메뉴 건너뛰기




Volumn 8, Issue 1, 2011, Pages

The ADAMs family of proteases: New biomarkers and therapeutic targets for cancer?

Author keywords

[No Author keywords available]

Indexed keywords

ADAM PROTEIN; ADAM10 ENDOPEPTIDASE; ADAM11 ENDOPEPTIDASE; ADAM12 ENDOPEPTIDASE; ADAM15 ENDOPEPTIDASE; ADAM22 ENDOPEPTIDASE; ADAM9 ENDOPEPTIDASE; ADERBASIB; ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; GEFITINIB; GI 254023X; GW 280264X; GW 2974; GW280264X; INCB 3619; INCB3619; JANUS KINASE; KB R7785; LAPATINIB; MATRIX METALLOPROTEINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; PACLITAXEL; PHOSPHATIDYLINOSITOL 3 KINASE; STAT PROTEIN; TMI 2; TRANSFORMING GROWTH FACTOR BETA; TRASTUZUMAB; TUMOR MARKER; UNCLASSIFIED DRUG; WAY 022;

EID: 84860641102     PISSN: 15426416     EISSN: 15590275     Source Type: Journal    
DOI: 10.1186/1559-0275-8-9     Document Type: Review
Times cited : (166)

References (80)
  • 1
    • 52949099119 scopus 로고    scopus 로고
    • The ADAM metalloproteinases
    • 10.1016/j.mam.2008.08.001 18762209
    • The ADAM metalloproteinases. Edwards DR, Handsley MH, Pennington CJ, Mol Aspects Med 2008 29 258 89 10.1016/j.mam.2008.08.001 18762209
    • (2008) Mol Aspects Med , vol.29 , pp. 258-289
    • Edwards, D.R.1    Handsley, M.H.2    Pennington, C.J.3
  • 2
    • 56749133149 scopus 로고    scopus 로고
    • The ADAMs: Signaling scissors in the tumour microenvironment
    • 19005493
    • The ADAMs: Signaling scissors in the tumour microenvironment. Murphy G, Nat Rev Cancer 2008 8 929 41 19005493
    • (2008) Nat Rev Cancer , vol.8 , pp. 929-941
    • Murphy, G.1
  • 3
    • 11244261160 scopus 로고    scopus 로고
    • ADAMs: Key components in egfr signalling and development
    • DOI 10.1038/nrm1548
    • ADAMS: key components in EGFR signalling and development. Blobel CP, Nature Rev Cancer 2005 6 32 43 (Pubitemid 40064897)
    • (2005) Nature Reviews Molecular Cell Biology , vol.6 , Issue.1 , pp. 32-43
    • Blobel, C.P.1
  • 5
    • 64949177302 scopus 로고    scopus 로고
    • The role of ADAMs in disease pathophysiology
    • 10.1016/j.cca.2009.01.007 19408347
    • The role of ADAMs in disease pathophysiology. Duffy MJ, McKiernan E, O'Donovan N, McGowan P, Clin Chim Acta 2009 403 31 36 10.1016/j.cca.2009.01.007 19408347
    • (2009) Clin Chim Acta , vol.403 , pp. 31-36
    • Duffy, M.J.1    McKiernan, E.2    O'Donovan, N.3    McGowan, P.4
  • 9
    • 33746381184 scopus 로고    scopus 로고
    • Breaking up the tie: Disintegrin-like metalloproteinases as regulators of cell migration in inflammation and invasion
    • DOI 10.1016/j.pharmthera.2006.02.009, PII S0163725806000295
    • Breaking up the tie: disintegrin-like metalloproteinases as regulators of cell migration in inflammation and invasion. Reiss K, Ludwig A, Saftig P, Pharmacol Ther 2006 111 985 1006 10.1016/j.pharmthera.2006.02.009 16626807 (Pubitemid 44118440)
    • (2006) Pharmacology and Therapeutics , vol.111 , Issue.3 , pp. 985-1006
    • Reiss, K.1    Ludwig, A.2    Saftig, P.3
  • 12
    • 0035985185 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase phosphorylates tumor necrosis factor α-converting enzyme at threonine 735: A potential role in regulated shedding
    • DOI 10.1091/mbc.01-11-0561
    • Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding. Díaz-Rodríguez E, Montero JC, Esparís-Ogando A, Yuste L, Pandiella A, Mol Biol Cell 2002 13 2031 44 10.1091/mbc.01-11-0561 12058067 (Pubitemid 34651490)
    • (2002) Molecular Biology of the Cell , vol.13 , Issue.6 , pp. 2031-2044
    • Diaz-Rodriguez, E.1    Montero, J.C.2    Esparis-Ogando, A.3    Yuste, L.4    Pandiella, A.5
  • 13
    • 76849107016 scopus 로고    scopus 로고
    • Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation
    • 10.1016/j.molcel.2010.01.034 20188673
    • Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation. Xu P, Derynck R, Mol Cell 2010 37 551 566 10.1016/j.molcel.2010.01.034 20188673
    • (2010) Mol Cell , vol.37 , pp. 551-566
    • Xu, P.1    Derynck, R.2
  • 14
    • 0037085256 scopus 로고    scopus 로고
    • Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases
    • DOI 10.1074/jbc.M107430200
    • Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases. Poghosyan Z, Robbins SM, Houslay MD, et al. J Biol Chem 2002 277 4999 5007 10.1074/jbc.M107430200 11741929 (Pubitemid 34968539)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.7 , pp. 4999-5007
    • Poghosyan, Z.1    Robbins, S.M.2    Houslay, M.D.3    Webster, A.4    Murphy, G.5    Edwards, D.R.6
  • 15
    • 33846817495 scopus 로고    scopus 로고
    • Targeting TACE-dependent EGFR ligand shedding in breast cancer
    • DOI 10.1172/JCI29518
    • Targeting TACE-dependent EGFR ligand shedding in breast cancer. Kenny PA, Bissell MJ, J Clin Invest 2007 117 337 345 10.1172/JCI29518 17218988 (Pubitemid 46203962)
    • (2007) Journal of Clinical Investigation , vol.117 , Issue.2 , pp. 337-345
    • Kenny, P.A.1    Bissell, M.J.2
  • 16
    • 34247846314 scopus 로고    scopus 로고
    • ADAM-17 expression in breast cancer correlates with variables of tumor progression
    • DOI 10.1158/1078-0432.CCR-06-2092
    • ADAM-17 expression in breast cancer correlates with variables of tumor progression. McGowan PM, Ryan BM, Hill AD, McDermott E, O'Higgins N, Duffy MJ, Clin Cancer Res 2007 13 2335 2343 10.1158/1078-0432.CCR-06-2092 17438092 (Pubitemid 46698582)
    • (2007) Clinical Cancer Research , vol.13 , Issue.8 , pp. 2335-2343
    • McGowan, P.M.1    Ryan, B.M.2    Hill, A.D.K.3    McDermott, E.4    O'Higgins, N.5    Duffy, M.J.6
  • 17
    • 0037416187 scopus 로고    scopus 로고
    • TACE is required for the activation of the EGFR by TGF-α in tumors
    • DOI 10.1093/emboj/cdg111
    • TACE is required for the activation of the EGFR by TGF-alpha in tumors. Borrell-Pages M, Rojo F, Albanell J, Baselga J, Arribas J, EMBO J 2003 22 1114 1124 10.1093/emboj/cdg111 12606576 (Pubitemid 36313595)
    • (2003) EMBO Journal , vol.22 , Issue.5 , pp. 1114-1124
    • Borrell-Pages, M.1    Rojo, F.2    Albanell, J.3    Baselga, J.4    Arribas, J.5
  • 18
    • 33748331284 scopus 로고    scopus 로고
    • ADAM12 is highly expressed in carcinoma-associated stroma and is required for mouse prostate tumor progression
    • DOI 10.1038/sj.onc.1209536, PII 1209536
    • ADAM12 is highly expressed in carcinoma-associated stroma and is required for mouse prostate tumor progression. Peduto L, Reuter VE, Sehara-Fujisawa A, Shaffer DR, Scher HI, Blobel CP, Oncogene 2006 25 5462 5466 10.1038/sj.onc. 1209536 16607276 (Pubitemid 44330288)
