Iron chelation inhibits osteoclastic differentiation in vitro and in Tg2576 mouse model of Alzheimer's disease

PLoS ONE

Volumn 10, Issue 11, 2015, Pages

  Guo, Jun Peng ^a,b,c   Pan, Jin Xiu ^a   Xiong, Lei ^a,b   Xia, Wen Fang ^a,d   Cui, Shun ^a,d   Xiong, Wen Cheng ^a,b  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c CHANGCHUN UNIVERSITY OF CHINESE MEDICINE   (China)

^d HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CLINOQUINOL; COLONY STIMULATING FACTOR 1; DEFEROXAMINE; FERROPORTIN; IRON; IRON CHELATING AGENT; OSTEOCALCIN; PROTEIN KINASE B; SWEDISH MUTANT AMYLOID PRECURSOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NFATC1; UNCLASSIFIED DRUG; CATION TRANSPORT PROTEIN; CLIOQUINOL; METAL TRANSPORTING PROTEIN 1; OSTEOCLAST DIFFERENTIATION FACTOR;

ADULT; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE MARROW MACROPHAGE; BONE MASS; CELL DIFFERENTIATION; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORTICAL BONE; DRUG SELECTIVITY; ENZYME PHOSPHORYLATION; IN VITRO STUDY; IRON CHELATION; MACROPHAGE; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; OSTEOPOROSIS; OUTCOME ASSESSMENT; PROTEIN EXPRESSION; TG2576 MOUSE; TRABECULAR BONE; WILD TYPE; YOUNG ADULT; ANIMAL; C57BL MOUSE; CELL CULTURE; DRUG EFFECTS; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGY; PRECLINICAL STUDY; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; ANIMALS; BONE RESORPTION; CATION TRANSPORT PROTEINS; CELL DIFFERENTIATION; CELLS, CULTURED; CLIOQUINOL; DRUG EVALUATION, PRECLINICAL; IRON CHELATING AGENTS; MACROPHAGE COLONY-STIMULATING FACTOR; MACROPHAGES; MALE; MICE, INBRED C57BL; MICE, TRANSGENIC; OSTEOBLASTS; OSTEOCLASTS; RANK LIGAND;

EID: 84957551762     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0139395     Document Type: Article

References (30)

