURE; GENE TARGETING; GENETIC ANALYSIS; GENETIC CONSERVATION; MOLECULAR EVOLUTION; NONHUMAN; ORTHOLOGY; PROTEIN PROTEIN INTERACTION; SPECIES IDENTIFICATION; BIOLOGICAL MODEL; COMPARATIVE STUDY; CONSERVED SEQUENCE; FACTUAL DATABASE; GENE; GENE LINKAGE DISEQUILIBRIUM; GENE ONTOLOGY; GENETICS; HUMAN; HUMAN GENOME; METABOLISM;

DRUG;

CONSERVED SEQUENCE; DATABASES, FACTUAL; EVOLUTION, MOLECULAR; GENE ONTOLOGY; GENES; GENOME, HUMAN; HUMANS; LINKAGE DISEQUILIBRIUM; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS; PROTEIN INTERACTION MAPS;

EID: 84958019558     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.6755     Document Type: Article

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