메뉴 건너뛰기




Volumn 6, Issue , 2016, Pages

A Dual Target-directed Agent against Interleukin-6 Receptor and Tumor Necrosis Factor α ameliorates experimental arthritis

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; HYBRID PROTEIN; IMMUNOGLOBULIN FC FRAGMENT; INTERLEUKIN 6 RECEPTOR; PEPTIDE LIBRARY; TUMOR NECROSIS FACTOR RECEPTOR 2;

EID: 84957542150     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep20150     Document Type: Article
Times cited : (29)

References (49)
  • 1
    • 84858795041 scopus 로고    scopus 로고
    • Current understanding of rheumatoid arthritis therapy
    • Colmegna, I., Ohata, B. R. & Menard, H. A. Current understanding of rheumatoid arthritis therapy. Clin Pharmacol Ther 91, 607-620 (2012).
    • (2012) Clin Pharmacol Ther , vol.91 , pp. 607-620
    • Colmegna, I.1    Ohata, B.R.2    Menard, H.A.3
  • 2
    • 79955040826 scopus 로고    scopus 로고
    • New therapies in the management of rheumatoid arthritis
    • Buch, M. H. & Emery, P. New therapies in the management of rheumatoid arthritis. Curr Opin Rheumatol 23, 245-251 (2011).
    • (2011) Curr Opin Rheumatol , vol.23 , pp. 245-251
    • Buch, M.H.1    Emery, P.2
  • 3
    • 77951529848 scopus 로고    scopus 로고
    • Therapeutic antibodies for autoimmunity and inflammation
    • Chan, A. C. & Carter, P. J. Therapeutic antibodies for autoimmunity and inflammation. Nat Rev Immunol 10, 301-316 (2010).
    • (2010) Nat Rev Immunol , vol.10 , pp. 301-316
    • Chan, A.C.1    Carter, P.J.2
  • 4
    • 34249720998 scopus 로고    scopus 로고
    • Cytokines in the pathogenesis of rheumatoid arthritis
    • McInnes, I. B. & Schett, G. Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol 7, 429-442 (2007).
    • (2007) Nat Rev Immunol , vol.7 , pp. 429-442
    • McInnes, I.B.1    Schett, G.2
  • 5
    • 77952746394 scopus 로고    scopus 로고
    • Pharmacology of TNF blockade in rheumatoid arthritis and other chronic inflammatory diseases
    • Taylor, P. C. Pharmacology of TNF blockade in rheumatoid arthritis and other chronic inflammatory diseases. Curr Opin Pharmacol 10, 308-315 (2010).
    • (2010) Curr Opin Pharmacol , vol.10 , pp. 308-315
    • Taylor, P.C.1
  • 6
    • 76249131022 scopus 로고    scopus 로고
    • P2X(1) and P2X(3) purinergic receptors differentially modulate the inflammatory response in human osteoarthritic synovial fibroblasts
    • Varani, K. et al. P2X(1) and P2X(3) purinergic receptors differentially modulate the inflammatory response in human osteoarthritic synovial fibroblasts. Cell Physiol Biochem 25, 325-336 (2010).
    • (2010) Cell Physiol Biochem , vol.25 , pp. 325-336
    • Varani, K.1
  • 7
    • 0013511183 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-fc fusion protein
    • Moreland, L. W. et al. Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein. N Engl J Med 337, 141-147 (1997).
    • (1997) N Engl J Med , vol.337 , pp. 141-147
    • Moreland, L.W.1
  • 8
    • 0033574147 scopus 로고    scopus 로고
    • Etanercept therapy in rheumatoid arthritis. A randomized, controlled trial
    • Moreland, L. W. et al. Etanercept therapy in rheumatoid arthritis. A randomized, controlled trial. Ann Intern Med 130, 478-486 (1999).
    • (1999) Ann Intern Med , vol.130 , pp. 478-486
    • Moreland, L.W.1
  • 9
    • 0036274944 scopus 로고    scopus 로고
    • Etanercept versus methotrexate in patients with early rheumatoid arthritis: Two-year radiographic and clinical outcomes
    • Genovese, M. C. et al. Etanercept versus methotrexate in patients with early rheumatoid arthritis: two-year radiographic and clinical outcomes. Arthritis Rheum 46, 1443-1450 (2002).
    • (2002) Arthritis Rheum , vol.46 , pp. 1443-1450
    • Genovese, M.C.1
  • 10
    • 0027136189 scopus 로고
    • Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6
    • Tamura, T. et al. Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6. Proc Natl Acad Sci USA 90, 11924-11928 (1993).
