The synthetic antimicrobial peptide 19-2.5 interacts with heparanase and heparan sulfate in murine and human sepsis

PLoS ONE

Volumn 10, Issue 11, 2015, Pages

  Martin, Lukas ^a   De Santis, Rebecca ^a   Koczera, Patrick ^a   Simons, Nadine ^a   Haase, Hajo ^b   Heinbockel, Lena ^c   Brandenburg, Klaus ^c   Marx, Gernot ^a   Schuerholz, Tobias ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^b TECHNISCHE UNIVERSITÄT BERLIN   (Germany)

^c RESEARCH CENTER BORSTEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMICROBIAL PEPTIDE 19-2.5; HEPARAN SULFATE; HEPARANASE; MESSENGER RNA; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BETA GLUCURONIDASE; PEPTIDE;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG PROTEIN BINDING; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; EX VIVO STUDY; FEMALE; HEART; HUMAN; IN VIVO STUDY; KIDNEY; LIVER; LUNG; MALE; MOUSE; NONHUMAN; SEPSIS; SEPTIC SHOCK; ANIMAL; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYMOLOGY; METABOLISM; SYNTHESIS;

ADULT; ANIMALS; ANTI-INFECTIVE AGENTS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GLUCURONIDASE; HEPARITIN SULFATE; HUMANS; MICE; PEPTIDES; SEPSIS;

EID: 84957922022     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0143583     Document Type: Article

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