Circulating Unsaturated Fatty Acids Delineate the Metabolic Status of Obese Individuals

EBioMedicine

Volumn 2, Issue 10, 2015, Pages 1513-1522

  Ni, Yan ^a,b   Zhao, Linjing ^a,b   Yu, Haoyong ^a   Ma, Xiaojing ^a   Bao, Yuqian ^a   Rajani, Cynthia ^b   Loo, Lenora W M ^b   Shvetsov, Yurii B ^b   Yu, Herbert ^b   Chen, Tianlu ^a   Zhang, Yinan ^a   Wang, Congrong ^a   Hu, Cheng ^a   Su, Mingming ^b   Xie, Guoxiang ^b   Zhao, Aihua ^a   Jia, Wei ^a,b   Jia, Weiping ^a  

^a SHANGHAI JIAO TONG UNIVERSITY AFFILIATED SIXTH PEOPLE S HOSPITAL   (China)

^b UNIVERSITY OF HAWAII CANCER CENTER   (United States)

Author keywords

Free fatty acids; Insulin resistance; Metabolic syndrome; Obesity; Type 2 diabetes; Unsaturated fatty acids

Indexed keywords

UNSATURATED FATTY ACID; BIOLOGICAL MARKER;

ADULT; ARTICLE; BODY FAT; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; METABOLIC ACTIVATION; METABOLIC SYNDROME X; MIDDLE AGED; OBESITY; PHENOTYPE; PRIORITY JOURNAL; QUALITY CONTROL; TIME OF FLIGHT MASS SPECTROMETRY; BLOOD; CLUSTER ANALYSIS; COMPLICATION; DIET THERAPY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MATRIX-ASSISTED LASER DESORPTION-IONIZATION MASS SPECTROMETRY; METABOLISM; METABOLOME; METABOLOMICS; NON INSULIN DEPENDENT DIABETES MELLITUS; ODDS RATIO; PROCEDURES;

ADULT; BIOMARKERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLUSTER ANALYSIS; DIABETES MELLITUS, TYPE 2; FATTY ACIDS, UNSATURATED; FEMALE; HUMANS; MALE; METABOLIC SYNDROME X; METABOLOME; METABOLOMICS; MIDDLE AGED; OBESITY; ODDS RATIO; OVERWEIGHT; PHENOTYPE; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84951906223     PISSN: None     EISSN: 23523964     Source Type: Journal    
DOI: 10.1016/j.ebiom.2015.09.004     Document Type: Article

References (38)