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 11924-11928
    • Tamura, T.1
  • 11
    • 0027518860 scopus 로고
    • Serum interleukin 6 levels in rheumatoid arthritis: Correlations with clinical and laboratory indices of disease activity
    • Madhok, R., Crilly, A., Watson, J. & Capell, H. A. Serum interleukin 6 levels in rheumatoid arthritis: correlations with clinical and laboratory indices of disease activity. Ann Rheum Dis 52, 232-234 (1993).
    • (1993) Ann Rheum Dis , vol.52 , pp. 232-234
    • Madhok, R.1    Crilly, A.2    Watson, J.3    Capell, H.A.4
  • 12
    • 79952772288 scopus 로고    scopus 로고
    • Tocilizumab: Is there life beyond anti-TNF blockade?
    • Alves, J. D., Marinho, A. & Serra, M. J. Tocilizumab: is there life beyond anti-TNF blockade? Int J Clin Pract 65, 508-513 (2011).
    • (2011) Int J Clin Pract , vol.65 , pp. 508-513
    • Alves, J.D.1    Marinho, A.2    Serra, M.J.3
  • 13
    • 40749114497 scopus 로고    scopus 로고
    • Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): A double-blind, placebo-controlled, randomised trial
    • Smolen, J. S. et al. Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial. Lancet 371, 987-997 (2008).
    • (2008) Lancet , vol.371 , pp. 987-997
    • Smolen, J.S.1
  • 14
    • 84873600423 scopus 로고    scopus 로고
    • Tocilizumab inhibits structural joint damage and improves physical function in patients with rheumatoid arthritis and inadequate responses to methotrexate: LITHE study 2-year results
    • Fleischmann, R. M. et al. Tocilizumab inhibits structural joint damage and improves physical function in patients with rheumatoid arthritis and inadequate responses to methotrexate: LITHE study 2-year results. J Rheumatol 40, 113-126 (2013).
    • (2013) J Rheumatol , vol.40 , pp. 113-126
    • Fleischmann, R.M.1
  • 15
    • 2642558925 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: A multicenter, doubleblind, placebo-controlled trial
    • Nishimoto, N. et al. Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multicenter, doubleblind, placebo-controlled trial. Arthritis Rheum 50, 1761-1769 (2004).
    • (2004) Arthritis Rheum , vol.50 , pp. 1761-1769
    • Nishimoto, N.1
  • 16
    • 62849110339 scopus 로고    scopus 로고
    • Available therapeutic options following failure of a first anti-TNF agent
    • Silman, A. J. Available therapeutic options following failure of a first anti-TNF agent. Nat Clin Pract Rheumatol 5, 115 (2009).
    • (2009) Nat Clin Pract Rheumatol , vol.5 , pp. 115
    • Silman, A.J.1
  • 17
    • 0347302952 scopus 로고    scopus 로고
    • Cytokines in cancer pathogenesis and cancer therapy
    • Dranoff, G. Cytokines in cancer pathogenesis and cancer therapy. Nat Rev Cancer 4, 11-22 (2004).
    • (2004) Nat Rev Cancer , vol.4 , pp. 11-22
    • Dranoff, G.1
  • 18
    • 77951523463 scopus 로고    scopus 로고
    • Bispecific antibodies for cancer therapy: The light at the end of the tunnel?
    • Chames, P. & Baty, D. Bispecific antibodies for cancer therapy: the light at the end of the tunnel? MAbs 1, 539-547 (2009).
    • (2009) MAbs , vol.1 , pp. 539-547
    • Chames, P.1    Baty, D.2
  • 19
    • 77951596808 scopus 로고    scopus 로고
    • Catumaxomab: Clinical development and future directions
    • Linke, R., Klein, A. & Seimetz, D. Catumaxomab: clinical development and future directions. MAbs 2, 129-136 (2010).
    • (2010) MAbs , vol.2 , pp. 129-136
    • Linke, R.1    Klein, A.2    Seimetz, D.3
  • 20
    • 77954232707 scopus 로고    scopus 로고
    • Therapeutic control of B cell activation via recruitment of fcgamma receptor IIb (CD32B) inhibitory function with a novel bispecific antibody scaffold
    • Veri, M. C. et al. Therapeutic control of B cell activation via recruitment of Fcgamma receptor IIb (CD32B) inhibitory function with a novel bispecific antibody scaffold. Arthritis Rheum 62, 1933-1943 (2010).
