Comparison of dorsocervical with abdominal subcutaneous adipose tissue in patients with and without antiretroviral therapy-associated lipodystrophy

Diabetes

Volumn 60, Issue 7, 2011, Pages 1894-1900

  Sevastianova, Ksenia ^a,b   Sutinen, Jussi ^b   Greco, Dario ^c   Sievers, Meline ^d   Salmenkivi, Kaisa ^b   Perttilä, Julia ^a   Olkkonen, Vesa M ^a   Wågsäter, Dick ^e   Lidell, Martin E ^f   Enerbäck, Sven ^f   Eriksson, Per ^e   Walker, Ulrich A ^g   Auvinen, Petri ^c   Ristola, Matti ^b   Yki Järvinen, Hannele ^b  

^a MINERVA FOUNDATION INSTITUTE FOR MEDICAL RESEARCH   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

^d UNIVERSITY OF FREIBURG   (Germany)

^e KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^f UNIVERSITY OF GOTHENBURG   (Sweden)

^g UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CD68 ANTIGEN; HOMEODOMAIN PROTEIN; MESSENGER RNA; MITOCHONDRIAL DNA; PROTEIN HOXC8; PROTEIN HOXC9; SHORT STATURE HOMEOBOX 2; TRANSCRIPTION FACTOR HOXA10; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1; CD68 ANTIGEN, HUMAN; DIFFERENTIATION ANTIGEN; LEUKOCYTE ANTIGEN;

ABDOMINAL SUBCUTANEOUS FAT; ADIPOSE TISSUE; ADULT; ANTIGEN EXPRESSION; ANTIVIRAL THERAPY; ARTICLE; BROWN ADIPOSE TISSUE; CLINICAL ARTICLE; CONTROLLED STUDY; DORSOCERVICAL ADIPOSE TISSUE; FEMALE; GENE DOSAGE; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN TISSUE; LIPOATROPHY; LIPODYSTROPHY; MACROPHAGE; MALE; MICROARRAY ANALYSIS; MICROSCOPY; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION; BACK; BIOSYNTHESIS; BODY COMPOSITION; CHEMICALLY INDUCED DISORDER; DNA MICROARRAY; GENETICS; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HIV ASSOCIATED LIPODYSTROPHY; MIDDLE AGED; PATHOLOGY; SUBCUTANEOUS FAT;

ADULT; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; BACK; BODY COMPOSITION; DNA, MITOCHONDRIAL; FEMALE; HIV-ASSOCIATED LIPODYSTROPHY SYNDROME; HUMANS; LIPODYSTROPHY; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; SUBCUTANEOUS FAT; SUBCUTANEOUS FAT, ABDOMINAL;

EID: 80052099398     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db11-0075     Document Type: Article

References (43)

