-
2
-
-
1642405087
-
The obesity epidemic, metabolic syndrome and future prevention strategies
-
James, P. T., Rigby, N., Leach, R. The obesity epidemic, metabolic syndrome and future prevention strategies. Eur J Cardiovasc Prev Rehabil 11, 3-8 (2004).
-
(2004)
Eur J Cardiovasc Prev Rehabil
, vol.11
, pp. 3-8
-
-
James, P.T.1
Rigby, N.2
Leach, R.3
-
3
-
-
84904621494
-
Prevalence of type 2 diabetes among high-risk adults in Shanghai from 2002 to 2012
-
Wang, C. et al. Prevalence of type 2 diabetes among high-risk adults in Shanghai from 2002 to 2012. PLoS ONE 9, e102926 (2014).
-
(2014)
PLoS ONE
, vol.9
, pp. e102926
-
-
Wang, C.1
-
4
-
-
84903692940
-
Serum and adipose tissue amino acid homeostasis in the metabolically healthy obese
-
Badoud, F. et al. Serum and adipose tissue amino acid homeostasis in the metabolically healthy obese. J Proteome Res 13, 3455-3466 (2014).
-
(2014)
J Proteome Res
, vol.13
, pp. 3455-3466
-
-
Badoud, F.1
-
5
-
-
34247397544
-
Evaluation of metabolite profiles as biomarkers for the pharmacological effects of thiazolidinediones in Type 2 diabetes mellitus patients and healthy volunteers
-
Doorn, M. V. et al. Evaluation of metabolite profiles as biomarkers for the pharmacological effects of thiazolidinediones in Type 2 diabetes mellitus patients and healthy volunteers. Br J Clin Pharmacol 63, 562-574 (2006).
-
(2006)
Br J Clin Pharmacol
, vol.63
, pp. 562-574
-
-
Doorn, M.V.1
-
6
-
-
78649735772
-
Metabolic footprint of diabetes: A multiplatform metabolomics study in an epidemiological setting
-
Suhre, K. et al. Metabolic footprint of diabetes: a multiplatform metabolomics study in an epidemiological setting. PLoS ONE 5, e13953 (2010).
-
(2010)
PLoS ONE
, vol.5
, pp. e13953
-
-
Suhre, K.1
-
7
-
-
84864386138
-
Circulating metabolite predictors of glycemia in middle-aged men and women
-
Tisnnrn, M. et al. Circulating metabolite predictors of glycemia in middle-aged men and women. Diabetes Care 35, 1749-1756 (2012).
-
(2012)
Diabetes Care
, vol.35
, pp. 1749-1756
-
-
Tisnnrn, M.1
-
8
-
-
84879550459
-
Branched chain amino acids are novel biomarkers for discrimination of metabolic wellness
-
Batch, B. C. et al. Branched chain amino acids are novel biomarkers for discrimination of metabolic wellness. Metabolism 62, 961-969 (2013).
-
(2013)
Metabolism
, vol.62
, pp. 961-969
-
-
Batch, B.C.1
-
9
-
-
79953737332
-
Metabolite profiles and the risk of developing diabetes
-
Wang, T. J. et al. Metabolite profiles and the risk of developing diabetes. Nat Med 17, 448-454 (2011).
-
(2011)
Nat Med
, vol.17
, pp. 448-454
-
-
Wang, T.J.1
-
10
-
-
63449111894
-
A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance
-
Newgard, C. B. et al. A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab 9, 311-326 (2009).
-
(2009)
Cell Metab
, vol.9
, pp. 311-326
-
-
Newgard, C.B.1
-
11
-
-
84874412069
-
Branched-chain and aromatic amino acids are predictors of insulin resistance in young adults
-
Weurtz, P. et al. Branched-chain and aromatic amino acids are predictors of insulin resistance in young adults. Diabetes Care 36, 648-655 (2013).
-
(2013)
Diabetes Care
, vol.36
, pp. 648-655
-
-
Weurtz, P.1
-
12
-
-
79953737553
-
An amino acid profile to predict diabetes?
-
Langenberg, C., Savage, D. B. An amino acid profile to predict diabetes? Nat Med 17, 418-420 (2011).