    • (2006) Oncogene , vol.25 , Issue.39 , pp. 5462-5466
    • Peduto, L.1    Reuter, V.E.2    Sehara-Fujisawa, A.3    Shaffer, D.R.4    Scher, H.I.5    Blobel, C.P.6
  • 19
    • 33748037366 scopus 로고    scopus 로고
    • Multiple acquired renal carcinoma tumor capabilities abolished upon silencing of ADAM17
    • DOI 10.1158/0008-5472.CAN-06-1595
    • Multiple acquired renal carcinoma tumor capabilities abolished upon silencing of ADAM17. Franovic A, Robert I, Smith K, et al. Cancer Res 2006 66 8083 8090 10.1158/0008-5472.CAN-06-1595 16912185 (Pubitemid 44299174)
    • (2006) Cancer Research , vol.66 , Issue.16 , pp. 8083-8090
    • Franovic, A.1    Robert, I.2    Smith, K.3    Kurban, G.4    Pause, A.5    Gunaratnam, L.6    Lee, S.7
  • 20
    • 36248992995 scopus 로고    scopus 로고
    • Involvement of NF-κB-mediated maturation of ADAM-17 in the invasion of oral squamous cell carcinoma
    • DOI 10.1016/j.bbrc.2007.11.010, PII S0006291X07024072
    • Involvement of NF-kappaB-mediated maturation of ADAM-17 in the invasion of oral squamous cell carcinoma. Takamune Y, Ikebe T, Nagano O, Shinohara M, Biochem Biophys Res Commun 2008 365 393 398 10.1016/j.bbrc.2007.11.010 17999917 (Pubitemid 350137302)
    • (2008) Biochemical and Biophysical Research Communications , vol.365 , Issue.2 , pp. 393-398
    • Takamune, Y.1    Ikebe, T.2    Nagano, O.3    Shinohara, M.4
  • 21
    • 67649095267 scopus 로고    scopus 로고
    • ADAM17 promotes breast cancer cell malignant phenotype through EGFR-PI3K-AKT activation
    • 19395875
    • ADAM17 promotes breast cancer cell malignant phenotype through EGFR-PI3K-AKT activation. Zheng X, Jiang F, Katakowski M, et al. Cancer Biol Ther 2009 8 1045 1054 19395875
    • (2009) Cancer Biol Ther , vol.8 , pp. 1045-1054
    • Zheng, X.1    Jiang, F.2    Katakowski, M.3
  • 24
    • 78649449540 scopus 로고    scopus 로고
    • Connective tissue growth factor is a substrate of ADAM28
    • 10.1016/j.bbrc.2010.10.077 20971063
    • Connective tissue growth factor is a substrate of ADAM28. Mochizuki S, Tanaka R, Shimoda M, et al. Biochem Biophys Res Commun 2010 402 651 7 10.1016/j.bbrc.2010.10.077 20971063
    • (2010) Biochem Biophys Res Commun , vol.402 , pp. 651-657
    • Mochizuki, S.1    Tanaka, R.2    Shimoda, M.3
  • 27
    • 3242799873 scopus 로고    scopus 로고
    • Increased mRNA expression of ADAMs in renal cell carcinoma and their association with clinical outcome
    • 14719095
    • Increased mRNA expression of ADAMs in renal cell carcinoma and their association with clinical outcome. Roemer A, Schwettmann L, Jung M, et al. Oncol Rep 2004 11 529 536 14719095
    • (2004) Oncol Rep , vol.11 , pp. 529-536
    • Roemer, A.1    Schwettmann, L.2    Jung, M.3
  • 28
    • 55649111365 scopus 로고    scopus 로고
    • ADAM9 Expression is a Significant and Independent Prognostic Marker of PSA Relapse in Prostate Cancer
    • 18061337
    • ADAM9 Expression is a Significant and Independent Prognostic Marker of PSA Relapse in Prostate Cancer. Fritzsche FR, Jung M, Tolle A, et al. Eur Urol 2007 54 1097 106 18061337
    • (2007) Eur Urol , vol.54 , pp. 1097-1106
