Ibrutinib inhibits BCR and NF-κB signaling and reduces tumor proliferation in tissue-resident cells of patients with CLL

Blood

Volumn 123, Issue 21, 2014, Pages 3286-3295

  Herman, Sarah E M ^a   Mustafa, Rashida Z ^a   Gyamfi, Jennifer A ^a   Pittaluga, Stefania ^b   Chang, Stella ^c   Chang, Betty ^c   Farooqui, Mohammed ^a   Wiestner, Adrian ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c PHARMACYCLICS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; CD69 ANTIGEN; CD86 ANTIGEN; IBRUTINIB; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

AGED; ARTICLE; BLOOD; BONE MARROW; CANCER INHIBITION; CELL ACTIVATION; CELL COMPARTMENTALIZATION; CELL PROLIFERATION; CHROMOSOME 17P; CHROMOSOME DELETION; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ARTICLE; COHORT ANALYSIS; DOWN REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; LEUKEMIA CELL; LYMPH NODE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

AGED; BONE MARROW; CELL PROLIFERATION; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; LYMPH NODES; NF-KAPPA B; PYRAZOLES; PYRIMIDINES; RECEPTORS, ANTIGEN, B-CELL; SIGNAL TRANSDUCTION;

EID: 84901439281     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-02-548610     Document Type: Article

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