-
(2011)
Nat Med
, vol.17
, pp. 418-420
-
-
Langenberg, C.1
Savage, D.B.2
-
13
-
-
84860439210
-
Interplay between lipids and branched-chain amino acids in development of insulin resistance
-
Newgard, C. B. Interplay between lipids and branched-chain amino acids in development of insulin resistance. Cell Metab 15, 606-614 (2012).
-
(2012)
Cell Metab
, vol.15
, pp. 606-614
-
-
Newgard, C.B.1
-
14
-
-
84939943688
-
Diabetes risk and amino acid profiles: Cross-sectional and prospective analyses of ethnicity, amino acids and diabetes in a South Asian and European cohort from the SABRE (Southall and Brent REvisited) Study
-
Tillin, T. et al. Diabetes risk and amino acid profiles: cross-sectional and prospective analyses of ethnicity, amino acids and diabetes in a South Asian and European cohort from the SABRE (Southall And Brent REvisited) Study. Diabetologia 58, 968-979 (2015).
-
(2015)
Diabetologia
, vol.58
, pp. 968-979
-
-
Tillin, T.1
-
15
-
-
84925172536
-
Visceral fat area as a new predictor of short-term diabetes remission after Roux-en-Y gastric bypass surgery in Chinese patients with a body mass index less than 35 kg/m2
-
Yu, H. et al. Visceral fat area as a new predictor of short-term diabetes remission after Roux-en-Y gastric bypass surgery in Chinese patients with a body mass index less than 35 kg/m2. Surg Obes Relat Dis 11, 6-13 (2015).
-
(2015)
Surg Obes Relat Dis
, vol.11
, pp. 6-13
-
-
Yu, H.1
-
16
-
-
84914170164
-
The metabolite profiles of the obese population are gender-dependent
-
Xie, G. et al. The metabolite profiles of the obese population are gender-dependent. J Proteome Res 13, 4062-4073 (2014).
-
(2014)
J Proteome Res
, vol.13
, pp. 4062-4073
-
-
Xie, G.1
-
17
-
-
84885189369
-
Potential role of branched-chain amino acid catabolism in regulating fat oxidation
-
Kainulainen, H., Hulmi, J. J., Kujala, U. M. Potential role of branched-chain amino acid catabolism in regulating fat oxidation. Exerc Sport Sci Rev 41, 194-200 (2013).
-
(2013)
Exerc Sport Sci Rev
, vol.41
, pp. 194-200
-
-
Kainulainen, H.1
Hulmi, J.J.2
Kujala, U.M.3
-
18
-
-
84888088346
-
Branched-chain amino acids in liver diseases
-
Tajiri, K., Shimizu, Y. Branched-chain amino acids in liver diseases. World J Gastroenterol 19, 7620-7629 (2013).
-
(2013)
World J Gastroenterol
, vol.19
, pp. 7620-7629
-
-
Tajiri, K.1
Shimizu, Y.2
-
19
-
-
85027942232
-
Branched-chain amino acid-enriched nutrients stimulate antioxidant DNA repair in a rat model of liver injury induced by carbon tetrachloride
-
Ichikawa, K. et al. Branched-chain amino acid-enriched nutrients stimulate antioxidant DNA repair in a rat model of liver injury induced by carbon tetrachloride. Mol Biol Rep 39, 10803-10810 (2012).
-
(2012)
Mol Biol Rep
, vol.39
, pp. 10803-10810
-
-
Ichikawa, K.1
-
20
-
-
84898879818
-
The complex role of branched chain amino acids in diabetes and cancer
-
O'Connell, T. M. The complex role of branched chain amino acids in diabetes and cancer. Metabolites 3, 931-945 (2013).
-
(2013)
Metabolites
, vol.3
, pp. 931-945
-
-
O'Connell, T.M.1
-
21
-
-
84874792421
-
Insulin resistance and the metabolism of branched-chain amino acids
-
Lu, J., Xie, G., Jia, W., Jia, W. Insulin resistance and the metabolism of branched-chain amino acids. Front Med 7, 53-59 (2013).