    • (2010) Arthritis Rheum , vol.62 , pp. 1933-1943
    • Veri, M.C.1
  • 21
    • 84866552180 scopus 로고    scopus 로고
    • Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis
    • Kanakaraj, P. et al. Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis. MAbs 4, 600-613 (2012).
    • (2012) MAbs , vol.4 , pp. 600-613
    • Kanakaraj, P.1
  • 22
    • 84868564380 scopus 로고    scopus 로고
    • A bispecific antibody against IL-1β and IL-17A is beneficial for experimental rheumatoid arthritis
    • Qi, J. et al. A bispecific antibody against IL-1β and IL-17A is beneficial for experimental rheumatoid arthritis. Int Immunopharmacol 14, 770-778 (2012).
    • (2012) Int Immunopharmacol , vol.14 , pp. 770-778
    • Qi, J.1
  • 23
    • 84904262338 scopus 로고    scopus 로고
    • A novel bispecific antibody targeting tumor necrosis factor α and ED-B fibronectin effectively inhibits the progression of established collagen-induce arthritis
    • Liu, M. et al. A novel bispecific antibody targeting tumor necrosis factor α and ED-B fibronectin effectively inhibits the progression of established collagen-induce arthritis. J Biotechnol 186, 1-12 (2014).
    • (2014) J Biotechnol , vol.186 , pp. 1-12
    • Liu, M.1
  • 24
    • 33846219169 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha induces vascular endothelial growth factor-C expression in rheumatoid synoviocytes
    • Cha, H. S. et al. Tumor necrosis factor-alpha induces vascular endothelial growth factor-C expression in rheumatoid synoviocytes. J Rheumatol 34, 16-19 (2007).
    • (2007) J Rheumatol , vol.34 , pp. 16-19
    • Cha, H.S.1
  • 25
    • 0025939257 scopus 로고
    • Expression of granulocyte-macrophage colony-stimulating factor in rheumatoid arthritis: Regulation by tumor necrosis factor-alpha
    • Haworth, C. et al. Expression of granulocyte-macrophage colony-stimulating factor in rheumatoid arthritis: regulation by tumor necrosis factor-alpha. Eur J Immunol 21, 2575-2579 (1991).
    • (1991) Eur J Immunol , vol.21 , pp. 2575-2579
    • Haworth, C.1
  • 26
    • 84937346392 scopus 로고    scopus 로고
    • Paeonol inhibited TNF-alpha-induced GM-CSF expression in fibroblast-like synoviocytes
    • Li, Y., Li, P., Lin, S. H., Zheng, Y. Q. & Zheng, X. X. Paeonol inhibited TNF-alpha-induced GM-CSF expression in fibroblast-like synoviocytes. Int J Clin Pharmacol Ther 52, 986-996 (2014).
    • (2014) Int J Clin Pharmacol Ther , vol.52 , pp. 986-996
    • Li, Y.1    Li, P.2    Lin, S.H.3    Zheng, Y.Q.4    Zheng, X.X.5
  • 27
    • 80052333632 scopus 로고    scopus 로고
    • Interleukin-6 plays an essential role in hypoxia-inducible factor 2alpha-induced experimental osteoarthritic cartilage destruction in mice
    • Ryu, J. H. et al. Interleukin-6 plays an essential role in hypoxia-inducible factor 2alpha-induced experimental osteoarthritic cartilage destruction in mice. Arthritis Rheum 63, 2732-2743 (2011).
    • (2011) Arthritis Rheum , vol.63 , pp. 2732-2743
    • Ryu, J.H.1
  • 28
    • 32844464795 scopus 로고    scopus 로고
    • IL-6 modulates alpha-smooth muscle actin expression in dermal fibroblasts from IL-6-deficient mice
    • Gallucci, R. M., Lee, E. G. & Tomasek, J. J. IL-6 modulates alpha-smooth muscle actin expression in dermal fibroblasts from IL-6-deficient mice. J Invest Dermatol 126, 561-568 (2006).
    • (2006) J Invest Dermatol , vol.126 , pp. 561-568
    • Gallucci, R.M.1    Lee, E.G.2    Tomasek, J.J.3
  • 29
    • 69449090213 scopus 로고    scopus 로고
    • Inhibition of interleukin-6 receptor directly blocks osteoclast formation in vitro and in vivo
    • Axmann, R. et al. Inhibition of interleukin-6 receptor directly blocks osteoclast formation in vitro and in vivo. Arthritis Rheum 60, 2747-2756 (2009).