1. Grinspoon S, Carr A. Cardiovascular risk and body-fat abnormalities in HIV-infected adults. N Engl J Med 2005;352:48-62 (Pubitemid 40075680)
2. Caron-Debarle M, Lagathu C, Boccara F, Vigouroux C, Capeau J. HIVassociated lipodystrophy: from fat injury to premature aging. Trends Mol Med 2010;16:218-229
3. Mallewa JE, Wilkins E, Vilar J, et al. HIV-associated lipodystrophy: a review of underlying mechanisms and therapeutic options. J Antimicrob Chemother 2008;62:648-660
4. Villarroya F Domingo P, Giralt M. Drug-induced lipotoxicity: lipodystrophy associated with HIV-1 infection and antiretroviral treatment. Biochim Biophys Acta 2010;1801:392-399
5. Mallon PW, Wand H, Law M, Miller J, Cooper DA, Carr A; HIV Lipodystrophy Case Definition Study; Australian Lipodystrophy Prevalence Survey Investigators. Buffalo hump seen in HIV-associated lipodystrophy is associated with hyperinsulinemia but not dyslipidemia. J Acquir Immune Defic Syndr 2005;38:156-162 (Pubitemid 40189322)
6. Grunfeld C, Rimland D, Gibert CL, et al. Association of upper trunk and visceral adipose tissue volume with insulin resistance in control and HIVinfected subjects in the FRAM study. J Acquir Immune Defic Syndr 2007; 46:283-290 (Pubitemid 350287354)
7. Dixon JB, O'Brien PE. Neck circumference a good predictor of raised insulin and free androgen index in obese premenopausal women: changes with weight loss. Clin Endocrinol (Oxf) 2002;57:769-778 (Pubitemid 36963005)
8. Laakso M, Matilainen V, Keinänen-Kiukaanniemi S. Association of neck circumference with insulin resistance-related factors. Int J Obes Relat Metab Disord 2002;26:873-875 (Pubitemid 34620881)
9. Thamer C, Machann J, Staiger H, et al. Interscapular fat is strongly associated with insulin resistance. J Clin Endocrinol Metab 2010;95:4736-4742
10. Cannon B, Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol Rev 2004;84:277-359 (Pubitemid 38054374)
11. Cinti S. The adipose organ. Prostaglandins Leukot Essent Fatty Acids 2005; 73:9-15 (Pubitemid 40826923)
12. Nedergaard J, Golozoubova V, Matthias A, et al. Life without UCP1: mitochondrial, cellular and organismal characteristics of the UCP1-ablated mice. Biochem Soc Trans 2001;29:756-763 (Pubitemid 33131776)
13. Golozoubova V, Hohtola E, Matthias A, Jacobsson A, Cannon B, Nedergaard J. Only UCP1 can mediate adaptive nonshivering thermogenesis in the cold. FASEB J 2001;15:2048-2050
14. Guallar JP, Gallego-Escuredo JM, Domingo JC, et al. Differential gene expression indicates that 'buffalo hump' is a distinct adipose tissue disturbance in HIV-1-associated lipodystrophy. AIDS 2008;22:575-584
15. Rodríguez de la Concepción ML, Domingo JC, Domingo P, Giralt M, Villarroya F. Uncoupling protein 1 gene expression implicates brown adipocytes in highly active antiretroviral therapy-associated lipomatosis. AIDS 2004;18:959-960 (Pubitemid 38553721)
16. Cypess AM, Lehman S, Williams G, et al. Identification and importance of brown adipose tissue in adult humans. N Engl J Med 2009;360:1509-1517
17. van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM, et al. Coldactivated brown adipose tissue in healthy men. N Engl J Med 2009;360: 1500-1508
18. Virtanen KA, Lidell ME, Orava J, et al. Functional brown adipose tissue in healthy adults. N Engl J Med 2009;360:1518-1525
19. Enerbäck S, Nuutila P, Oksi J. The importance of brown adipose tissue. N Engl J Med 2009;361:420-421
20. Sievers M, Walker UA, Sevastianova K, et al. Gene expression and immunohistochemistry in adipose tissue of HIV type 1-infected patients with nucleoside analogue reverse-transcriptase inhibitor-associated lipoatrophy. J Infect Dis 2009;200:252-262
21. Sutinen J, Walker UA, Sevastianova K, et al. Uridine supplementation for the treatment of antiretroviral therapy-associated lipoatrophy: a randomized, double-blind, placebo-controlled trial. Antivir Ther 2007;12:97-105 (Pubitemid 46340431)