1. Bao Y.Q., Ma X.J., Yang R., et al. Inverse relationship between serum osteocalcin levels and visceral fat area in Chinese men. J. Clin. Endocrinol. Metab. 2013, 98(1):345-351.
2. Bei-Fan Z., Cooperative Meta-Analysis Group of Working Group on Obesity in C Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults: study on optimal cut-off points of body mass index and waist circumference in Chinese adults. Asia Pac. J. Clin. Nutr. 2002, 8(11 Suppl.):S685-S693.
3. Boden G. Effects of free fatty acids (FFA) on glucose metabolism: significance for insulin resistance and type 2 diabetes. Exp. Clin. Endocrinol. Diabetes 2003, 111(3). (121-124).
4. Boden G. Obesity, insulin resistance and free fatty acids. Curr. Opin. Endocrinol. Diabetes Obes. 2011, 18(2):139-143.
5. Boden G., Shulman G.I. Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction. Eur. J. Clin. Investig. 2002, 32:14-23.
6. Cao H., Gerhold K., Mayers J.R., Wiest M.M., Watkins S.M., Hotamisligil G.S. Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell 2008, 134(6):933-944.
7. Charles M.A., Eschwege E., Thibult N., et al. The role of non-esterified fatty acids in the deterioration of glucose tolerance in Caucasian subjects: results of the Paris Prospective Study. Diabetologia 1997, 40(9):1101-1106.
8. Connor W.E., Lin D.S., Colvis C. Differential mobilization of fatty acids from adipose tissue. J. Lipid Res. 1996, 37(2):290-298.
9. Fabbrini E., Sullivan S., Klein S. Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology 2010, 51(2):679-689.
10. Forouhi N.G., Koulman A., Sharp S.J., et al. Differences in the prospective association between individual plasma phospholipid saturated fatty acids and incident type 2 diabetes: the EPIC-InterAct case-cohort study. Lancet Diabetes Endocrinol. 2014, 2(10):810-818.
11. Gong J., Campos H., McGarvey S., Wu Z., Goldberg R., Baylin A. Adipose tissue palmitoleic acid and obesity in humans: does it behave as a lipokine?. Am. J. Clin. Nutr. 2011, 93(1):186-191.
12. Gruben N., Shiri-Sverdlov R., Koonen D.P., Hofker M.H. Nonalcoholic fatty liver disease: a main driver of insulin resistance or a dangerous liaison?. Biochim. Biophys. Acta 2014, 1842(11):2329-2343.
13. Gu Y.J., Zhao A.H., Huang F.J., et al. Very Low carbohydrate diet significantly alters the serum metabolic profiles in obese subjects. J. Proteome Res. 2013, 12(12):5801-5811.
14. Gu Y., Yu H., Li Y., et al. Beneficial effects of an 8-week, very low carbohydrate diet intervention on obese subjects. Evid. Based Complement. Alternat. Med. 2013, 2013:760804.
15. Hamer M., Stamatakis E. Metabolically healthy obesity and risk of all-cause and cardiovascular disease mortality. J. Clin. Endocrinol. Metab. 2012, 97(7):2482-2488.
16. Jia W.P., Pang C., Chen L., et al. Epidemiological characteristics of diabetes mellitus and impaired glucose regulation in a Chinese adult population: the Shanghai Diabetes Studies, a cross-sectional 3-year follow-up study in Shanghai urban communities. Diabetologia 2007, 50(2):286-292.
17. Kahn S.E., Hull R.L., Utzschneider K.M. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 2006, 444(7121):840-846.
18. Karelis A.D., St-Pierre D.H., Conus F., Rabasa-Lhoret R., Poehlman E.T. Metabolic and body composition factors in subgroups of Obesity: what do we know?. J. Clin. Endocrinol. Metab. 2004, 89(6):2569-2575.
19. Kramer C.K., Zinman B., Retnakaran R. Are metabolically healthy overweight and obesity benign conditions?: a systematic review and meta-analysis. Ann. Intern. Med. 2013, 159(11):758-769.
20. Kurotani K., Sato M., Ejima Y., et al. High levels of stearic acid, palmitoleic acid, and dihomo-gamma-linolenic acid and low levels of linoleic acid in serum cholesterol ester are associated with high insulin resistance. Nutr. Res. 2012, 32(9):669-675. e3.
21. Kusunoki J., Kanatani A., Moller D.E. Modulation of fatty acid metabolism as a potential approach to the treatment of obesity and the metabolic syndrome. Endocrine 2006, 29(1):91-100.
22. Ma W., Wu J.H., Wang Q., et al. Prospective association of fatty acids in the de novo lipogenesis pathway with risk of type 2 diabetes: the Cardiovascular Health Study. Am. J. Clin. Nutr. 2015, 101(1):153-163.
23. Micha R., Mozaffarian D. Saturated fat and cardiometabolic risk factors, coronary heart disease, stroke, and diabetes: a fresh look at the evidence. Lipids 2010, 45(10):893-905.
24. Mordier S., Iynedjian P.B. Activation of mammalian target of rapamycin complex 1 and insulin resistance induced by palmitate in hepatocytes. Biochem. Biophys. Res. Commun. 2007, 362(1):206-211.
25. Pankow J.S., Duncan B.B., Schmidt M.I., et al. Fasting plasma free fatty acids and risk of type 2 diabetes - the atherosclerosis risk in communities study. Diabetes Care 2004, 27(1):77-82.
26. Pankow J.S., Duncan B.B., Schmidt M.I., et al. Fasting plasma free fatty acids and risk of type 2 diabetes: the ARIC Study. Circulation 2004, 109(7).
27. Paolisso G., Tataranni P.A., Foley J.E., Bogardus C., Howard B.V., Ravussin E. A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM. Diabetologia 1995, 38(10):1213-1217.
28. Patel P.S., Sharp S.J., Jansen E., et al. Fatty acids measured in plasma and erythrocyte-membrane phospholipids and derived by food-frequency questionnaire and the risk of new-onset type 2 diabetes: a pilot study in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk cohort. Am. J. Clin. Nutr. 2010, 92(5):1214-1222.
29. Perreault M., Zulyniak M.A., Badoud F., et al. A distinct fatty acid profile underlies the reduced inflammatory state of metabolically healthy obese individuals. PLoS One 2014, 9(2).
30. Perry R.J., Samuel V.T., Petersen K.F., Shulman G.I. The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes. Nature 2014, 510(7503):84-91.
31. Phillips C.M., Perry I.J. Does inflammation determine metabolic health status in obese and nonobese adults?. J. Clin. Endocrinol. Metab. 2013, 98(10):E1610-E1619.
32. Puttmann M., Krug H., Vonochsenstein E., Kattermann R. Fast Hplc determination of serum-free fatty-acids in the picomole range. Clin. Chem. 1993, 39(5):825-832.
33. Reynoso R., Salgado L.M., Calderon V. High levels of palmitic acid lead to insulin resistance due to changes in the level of phosphorylation of the insulin receptor and insulin receptor substrate-1. Mol. Cell. Biochem. 2003, 246(1-2):155-162.
34. Stefan N., Haring H.U., Hu F.B., Schulze M.B. Metabolically healthy obesity: epidemiology, mechanisms, and clinical implications. Lancet Diabetes Endocrinol. 2013, 1(2):152-162.
35. Steffen B.T., Steffen L.M., Tracy R., et al. Obesity modifies the association between plasma phospholipid polyunsaturated fatty acids and markers of inflammation: the Multi-Ethnic Study of Atherosclerosis. Int. J. Obes. 2012, 36(6):797-804.
36. St-Onge M.P., Janssen I., Heymsfield S.B. Metabolic syndrome in normal-weight Americans: new definition of the metabolically obese, normal-weight individual. Diabetes Care 2004, 27(9):2222-2228.
37. Trufelli H., Famiglini G., Termopoli V., Cappiello A. Profiling of non-esterified fatty acids in human plasma using liquid chromatography-electron ionization mass spectrometry. Anal. Bioanal. Chem. 2011, 400(9):2933-2941.
38. Wang L., Folsom A.R., Zheng Z.J., Pankow J.S., Eckfeldt J.H., Investigators A.S. Plasma fatty acid composition and incidence of diabetes in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study. Am. J. Clin. Nutr. 2003, 78(1):91-98.