    • (2009) Arthritis Rheum , vol.60 , pp. 2747-2756
    • Axmann, R.1
  • 30
    • 33748092926 scopus 로고    scopus 로고
    • Interleukin-6 and rheumatic diseases
    • Lipsky, P. E. Interleukin-6 and rheumatic diseases. Arthritis Res Ther 8 (Suppl 2), S4 (2006).
    • (2006) Arthritis Res Ther , vol.8 , pp. S4
    • Lipsky, P.E.1
  • 31
    • 84872299740 scopus 로고    scopus 로고
    • Etanercept attenuates collagen-induced arthritis by modulating the association between BAFFR expression and the production of splenic memory B cells
    • Wang, Q. T. et al. Etanercept attenuates collagen-induced arthritis by modulating the association between BAFFR expression and the production of splenic memory B cells. Pharmacol Res 68, 38-45 (2013).
    • (2013) Pharmacol Res , vol.68 , pp. 38-45
    • Wang, Q.T.1
  • 32
    • 84905568296 scopus 로고    scopus 로고
    • A new strategy to deliver synthetic protein drugs: Self-reproducible biologics using minicircles
    • Yi, H. et al. A new strategy to deliver synthetic protein drugs: self-reproducible biologics using minicircles. Sci Rep 4, 5961 (2014).
    • (2014) Sci Rep , vol.4 , pp. 5961
    • Yi, H.1
  • 33
    • 0041315884 scopus 로고    scopus 로고
    • Minicircle DNA vectors devoid of bacterial DNA result in persistent and high-level transgene expression in vivo
    • Chen, Z. Y., He, C. Y., Ehrhardt, A. & Kay, M. A. Minicircle DNA vectors devoid of bacterial DNA result in persistent and high-level transgene expression in vivo. Mol Ther 8, 495-500 (2003).
    • (2003) Mol Ther , vol.8 , pp. 495-500
    • Chen, Z.Y.1    He, C.Y.2    Ehrhardt, A.3    Kay, M.A.4
  • 34
    • 13844292517 scopus 로고    scopus 로고
    • Improved production and purification of minicircle DNA vector free of plasmid bacterial sequences and capable of persistent transgene expression in vivo
    • Chen, Z. Y., He, C. Y. & Kay, M. A. Improved production and purification of minicircle DNA vector free of plasmid bacterial sequences and capable of persistent transgene expression in vivo. Hum Gene Ther 16, 126-131 (2005).
    • (2005) Hum Gene Ther , vol.16 , pp. 126-131
    • Chen, Z.Y.1    He, C.Y.2    Kay, M.A.3
  • 35
    • 84871919467 scopus 로고    scopus 로고
    • Minicircle DNA vectors achieve sustained expression reflected by active chromatin and transcriptional level
    • Gracey Maniar, L. E. et al. Minicircle DNA vectors achieve sustained expression reflected by active chromatin and transcriptional level. Mol Ther 21, 131-138 (2012).
    • (2012) Mol Ther , vol.21 , pp. 131-138
    • Gracey Maniar, L.E.1
  • 36
    • 84858257263 scopus 로고    scopus 로고
    • Dual targeting strategies with bispecific antibodies
    • Kontermann, R. E. Dual targeting strategies with bispecific antibodies. MAbs 4, 182-197 (2012).
    • (2012) MAbs , vol.4 , pp. 182-197
    • Kontermann, R.E.1
  • 37
    • 84886099419 scopus 로고    scopus 로고
    • A tale of two specificities: Bispecific antibodies for therapeutic and diagnostic applications
    • Byrne, H., Conroy, P. J., Whisstock, J. C. & O'Kennedy, R. J. A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications. Trends Biotechnol 31, 621-632 (2013).
    • (2013) Trends Biotechnol , vol.31 , pp. 621-632
    • Byrne, H.1    Conroy, P.J.2    Whisstock, J.C.3    O'Kennedy, R.J.4
  • 38
    • 80155150449 scopus 로고    scopus 로고
    • Buy buy bispecific antibodies
    • Holmes, D. Buy buy bispecific antibodies. Nat Rev Drug Discov 10, 798-800 (2011).
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 798-800
    • Holmes, D.1
  • 41
    • 79957636974 scopus 로고    scopus 로고
    • Baseline tumour necrosis factor alpha levels predict the necessity for dose escalation of infliximab therapy in patients with rheumatoid arthritis
    • Takeuchi, T. et al. Baseline tumour necrosis factor alpha levels predict the necessity for dose escalation of infliximab therapy in patients with rheumatoid arthritis. Ann Rheum Dis 70, 1208-1215 (2011).