    • Fritzsche, F.R.1    Jung, M.2    Tolle, A.3
  • 34
    • 52049111595 scopus 로고    scopus 로고
    • Synergistic Inhibition with a dual epidermal growth factor receptor/HER-2/neu tyrosine kinase inhibitor and a disintegrin and metalloprotease inhibitor
    • 10.1158/0008-5472.CAN-08-0739 18757423
    • Synergistic Inhibition with a dual epidermal growth factor receptor/HER-2/neu tyrosine kinase inhibitor and a disintegrin and metalloprotease inhibitor. Witters L, Scherle P, Friedman S, et al. Cancer Res 2008 68 7083 7089 10.1158/0008-5472.CAN-08-0739 18757423
    • (2008) Cancer Res , vol.68 , pp. 7083-7089
    • Witters, L.1    Scherle, P.2    Friedman, S.3
  • 36
    • 33845729910 scopus 로고    scopus 로고
    • Ectodomain shedding of the EGF-receptor ligand epigen is mediated by ADAM17
    • DOI 10.1016/j.febslet.2006.11.074, PII S0014579306014177
    • Ectodomain shedding of the EGF-receptor ligand epigen is mediated by ADAM17. Sahin U, Blobel CP, FEBS Lett 2007 581 41 44 10.1016/j.febslet.2006.11. 074 17169360 (Pubitemid 46001649)
    • (2007) FEBS Letters , vol.581 , Issue.1 , pp. 41-44
    • Sahin, U.1    Blobel, C.P.2
  • 38
    • 61449162243 scopus 로고    scopus 로고
    • Anti-epidermal growth factor receptor monotherapy in the treatment of metastatic colorectal cancer: Where are we today?
    • 10.1634/theoncologist.2008-0167 19144681
    • Anti-epidermal growth factor receptor monotherapy in the treatment of metastatic colorectal cancer: where are we today? Peeters M, Price T, Van Laethem JL, Oncologist 2009 14 29 39 10.1634/theoncologist.2008-0167 19144681
    • (2009) Oncologist , vol.14 , pp. 29-39
    • Peeters, M.1    Price, T.2    Van Laethem, J.L.3
  • 39
    • 65649142532 scopus 로고    scopus 로고
    • HER-2 signaling and inhibition in breast cancer
    • 10.2174/156800909788166484
    • HER-2 signaling and inhibition in breast cancer. Browne BC, O'Brien N, Duffy MJ, et al. Current Cancer Drug Ther 2009 9 419 38 10.2174/ 156800909788166484
    • (2009) Current Cancer Drug Ther , vol.9 , pp. 419-438
    • Browne, B.C.1    O'Brien, N.2    Duffy, M.J.3
  • 40
    • 33847718214 scopus 로고    scopus 로고
    • The EGF receptor family: Spearheading a merger of signaling and therapeutics
    • DOI 10.1016/j.ceb.2007.02.008, PII S0955067407000221
    • The EGF receptor family: spearheading a merger of signaling and therapeutics. Bublil EM, Yarden Y, Curr Opin Cell Biol 2007 19 124 34 10.1016/j.ceb.2007.02.008 17314037 (Pubitemid 46386405)
    • (2007) Current Opinion in Cell Biology , vol.19 , Issue.2 , pp. 124-134
    • Bublil, E.M.1    Yarden, Y.2
  • 41
    • 58149288674 scopus 로고    scopus 로고
    • UV-induced EGFR signal transactivation is dependent on proligand shedding by activated metalloproteases in skin cancer cell lines
    • 10.1002/ijc.23974 19003995
    • UV-induced EGFR signal transactivation is dependent on proligand shedding by activated metalloproteases in skin cancer cell lines. Singh B, Schneider M, Knyazev P, Ullrich A, Int J Cancer 2009 124 531 539 10.1002/ijc.23974 19003995
    • (2009) Int J Cancer , vol.124 , pp. 531-539
    • Singh, B.1    Schneider, M.2    Knyazev, P.3    Ullrich, A.4
  • 42
    • 77955293472 scopus 로고    scopus 로고