-
(2013)
Front Med
, vol.7
, pp. 53-59
-
-
Lu, J.1
Xie, G.2
Jia, W.3
Jia, W.4
-
22
-
-
84948451747
-
Metabolic and physiological roles of branched-chain amino acids
-
Monirujjaman, M., Ferdouse, A. Metabolic and physiological roles of branched-chain amino acids. Adv Mol Bio 2014, e364976 (2014).
-
(2014)
Adv Mol Bio
, vol.2014
, pp. e364976
-
-
Monirujjaman, M.1
Ferdouse, A.2
-
23
-
-
84861304175
-
Baseline metabolomic profiles predict cardiovascular events in patients at risk for coronary artery disease
-
Shah, S. H. et al. Baseline metabolomic profiles predict cardiovascular events in patients at risk for coronary artery disease. Am Heart J 163, 844-850 (2012).
-
(2012)
Am Heart J
, vol.163
, pp. 844-850
-
-
Shah, S.H.1
-
24
-
-
84874649474
-
A diabetes-predictive amino acid score and future cardiovascular disease
-
Magnusson, M. et al. A diabetes-predictive amino acid score and future cardiovascular disease. Eur Heart J 34, 1982-1989 (2013).
-
(2013)
Eur Heart J
, vol.34
, pp. 1982-1989
-
-
Magnusson, M.1
-
25
-
-
84902578918
-
Association of branched-chain amino acids with carotid intima-media thickness and coronary artery disease risk factors
-
Yang, R. et al. Association of branched-chain amino acids with carotid intima-media thickness and coronary artery disease risk factors. PLoS ONE 9, e99598 (2014).
-
(2014)
PLoS ONE
, vol.9
, pp. e99598
-
-
Yang, R.1
-
26
-
-
84921950738
-
Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development
-
Mayers, J. R. et al. Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development. Nat Med 20, 1193-1203 (2014).
-
(2014)
Nat Med
, vol.20
, pp. 1193-1203
-
-
Mayers, J.R.1
-
27
-
-
84872227252
-
Branched chain amino acid profile in early chronic kidney disease
-
Kumar, M. A. et al. Branched chain amino acid profile in early chronic kidney disease. Saudi J Kidney Dis Transpl 23, 1202-1207 (2012).
-
(2012)
Saudi J Kidney Dis Transpl
, vol.23
, pp. 1202-1207
-
-
Kumar, M.A.1
-
28
-
-
84876873082
-
Metabolite profiling identifies a branched chain amino acid signature in acute cardioembolic stroke
-
Kimberly, W. T., Pham, L., Furie, K. L., Gerszten, R. E. Metabolite profiling identifies a branched chain amino acid signature in acute cardioembolic stroke. Stroke 44, 1389-1395 (2013).
-
(2013)
Stroke
, vol.44
, pp. 1389-1395
-
-
Kimberly, W.T.1
Pham, L.2
Furie, K.L.3
Gerszten, R.E.4
-
29
-
-
84857861919
-
Mechanisms for insulin resistance: Common threads and missing links
-
Samuel, V. T., Shulman, G. I. Mechanisms for insulin resistance: common threads and missing links. Cell 148, 852-871 (2012).
-
(2012)
Cell
, vol.148
, pp. 852-871
-
-
Samuel, V.T.1
Shulman, G.I.2
-
30
-
-
84861905329
-
Endoplasmic reticulum stress and type 2 diabetes
-
Back, S. H., Kaufman, R. J. Endoplasmic reticulum stress and type 2 diabetes. Annu Rev Biochem 81, 767-793 (2012).
-
(2012)
Annu Rev Biochem
, vol.81
, pp. 767-793
-
-
Back, S.H.1
Kaufman, R.J.2
-
31
-
-
84897360881
-
High-normal 2 h glucose is associated with defects of insulin secretion and predispose to diabetes in Chinese adults
-
Lin, Z. et al. High-normal 2 h glucose is associated with defects of insulin secretion and predispose to diabetes in Chinese adults. Endocrine 48, 179-186 (2015).
