Blocking heme oxygenase-1 by zinc protoporphyrin reduces tumor hypoxia-mediated VEGF release and inhibits tumor angiogenesis as a potential therapeutic agent against colorectal cancer

Journal of Biomedical Science

Volumn 23, Issue 1, 2016, Pages

  Cheng, Chun Chia ^a,b   Guan, Siao Syun ^a   Yang, Hao Jhih ^a   Chang, Chun Chao ^c,d   Luo, Tsai Yueh ^a   Chang, Jungshan ^d   Ho, Ai Sheng ^e,f  

^a INSTITUTE OF NUCLEAR ENERGY RESEARCH   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^e CHENG HSIN GENERAL HOSPITAL   (Taiwan)

^f Kang Ning Junior College of M C and M   (Taiwan)

Author keywords

Angiogenesis; Heme oxygenase 1; Tumor hypoxia; Vascular endothelial growth factor; Zinc protoporphyrin

Indexed keywords

HEME OXYGENASE 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROTOPORPHYRIN ZINC; VASCULOTROPIN; VITRONECTIN RECEPTOR; HMOX1 PROTEIN, HUMAN; METALLOPORPHYRIN; TUMOR PROTEIN; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN; ZINC HEMATOPORPHYRIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANGIOGENIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER INHIBITION; CELL HYPOXIA; CLINICAL ARTICLE; COLORECTAL CANCER; COLORECTAL CANCER CELL LINE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR XENOGRAFT; ANIMAL; ANTAGONISTS AND INHIBITORS; COLORECTAL NEOPLASMS; DRUG SCREENING; ENZYMOLOGY; HYPOXIA; METABOLISM; NEOVASCULARIZATION, PATHOLOGIC; PATHOLOGY; SECRETION (PROCESS); TUMOR CELL LINE; VASCULARIZATION;

ANIMALS; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; HEME OXYGENASE-1; HUMANS; HYPOXIA; METALLOPORPHYRINS; MICE; NEOPLASM PROTEINS; NEOVASCULARIZATION, PATHOLOGIC; VASCULAR ENDOTHELIAL GROWTH FACTOR A; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84957824307     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1186/s12929-016-0219-6     Document Type: Article

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