    • Stimulation of platelet-derived growth factor receptor beta [PDGFRbeta] activates ADAM17 and promotes metalloproteinase-dependent cross-talk between the PDGFRbeta and epidermal growth factor receptor [EGFR] signaling pathways
    • 10.1074/jbc.M110.102566 20529858
    • Stimulation of platelet-derived growth factor receptor beta [PDGFRbeta] activates ADAM17 and promotes metalloproteinase-dependent cross-talk between the PDGFRbeta and epidermal growth factor receptor [EGFR] signaling pathways. Mendelson K, Swendeman S, Saftig P, Blobel CP, J Biol Chem 2010 285 25024 32 10.1074/jbc.M110.102566 20529858
    • (2010) J Biol Chem , vol.285 , pp. 25024-25032
    • Mendelson, K.1    Swendeman, S.2    Saftig, P.3    Blobel, C.P.4
  • 43
    • 0242425875 scopus 로고    scopus 로고
    • Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF
    • DOI 10.1083/jcb.200303017
    • Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF. Nanba D, Mammoto A, Hashimoto K, et al. J Cell Biol 2003 163 489 502 10.1083/jcb.200303017 14597771 (Pubitemid 37429863)
    • (2003) Journal of Cell Biology , vol.163 , Issue.3 , pp. 489-502
    • Nanba, D.1    Mammoto, A.2    Hashimoto, K.3    Higashiyama, S.4
  • 44
    • 52449113579 scopus 로고    scopus 로고
    • Suppression of proHB-EGF carboxy-terminal fragment nuclear translocation: A new molecular target therapy for gastric cancer
    • 10.1158/1078-0432.CCR-07-4794 18559618
    • Suppression of proHB-EGF carboxy-terminal fragment nuclear translocation: a new molecular target therapy for gastric cancer. Shimura T, Kataoka H, Ogasawara N, et al. Clin Cancer Res 2008 14 3956 65 10.1158/1078-0432.CCR-07- 4794 18559618
    • (2008) Clin Cancer Res , vol.14 , pp. 3956-3965
    • Shimura, T.1    Kataoka, H.2    Ogasawara, N.3
  • 45
    • 77952896646 scopus 로고    scopus 로고
    • TGFbeta signalling: A complex web in cancer progression
    • Review 10.1038/nrc2853 20495575
    • TGFbeta signalling: a complex web in cancer progression. Ikushima H, Miyazono K, Nat Rev Cancer 2010 10 415 24 Review 10.1038/nrc2853 20495575
    • (2010) Nat Rev Cancer , vol.10 , pp. 415-424
    • Ikushima, H.1    Miyazono, K.2
  • 46
    • 67649664111 scopus 로고    scopus 로고
    • TACE-mediated ectodomain shedding of the type i TGF-beta receptor downregulates TGF-beta signaling
    • 10.1016/j.molcel.2009.06.018 19595713
    • TACE-mediated ectodomain shedding of the type I TGF-beta receptor downregulates TGF-beta signaling. Liu C, Xu P, Lamouille S, Xu J, Derynck R, Mol Cell 2009 35 26 36 10.1016/j.molcel.2009.06.018 19595713
    • (2009) Mol Cell , vol.35 , pp. 26-36
    • Liu, C.1    Xu, P.2    Lamouille, S.3    Xu, J.4    Derynck, R.5
  • 48
    • 49649103585 scopus 로고    scopus 로고
    • The ectodomain shedding of E-cadherin by ADAM15 supports ErbB receptor activation
    • 10.1074/jbc.M801329200 18434311
    • The ectodomain shedding of E-cadherin by ADAM15 supports ErbB receptor activation. Najy AJ, Day KC, Day ML, J Biol Chem 2008 283 18393 401 10.1074/jbc.M801329200 18434311
    • (2008) J Biol Chem , vol.283 , pp. 18393-18401
    • Najy, A.J.1    Day, K.C.2    Day, M.L.3
  • 49
    • 34547630698 scopus 로고    scopus 로고
    • Tumor angiogenesis: Cause or consequence of cancer?
