Solamargine triggers cellular necrosis selectively in different types of human melanoma cancer cells through extrinsic lysosomal mitochondrial death pathway

Cancer Cell International

Volumn 16, Issue 1, 2016, Pages

  Al Sinani, Sana S ^a   Eltayeb, Elsadig A ^a   Coomber, Brenda L ^b   Adham, Sirin A ^a  

^a SULTAN QABOOS UNIVERSITY   (Oman)

^b UNIVERSITY OF GUELPH   (Canada)

Author keywords

Cathepsin B; Cytochrome c; Melanoma; Solamargine; TNFR1

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 3; CATHEPSIN B; CYTOCHROME C; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; SOLAMARGINE; TUMOR NECROSIS FACTOR RECEPTOR 1; X LINKED INHIBITOR OF APOPTOSIS;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL DEATH; CELL PERMEABILIZATION; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; LYSOSOME; MELANOMA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NECROSIS; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN SECRETION; TRANSMISSION ELECTRON MICROSCOPY; UPREGULATION; WESTERN BLOTTING;

EID: 84957973751     PISSN: None     EISSN: 14752867     Source Type: Journal    
DOI: 10.1186/s12935-016-0287-4     Document Type: Article

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