Discovery of a new selective inhibitor of A Disintegrin and Metalloprotease 10 (ADAM-10) able to reduce the shedding of NKG2D ligands in Hodgkin's lymphoma cell models

European Journal of Medicinal Chemistry

Volumn 111, Issue , 2016, Pages 193-201

  Camodeca, Caterina ^a   Nuti, Elisa ^b   Tepshi, Livia ^b,c   Boero, Silvia ^d   Tuccinardi, Tiziano ^b   Stura, Enrico A ^c   Poggi, Alessandro ^d   Zocchi, Maria Raffaella ^a   Rossello, Armando ^b  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b UNIVERSITY OF PISA   (Italy)

^c SERVICE DE CHIMIE BIOORGANIQUE ET DE MARQUAGE   (France)

^d UNIVERSITY OF GENOA   (Italy)

Author keywords

ADAM 10 inhibitors; Hodgkin's lymphoma; NKG2D L; Sulfonamido based hydroxamates

Indexed keywords

3 METHYL 4 (PIPERAZIN 1 YL)BENZONITRILE; 3 [[4 (4 CYANO 2 METHYLPHENYL)PIPERAZIN 1 YL]SULFONYL]THIAZOLIDINE 4 CARBOXYLIC ACID; 3 [[4 (4 CYANO 2 METHYLPHENYL)PIPERAZIN 1 YL]SULFONY] N HYDROXYTHIAZOLIDINE 4 CARBOXAMIDE; 4 (4 CYANO 2 METHYLPHENYL)PIPERAZINE 1 SULFONYL CHLORIDE; 5 (BENZYLOXYCARBONYLAMINO) 2 [4 (4 CYANO 2 PIPERAZINE 1 SULFONAMIDO)PENTANOIC ACID; A DISINTEGRIN AND METALLOPROTEASE 10 INHIBITOR; ADAM10 ENDOPEPTIDASE; ANTINEOPLASTIC AGENT; BENZYL [4 [4 (4 CYANO 2 METHYLPHENYL)PIPERAZINE 1 SULFONAMIDO] 5 (HYDROXYAMINO) 5 OXOPENTYL]CARBAMATE; GI 254023X; METALLOPROTEINASE INHIBITOR; NATURAL KILLER CELL RECEPTOR NKG2D; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; UNCLASSIFIED DRUG; ADAM PROTEIN; ADAM10 PROTEIN, HUMAN; ENZYME INHIBITOR; KLRK1 PROTEIN, HUMAN; LIGAND; MEMBRANE PROTEIN; NATURAL KILLER CELL LECTIN LIKE RECEPTOR SUBFAMILY K; SECRETASE;

ARTICLE; CELL VIABILITY; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFICACY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; FEMALE; HODGKIN DISEASE; HUMAN; HUMAN CELL; LYMPHOMA CELL LINE; MOLECULAR DOCKING; MOLECULAR MODEL; OVARIAN CANCER CELL LINE; X RAY CRYSTALLOGRAPHY; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG DEVELOPMENT; ENZYMOLOGY; METABOLISM; PATHOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ADAM PROTEINS; ADAM10 PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; ENZYME INHIBITORS; HODGKIN DISEASE; HUMANS; LIGANDS; MEMBRANE PROTEINS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY K; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84957547562     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2016.01.053     Document Type: Article

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