    • DOI 10.1158/0008-5472.CAN-07-2053
    • Tumor angiogenesis: cause or consequence of cancer? Schors K, Evan G, Cancer Res 2007 67 7059 61 10.1158/0008-5472.CAN-07-2053 17671171 (Pubitemid 47206529)
    • (2007) Cancer Research , vol.67 , Issue.15 , pp. 7059-7061
    • Shchors, K.1    Evan, G.2
  • 50
    • 0035313164 scopus 로고    scopus 로고
    • Pulmonary hypoplasia in mice lacking tumor necrosis factor-α converting enzyme indicates an indispensable role for cell surface protein shedding during embryonic lung branching morphogenesis
    • DOI 10.1006/dbio.2001.0176
    • Pulmonary hypoplasia in mice lacking tumor necrosis factor-alpha converting enzyme indicates an indispensable role for cell surface protein shedding during embryonic lung branching morphogenesis. Zhao J, Chen H, Peschon JJ, et al. Dev Biol 2001 232 204 218 10.1006/dbio.2001.0176 11254358 (Pubitemid 32250955)
    • (2001) Developmental Biology , vol.232 , Issue.1 , pp. 204-218
    • Zhao, J.1    Chen, H.2    Peschon, J.J.3    Shi, W.4    Zhang, Y.5    Frank, S.J.6    Warburton, D.7
  • 51
    • 59649123850 scopus 로고    scopus 로고
    • ADAM-17 regulates endothelial cell morphology, proliferation and in vitro angiogenesis
    • 10.1016/j.bbrc.2009.01.013 19150341
    • ADAM-17 regulates endothelial cell morphology, proliferation and in vitro angiogenesis. Gooz P, Gooz M, Baldys A, et al. Biochem Biophys Res Commun 2009 380 33 8 10.1016/j.bbrc.2009.01.013 19150341
    • (2009) Biochem Biophys Res Commun , vol.380 , pp. 33-38
    • Gooz, P.1    Gooz, M.2    Baldys, A.3
  • 52
    • 0034968363 scopus 로고    scopus 로고
    • Clinical uses of tumor markers: A critical review
    • Clinical uses of tumor markers: a critical review. Duffy MJ, Crit Rev Clin Lab Sci 2001 38 225 262 10.1080/20014091084218 11451209 (Pubitemid 32614076)
    • (2001) Critical Reviews in Clinical Laboratory Sciences , vol.38 , Issue.3 , pp. 225-262
    • Duffy, M.J.1
  • 53
    • 10944263573 scopus 로고    scopus 로고
    • ADAM 12 cleaves extracellular matrix proteins and correlates with cancer status and stage
    • DOI 10.1074/jbc.M409565200
    • ADAM 12 cleaves extracellular matrix proteins and correlates with cancer status and stage. Roy R, Wewer UM, Zurakowski D, Pories SE, Moses MA, J Biol Chem 2004 279 51323 30 10.1074/jbc.M409565200 15381692 (Pubitemid 40017878)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.49 , pp. 51323-51330
    • Roy, R.1    Wewer, U.M.2    Zurakowski, D.3    Pories, S.E.4    Moses, M.A.5
  • 55
    • 33644544070 scopus 로고    scopus 로고
    • Serum tumor markers in breast cancer: Are they of clinical value?
