Correction of the auditory phenotype in C57BL/6N mice via CRISPR/Cas9-mediated homology directed repair

Genome Medicine

Volumn 8, Issue 1, 2016, Pages

  Mianné, Joffrey ^a   Chessum, Lauren ^b   Kumar, Saumya ^b   Aguilar, Carlos ^b   Codner, Gemma ^a   Hutchison, Marie ^a   Parker, Andrew ^b   Mallon, Ann Marie ^b   Wells, Sara ^a   Simon, Michelle M ^b   Teboul, Lydia ^a   Brown, Steve D M ^b   Bowl, Michael R ^b  

^a Medical Research Council Harwell Institute   (United Kingdom)

^b MRC Harwell   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CADHERIN 23; OLIGONUCLEOTIDE; RNA; CADHERIN; CDH23 PROTEIN, MOUSE; GUIDE RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; COCHLEA; CONTROLLED STUDY; CRISPR CAS SYSTEM; DNA REPAIR; EMBRYO; EVOKED BRAIN STEM AUDITORY RESPONSE; GENE MUTATION; GENE SEQUENCE; HAIR CELL; HEARING IMPAIRMENT; HOMOLOGY DIRECTED REPAIR; MOUSE; MOUSE MODEL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; STEREOCILIUM; ZYGOTE; ANIMAL; AUDITORY EVOKED POTENTIAL; C57BL MOUSE; GENE THERAPY; GENETICS; HEARING LOSS; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; RECOMBINATION REPAIR;

ANIMALS; CADHERINS; CRISPR-CAS SYSTEMS; EVOKED POTENTIALS, AUDITORY; GENETIC THERAPY; HEARING LOSS; MICE; MICE, INBRED C57BL; RECOMBINATIONAL DNA REPAIR; RNA, GUIDE; STEREOCILIA;

EID: 84957890081     PISSN: None     EISSN: 1756994X     Source Type: Journal    
DOI: 10.1186/s13073-016-0273-4     Document Type: Article

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