    • (2011) Ann Rheum Dis , vol.70 , pp. 1208-1215
    • Takeuchi, T.1
  • 42
    • 26844553332 scopus 로고    scopus 로고
    • Anti-tumor necrosis factor (TNF) therapy in rheumatoid arthritis: Correlation of TNFalpha serum level with clinical response and benefit from changing dose or frequency of infliximab infusions
    • Edrees, A. F., Misra, S. N. & Abdou, N. I. Anti-tumor necrosis factor (TNF) therapy in rheumatoid arthritis: correlation of TNFalpha serum level with clinical response and benefit from changing dose or frequency of infliximab infusions. Clin Exp Rheumatol 23, 469-474 (2005).
    • (2005) Clin Exp Rheumatol , vol.23 , pp. 469-474
    • Edrees, A.F.1    Misra, S.N.2    Abdou, N.I.3
  • 43
    • 0037224934 scopus 로고    scopus 로고
    • Synergistic effect on the attenuation of collagen induced arthritis in tumor necrosis factor receptor I (TNFRI) and interleukin 6 double knockout mice
    • Yamaguchi, N. et al. Synergistic effect on the attenuation of collagen induced arthritis in tumor necrosis factor receptor I (TNFRI) and interleukin 6 double knockout mice. J Rheumatol 30, 22-27 (2003).
    • (2003) J Rheumatol , vol.30 , pp. 22-27
    • Yamaguchi, N.1
  • 44
    • 52149099504 scopus 로고    scopus 로고
    • IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: Results from a 24-week multicentre randomised placebo-controlled trial
    • Emery, P. et al. IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial. Ann Rheum Dis 67, 1516-1523 (2008).
    • (2008) Ann Rheum Dis , vol.67 , pp. 1516-1523
    • Emery, P.1
  • 45
    • 84866506602 scopus 로고    scopus 로고
    • IL-6 receptor inhibition positively modulates bone balance in rheumatoid arthritis patients with an inadequate response to anti-tumor necrosis factor therapy: Biochemical marker analysis of bone metabolism in the tocilizumab RADIATE study (NCT00106522)
    • Karsdal, M. A. et al. IL-6 receptor inhibition positively modulates bone balance in rheumatoid arthritis patients with an inadequate response to anti-tumor necrosis factor therapy: biochemical marker analysis of bone metabolism in the tocilizumab RADIATE study (NCT00106522). Semin Arthritis Rheum 42, 131-139 (2012).
    • (2012) Semin Arthritis Rheum , vol.42 , pp. 131-139
    • Karsdal, M.A.1
  • 46
    • 40649110475 scopus 로고    scopus 로고
    • + T cells in collageninduced arthritis
    • + T cells in collageninduced arthritis. Immunol Lett 117, 16-25 (2008).
    • (2008) Immunol Lett , vol.117 , pp. 16-25
    • Ju, J.H.1
  • 47
    • 70350503333 scopus 로고    scopus 로고
    • Attenuation of murine antigen-induced arthritis by treatment with a decoy oligodeoxynucleotide inhibiting signal transducer and activator of transcription-1 (STAT-1)
    • Hückel, M. et al. Attenuation of murine antigen-induced arthritis by treatment with a decoy oligodeoxynucleotide inhibiting signal transducer and activator of transcription-1 (STAT-1). Arthritis Res Ther 8, R17 (2006).
    • (2006) Arthritis Res Ther , vol.8 , pp. R17
    • Hückel, M.1
  • 48
    • 78650028269 scopus 로고    scopus 로고
    • A robust system for production of minicircle DNA vectors
    • Kay, M. A., He, C. Y. & Chen, Z. Y. A robust system for production of minicircle DNA vectors. Nat Biotechnol 28, 1287-1289 (2010).
    • (2010) Nat Biotechnol , vol.28 , pp. 1287-1289
    • Kay, M.A.1    He, C.Y.2    Chen, Z.Y.3
  • 49
    • 79960492398 scopus 로고    scopus 로고
    • IL-23 is critical for induction of arthritis, osteoclast formation, and maintenance of bone mass
    • Adamopoulos, I. E. et al. IL-23 is critical for induction of arthritis, osteoclast formation, and maintenance of bone mass. J Immunol 187, 951-959 (2011).
    • (2011) J Immunol , vol.187 , pp. 951-959
    • Adamopoulos, I.E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.