    • 10.1373/clinchem.2005.059832 16410341
    • Serum tumor markers in breast cancer: are they of clinical value? Duffy MJ, Clin Chem 2006 52 345 51 10.1373/clinchem.2005.059832 16410341
    • (2006) Clin Chem , vol.52 , pp. 345-351
    • Duffy, M.J.1
  • 59
    • 14544270950 scopus 로고    scopus 로고
    • Predictive markers in breast and other cancers: A review
    • DOI 10.1373/clinchem.2004.046227
    • Predictive markers in breast and other cancers: a review. Duffy MJ, Clin Chem 2005 51 494 503 10.1373/clinchem.2004.046227 15637130 (Pubitemid 40300223)
    • (2005) Clinical Chemistry , vol.51 , Issue.3 , pp. 494-503
    • Duffy, M.J.1
  • 62
    • 3843096112 scopus 로고    scopus 로고
    • Inhibition of the tumor necrosis factor-α-converting enzyme by its pro domain
    • DOI 10.1074/jbc.M401311200
    • Gonzales PE, Solomon A, Miller AB, et al. J Biol Chem 2004 279 31638 31645 Kveiborg M, Jacobsen J, Lee M-H, et al. Inhibition of the tumor necrosis factor-alpha-converting enzyme by its pro domain. J Biol Chem 2004, 279:31638-45 10.1074/jbc.M401311200 15100227 (Pubitemid 39037834)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.30 , pp. 31638-31645
    • Gonzales, P.E.1    Solomon, A.2    Miller, A.B.3    Leesnitzer, M.A.4    Sagis, I.5    Milla, M.E.6
  • 63
    • 42449131043 scopus 로고    scopus 로고
    • The isolated N-terminal domains of TIMP-1 and TIMP-3 are insufficient for ADAM10 inhibition
    • DOI 10.1042/BJ20071430
    • The isolated N-terminal domains of TIMP-1 and TIMP-3 are insufficient for ADAM10 inhibition. Rapti M, Atkinson SJ, Lee MH, Trim A, Moss M, Murphy G, Biochem J 2008 411 433 9 10.1042/BJ20071430 18215140 (Pubitemid 351580196)
    • (2008) Biochemical Journal , vol.411 , Issue.2 , pp. 433-439
    • Rapti, M.1    Atkinson, S.J.2    Lee, M.-H.3    Trim, A.4    Moss, M.5    Murphy, G.6
  • 64
    • 77955505776 scopus 로고    scopus 로고
    • Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 [TIMP-2]
    • 10.1042/BJ20100649 20533908
    • Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 [TIMP-2]. Kveiborg M, Jacobsen J, Lee MH, Nagase H, Wewer UM, Murphy G, Biochem J 2010 430 79 86 10.1042/BJ20100649 20533908
    • (2010) Biochem J , vol.430 , pp. 79-86
    • Kveiborg, M.1    Jacobsen, J.2    Lee, M.H.3    Nagase, H.4    Wewer, U.M.5    Murphy, G.6
  • 65
    • 11244269560 scopus 로고    scopus 로고
    • Increased expression of ADAM family members in human breast cancer and breast cancer cell lines
    • 10.1007/s00432-004-0619-y
    • Increased expression of ADAM family members in human breast cancer and breast cancer cell lines. Lendeckel U, Kohl J, Arndt M, et al. J Clin Res Clin Oncol 2005 131 41 8 10.1007/s00432-004-0619-y
    • (2005) J Clin Res Clin Oncol , vol.131 , pp. 41-48
    • Lendeckel, U.1    Kohl, J.2    Arndt, M.3
  • 66
    • 33645844249 scopus 로고    scopus 로고
    • Synthesis and structure-activity relationship of a novel achiral series of TNF-alpha converting enzyme inhibitors
    • 10.1016/j.bmcl.2006.02.015
    • Synthesis and structure-activity relationship of a novel achiral series of TNF-alpha converting enzyme inhibitors. Gilmore JL, King BW, Harris K, et al. Bioorganic Med Chem 2006 16 2699 704 10.1016/j.bmcl.2006.02.015
    • (2006) Bioorganic Med Chem , vol.16 , pp. 2699-2704
    • Gilmore, J.L.1    King, B.W.2    Harris, K.3
  • 68
    • 44849120587 scopus 로고    scopus 로고
    • Drug Insight: Tumor necrosis factor-converting enzyme as a pharmaceutical target for rheumatoid arthritis
    • DOI 10.1038/ncprheum0797, PII NCPRHEUM0797
    • Drug insight: tumor necrosis factor-converting enzyme as a pharmaceutical target for rheumatoid arthritis. Moss ML, Sklair-Tavron L, Nudelman R, Nat Clin Pract Rheumatol 2008 4 300 9 10.1038/ncprheum0797 18414459 (Pubitemid 351791441)
    • (2008) Nature Clinical Practice Rheumatology , vol.4 , Issue.6 , pp. 300-309
    • Moss, M.L.1    Sklair-Tavron, L.2    Nudelman, R.3
  • 70