-
(2015)
Endocrine
, vol.48
, pp. 179-186
-
-
Lin, Z.1
-
32
-
-
0031823666
-
Assessing the potential for alpha-glucosidase inhibitors in prediabetic states
-
Holman, R. R. Assessing the potential for alpha-glucosidase inhibitors in prediabetic states. Diabetes Res Clin Pract 40 (Suppl), S21-S25 (1998).
-
(1998)
Diabetes Res Clin Pract
, vol.40
, pp. S21-S25
-
-
Holman, R.R.1
-
33
-
-
84866128888
-
Leucine signaling in the pathogenesis of type 2 diabetes and obesity
-
Melnik, B. C. Leucine signaling in the pathogenesis of type 2 diabetes and obesity. World J Diabetes 3, 38-53, doi: 10.4239/wjd. v3.i3.38 (2012).
-
(2012)
World J Diabetes
, vol.3
, pp. 38-53
-
-
Melnik, B.C.1
-
34
-
-
84860872990
-
The role of mammalian target of rapamycin (mTOR) in the regulation of pancreatic beta-cell mass: Implications in the development of type-2 diabetes
-
Xie, J., Herbert, T. P. The role of mammalian target of rapamycin (mTOR) in the regulation of pancreatic beta-cell mass: implications in the development of type-2 diabetes. Cell Mol Life Sci 69, 1289-1304, doi: 10.1007/s00018-011-0874-4 (2012).
-
(2012)
Cell Mol Life Sci
, vol.69
, pp. 1289-1304
-
-
Xie, J.1
Herbert, T.P.2
-
35
-
-
0036313574
-
Mechanism of amino acid-induced skeletal muscle insulin resistance in humans
-
Krebs, M. et al. Mechanism of amino acid-induced skeletal muscle insulin resistance in humans. Diabetes 51, 599-605 (2002).
-
(2002)
Diabetes
, vol.51
, pp. 599-605
-
-
Krebs, M.1
-
36
-
-
0036926381
-
Leucine promotes glucose uptake in skeletal muscles of rats
-
Nishitani, S. et al. Leucine promotes glucose uptake in skeletal muscles of rats. Biochem Biophys Res Commun 299, 693-696 (2002).
-
(2002)
Biochem Biophys Res Commun
, vol.299
, pp. 693-696
-
-
Nishitani, S.1
-
37
-
-
84883110880
-
Richness of human gut microbiome correlates with metabolic markers
-
Chatelier, E. L. et al. Richness of human gut microbiome correlates with metabolic markers. Nature 500, 541-546 (2013).
-
(2013)
Nature
, vol.500
, pp. 541-546
-
-
Chatelier, E.L.1
-
38
-
-
84878709716
-
Gut metagenome in European women with normal, impaired and diabetic glucose control
-
Karlsson, F. H. et al. Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature 498, 99-103 (2013).
-
(2013)
Nature
, vol.498
, pp. 99-103
-
-
Karlsson, F.H.1
-
39
-
-
84927668122
-
Mechanisms in endocrinology: Gut microbiota in patients with type 2 diabetes mellitus
-
Allin, K. H., Nielsen, T., Pedersen, O. Mechanisms in endocrinology: Gut microbiota in patients with type 2 diabetes mellitus. Eur J Endocrinol 172, R167-177 (2015).
-
(2015)
Eur J Endocrinol
, vol.172
, pp. R167-177
-
-
Allin, K.H.1
Nielsen, T.2
Pedersen, O.3
-
40
-
-
74149089019
-
Fermentative production of branched chain amino acids: A focus on metabolic engineering
-
Park, J. H., Lee, S. Y. Fermentative production of branched chain amino acids: a focus on metabolic engineering. Appl Microbiol Biotechnol 85, 491-506, doi: 10.1007/s00253-009-2307-y (2010).
-
(2010)
Appl Microbiol Biotechnol
, vol.85
, pp. 491-506
-
-
Park, J.H.1
Lee, S.Y.2
-
41
-
-
84951906223
-
Circulating unsaturated fatty acids delineate the metabolic status of obese individuals
-
epub ahead of print
-
Ni, Y. et al. Circulating unsaturated fatty acids delineate the metabolic status of obese individuals. eBioMedicine epub ahead of print, doi: http://dx.doi.org/10.1016/j.ebiom.2015.09.004 (2015).