1. Rachner TD, Khosla S, and Hofbauer LC. Osteoporosis: now and the future. Lancet. 2011; 377:1276-1287. doi: 10.1016/S0140-6736(10)62349-5 PMID: 21450337
2. Tysiewicz-Dudek M, Pietraszkiewicz F, and Drozdzowska B. Alzheimer's disease and osteoporosis: common risk factors or one condition predisposing to the other? Ortopedia, traumatologia, rehabilitacja. 2008; 10:315-323. PMID: 18779764
3. Melton LJ, Beard CM, Kokmen E, Atkinson EJ, and O'Fallon WM. Fracture risk in patients with Alzheimer's disease. J. Ameri. Geriat. Soc.1994; 42:614-619.
4. Esler WP, and Wolfe MS. A portrait of Alzheimer secretases-new features and familiar faces. Science. 2001; 293:1449-1454. PMID: 11520976
5. Hardy J. A hundred years of Alzheimer's disease research. Neuron. 2006; 52:3-13. PMID: 17015223
6. Hardy J. Alzheimer's disease: the amyloid cascade hypothesis: an update and reappraisal. J. Alzheimer's dis. 2006; 9:151-153.
7. Cui S, Xiong F, Hong Y, Jung JU, Li XS, Liu JZ, Yan R, Mei L, Feng X, and Xiong WC. APPswe/Abeta regulation of osteoclast activation and RAGE expression in an age-dependent manner. J. Bone & Min. Res. 2011; 26:1084-1098. doi: 10.1002/jbmr.299 PMID: 21542009
8. Xia WF, Jung JU, Shun C, Xiong S, Xiong L, Shi XM, Mei L, and Xiong WC. Swedish mutant APP suppresses osteoblast differentiation and causes osteoporotic deficit, which are ameliorated by n-acetyl-lcysteine. J. Bone & Min. Res. 2013; 28(10):2122-35. doi: 10.1002/jbmr.1954 PMID: 23649480
9. Zatta P, Drago D, Bolognin S, and Sensi SL. Alzheimer's disease, metal ions and metal homeostatic therapy. Trends in Pharmacol. Sci. 2009; 30:346-355.
10. Duce JA, Tsatsanis A, Cater MA, James SA, Robb E, Wikhe K, Leong SL, Perez K, Johanssen T, Greenough MA, et al. Iron-export ferroxidase activity of beta-amyloid precursor protein is inhibited by zinc in Alzheimer's disease. Cell. 2010; 142:857-867. doi: 10.1016/j.cell.2010.08.014 PMID: 20817278
11. De Domenico I, Ward DM, and Kaplan J. Hepcidin and ferroportin: the new players in iron metabolism. Seminars in liver Dis. 2011; 31:272-279.
12. Pauk M, Grgurevic L, Brkljacic J, Kufner V, Bordukalo-Niksic T, Grabusic K, Razdorov G, Rogic D, Zuvic M, Oppermann H, et al. Exogenous BMP7 corrects plasma iron overload and bone loss in Bmp6-/- mice. International orthopaedics. 2015; 39(1):161-72. doi: 10.1007/s00264-014-2550-4 PMID: 25300398
13. Rossi F, Perrotta S, Bellini G, Luongo L, Tortora C, Siniscalco D, Francese M, Torella M, Nobili B, Di Marzo V, et al. Iron overload causes osteoporosis in thalassemia major patients through interaction with transient receptor potential vanilloid type 1 (TRPV1) channels. Haematologica. 2014; 99:1876-1884. doi: 10.3324/haematol.2014.104463 PMID: 25216685
14. Wright I, Blanco-Rojo R, Fernandez MC, Toxqui L, Moreno G, Perez-Granados AM, de la Piedra C, Remacha AF, and Vaquero MP. Bone remodelling is reduced by recovery from iron-deficiency anaemia in premenopausal women. J. Physiol. and Biochem. 2013; 69:889-896.
15. Jia P, Xu YJ, Zhang ZL, Li K, Li B, Zhang W, and Yang H. Ferric ion could facilitate osteoclast differentiation and bone resorption through the production of reactive oxygen species. J. Orthopaedic Res. 2012; 30:1843-1852.
16. Ayton S, Lei P, and Bush AI. Metallostasis in Alzheimer's disease. Free Rad. Biol. & Med. 2013; 62:76-89. doi: 10.1016/j.freeradbiomed.2012.10.558 PMID: 23142767
17. Zhou Z, Immel D, Xi CX, Bierhaus A, Feng X, Mei L, Nawroth P, Stern DM, and Xiong WC. Regulation of osteoclast function and bone mass by RAGE. J Exp Med. 2006; 203:1067-1080. PMID: 16606672
18. Zhou Z, Han JY, Xi CX, Xie JX, Feng X, Wang CY, Mei L, and Xiong WC. HMGB1 regulates RANKLinduced osteoclastogenesis in a manner dependent on RAGE. J. Bone & Min. Res. 2008; 23:1084-1096. doi: 10.1359/jbmr.080234 PMID: 18302500
19. Zhang W, Yang N, and Shi XM. Regulation of mesenchymal stem cell osteogenic differentiation by glucocorticoid- induced leucine zipper (GILZ). J. Biol. Chem. 2008; 283:4723-4729. PMID: 18084007
20. Robert AC, Craig SA, Michel EX, Danielle NG, Walton DJ, Catriona AM, Kevin JB, Irene V, Fiona WF, Young SK, Xudong H, Lee EG, Robert DM, James TL, Konrad B, Hui Z, Rudolph ET, Colin LM, and Ashley IB. Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron. 2001; 30:665-676. PMID: 11430801
21. Nguyen T, Hamby A, and Massa SM. Clioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease mouse model. Proc Natl Acad Sci USA.2005; 33:11840-5.
22. De Domenico I, Ward DM, and Kaplan J. Specific iron chelators determine the route of ferritin degradation. Blood. 2009; 114(20):4546-51. doi: 10.1182/blood-2009-05-224188 PMID: 19671920
23. Peng L, Scott A, David IF, Loredana S, Giuseppe DC, David KW, Bruce XW, Paul AA, Robert AC, Linh QL, Blaine RR, Irene V, Gary FE, Catriona AM, Roberto C, James AD, and Ashley IB. Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export. Nat. Med. 2012; 18:291-296. doi: 10.1038/nm.2613 PMID: 22286308
24. Steven L. Teitelbaum. Bone resorption by osteoclasts. Science. 2000; 289:1504-1508.
25. Hyunsoo K, Taesoo K, Byung CJ, Il-Taeg C, Daehee H, Noriko T, Takako NK, Hiroshi T, Jae HL, Jai YS, Vikram P, Seoung HL, and Yongwon C. Tmem64 modulates calcium signaling during RANKLmediated osteoclast differentiation. Cell Metabol.2013; 17:249-260.
26. Irina V, Noelle O, Valentin J, Celeste O, Morris FM, and Jane EA. The R740S mutation in the V-ATPase a3 subunit increases lysosomal pH, impairs NFATc1 translocation, and decreases in vitro osteoclastogenesis. J. Bone & Min. Res. 2013; 28:108-118. doi: 10.1002/jbmr.1727 PMID: 22865292
27. Elizabeta N, Marie ST, Julie P, Michael BV, Adriana D, Diane MW, Tomas G, and Jerry K. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004; 306:2090-2093. PMID: 15514116
28. Jaime T, Zhei WY, Patrick R, Susanna CR, Hong L, Rhima C, Philipp MK, Stephen BD, Robert WG, Patricia JG, and Adele LB. Bone loss caused by iron overload in a murine model: importance of oxidative stress. Blood. 2010; 116: 2582-2589. doi: 10.1182/blood-2009-12-260083 PMID: 20554970
29. Roodman GD. Osteoclasts pump iron. Cell Metabol. 2009; 9:405-406.
30. Ishii KA, Fumoto T, Iwai K, Takeshita S, Ito M, Shimohata N, Aburatani H, Taketani S, Lelliott CJ, Vidal- Puig A, and Ikeda K. Coordination of PGC-1beta and iron uptake in mitochondrial biogenesis and osteoclast activation. Nat. Med. 2009; 15:259-266. doi: 10.1038/nm.1910 PMID: 19252502