Enantioselective synthesis of α-methyl-β-cyclopropyldihydrocinnamates

Journal of Organic Chemistry

Volumn 81, Issue 3, 2016, Pages 824-830

  Christensen, Melodie ^a   Nolting, Andrew ^a   Shevlin, Michael ^a   Weisel, Mark ^a   Maligres, Peter E ^a   Lee, Joshua ^a   Orr, Robert K ^a   Plummer, Christopher W ^a   Tudge, Matthew T ^a   Campeau, Louis Charles ^a   Ruck, Rebecca T ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOACTIVITY; CHEMICAL REACTIONS;

ASYMMETRIC HYDROGENATION; DIASTEREOSELECTIVITIES; DRUG CANDIDATES; ENANTIOSELECTIVE SYNTHESIS; HIGH SELECTIVITY; HIGH THROUGHPUT EXPERIMENTATION; PHARMACOPHORES; SUZUKI-MIYAURA CROSS-COUPLING;

HYDROGENATION;

HYDROCINNAMIC ACID; METHYL 3 CYCLOPROPYL 2 METHYL 3 (TOSYLOXY)ACRYLATE; METHYL 3 CYCLOPROPYL 2 METHYL 3 OXOPROPANOATE; METHYL 3 CYCLOPROPYL 3 (2 FLUORO 3 HYDROXYPHENYL) 2 METHYL ACRYLATE; METHYL 3 CYCLOPROPYL 3 (2 FLUORO 3 HYDROXYPHENYL) 2 METHYLPROPANOATE; METHYL 3 [3 (BENZYLOXY)PHENYL] 3 CYCLOPROPYL 2 METHYL ACRYLATE; METHYL 3 [3 (BENZYLOXY)PHENYL] 3 CYCLOPROPYL 2 METHYLPROPANOATE; METHYL 3 [4 (BENZYLOXY)PHENYL] 3 CYCLOPROPYL 2 METHYL ACRYLATE; METHYL 3 [4 (BENZYLOXY)PHENYL] 3 CYCLOPROPYL 2 METHYLPROPANOATE; UNCLASSIFIED DRUG;

ARTICLE; CATALYST; CROSS COUPLING REACTION; DRUG SYNTHESIS; ENANTIOSELECTIVITY; HYDROGENATION; ISOMERIZATION; PHARMACOPHORE; STEREOCHEMISTRY; STEREOISOMERISM; SUZUKI REACTION;

EID: 84957535611     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/acs.joc.5b02296     Document Type: Article

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