-
(2015)
EBioMedicine
-
-
Ni, Y.1
-
42
-
-
84875641584
-
Type 2 diabetes in East Asians: Similarities and differences with populations in Europe and the United States
-
Ma, R. C., Chan, J. C. Type 2 diabetes in East Asians: similarities and differences with populations in Europe and the United States. Ann NY Acad Sci 1281, 64-91 (2013).
-
(2013)
Ann NY Acad Sci
, vol.1281
, pp. 64-91
-
-
Ma, R.C.1
Chan, J.C.2
-
43
-
-
84655162045
-
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians
-
Cho, Y. S. et al. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat Genet 44, 67-72, doi: 10.1038/ng.1019 (2012).
-
(2012)
Nat Genet
, vol.44
, pp. 67-72
-
-
Cho, Y.S.1
-
44
-
-
80053384809
-
Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits
-
Kim, Y. J. et al. Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits. Nat Genet 43, 990-995, doi: 10.1038/ng.939 (2011).
-
(2011)
Nat Genet
, vol.43
, pp. 990-995
-
-
Kim, Y.J.1
-
45
-
-
34247631405
-
Epidemiological characteristics of diabetes mellitus and impaired glucose regulation in a Chinese adult population: The Shanghai Diabetes Studies, a cross-sectional 3-year follow-up study in Shanghai urban communities
-
Jia, W. P. et al. Epidemiological characteristics of diabetes mellitus and impaired glucose regulation in a Chinese adult population: the Shanghai Diabetes Studies, a cross-sectional 3-year follow-up study in Shanghai urban communities. Diabetologia 50, 286-292 (2007).
-
(2007)
Diabetologia
, vol.50
, pp. 286-292
-
-
Jia, W.P.1
-
46
-
-
28344432465
-
Recommendations on metabolic syndrome by Chinese Diabetes Society
-
Society M. S. R. G. O. C. D
-
Society, M. S. R. G. O. C. D. Recommendations on metabolic syndrome by Chinese Diabetes Society. Clin J Diabetes 12, 156-161 (2004).
-
(2004)
Clin J Diabetes
, vol.12
, pp. 156-161
-
-
-
48
-
-
84872088269
-
Inverse relationship between serum osteocalcin levels and visceral fat area in Chinese men
-
Bao, Y. et al. Inverse relationship between serum osteocalcin levels and visceral fat area in chinese men. J Clin Endocrinol Metab 98, 345-351 (2013).
-
(2013)
J Clin Endocrinol Metab
, vol.98
, pp. 345-351
-
-
Bao, Y.1
-
49
-
-
0036516860
-
Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults-study on optimal cut-off points of body mass index and waist circumference in Chinese adults
-
China C. M.-A G. o. t. W. G. o. O. i
-
Zhou, B. F., China, C. M.-A. G. o. t. W. G. o. O. i. Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults-study on optimal cut-off points of body mass index and waist circumference in Chinese adults. Biomed Environ Sci 15, 83-96 (2002).
-
(2002)
Biomed Environ Sci
, vol.15
, pp. 83-96
-
-
Zhou, B.F.1
-
50
-
-
84890059083
-
Very low carbohydrate diet significantly alters the serum metabolic profiles in obese subjects
-
Gu, Y. et al. Very low carbohydrate diet significantly alters the serum metabolic profiles in obese subjects. J Proteome Res 12, 5801-5811 (2013).
-
(2013)
J Proteome Res
, vol.12
, pp. 5801-5811
-
-
Gu, Y.1
-
51
-
-
0021813187
-
Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
-
Matthews, D. et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28, 412-419 (1985).
-
(1985)
Diabetologia
, vol.28
, pp. 412-419
-
-
Matthews, D.1
-
52
-
-
0034456568
-
Quantitative insulin sensitivity check index: A simple, accurate method for assessing insulin sensitivity in humans
-
Katz, A. et al. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 85, 2402-2410 (2000).
-
(2000)
J Clin Endocrinol Metab
, vol.85
, pp. 2402-2410
-
-
Katz, A.1
|