Balance between short and long isoforms of cFLIP regulates Fas-mediated apoptosis in vivo

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 6, 2016, Pages 1606-1611

  Ram, Daniel R ^a   Ilyukha, Vladimir ^b   Volkova, Tatyana ^b   Buzdin, Anton ^c,d   Tai, Albert ^e   Smirnova, Irina ^e   Poltorak, Alexander ^a,b,e  

^a TUFTS UNIVERSITY   (United States)

^b PETROZAVODSK STATE UNIVERSITY   (Russian Federation)

^c Clinical Center of Pediatric Hematology Oncology and Immunology   (Russian Federation)

^d KURCHATOV INSTITUTE   (Russian Federation)

^e TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Caspase 8; cFLIP; Fas receptor; Liver failure

Indexed keywords

CASPASE 8; FAS ANTIGEN; FAS LIGAND; FLICE INHIBITORY PROTEIN; HETERODIMER; ISOPROTEIN; LONG ISOFORM; MESSENGER RNA; SHORT ISOFORM; UNCLASSIFIED DRUG; ANTIBODY; FAS PROTEIN, MOUSE;

3' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROTECTION; COMPARATIVE STUDY; DISEASE PREDISPOSITION; ENZYME ACTIVITY; EXON; FEMALE; GENE EXPRESSION; GENE INSERTION; GENETIC ASSOCIATION; GENETIC LINKAGE; IN VIVO STUDY; LINKAGE ANALYSIS; LIVER CELL; LIVER FAILURE; LIVER INJURY; MALE; MOUSE; NECROPTOSIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROGENY; PROTEIN CROSS LINKING; RNA SEQUENCE; RNA SPLICING; ALTERNATIVE RNA SPLICING; ANIMAL; BASE PAIRING; C57BL MOUSE; DNA SEQUENCE; GENE EXPRESSION REGULATION; GENE LOCUS; GENETICS; GENOME; LIVER; MACROPHAGE; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PATHOLOGY; QUANTITATIVE TRAIT; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM;

ALTERNATIVE SPLICING; ANIMALS; ANTIBODIES; ANTIGENS, CD95; APOPTOSIS; BASE PAIRING; BASE SEQUENCE; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CASPASE 8; DISEASE SUSCEPTIBILITY; FAS LIGAND PROTEIN; GENETIC LINKAGE; GENETIC LOCI; GENOME; LIVER; MACROPHAGES; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN ISOFORMS; QUANTITATIVE TRAIT, HERITABLE; SEQUENCE ANALYSIS, DNA; SIGNAL TRANSDUCTION;

EID: 84957837066     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1517562113     Document Type: Article

References (36)

