Identification of potent and selective TACE inhibitors via the S1 pocket

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 1, 2007, Pages 34-39

  Condon, Jeffrey S ^a   Joseph McCarthy, Diane ^a   Levin, Jeremy I ^b   Lombart, Henry Georges ^a   Lovering, Frank E ^a   Sun, Linhong ^a   Wang, Weiheng ^a   Xu, Weixin ^a   Zhang, Yuhua ^a  

^a PFIZER INC   (United States)

^b WYETH RESEARCH   (United States)

Author keywords

Inflammation; Rheumatoid arthritis; TACE

Indexed keywords

4,4' PIPERIDINE BETA SULFONE HYDROXAMATE INHIBITOR; COLLAGENASE 3; COLLAGENASE 3 INHIBITOR; ENZYME INHIBITOR; ETANERCEPT; GELATINASE A; GELATINASE A INHIBITOR; GELATINASE B; GELATINASE B INHIBITOR; HYDROXAMIC ACID DERIVATIVE; INFLIXIMAB; INTERSTITIAL COLLAGENASE; INTERSTITIAL COLLAGENASE INHIBITOR; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE 14 INHIBITOR; MATRIX METALLOPROTEINASE INHIBITOR; PIPERIDINE; SULFONE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME INHIBITOR;

ARTICLE; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME BINDING; ENZYME INHIBITION; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; IMMUNOMODULATION; IN VITRO STUDY;

ADAM PROTEINS; CRYSTALLOGRAPHY, X-RAY; LIGANDS; METALLOENDOPEPTIDASES; PIPERIDINES; PROTEASE INHIBITORS; SULFONES;

EID: 33845646703     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.10.004     Document Type: Article

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