Virus-mediated EpoR76E gene therapy preserves vision in a glaucoma model by modulating neuroinflammation and decreasing oxidative stress

Journal of Neuroinflammation

Volumn 13, Issue 1, 2016, Pages

  Hines Beard, Jessica ^a,b   Bond, Wesley S ^a,b   Backstrom, Jon R ^a,b   Rex, Tonia S ^a,b  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Erythropoietin; Gene therapy; Glaucoma; Microglia; Neuroinflammation; Neuroprotection; Oxidative stress

Indexed keywords

EPOR76E; ERYTHROPOIETIN; INTERLEUKIN 1; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 17; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MESSENGER RNA; PARVOVIRUS VECTOR; RANTES; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ACTIN BINDING PROTEIN; AIF1 PROTEIN, MOUSE; CALCIUM BINDING PROTEIN; CHOLERA TOXIN; CYTOKINE; EPO PROTEIN, HUMAN; KI 67 ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD RETINA BARRIER; CELL COUNT; CELL STRUCTURE; CONTROLLED STUDY; EPOR76E GENE; EVOKED VISUAL RESPONSE; GENE EXPRESSION REGULATION; GLAUCOMA; IMMUNOREACTIVITY; MICROGLIA; MOUSE; NERVE FIBER TRANSPORT; NERVOUS SYSTEM INFLAMMATION; NEUROMODULATION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; VIRAL GENE DELIVERY SYSTEM; ANIMAL; COMPLICATION; DBA MOUSE; DEPENDOPARVOVIRUS; DISEASE MODEL; FLUORESCENCE ANGIOGRAPHY; GENE THERAPY; GENETIC TRANSDUCTION; GENETICS; METABOLISM; PATHOLOGY; PHOTOSTIMULATION; PHYSIOLOGY; PROCEDURES; RETINA; VISUAL EVOKED POTENTIAL;

ANIMALS; CALCIUM-BINDING PROTEINS; CHOLERA TOXIN; CYTOKINES; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; ERYTHROPOIETIN; EVOKED POTENTIALS, VISUAL; FLUORESCEIN ANGIOGRAPHY; GENE EXPRESSION REGULATION; GENETIC THERAPY; GLAUCOMA; KI-67 ANTIGEN; MICE; MICE, INBRED DBA; MICROFILAMENT PROTEINS; MICROGLIA; OXIDATIVE STRESS; PHOTIC STIMULATION; RETINA; TRANSDUCTION, GENETIC;

EID: 84957927970     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/s12974-016-0499-5     Document Type: Article

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