22. Huang W, Sherman BT, Tan Q, et al. The DAVID Gene Functional Classification Tool: a novel biological module-centric algorithm to functionally analyze large gene lists. Genome Biol 2007;8:R183
23. Silver N, Best S, Jiang J, Thein SL. Selection of housekeeping genes for gene expression studies in human reticulocytes using real-time PCR. BMC Mol Biol 2006;7:33
24. Pfaffl MW. A new mathematical model for relative quantification in realtime RT-PCR. Nucleic Acids Res 2001;29:e45
25. Yki-Järvinen H, Koivisto VA. Effects of body composition on insulin sensitivity. Diabetes 1983;32:965-969 (Pubitemid 13000662)
26. Sutinen J, Häkkinen AM, Westerbacka J, et al. Rosiglitazone in the treatment of HAART-associated lipodystrophy-a randomized double-blind placebo-controlled study. Antivir Ther 2003;8:199-207 (Pubitemid 36960893)
27. Sutinen J, Häkkinen AM, Westerbacka J, et al. Increased fat accumulation in the liver in HIV-infected patients with antiretroviral therapy-associated lipodystrophy. AIDS 2002;16:2183-2193 (Pubitemid 35387273)
28. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18:499-502
29. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-419 (Pubitemid 15018832)
30. Nolan D, Hammond E, Martin A, et al. Mitochondrial DNA depletion and morphologic changes in adipocytes associated with nucleoside reverse transcriptase inhibitor therapy. AIDS 2003;17:1329-1338 (Pubitemid 36819847)
31. Walker UA, Bickel M, Lütke Volksbeck SI, et al. Evidence of nucleoside analogue reverse transcriptase inhibitor-associated genetic and structural defects of mitochondria in adipose tissue of HIV-infected patients. J Acquir Immune Defic Syndr 2002;29:117-121 (Pubitemid 34164881)
32. Villarroya F, Domingo P, Giralt M. The importance of brown adipose tissue. N Engl J Med 2009;361:417-421
33. Domingo P, Matias-Guiu X, Pujol RM, et al. Subcutaneous adipocyte apoptosis in HIV-1 protease inhibitor-associated lipodystrophy. AIDS 1999;13: 2261-2267 (Pubitemid 29531445)
34. Jan V, Cervera P, Maachi M, et al. Altered fat differentiation and adipocytokine expression are inter-related and linked to morphological changes and insulin resistance in HIV-1-infected lipodystrophic patients. Antivir Ther 2004;9:555-564 (Pubitemid 39150213)
35. Lloreta J, Domingo P, Pujol RM, et al. Ultrastructural features of highly active antiretroviral therapy-associated partial lipodystrophy. Virchows Arch 2002;441:599-604 (Pubitemid 35435831)
36. Shah N, Sukumar S. The Hox genes and their roles in oncogenesis. Nat Rev Cancer 2010;10:361-371
37. Cantile M, Procino A, D'Armiento M, Cindolo L, Cillo C. HOX gene network is involved in the transcriptional regulation of in vivo human adipogenesis. J Cell Physiol 2003;194:225-236 (Pubitemid 36043637)
38. Gesta S, Blüher M, Yamamoto Y, et al. Evidence for a role of developmental genes in the origin of obesity and body fat distribution. Proc Natl Acad Sci USA 2006;103:6676-6681
39. Vohl MC, Sladek R, Robitaille J, et al. A survey of genes differentially expressed in subcutaneous and visceral adipose tissue in men. Obes Res 2004;12:1217-1222 (Pubitemid 41137463)
40. Dankel SN, Fadnes DJ, Stavrum AK, et al. Switch from stress response to homeobox transcription factors in adipose tissue after profound fat loss. PLoS ONE 2010;5:e11033
41. Tchkonia T, Lenburg M, Thomou T, et al. Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns. Am J Physiol Endocrinol Metab 2007;292: E298-E307 (Pubitemid 46052953)
42. Levi B, James AW, Glotzbach JP, Wan DC, Commons GW, Longaker MT. Depot-specific variation in the osteogenic and adipogenic potential of human adipose-derived stromal cells. Plast Reconstr Surg 2010;126:822-834
43. Cowherd RM, Lyle RE, Miller CP, Mcgehee RE Jr. Developmental profile of homeobox gene expression during 3T3-L1 adipogenesis. Biochem Biophys Res Commun 1997;237:470-475 (Pubitemid 27406055)