1. Jost PJ, et al. (2009) XIAP discriminates between type I and type II FAS-induced apoptosis. Nature 460(7258):1035-1039.
2. Ehrenschwender M, Wajant H (2009) The role of FasL and Fas in health and disease. Adv Exp Med Biol 647:64-93.
3. Ogasawara J, Suda T, Nagata S (1995) Selective apoptosis of CD4+CD8+ thymocytes by the anti-Fas antibody. J Exp Med 181(2):485-491.
4. Muppidi JR, Tschopp J, Siegel RM (2004) Life and death decisions: Secondary complexes and lipid rafts in TNF receptor family signal transduction. Immunity 21(4): 461-465.
5. Schütze S, Tchikov V, Schneider-Brachert W (2008) Regulation of TNFR1 and CD95 signalling by receptor compartmentalization. Nat Rev Mol Cell Biol 9(8):655-662.
6. Feoktistova M, et al. (2011) cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol Cell 43(3):449-463.
7. Oztürk S, Schleich K, Lavrik IN (2012) Cellular FLICE-like inhibitory proteins (c-FLIPs): Fine-tuners of life and death decisions. Exp Cell Res 318(11):1324-1331.
8. Pop C, et al. (2011) FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity. Biochem J 433(3):447-457.
9. Boatright KM, Deis C, Denault JB, Sutherlin DP, Salvesen GS (2004) Activation of caspases-8 and -10 by FLIP(L). Biochem J 382(Pt 2):651-657.
10. Fricker N, et al. (2010) Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIPL. J Cell Biol 190(3):377-389.
11. Ueffing N, et al. (2008) Mutational analyses of c-FLIPR, the only murine short FLIP isoform, reveal requirements for DISC recruitment. Cell Death Differ 15(4):773-782.
12. Weinlich R, et al. (2013) Protective roles for caspase-8 and cFLIP in adult homeostasis. Cell Reports 5(2):340-348.
13. Dillon CP, et al. (2012) Survival function of the FADD-CASPASE-8-cFLIP(L) complex. Cell Reports 1(5):401-407.
14. Weinlich R, Green DR (2014) The two faces of receptor interacting protein kinase-1. Mol Cell 56(4):469-480.
15. Walter D, et al. (2008) Switch from type II to I Fas/CD95 death signaling on in vitro culturing of primary hepatocytes. Hepatology 48(6):1942-1953.
16. Schüngel S, et al. (2009) The strength of the Fas ligand signal determines whether hepatocytes act as type 1 or type 2 cells in murine livers. Hepatology 50(5):1558-1566.
17. Ogasawara J, et al. (1993) Lethal effect of the anti-Fas antibody in mice. Nature 364(6440):806-809.
18. Nishimura Y, et al. (1997) In vivo analysis of Fas antigen-mediated apoptosis: Effects of agonistic anti-mouse Fas mAb on thymus, spleen and liver. Int Immunol 9(2): 307-316.
19. Staelens J, et al. (2002) Hyporesponsiveness of SPRET/Ei mice to lethal shock induced by tumor necrosis factor and implications for a TNF-based antitumor therapy. Proc Natl Acad Sci USA 99(14):9340-9345.
20. Shao C, et al. (2014) Mechanisms for U2AF to define 3' splice sites and regulate alternative splicing in the human genome. Nat Struct Mol Biol 21(11):997-1005.
21. Mahieu T, et al. (2006) The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-beta production. Proc Natl Acad Sci USA 103(7):2292-2297.
22. Beutler B, Krochin N, Milsark IW, Luedke C, Cerami A (1986) Control of cachectin (tumor necrosis factor) synthesis:mechanisms of endotoxin resistance. Science 232(4753): 977-980.
23. Tuñón MJ, Alvarez M, Culebras JM, González-Gallego J (2009) An overview of animal models for investigating the pathogenesis and therapeutic strategies in acute hepatic failure. World J Gastroenterol 15(25):3086-3098.
24. Krammer PH, Arnold R, Lavrik IN (2007) Life and death in peripheral T cells. Nat Rev Immunol 7(7):532-542.
25. Jodo S, et al. (2000) CD95 (Fas) ligand-expressing vesicles display antibody-mediated, FcR-dependent enhancement of cytotoxicity. J Immunol 165(10):5487-5494.
26. Neumann L, et al. (2010) Dynamics within the CD95 death-inducing signaling complex decide life and death of cells. Mol Syst Biol 6:352.
27. Jeong J, Adamson LK, Hatam R, Greenhalgh DG, Cho K (2003) Alterations in the expression and modification of histones in the liver after injury. Exp Mol Pathol 75(3): 256-264.
28. Manichaikul A, Moon JY, Sen S, Yandell BS, Broman KW (2009) A model selection approach for the identification of quantitative trait loci in experimental crosses, allowing epistasis. Genetics 181(3):1077-1086.
29. Carmel I, Tal S, Vig I, Ast G (2004) Comparative analysis detects dependencies among the 5' splice-site positions. RNA 10(5):828-840.
30. Wu E, Nance T, Montgomery SB (2014) SplicePlot: A utility for visualizing splicing quantitative trait loci. Bioinformatics 30(7):1025-1026.
31. Rogaev EI, Grigorenko AP, Faskhutdinova G, Kittler EL, Moliaka YK (2009) Genotype analysis identifies the cause of the "royal disease". Science 326(5954):817.
32. Tward AD, et al. (2007) Distinct pathways of genomic progression to benign and malignant tumors of the liver. Proc Natl Acad Sci USA 104(37):14771-14776.
33. Kallenberger SM, et al. (2014) Intra- and interdimeric caspase-8 self-cleavage controls strength and timing of CD95-induced apoptosis. Sci Signal 7(316):ra23.
34. Jiang Y, Woronicz JD, Liu W, Goeddel DV (1999) Prevention of constitutive TNF receptor 1 signaling by silencer of death domains. Science 283(5401):543-546.
35. Micheau O, et al. (2002) The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex. J Biol Chem 277(47):45162-45171.
36. Kaufmann T, Strasser A, Jost PJ (2012) Fas death receptor signalling: Roles of Bid and XIAP. Cell Death Differ 19(1):42-50.