Sphingosine-1-phosphate lyase is an endogenous suppressor of pulmonary fibrosis: Role of S1P signalling and autophagy

Thorax

Volumn 70, Issue 12, 2015, Pages 1138-1148

  Shuang Huang, Long ^a   Berdyshev, Evgeny V ^b   Tran, John T ^a   Xie, Lishi ^a   Chen, Jiwang ^b   Ebenezer, David L ^a   Mathew, Biji ^b   Gorshkova, Irina ^b   Zhang, Wei ^a,c   Reddy, Sekhar P ^a   Harijith, Anantha ^a   Wang, Gang ^d   Feghali Bostwick, Carol ^e   Noth, Imre ^f   Ma, Shwu Fan ^f   Zhou, Tong ^g   Ma, Wenli ^g   Garcia, Joe G N ^g   Natarajan, Viswanathan ^a,b  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b UNIVERSITY OF ILLINOIS   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d XUZHOU MEDICAL UNIVERSITY   (China)

^e MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^f UNIVERSITY OF CHICAGO   (United States)

^g UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BECLIN 1; LYASE; MESSENGER RNA; SMAD3 PROTEIN; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE LYASE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; SMAD PROTEIN; SPHINGOSINE 1-PHOSPHATE LYASE (ALDOLASE);

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; BLEOMYCIN-INDUCED PULMONARY FIBROSIS; CELL ACTIVATION; CELL DIFFERENTIATION; CELL ISOLATION; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVITY; ENZYME INDUCTION; FIBROGENESIS; FIBROSING ALVEOLITIS; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG FIBROBLAST; LUNG FUNCTION; LUNG PARENCHYMA; MOUSE; NONHUMAN; OVERALL SURVIVAL; PATHOPHYSIOLOGY; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; SGPL1 GENE; SIGNAL TRANSDUCTION; SURVIVAL RATE; UPREGULATION; ANIMAL; CYTOLOGY; DISEASE MODEL; FIBROBLAST; IMMUNOHISTOCHEMISTRY; LUNG; LUNG FIBROSIS; METABOLISM; MONONUCLEAR CELL; PHYSIOLOGY;

ALDEHYDE-LYASES; ANIMALS; AUTOPHAGY; CELL DIFFERENTIATION; DISEASE MODELS, ANIMAL; FIBROBLASTS; HUMANS; IMMUNOHISTOCHEMISTRY; LEUKOCYTES, MONONUCLEAR; LUNG; MICE; PULMONARY FIBROSIS; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION;

EID: 84957839967     PISSN: 00406376     EISSN: 14683296     Source Type: Journal    
DOI: 10.1136/thoraxjnl-2014-206684     Document Type: Article

References (27)

1. Wynn TA. Integrating mechanisms of pulmonary fibrosis. J Exp Med 2011;208:1339-50.
2. Mouratis MA, Aidinis V. Modeling pulmonary fibrosis with bleomycin. Curr Opin Pulm Med 2011;17:355-61.
3. Wolters PJ, Collard HR, Jones KD. Pathogenesis of idiopathic pulmonary fibrosis. Annu Rev Pathol 2014;9:157-79.
4. Natarajan V, Dudek SM, Jacobson JR, et al. Sphingosine-1-phosphate, FTY720, and sphingosine-1-phosphate receptors in the pathobiology of acute lung injury. Am J Respir Cell Mol Biol 2013;49:6-17.
5. Huang LS, Berdyshev E, Mathew B, et al. Targeting sphingosine kinase 1 attenuates bleomycin-induced pulmonary fibrosis. FASEB J 2013;27:1749-60.
6. Liu X, Zhang QH, Yi GH. Regulation of metabolism and transport of sphingosine-1-phosphate in mammalian cells. Mol Cell Biochem 2012;363:21-33.
7. Saba JD, de la Garza-Rodea AS. S1P lyase in skeletal muscle regeneration and satellite cell activation: exposing the hidden lyase. Biochim Biophys Acta 2013;1831:167-75.
8. Zhao Y, Gorshkova IA, Berdyshev E, et al. Protection of LPS-induced murine acute lung injury by sphingosine-1-phosphate lyase suppression. Am J Respir Cell Mol Biol 2011;45:426-35.
9. Milara J, Navarro R, Juan G, et al. Sphingosine-1-phosphate is increased in patients with idiopathic pulmonary fibrosis and mediates epithelial to mesenchymal transition. Thorax 2012;67:147-56.
10. Sappino AP, Schurch W, Gabbiani G. Differentiation repertoire of fibroblastic cells: expression of cytoskeletal proteins as marker of phenotypic modulations. Lab Invest 1990;63:144-61.
11. Phan SH. The myofibroblast in pulmonary fibrosis. Chest 2002;122(6 Suppl):286S-9S.
12. Araya J, Kojima J, Takasaka N, et al. Insufficient autophagy in idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 2013;304:L56-69.
13. Patel AS, Lin L, Geyer A, et al. Autophagy in idiopathic pulmonary fibrosis. PLoS ONE 2012;7:e41394.
14. Nho RS, Hergert P. IPF fibroblasts are desensitized to type I collagen matrix-induced cell death by suppressing low autophagy via aberrant Akt/mTOR kinases. PLoS ONE 2014;9:e94616.
15. Mizushima N, Yoshimori T, Levine B. Methods in mammalian autophagy research. Cell 2010;140:313-26.
16. Chang CL, Ho MC, Lee PH, et al. S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells. Am J Physiol Cell Physiol 2009;297:C451-8.
17. Huang YL, Huang WP, Lee H. Roles of sphingosine 1-phosphate on tumorigenesis. World J Biol Chem 2011;2:25-34.
18. Huang YL, Chang CL, Tang CH, et al. Extrinsic sphingosine 1-phosphate activates S1P5 and induces autophagy through generating endoplasmic reticulum stress in human prostate cancer PC-3 cells. Cell Signal 2014;26:611-18.
19. Lépine S, Allegood JC, Park M, et al. Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy. Cell Death Differ 2011;18:350-61.
20. Sheng R, Zhang TT, Felice VD, et al. Preconditioning stimuli induce autophagy via sphingosine kinase 2 in mouse cortical neurons. J Biol Chem 2014;289:20845-57.
21. Wang F, Ye P. Improving heart function by modulating myocardiocyte autophagy: a possible novel mechanism for cardiovascular protection of high-density lipoprotein. Lipids Health Dis 2014;13:163.
22. Slattum G, Gu Y, Sabbadini R, et al. Autophagy in oncogenic K-Ras promotes basal extrusion of epithelial cells by degrading S1P. Curr Biol 2014;24:19-28.
23. Taniguchi M, Kitatani K, Kondo T, et al. Regulation of autophagy and its associated cell death by "sphingolipid rheostat": reciprocal role of ceramide and sphingosine 1-phosphate in the mammalian target of rapamycin pathway. J Biol Chem 2012;287:39898-910.
24. Huang LS, Mathew B, Li H, et al. The mitochondrial cardiolipin remodeling enzyme lysocardiolipin acyltransferase is a novel target in pulmonary fibrosis. Am J Respir Crit Care Med 2014;189:1402-15.
25. Bradley E, Dasgupta S, Jiang X, et al. Critical role of spns2, a sphingosine-1-phosphate transporter, in lung cancer cell survival and migration. PLoS One 2014;9:e110119.
26. Gorshkova I, Zhou T, Mathew B, et al. Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression. J Lipid Res 2012;53:1553-68.
27. Jung CH, Ro SH, Cao J, et al. mTOR regulation of autophagy. FEBS Lett 2010;584:1287-95.