    • 63449123884 scopus 로고    scopus 로고
    • Preclinical characterization of INCB7839, a potent and selective inhibitor of ErbB ligand and HER2 receptor shedding: Inhibition of ADAM10 and ADAM17 for the treatment of breast cancer
    • Preclinical characterization of INCB7839, a potent and selective inhibitor of ErbB ligand and HER2 receptor shedding: inhibition of ADAM10 and ADAM17 for the treatment of breast cancer. Fridman JS, Scherle PA, Liu X, et al. Breast Cancer Res Treat 2007 106 Supp1 82
    • (2007) Breast Cancer Res Treat , vol.106 , Issue.SUPPL. , pp. 1982
    • Fridman, J.S.1    Scherle, P.A.2    Liu, X.3
  • 71
    • 63449120497 scopus 로고    scopus 로고
    • A multicenter phase Ib study of the safety, pharmacokinetics, biological activity and clinical efficacy of INCB7839, a potent and selective inhibitor of ADAM10 and ADAM17
    • A multicenter phase Ib study of the safety, pharmacokinetics, biological activity and clinical efficacy of INCB7839, a potent and selective inhibitor of ADAM10 and ADAM17. Infante J, Burris HA, Lewis N, et al. Breast Cancer Res Treat 2007 106 Supp1 269
    • (2007) Breast Cancer Res Treat , vol.106 , Issue.SUPPL. , pp. 19269
    • Infante, J.1    Burris, H.A.2    Lewis, N.3
  • 72
    • 79960211001 scopus 로고    scopus 로고
    • Clinical benefit of INCB7839, a potential and selective ADAM inhibitor, in combination with trastuzumab in patients with metastatic HER2-positive breast cancer
    • ABST 3025
    • Clinical benefit of INCB7839, a potential and selective ADAM inhibitor, in combination with trastuzumab in patients with metastatic HER2-positive breast cancer. Newton RC, Bradley EC, Levy RS, et al. J Clin Oncol 2010 28 Suppl; abst 3025 7s
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL.
    • Newton, R.C.1    Bradley, E.C.2    Levy, R.S.3
  • 76
    • 33846120591 scopus 로고    scopus 로고
    • Matrix metalloproteinases as valid clinical targets
    • DOI 10.2174/138161207779313551
    • Matrix metalloproteinases as valid clinical targets. Fingleton B, Current Pharm Design 2007 13 333 46 10.2174/138161207779313551 (Pubitemid 46085282)
    • (2007) Current Pharmaceutical Design , vol.13 , Issue.3 , pp. 333-346
    • Fingleton, B.1
  • 77
    • 0034722898 scopus 로고    scopus 로고
    • Critical appraisal of the use of matrix metalloproteinase inhibitors in cancer treatment
    • DOI 10.1038/sj.onc.1204097
    • Critical appraisal of the use of matrix metalloproteinases inhibitors in cancer treatment. Zucker S, Cao J, Chen W-T, Oncogene 2000 19 6642 650 10.1038/sj.onc.1204097 11426650 (Pubitemid 32197703)
    • (2000) Oncogene , vol.19 , Issue.56 , pp. 6642-6650
    • Zucker, S.1    Cao, J.2    Chen, W.-T.3
  • 78
    • 0029991439 scopus 로고    scopus 로고
    • Phase II study of weakly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu overexpressing metastatic breast cancer
    • 8622019
    • Phase II study of weakly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu overexpressing metastatic breast cancer. Baselga J, Tripathy D, Mendelsohn J, et al. J Clin Oncol 1996 14 737 744 8622019
    • (1996) J Clin Oncol , vol.14 , pp. 737-744
    • Baselga, J.1    Tripathy, D.2    Mendelsohn, J.3
  • 79
    • 0032850677 scopus 로고    scopus 로고
    • Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease
    • Multinational study of the efficiacy and safety of humanised anti-HER2 monoclonal antibody in women who have HER2 overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. Cobleigh MA, Vogel CL, Tripathy D, Robert NJ, Scholl S, Fehrenbacher L, et al. J Clin Oncol 1999 17 2639 2648 10561337 (Pubitemid 29415219)
    • (1999) Journal of Clinical Oncology , vol.17 , Issue.9 , pp. 2639-2648
    • Cobleigh, M.A.1    Vogel, C.L.2    Tripathy, D.3    Robert, N.J.4    Scholl, S.5    Fehrenbacher, L.6    Wolter, J.M.7    Paton, V.8    Shak, S.9    Lieberman, G.10    Slamon, D.J.11


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.