An in vivo pharmacological screen identifies cholinergic signaling as a therapeutic target in glial-based nervous system disease

Journal of Neuroscience

Volumn 36, Issue 5, 2016, Pages 1445-1455

  Wang, Liqun ^a   Hagemann, Tracy L ^b   Messing, Albee ^b   Feany, Mel B ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Alexander disease; Chemical screen; Cholinergic signaling; Drosophila; Glia

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; GLYCOPYRRONIUM BROMIDE; MUSCARINIC RECEPTOR; CHOLINERGIC RECEPTOR STIMULATING AGENT; MUSCARINIC RECEPTOR BLOCKING AGENT;

ADOLESCENT; ADULT; ALEXANDER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BEHAVIOR; CELL DEATH; CHILD; CHOLINERGIC SYSTEM; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DROSOPHILA; FEMALE; GLIA; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NEUROLOGIC DISEASE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; TUNEL ASSAY; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; CHOLINERGIC NERVE CELL; DRUG DELIVERY SYSTEM; DRUG EFFECTS; INFANT; METABOLISM; NERVOUS SYSTEM DISEASES; PATHOLOGY; PRECLINICAL STUDY; PRESCHOOL CHILD; PROCEDURES; TRANSGENIC ANIMAL; TRANSGENIC MOUSE; YOUNG ADULT;

ADOLESCENT; ADULT; ALEXANDER DISEASE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CHILD; CHILD, PRESCHOOL; CHOLINERGIC AGENTS; CHOLINERGIC NEURONS; DROSOPHILA; DRUG DELIVERY SYSTEMS; DRUG EVALUATION, PRECLINICAL; FEMALE; HUMANS; INFANT; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUSCARINIC ANTAGONISTS; NERVOUS SYSTEM DISEASES; NEUROGLIA; YOUNG ADULT;

EID: 84957837771     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0256-15.2016     Document Type: Article

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